Sickle Cell Disease : Definition, Pathophysiology, Clinical & Lab Findings, Treatment
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- Опубликовано: 7 сен 2013
- Sickle Cell Disease is a hereditary disorder of Haemoglobin. An abnormal haemoglobin named HbS is responsible for this disease . This video will discuss Sickle Cell Disease and try to answer the following questions . Hope it is helpful - Dr. Rabiul
What is Sickle Cell Disease ?
What is hemoglobinopathy ?
What is Haemoglobin S ?
What do we mean by Sickle Cell ?
How Sickle Cells are formed ?
Variables of Sickling .
Problems caused by HbS - haemolysis, microvascular occlusion, tissue damage .
Why HbS protects from falciparum malaria
Common clinical findings of Sickcle Cell Disease
Common lab findings of Sickle Cell Disease
Treatment options
My new RUclips video ! "Sickle Cell Disease" . Topics covered are -
What is Sickle Cell Disease ?
What is hemoglobinopathy ?
What is Haemoglobin S ?
What do we mean by Sickle Cell ?
How Sickle Cells are formed ?
Homozygous vs Heterozygous point mutation of HbS .
Role of calcium , potassium channels and water in sickling of RBC .
Variables of Sickling .
Problems caused by HbS - haemolysis, microvascular occlusion, tissue damage .
Vasoocclusive crises .
Splenic crises .
Autosplenectomy in Sickle Cell Disease .
Acute Chest Syndrome .
Hand and Foot Disease .
Renal problems in Sickle Cell Disease .
Why HbS protects from falciparum malaria .
Common clinical findings of Sickcle Cell Disease .
Common lab findings of Sickle Cell Disease .
Treatment options .
If you like this video don't forget to comment and like this video in my youtube channel ruclips.net/user/DrRabiulHaque
Subcribe to my channel for more videos coming soon !
What do U know about Sickle Cell? Find out what Sickle Cell Patients Go Through Up Close & Personal w/@LyricalXteele t.co/nUm7MKbzZs
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this was so helpful thnx
Thanks
Dr. Rabiul Thank you for making all your videos. You explained pathophysiology very well and I am a big fan.
+Perfect Blue Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
Thank you so mush for your detailed videos. It`s really helping me through medical school. God bless you.
Thank you very much! I'm working towards an NP degree and I have found many many of your videos to be helpful in achieving understanding!!
brenda karibian Thank you very much for liking my videos. Glad to know they were helpful. Best wishes from Bangladesh.
It was in 2014 when I found this video with a friend on his laptop...and here we are in 2022, I found it on RUclips. Powerful and most expensive information given for free...Thankyou so much
Thank you for your feedback. Take care and stay blessed.
Have found it very very useful.
Presentation was clear and wasn't first and was able to get clearly every steps
Thank you for your feedback, wish you all the best.
i loved your clarity, you made this so easy to understand, thank you veery much
Katherine Stevenson Thank you for your kind comments. Glad to know it was easy to understand. I have uploaded a new video about wound healing. You can check it out too ! Here is it's link: Wound Healing: Part 1 - Concept of Regeneration, Repair, Granulation Tissue & Angiogenesis (HD) Take care and stay blessed. Best wishes from Bangladesh.
Thanks a lot,Sir.
All of your lectures are very very helpful and effective. God bless you.
Hope we'll get a lot of your lectures soon.
Thanks for liking my videos , I just bought a new camera !! (Canon 700D ) Hope to make and upload a new video next week with it ! take care and God bless you too ! :)
thnkuu
your all lecture videos are very helpfull
May Allah Bless u
If it weren’t for you I wouldn’t have passed my finals , thank you sir or should i say the greatest tutor , god bless you and I’ll always pray for you 🙏
Thank you for your feedback. Take care and stay blessed.
Thank you so much Doctor for the amzing lecture. That was very helpful, may Allah bless you !
Greetings from Algeria :)
+TheUmmaHope Alhamdulillah ! Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
The video has been very educative and it is concise and succinct too.
ALI SAINE Thank you very much for liking my video. Glad to know it was helpful. Take care and stay blessed. Best wishes from Bangladesh.
ur explanation is very nice sir &ur very talented , Thk u 4r giving ur wonderful explanation
Thanks. Dear , as a lecturer of haematology , have enjoyed.
Thank you sir for your feedback. Take care and stay blessed. :)
Dr. Rabuil, thank you so much. I've been watching your videos. In fact, you are a polymath.
+Evans Asamoah Twum Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
Thank you so much for making these.
