A Man Drank Throat Numbing Spray While Eating Spicy Food. This Is What Happened To His Brain.
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- Опубликовано: 14 май 2024
- Patient RJ by Jake Rattan, Friend 1 by Matt Hernandez, Food Enjoyer by Lexi Richmond, PA/Friend 4 by Luke Menzies
Mark Rober Hot Ones: • Mark Rober Gives Up on...
Peer Review: Dr Araceli Morga Vera, Dr Yue Wu, Dr Katherine Johns
Spanish translation and dub: Cenzontle Voices Inc, CDMX
Portugese translation and dub: George Frederico
Music by @Lifeformed ► lifeformed.bandcamp.com
In-depth (podcast) channel @HemeReview
Secret Channel @BigEmus
Medicine ► • Medicine
There's a secret version of this video in 8k: • A Man Drank 1 Bottle T... the music levels were out of whack on that one so I elected to publish this one instead
0:00 Throat Numbing Spray Label
0:14 A Man Swallowed 1 Bottle Throat Numbing Spray While Eating Spicy Food
2:00 haha spray go glug 😳 glug
3:29 The emergency room 🚑 where we are now
4:10 Cyanosis and oxygen saturation
5:05 Arterial blood gas vs oxygen saturation
5:58 ...but something's wrong
6:38 This brings us back to the spray...
7:16 I promise you that stuff you learned in high school chemistry was worth it because it applies here
10:07 What does the throat numbing spray have to do with this?
12:10 ONOO😞- (Biochemical breakdown)
14:49 Throat numbing spray misuse isn't new
15:52 When you misuse the antidote and it becomes a poison itself
Some images by Getty Images
These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.
References:
Benzocaine-induced Methemoglobinemia. www.ncbi.nlm.nih.gov/pmc/arti...
Reported Adverse Event Cases of Methemoglobinemia Associated With Benzocaine Products. jamanetwork.com/journals/jama...
Safety Information on Benzocaine-Containing Products. www.fda.gov/drugs/postmarket-...
Benzocaine. www.cureus.com/articles/68795...
Continuous Methylene Blue Infusions for Treating Recurrent Methemoglobinemia. toxandhound.com/toxhound/refr...
Methemoglobinemia emcrit.org/ibcc/methemoglobin...
Pulse Oximetry emcrit.org/pulmcrit/pulse-oxi...
Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine. www.tandfonline.com/doi/abs/1...
Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure. pubmed.ncbi.nlm.nih.gov/25211...
A mitochondrial superoxide theory for oxidative stress diseases and aging. www.ncbi.nlm.nih.gov/pmc/arti...
4.2 Oxygen Binding: chem.libretexts.org/Bookshelv...
Benzocaine Label without Methemoglobinemia warning: fda.report/DailyMed/29890aa7-...
Acute Phenol Poisoning: www.jstor.org/stable/27720955
Goldfrank's Toxicologic Emergencies 11th Edition Text
Methemoglobinemia. UpToDate. Accessed 01 Feb 2023. 
Наука
that's so _meta_ 😏
5 little monkeys jumping on the bed
one fell off and bumped it's head
the monkey called the doctor and the doctor said...
"you are diagnosed with chronic traumatic encephalopathy."
Did the Spanish voice dub change? It sounds better. De verás, suena muy bien
Meta also downloading 4+ Apps on All Android devices: 👁👄👁
o//o
I'm thinking the HOT ONE'S episode with Mark Rober!! 😳
Edit: I had paused it right away. I didn't realize you were gonna show it!! 🤣
This channel has taught me that people will ingest literally anything
it is a pretty big hallmark of the human race since the ice age
yup. no wonder they're poison control labels on everything
Babies when they see a bottle that says highly corrosive
Humans are so curious and dumb at the same time
I thought you wrote "digest". Better not try it.
He may have made a full recovery physically, but his friends will never let him forget what he did.
Deservedly so!
He made *... a ...* social recovery.
Good!
@@ForestFire369 yes!
True that.
I am incredibly amazed that the doctors picked up on what was happening with the chemical reactions. To learn those specifics, then remember them, then remember them in an applicable situation is very impressive.
I thought that, too.
