I cannot believe how simple it actually is but our presenters made such complicated annotations with confusing markings and an unwelcoming font. This was great!
All the years Iv been studying and scouring the internet for little bits of simply put explanations, this is one of the nicest and easiest videos to follow. I'm not one to usually comment on things, but I feel like this deserved a big thank you! Love the videos, please keep it up! :-)
I could not understand Coagulation Cascade for long time but your tutorials which is long just 4 mins can make me clearly understand and also I can remember it. Thank you so much.
Hello there! I'm back after 5 years. I used to watch your video and incorporate it whenever I study back in college. And all of them helped me a lot. Thank you so much. God bless! *i always fell asleep whenever I read the whole chapter of the book, so this video saved me from all the reading that usually don't get into my mind*
Your Tutorial was one way helpful but at the same time you have forgotten I think.. That Factor 7 in the extrinsic pathway and Factor 9 in the intrinsic pathway require Calcium ions as their cofactors for the activation of the respective factors in their respective pathways.. :) :)
They are just wonderful and especially for the undergraduates and postgraduates as well, just keep it up and keep posting more and more ...thanks once agasin
Basically it rains down Roman numerals until Prothrombin get converted to Thrombin. Then fibrinogen converts to Fibrin mesh (which all the platelets and crap stick to). Got it. Ty.
you forgot to include the factors that requires calcium ions to get activated. that's pretty much important though! so, in this case; i would add calcium with factor VIIIa to activate factor X, and would add it as well with factor Va to transform prothrombin to thrombin. In addition, i guess that u miss that VIIa in the extrinsic pathway can activate IX to IXa. Otherwise i like ur simplicity.
Great presentation for lay person like me. I heard that Ca++(IV) is not considered a special factor as it is abundantly available around. Please correct me if I were wrong. Regards
You didn't mention that the thrombin produced in the extrinsic pathway is not enough to activate conversion of fibrinogen to fibrin. The extrinsic pathway only enables the activation of intrinsic pathway from which you can generate enough thrombin to produce fibrin. Pretty important step to mention 😬 I do really like the style of the videos though :)
can you tell me if you have a video about the antagonists and the agonists and about the different receptors like endogene agonists. thanks a lot for your helpful videos :)
After watching this vid it's easier for me to understand now and I realized that our teacher made mistake about the the extrinsic and intrinsic pathway's😬
This is a good video for someone new to the Coagulation Cascade but... You didn't add the HMWK and prekalikrein in the video. Both of which are part of the intrinsic pathway. You also didn't include Factor XIII (Fibrin Stabilizing Factor), in the presence of calcium, stabilizes factor Ia or soluble fibrin monomers into a insoluble Fibrin polymer. Other than that, it's good. :)
Has anyone told you that you sound a lot like Stewie. Cause - you do. And when I realized that you do whilst listening to your vid. I start to giggle a bit. I do apologize :< but thanks for these great videos. :)
I saw this video 9 years , back then I had just entered med school..
Now in 2023, im watching it again for my MS exam...
Time flies...
Thank you
I cannot believe how simple it actually is but our presenters made such complicated annotations with confusing markings and an unwelcoming font. This was great!
a
you are right
All the years Iv been studying and scouring the internet for little bits of simply put explanations, this is one of the nicest and easiest videos to follow. I'm not one to usually comment on things, but I feel like this deserved a big thank you! Love the videos, please keep it up! :-)
I could not understand Coagulation Cascade for long time but your tutorials which is long just 4 mins can make me clearly understand and also I can remember it. Thank you so much.
I watched literally 2 hours of videos before I FINALLY FOUND ONE I UNDERSTOOD! THIS ONE! THANK YOU!
Hello there! I'm back after 5 years. I used to watch your video and incorporate it whenever I study back in college. And all of them helped me a lot. Thank you so much. God bless! *i always fell asleep whenever I read the whole chapter of the book, so this video saved me from all the reading that usually don't get into my mind*
THANK YOU SO MUCH!!! People really make things harder than what it is! I saved so much time watching this video!
Simple, directly to the point... I love it
that's what's missing in our classes
I have watched countless videos trying to grasp this concept in time for my exam and this was by far the easiest to remember.
This is just perfect! Thank you for clearly explaining what my textbook couldn't do
Thanks 😊.
I can't tell you
How much easy you make this for me :)
don't know what any of this means, i just memorized the entire video 🙌💁
Your Tutorial was one way helpful but at the same time you have forgotten I think.. That Factor 7 in the extrinsic pathway and Factor 9 in the intrinsic pathway require Calcium ions as their cofactors for the activation of the respective factors in their respective pathways.. :) :)
Ravindranath Kamath right it's written in my book , but really he is amazing in explaining
I was thinking the same thing the factor 7 was helped by factor 3 and Ca2+ so it converted into 7 a, well its okay tho he can forget about something
Thank you
They are just wonderful and especially for the undergraduates and postgraduates as well, just keep it up and keep posting more and more ...thanks once agasin
The best explanation so far
Very super explanation actually ur vedio is more effective than others
this guy has the same voice as that curly haired chef tutorial guy on the food network. love it
Dude, you killed that. Well done
Basically it rains down Roman numerals until Prothrombin get converted to Thrombin. Then fibrinogen converts to Fibrin mesh (which all the platelets and crap stick to). Got it. Ty.
Best tutorial I've seen so far! Thanks a lot!
Thank u .... This was simply Awesome..... Undesrstood the thing in just 4 mins !!
you have the best tutorials online!