Thank you so much for this video. It really helped me a lot to finish my research project regarding Sickle cell anemia!
Thank you for liking my video. Glad to know it was helpful. I began uploading videos when my students could not come to their classes due to political crisis. My newer videos are shot with a better camera . You can check them out too ! Best of luck and best wishes from Bangladesh. :)
How did you do on your research??
thank you dr.rabiul for this wonderful class. this session was taught in a very simple way starting of with the required basics; easy understanding and remembering. thank you once again dr. rabiul.
Anitha Varghese Thank you for your inspiring comments. Very happy to know my video was easy to understand. Best wishes from Bangladesh.
Thank you so much Dr .. much appreciation.. your lectures are really helping me in my medical field.. ive learnt alot from you right from year one
Thank you for your feedback. Take care and stay blessed.
Let me be one of your students from Nigeria.... I have to teach this to over 1700 freshmen. Your video was very helpful
Thank you for your feedback. Wish you all the best.
thank you Dr. Osade for your help
Clear and informative video - thanks.
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Thanks Dr Rabiul. Ur lecture very interesting.
Can u make more of videos of the human body.. and what the cells needs to not be sickled shaped . I learned alot with dandelion in raising the hemoglobin on a daiily basis.. good job doctor. Good job 👌👍
Thank you sir..want more lectures of medicine from you🙏
Thank you very much doctor for this helpful video... well done
+Hadeel Alameen Thank you for liking my video. Glad to know it was helpful. Best wishes from Bangladesh. :)
Thanks a lot to make the conception clear❤
Thank you for your feedback. Take care and stay blessed. If possible do share the lecture with your friends. :)
Very good! Well done.
this was so helpful, am a nursing student in Barbados and it has really helped me,your accent is really funny and the way you say "you know".....thanks
Thank you for liking my videos. Glad to know they were helpful. Regarding accent : My earlier videos were recorded with a mobile phone ! ( I began uploading when my students could not come to classes for political crisis and my earlier videos were shot with what ever available to me ) Plus English is not my Native Language. These two reasons may lead to "you know" funny accent ! :P ... I do have plans for using a good microphone soon. Best wishes from Bangladesh.
From Tanzania Africa... give me more plz I real understand ur lectures ♥️
So nice video.. sir . fully detailed explanationed.. thanks
Thank you for liking my videos. Best wishes from Bangladesh. :)
thank you boss for your lectures of pathology
Thank you for your feedback. Take care and stay blessed. :)
Thank you sir for the video.. As im doing my research work regarding medication adherence among sickle cell patients who are living in tribal area of Attappady (kERALA). Your video helped me to knw the basics and also it helps me to answer some questions which raised during my preliminary seminars.
THNK U.. THANKU SO MUCH
Hello, thank you for liking my video. Glad to know it was helpful. Best of luck with your research ! Best wishes from Bangladesh.
Thank you very much for your videos may the ALMIGHTY ALLAH bless you.please doctor i need clinical biochemistry lectures. can you do some for us.from Ghana
Thank you for liking my videos. Best wishes from Bangladesh. :)
really this lecture is very helpful
Sirajum Munira Thank you for liking my videos. Best wishes from Bangladesh. Here is a link of my new educational video on Hyperthermia and it's management. You can check it out too ! Take care and stay blessed. ruclips.net/video/o7PKXECuFsM/видео.html
Thank you so much Dr. for this wonderful lecture, I am a RN from west Africa( Sierra Leone). I have never given this topic a thought until last year when my my Son's girlfriends( a magistrate) was admitted with a crisis. and since then, She had been having frequent attacks; and had been even transfused. As I am writing this to you now, She is admitted not for the crisis but due to Anemia and had received 6 units of blood.This vedio will help me greatly. Can you please help me again with the name of the drugs you mentioned at the end ? ( in Writing ) so that we can search for them in our country. Thanks and God bless you Sir.
Thanx for the powerful information
Thank you for your feedback. Take care and stay safe.
Allah help you as you help me
thank you from my bottom of the heart
really very very helpful
you are my best teacher ❤❤❤
Alhamdulillah. Thank you for your feedback. Take care and stay blessed. :)
DR @@RabiulHaque are u making new videos>?
can you give me the website of this disease, the precise one.Thanks
Thank you for taking time out of your busy productive investigative studies to enlighten our family world-wide. I was mislead to believe that any form of the anemia or trait was racially specific. I know that even though physically imposing, and it can be, it can also be lived with (Please clarify).