I imagine emergency rooms have protocol to follow with poison cases, which are found in the computer. Maybe some doctors understand the chemical reactions behind the symptoms and treatment, especially if their specialty calls for it.
I know. lol He lost me a long time ago when explaining the chemical reactions.
Yeah, that's some real Dr. House shit irl
They do be learning tho
His friends saved his life. I'm glad they were aware, some people are oblivious to their surroundings.
Shoutout to RJ's friends for realizing what was happening and taking the appropriate steps.
Was gonna say thank god they got him there quickly, with the bottle too, apparently
Brings me back to : "are ya winning son?"
I know right
@@rangedeth107 ArE yA wInNiNg SoN?
Though seriously, RJ was lucky that his friends saw what happened. If he was alone, he would likely have passed away.
RJ's friends the real mvps. Get yourself some friends who will SAVE YOUR LIFE
"One of the roommates dropped out quick because they didn't like spicy foods, they just wanted to taste flavor and enjoy what they ate." - The smart friend.
No, that's just the white guy from the midwest
Yeah, I don’t enjoy walking away from a meal just feeling like my whole mouth is on fire.
@@BoxStudioExecutive enjoy it the way that you like it, it's not a competition
Maybe until that level of spices doesn't give you the same experience anymore then maybe increase it just a bit
@@BoxStudioExecutive I'm a black woman who would be excusing myself from that challenge.
@@BoxStudioExecutive I'm a brown guy and can handle spice, but if I eat too much then it gives me heartburn and this is something that runs in my family. So tbf it's not as simple as that
Props to that friend who had the base intellect to read the bottle.
6:23: This is where it got really scary.
Really love that you explained the electron interactions.
6:24 I knew I saw something.
6:24 ya me to
its mark zuckerberg
@@KKING3I saw it too, had to slow it down 😂
It was probably the friend who had the sense not to eat a bunch of hot sauce in a competition.
Apparently the way to deal with spicy foods is frozen key lime pie. The cold helps soothe. The fat coats your tongue, and the capsaicin is fat soluble. The acid from the lime juice breaks down the capsaicin. And the strong sugar flavor competes with the signals from the pain receptors in your tongue to drown it out. Also, holding your nose when you eat helps dull the sensation some too.
Also heard this to be an effective method, source - "Food Theory: Conquering Spicy Food with Key Lime Pie and Unconventional Solutions"
RUclips vid by "The Food Theorists"
“A man ate 36 key lime pies in two days. This is what happened to his brain”
If you need to go to those extremes, what you're trying to do in the first place is stupid.
If it's too spicy to enjoy (without weird dubious hacks) then don't eat it.
@@alkaholic4848 ...the extreme of enjoying some key lime pie to cool down the spice, or plugging your nose? Maybe you're replying to the wrong comment lol.
But yes, stupid, to want to try and enjoy something that might otherwise not be an option.
Do your own thing, stop trying to sht on other people doing theirs :)
(In a comment on RUclips even lol, kinda sad tbh)
@@alkaholic4848bro has never eaten spicy food before
The stories featured on this channel range from "oh my god, what an extreme outcome to something so mundane, this could happen to anyone" to "why on earth would someone drink a snow globe"
The whole bottle of pickle juice drinker is one that I can't forget for some reason
Tsukasa fan as well I see :)
People might drink a snow globe because if you remove the plastic covering it reveals a metal "soda pop" looking cap, but while it might resemble a bottle of pop, it is in fact not one.
Just to be clear, this story is WAY closer to the snowglobe end of the specturm
@@alisonmercer5946 it's not the juice itself, it's the fact she ate pounds of pickles and drank gallons of juice after.
your body should reject that much salt and acid.
Is anyone going to talk about how dedicated this young doctor is? I mean. Dubbing his videos on Spanish and Portuguese just so more people can access to this kind of content isn't something your average RUclips is willing to do. Congrats on your expansion efforts, Chubbyemu!
I'm Latino and studied English with the objective to have access to more information. It's funny when I still prefer the English version
I have a friend who's venezuelan and he was REALLY confused when he watched the last video and there was someone speaking Spanish in a very text to speech like voice.
@@LUCTIANITO same, bro. But still, I find it commendable the fact that he's taking a step further to spread medical content in more languages given the fact that not so many people are as privileged as you and me to learn a second language.