This is great. I need to present this in class and this video helped me a great lot in summarising all the info I read, much thanks :)
Whose amazing idea was it to denote this cascade using roman numerals? /sarcasm
Yeah, it's like it could not be anymore convoluted if you tried really, really hard.
pretentious scientists probably lol
...Probably to differentiate it from the complement cascade that uses Arabic numerals?
How stupid are you that you can't read Roman numerals?
My professors did the thing too probably to differentiate it and so it'd help you when you're actually try to remember the scheme
These are so useful and clear. Thank you very much!
you forgot to include the factors that requires calcium ions to get activated. that's pretty much important though! so, in this case; i would add calcium with factor VIIIa to activate factor X, and would add it as well with factor Va to transform prothrombin to thrombin. In addition, i guess that u miss that VIIa in the extrinsic pathway can activate IX to IXa. Otherwise i like ur simplicity.
This is the Most important comment I was replicating my teachers work and was missing that
Great presentation for lay person like me. I heard that Ca++(IV) is not considered a special factor as it is abundantly available around. Please correct me if I were wrong. Regards
this is the best, short but brief. Thanks a lot
I appreciate your work! It is so so so clear~
Very good video sir ....thank you sir....sir please send videos on all topics of biochemistry and physiology
This was wonderful! Thanks! You must continue the good work!
Amazing explanation
Thank you for your help. I have a question
What is the role of calcium in coagulation
thanks immensely for making it sooo simple!
Most useful video in coagulation cascade , thx very much
You didn't mention that the thrombin produced in the extrinsic pathway is not enough to activate conversion of fibrinogen to fibrin. The extrinsic pathway only enables the activation of intrinsic pathway from which you can generate enough thrombin to produce fibrin. Pretty important step to mention 😬
I do really like the style of the videos though :)
can you tell me if you have a video about the antagonists and the agonists and about the different receptors like endogene agonists. thanks a lot for your helpful videos :)
can anyone explain how do scientists identify all these
Very helpful thank you! I was struggling with my med class notes.
thank you
it really makes it too much easier
Love it, but you didn't include factor 13? and calcium
You made it very simple for me, thanks
After watching this vid it's easier for me to understand now and I realized that our teacher made mistake about the the extrinsic and intrinsic pathway's😬
Thank u sooo much for ur amazing explanations
Excuse me but you forgot to add factor IX which is needed for stabilizing the fibrin clot and it was activated also by thrombin :)
Thank you so much. This clarified my doubts :)
comprehensive. Awesome and really helpful. Thanks a bunch tutor
Thank you thank youuuu i was suffering from it 😂
Tomorrow is my practical exam wish me luck i don't know shit about hematology 🔥💔
Great tutorial sir...👍😃
of great help n I can even wrt it for 1st MBBS paper with other details. I love the wrtn part...its great.
OMG!! So it was easy like this! thank you soooo much 🥺❤️🩹
it haa been a great vedio.. thank you alot
but unfortunately i have to know their names which is hard to remember
Thank you so much this helped me a lot 🙏.
you miss Ca but it's ok, but still a good work :)
excellent tutorial! very helpful indeed
Please can you update to do new cell based model? Intrinsic and extrinsic aren't taught anymore...
thank you. this was very helpful
Thank you!! that was so helpful
Thank you for this!📚
Factor 9 needs COFACTORS 8 & 4 to activate Factor 10 :)
Excellent explanation thank you☺️
Omg I love this guy #nohomo ..... I have a final tomorow , this is my intervention 💯
Where is the factor 4 used (ca++)
you made it very simple. thanks!
Simple, clear , effective
Very informative. Thanks a ton!
I think you forgot factor 3 on the extrinsic pathway
factor 3 is the Tissue Factor
What initiated factor 12? Is it in active form always? Thanks
HMWK & Prekallikrein
Thank you, thank you soooo much 😭😭
This is a good video for someone new to the Coagulation Cascade but...
You didn't add the HMWK and prekalikrein in the video. Both of which are part of the intrinsic pathway.
You also didn't include Factor XIII (Fibrin Stabilizing Factor), in the presence of calcium, stabilizes factor Ia or soluble fibrin monomers into a insoluble Fibrin polymer.
Other than that, it's good. :)
Who attends lectures? I haven't been to one in months :P
Such a good tutorial!!
Does tissue factor activate VII? If not, what activates VII?
Yes
He baghwan... Sab sirr ke upar se nikal gaya....
Woooow thank you sooo much!!! Very helpful! So clear and well explained! Love yooou!! XD
Yeah, please turn your microphone up! Thanks!
It is OK but u have not discussed about calcium ion
pray for me so that I'll be a successful doctor in 5 years and I'll donate some money. I'm broke now.
YOU SIR ARE AWESOME!
Well explained.. 🎉 thanks..
You're amazing😘😘 thank you so much 😍😍😘😘
Nice presentation
I really don't know how to thank-you !
I can't thank you enough!
This was great!
This is great, thanks a lot!!
JUST AWESOME. THANK YOU.
I always write it down with normal numbers and then during an exam I write it down and just put a roman number in my answer book
Laila Samadi TRUE! The roman numerals get so confusing during crunch time lol
is there any factor 13 ah??
Has anyone told you that you sound a lot like Stewie. Cause - you do. And when I realized that you do whilst listening to your vid. I start to giggle a bit. I do apologize :< but thanks for these great videos. :)
amazing video, thanks
Wow its so amazing thank u so much
thank you very much
that was helpful .
That was helpful. Thanks!
thank you!!
Great video..comment after 8 year
Great video. Thanks!
Thanks 🙏🏻
God bless you ❤️
Thank you very much !!
Thanxs to ancestors. Why it was so hard to use the name of clotting factors.:()
ooooo... time saver ....thank you.