I have not been diagnosed (with the trait), but two of my siblings have. It must have just skipped me. Although inherited, not all immediate family members are subjected to the acquiring it. ( Please confirm)
We are of origin in Spaniard and African roots. Our ancestors are from Spain, Africa, and finally mixed together in the Caribbean. My brother (has trait), could not be a Navy Combat Pilot because he was subject to blackouts due to the lack of enough oxygen at high altitudes during exesive speeds. I have never been diagnosed by my PCP. Either way, I'm not worried. Should I be?
Malaria is the progenitor of the disorder, but does it become associated with geographics, or genetics? Bottom line.
Thank you again Professor Haque. My babies live in the Caribbean.
I realize I am long winded, but these are my questions and no one has attacked the issue as well and learned as you have. At least to the layman.
thank you that was amazingly clear!
Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
Good work Dr. very goog I understand all
+Edwin Vilca Pajares Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
Sir my doubt is why in hemolytic anemia reticulocyte count increases and decreases in megaloblastic anemia.
Excellent explanation sir.. thanx a lot and keep it up..
Thank you for your feedback. Take care and stay blessed. :)
sickle-cell-disease is a hemoglobinopathy but its qualitative hemoglobinopathy, THALASEMIA is quantitative hemoglobinopathy ... both r hemoglobinopathies. tq
Thank you Dr for your videos they are so helpfull for sure
Thank you for watching my videos and for your feedback. Take care & stay blessed. :)
most important things you never touch ,complications and clinical implications.
Thanks a lot sir...
I love love your videos!!!!! Im so thankful
Thank you for liking my videos, best wishes from Bangladesh. :)
thank u allah bless u this lecture is really use ful
Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
I LOVED THAT U R AMAZING THANK U SO SO MUCH GREETINGS FROM IRAQ :)
I just received my test result and don't understand the reading and the doctor doesn't seem to understand himself,please any specialist here who can help?because I'm tired of asking questions from this doctor.
Why the sickle cell goes to lipid bilayer and water is looosed kindly explain thanks
Great work
Thank you for your feedback. Best wishes from Bangladesh.
Very educative
Thank you for your feedback, take care and stay blessed.
Good professor
THIS video is very helpful....
Thank you for liking my video. Glad to know it was helpful. Take care & stay blessed. Best wishes from Bangladesh.
thank you very much for the best explenations of the sickke cell disease.i will be waching all your videos.i will like to know more about my pains because most of people are saying that sickle cell trait should not have these pain.i'm an African woman 47 y 8 m.i live in brunei where I have been diagnose with sickle cell trait and i'm not suffering of anythink else.my bp this morning is 125/88 my pulse 73.my sugar in the border line.i just started to have a lot of pains.nice doctor from Pakistan working here at ripas hospital tall me to go to see the doctor immediately because there are no auther patient because there're just few African or auther scd patient here.the hematologist told me that same bruneians have tallasemia.i have no raison to imagine any pains I just will lie to have same more info.thank you and god bless you.
thank u sir very very much ..............
your videos are really helpful
Thank you for liking my video. Glad to know it was helpful. Best wishes from Bangladesh. :)
Thanks for this helpful lecture
Thank you for your feed back. Take care and stay safe. :)
Thank you sir...😍
Thank you for your feedback. Take care and stay blessed. :)
what could be causing the point mutation in the beta-globin?
Hello Dr. will the Covid vaccination enhance clots with Sickle Cell Trait disease.
nice and informative...thankx
Osama Badawy Thank you for liking my videos. Glad to know they were helpful. Take care and stay blessed. As always ,best wishes from Bangladesh.
I don't know haw I thank you
Really is very helpfull
You save may exam thank you Dr a lot and a lot and I Will be big fun for you
Thank you for your feedback. Take care and stay blessed. :)
Thanks for the video.
Thanks for liking my video. I will try to upload one new video every week. Take care and stay blessed.
Thanku sir. Ur videos helped a lot.
Please also upload videos on Parkinson's disease , epilepsy,eczema,pemphigus,rehematoid arthritis and other similar topics. Plzz sir
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Thank u👍🏽
Greetings from kerala ❤
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thanku so much sir for uploading vedio ,I request for uploading the topics disorder of WBC and lymphoid
Thank you for liking my videos. Best wishes from Bangladesh. :)
Thank you. do u have video on spherocytosis sir? Anything regarding membrane defect.