He isn’t doing that. It some new feature built into RUclips.
@@Robert-Wilson he also isn’t a doctor by degree as far as I know. Just highly educated and works in a medical related profession
I love how he says "And be well" and makes it sound like a threat
This guy amazes me. Literally Everything he says he explains in thorough detail. This guy will teach you so much
props to the patient's friends for reading the label carefully and taking appropriate and swift action. probably saved his life
His friends made me very, very happy with their abundance of good sense and making wise choices again and again. After seeing several ChubbyEmu videos where people who could have said, "Yeah, [patient] ate/drank [stuff] before [problems]" but didn't, it was very nice to see people who didn't have their heads up their asses, leading to time needlessly being wasted on figuring out what was wrong.
Yeah luckily they were actual friends and saved his life instead of being making fun of him for his stupid decisions and letting him die.
@@hoppytoad79 I bet his friends were big brained ChubbyEmu subscribers
Except for the part where it seems like they didnt tell the doctors/give them the bottle? It sounds like the doctors had to figure it all out for some reason
@Repent and believe in Jesus Christ stop living for an imaginary future, and enjoy the short time we have on earth. Hail Satan! ♥️🤘🏻
The unusual thing in this case isn’t the irresponsible use or consumption of medicine/food/nonfood, it’s the quick and measured response from RJs friends. It’s always sad hearing the stories where they would’ve been fine if immediately treated but no one figured out they needed help until much later. Bravo to them!
I do wonder what would have happened if RJ took the bottle with him to the bathroom, rather than leave it on his chair for his friends to find. I mean the fact that they acted quickly here makes me think they wouldn’t have forgotten about him or anything, but it might easily have been an extra 20 minutes before they realised something was wrong.
Nice pfp :)
Yes but seeing someone having blue tinted skin and laughing and calling them papa Smurf seemed kinda stupid. You don’t have to have medical knowledge to know that when someone’s turning blue, they’re literally dying.
@@shannond1511 The patient himself doesn't even know turning blue means he is dying you expect his friends to know it because?
@@shannond1511 they probably just thought he had dyed himself blue with whatever he was using!
You're honestly such a great storyteller. I've been binge watching your videos for the past days and even though I have no idea what you're talking about some times, the effort that is put in these videos is immaculate. Keep up the good work!
Amen!
Same me too love these videos my dream was to be a doctor life and medical issues happened so now I’m planning on getting my RN in a couple years 🙂
@@cheyenneyoon4353RNs are just as important as doctors, good luck and never give up! 🤩
If you continue, you may start speaking like him, and everyone at work will hate you 😂
A while ago when I was in the hospital I (briefly) had to have an NG tube placed and it really irritated my throat so they gave me the same kind of throat spray. It didnt really work so I kept asking for more but they had a very strict schedule of how often i could have it, and they wouldn't leave it in my room, I had to ask the nurse for it each time. I got fed up and asked my dad to go down to the pharmacy/convenience store and just buy some for me, but they didnt have any. So thank you to Johns Hopkins for being so "mean" to me because I totally would have been dumb enough the down the bottle
i love when the consequences seem completely hyperbolic compared to the cause. like “a man stubbed his toe on a grand piano. this is how his entire nervous system shut down.”
This comment reminded me of an actual case
Jean-Baptiste Lully was a composer and conductor. Back in the day, conductors didn't use those little sticks you wave around. They used a staff that they'd bang on the floor to indicate the beat of the song. During one performance, he accidentally hit his foot. The wound turned gangrenous, but he refused to have the limb amputated, and he died. Not quite stubbing your toe on a grand piano, but pretty close I think
also the title "this is what happened to his brain" would probably apply pretty well, because he died after the infection spread to his brain
I stubbed my toe before taking a wee and passed out.
A Man Ate A Lettuce. This Is What Happened To His House.
@@crptpyr New fear unlocked
“As they drive him to the emergency room” what good friends knowing an RJ didn’t need an ambulance with a 5k bill on top of the 20k hospital bill 😊
i'm guessing rj will be very familiar with the emergency room by the time he's 30... if he makes it that long.
real ones
Next vid: Mark Rober ate hot wings while spraying Fart-Spray in his throat. This is what happened to his social life. 😳🤣
@@Gg-ij7li And burn in hell for eternity if you refuse this offer!
The real bro
Any video related to medical procedures in the USA should mention the hospital bill at the end.
The interplay of these metabolic pathways is just beautiful to me! Love your videos, thank you.
The production quality on this reenactment is unparalleled
I was just noticing, too! How bis is exactly the ChubbyEmu production??😮😮
@@alchemyofcolorandstyle he's got videos on it on his other channel, it's just him he does this as a passion project.
that subtle metaverse pic of mark zuckerberg in the meta explanation
@@zeffmalchazeen3429 is that what it is? I saw a flash of something but I couldnt pause it at the right time to see what it is 🤣
I'm a paramedic and your videos are super helpful because this is _exactly_ the sort of thing we get called out to, but never got told in medic school. I've relayed a few of your stories to the EMT classes I've taught though!
(This Happened.)
@@hyperbaroque what he said seems realistic enough
And he also made it possible for non-medic people to understand these cases and take precautions too!
His heme reviews are also very enlightening!
@@erazn9077 Yeah, I didn't know what the guy above you meant by that, thanks for clarifying. But in our case, we got sent to a suspected OD case because they thought a guy drugged his date, turns out she was trying to deepthroat him and kept spraying the stuff down her throat before becoming altered. Never found out if she ever succeeded...
You’re a great paramedic too ❤
I always love hearing the stories of full recoveries
Perfectly put together video! The level of detail on the organic chemistry level was phenomenal.
Glad to see a story where the friends read what he took and dealt with it immediately. They can make fun of him forever but they had his back.
throat numbing spray is not cheating cause it can take you down allow the stronger person still win
I imagine it will come up in the future. "Yeah remember that throat numbing spray incident? We're coming with you on that trip so you don't hurt yourself."
This makes me realize that, no matter how ridiculous the situation you think of is, someone has already experienced that.
Yup, and it's good to remember that those warnings on the medicine bottle are probably there bc someone Died.
Sometimes, a lot of people died.
has someone died while fighting 3 gorillas with an rpg whilst unicycling?
@@dustlicker3
The possibility is never 0
You woukd be surprised how little oral jell it takes to start this process
@@dustlicker3 Never say never.
I love , love your channel! I have always been intrigued with science. Scored A's all through High School and in college. People can learn more and more just by listening and watching your channel. Better than a professor in a college!
sheesh, i sure like this presentation, and how it is explained in a way so that if people don't have a chemistry or physics science background, they can still understand it.
thank you for also explaining just how dangerous it was for mark rober to use throat numbing spray for his hot ones challenge.
RJ has really great friends! To not only read the warnings and recognize the signs but do something about it.
There is a story of a girl at a party who got too drunk and ended up passing away in the bathroom, and her friends were having too much fun and figured she was just asleep or something for the whole night, never checking up on her. Ever since that story I've always been proud of friends that are willing to take a moment to check on their group even if it means ending the festivities.
Sorry... passing AWAY?!? Good grief.
Similar to the story you mentioned, there is an incredibly sad short documentary about a young man's death from alcohol intoxication at a frat party - you can find it on youtube it's called "BREATHE, NOLAN, BREATHE". That is an example of when friends don't do right by their friends and don't pay attention to warning signs. It's terribly sad, but I think it's a very important film.
Truly awful, you're right RJ was very lucky to have smart, caring friends.
Lol
There was a story on RUclips with a drunk girl that got dropped off by her friends at her house but they never really checked that she got inside the house. She passed out for 9 hours in front of her house in the cold and ended up having her limbs amputated to save her life
They probably laughed a lot longer after seeing the bottle than this video shows. This video just needed to keep it short.
I know this case has been altered for obvious reasons, but mad props for the friends to do the right thing and call an ambulance/tell the ambulance crew what happened.
Please remember to read the label for any medication you are taking and be aware of the side-effects. It might just save your life one day.
Yeah, that was I was going to comment. Friends like that are not very easy to find or keep anymore.
What do you mean it's been altered? Why?
@@HadenBlake Hence why I said to please read the label for any medication you are taking.