Lockerstein Dr Thank you for liking my video. Glad to know it was helpful. I have not made videos on membrane defect so far. Best wishes from Bangladesh. :)
I like ur videos sir...keep Posting few more topics
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Still useful in 2020
Dr thanks for your helping
Mahad Mohamed Thank you for liking my video. Glad to know it was helpful. As always, best wishes from Bangladesh. :)
+Rabiul Haque MY daughter was recently given a sickle cell blood screening. They sent a letter saying there was an abnormality. What exactly does that mean? she is also 4 months pregnant
god bless you sir thank you very much
Thank you for liking my videos, best wishes from Bangladesh. :)
Well done. Nice video
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U r a life saver...thnk u!!
Pamela Mkhwanazi Thank you for liking my video. Glad to know it was helpful. Take care & stay blessed. Best wishes from Bangladesh.
Yes
🙏🙏tq so much sir
What is target cells ?
Thank you for your video
Bora Huot Thank you for liking my video. Best wishes from Bangladesh. :)
Thank.you.so.much.sir.
thanks
good explanation
+Nithya Nanthan Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
Do you have any papers or written forms of this? It's been really helpful in my research so far
Hello, Glad to know that it was helpful. Actually I recorded most of my videos with out any scripts. (My students could not come to classes due to political crisis and that led me to uploading videos for them in the first place). I just write down the topics name on white board in advance so that I don't forget or skip any topics. I have taken the information from Pathology Text Books. They include : "de Gruchy's Clinical Haematology in Medical Practice 5th Revised Edition" , "Robbins & Cortan Pathological Basis of Disease 7th Edition" ( 8 th Edition is now available by the way ) , "Rapid Review Pathology Edward F. Goljan 3rd Edition (South East Asia Region) ", "Dacie & Lewis Practical haematology 9th Edition" etc. I highlighted texts on these books when I read them but did not make a script for my videos. I recommend you De gruchy's Clinical Hematology book and It's Chapter 7 ( Disorders of Haemoglobin Structure & Synthesis) for more information. Also I have bought a new camera ! My new videos are flicker free & of better image quality (HD) . Hope it is helpful. Pray for my country and best of luck for your researches . Best Wishes From Bangladesh ! :) - Dr. Rabiul
So nice teaching sir
Thank you for your feedback. Take care and stay blessed. :)
Jazakallah khair
Thank you for liking my videos. Take care and stay blessed. :)
God bless you
thank u very mush sir
Thank you for liking my videos. Take care and stay blessed. :)
thank you soo much
from india
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Thank u sir❤️
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Dr thank you thank you so much
Thank you for your feedback. Wish you all the best.
thank u sir
Thank you for liking my videos. Best wishes from Bangladesh.
Thank you alot
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Sir glutamate replacement dunno beta chain main husakta Hain ya sirf ik main hugi??
Thank you for your question. In Homozygous sickle cell anaemia (Hb SS) both beta chains have the defect and results in haemolytic anaemia, in heterozygous state (known as sickle cell trait) one beta chain has the defect while the other beta chain is normal and the person is asymptomatic. Take care and stay safe.
Thanks you alot
Thank you for your feedback. Take care and stay blessed. :)
what's different of pathophysiology and pathogenesis ? thanks
Hello, Thanks for asking. The term "Pathogenesis" is derived from two Greek words : "Pathos" = suffering ( Disease ) & "Genesis" = creation . So pathogenesis means the mechanism that caused the disease. ( i.e how the patient developed the disease ).The term "Pathophysiology" means the functional changes that are "associated with" or "resulting" from disease or injury . ( i.e. what the disease is doing to the patient ) . To be honest, I included both pathogenesis & pathophysiology in this topic briefly. (eg. how sickle cell disease is developed = pathogenesis,what functional changes the disease is causing to the patient = pathophysiology . There is subtle difference between the two words but once you know the entire process : It is easy to answer both . Hope this video was helpful. Take care & stay blessed. ! Best wishes from Bangladesh :)
***** thanks. and im waiting the cardiovascular topic to be uploaded
Both Sickle cell anaemia and thalassaemia are called haemoglobinopathy
Sir plzz upload haemolytic anaemia videos
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Dr thanks for your helping
it's amazing
+Alaa Aloshoush Thank you for liking my video. Take care and stay blessed. Best wishes from Bangladesh. :)
😊😊
this is very well informing.. i have a question is there a way i can e mail it to you?
Fatuma haji Thank you for liking my videos. Glad to know they are helpful. Take care and stay blessed. Best wishes from Bangladesh. You can visit my website and use the "feedback" option or "mail to" option to mail me. Website Link: pathologytutorials.weebly.com
hi wonderful.(from italy)
Mahnaz Ashrafi Thank you for liking my videos. Best wishes from Bangladesh. :)