@@Aramil4 For patient privacy. Dr Bernard cannot just take the exact events and explain them on youtube, because that would violate HIPPA. (Or the Health Insurance Portability and Accountability Act.)
@@Aramil4 each of the stories are changed slightly so that it has no biases and dosent violate HIPPA protecting the medical records abd privacy of the patient. doctors use these all the time for case studies and learning.
One could have done all sorts of useless associations to talk about a case but you are have really explored it in such a good and informative way. Ty.
I’m not even a medical student and I understood at least a tiny amount from this. Explained very nicely! Thank you! 😳
Amazing he wasn’t brain damaged! Great job to his friends for finding the spray, figuring it out, getting him to the hospital, and telling the doctors about what he took! They probably saved his life, or at least his brain!
100%
He may have had brain damage before the incident which is why this happened
Let's be real. He was brain-damaged even before he took the spray.
💯 not enough being said! They're definitely friend to keep for life -double pun intended-
He was probably already brain damaged from prior shenanigans that lead him to take the stuff in the first place.
The fact that a body can recover from that state after so much time, with probable hypoxia is amazing
We are miracles 😊
He wouldn't have made such a recovery without medical intervention, but I know what you mean
@@aliveandwellinisrael2507 Nice name and profile pic lol
It's pretty amazing. I didn't think you could live with half a brain but you can... my youngest daughter had a hemispherectomy done at age 1.5 and she does have issues but overall is doing amazing. She had brain damage from hypoxia and a stroke during delivery..causing brain damage, epilepsy, cerebral palsy,etc.
The body is resilient. For us in the field, 5 minutes of complete hypoxia is typically the cut-off before encroaching brain damage. At 10, it's begun without a doubt, after that you're either a vegetable or dead. Preferably you're dead.
I love how u explain everything. That just satisfies my curiosity. I love it.
This guy makes truly top tier videos
Professional singers sometimes used throat numbing spray to suppress the pain of a sore throat so they can perform when they're supposed to. But my daughter-in-law the opera singer explained that this is a bad idea, because a person can injure and possibly permanently damage their vocal cords doing that.
Yes, but not because of the numbing spray itself. Because the pain is supposed to stop over exertion, which could damage vocal chords.
Its probably the same thing like taking pain killers so you can make it through a physical competition without pain stopping you. The medicine masks the pain so you keep going and end up damaging your body because that warning is masked.
@@omarb7164 its like a device that doesnt start if a critical error occurs. It doesnt want the rest of the system to be damaged
Yes. Pain is most of the time a message that something is wrong , broken bone , rotten tooth , burn , throat pain, muscle breakdown etc etc
Being able to suppress it is great if we aknowelegde the problem and work to solve the issue. Yeah you have a broken bone , but doctors made a radiography and put a plaster on it , the pain is not needed. But you know you should not force on it.
Yep. Another student ripped up her throat pretty well back when I was in music school
One of your best videos.
Big flex of knowledge in this one.
I really enjoy the chemistry explanations. Fascinating
I don’t know how other viewers feel, but I love how thoroughly you explain the chemistry behind what’s happening in the patient’s system. I have a background in chemistry and medicine, so the additional information helps me understand what is happening to the patient. Dr. Bernard explains the chemistry in a way that it can be understood by anyone (I think?).
A sign of high intelligence is taking complex information and simplifying/summarizing it so others can understand.
He is awesome
Truly awesome! As a former EMT and MA, I can fully appreciate how hard some doctors really work to save a patient with no history of what is going on. The way he breaks it down is even easier for my 5 yr old to understand. We love your channel 💝. She wants to be a Dr though. I have been saving since birth. This gives me hope she will make it through it.
i've always sucked at chemistry but his videos are the most comprehensive and always help me understand what's happening.
I think most people can understand because of the way he teaches things
that's party of the magic :0
I'm amazed that he made a full recovery even with as fearsome as this case sounded.
scary.
When it says „this is what happened to his brain“ you know it will be bad.
Knowing exactly what happened helps a lot with increasing your survival rate
Me too, although "full recovery" doesn't mean he wouldn't now score lower on a cognitive test than before his mishap, just that his cognitive functions weren't affected enough to noticeably interfere with his life.
I was sure he'd be boned because "your haemoglobin is haemoglobin't" sounds pretty scary, but I guess it's a fairly well understood condition
I love this channel, I always learn something new not to mention I really enjoy the posts of medical definitions... Namaste 🕉️🙏☯️
the Mark Rober call out is hilarious. 10/10 video, top 5 youtube channels imo
You know a guy is good when he makes Chemistry interesting to learn. I think practical cases like these during normal classes at high school would be crucial both for understanding why people study that and to peak interest on future doctors as well. Hell, I'm a graduated engineer and I want to be a doctor because of Chubbyemu videos, cause everything he says is interesting.
Exactly! And this is especially true of mathematics. Sure, 99% of what you learn the average person won't use, but there are use cases, and some of them can be game changing and fascinating and really spark that smoldering interest that just needed a little breath of fresh air.
Yeah I can’t even wrap my head around learning this stuff or even pronouncing it but he makes every second of these videos incredibly entertaining and educational.
A doctor, like “doctor” Fauci…good luck!
Not only does he make it more interesting, he also shows how/why chemistry is relevant IRL. The majority of high schoolers would be better served by classes in the applied sciences, which would focus on what's useful for non-sciences people (i.e., why you shouldn't hold kids on your lap in the car; why to follow the directions on the asprin bottle; why to finish that course of antibiotics; why peeing after sex won't flush sperm out of a female). The traditional, academic classes can be available for kids who want to go into the sciences.
Teachers: Pull up a Nile red video
thank you guys! complacency gets people. he's really lucky his friend spotted the bottle, read the warning, and sought out help. I can totally see a group of young adults just sending someone to bed after that kind of disqualification thinking they'd only consumed too much chicken and spice.
I really love the tactful way you guys handled the PSA concerning throat spray being used on YT. masterclass. thank you thank you thank you.
I think he may have lucked out looking like such a smurf that his friends were like "wait... humans aren't normally blue we should probably check on him."
That 'o, hi Mark' moment at 14:50. I guess Mark R will receive some notifications that he's in a Chubbyemu video 🤣
@@thaloblue I'm more curious why they thought it was within normal human skin tone that his skin was suddenly turning blue; only when they read the bottle that said the blue skin is dangerous, did they somehow realize "Wait... HOOMANS NOT BLUE! 'MERGENCY!" But even then, they appear to have failed to convey that he was poisoned with that spray to the doctors in a timely manner, as the case as covered sounds like the doctors were clueless when he came in on what caused his symptoms, tried several things, before discovering that there was a condition which, if they knew the ingested substance, would've been an immediate candidate.
@@MeriaDuck I will never not like a The Room reference, good job!
@@oniryuuko You're very correct. One thing I've learned in all my viewing of medical content is this: We are all incredibly stupid. We will rattle off our favorite Chipotle order in extreme detail, but 24 hours later when the Chipotle gives us listeria we simply *forget to mention we ate at Chipotle.* And then when we are near death, one of our friends will happen to say "ew I still smell like chipotle grease" within earshot. So doctors spend 8-15 years studying the human body in order to try and save our lives within 5 minutes even though we've been in the ER for two days.
I knew doctors needed to know some chemistry, but this level is impressive!
chubbyemu always gives me the vibes of those TLC ER shows, these videos feel like something Id catch on tv in the middle of the afternoon at my grandparents house and I love it
The b-roll footage of RJ hiding the bottle in his napkin while using the spray is hilarious.
I know 😄 gee I wonder if his friends noticed.
Presumably they heard the spritzing sound as well
Not a medical person, but I find your videos fascinating. The mental gymnastics involved in diagnosing and treating some of these cases is astounding.
Finally, "mental gymnastics" have a positive connotation. Me likey.
@Nero Hey. I think this dropped off your name: g
I don't think this is the same as doing "mental gymnastics". Because everything is based on medicine and correlations.
@@martiddy she stated "some of these cases" not specifically _this one._
She probably meant to include the lava lamp case, where the medics were left in the dark about the underlying factor and left to solve the case just by diagnosing his current symptoms. In that video, they really did some mental gymnastic tbh
@@MarioGoatse you are 12 years old
At 55, I now understand the periodic table even better. Thank you
RUclips has recommended me two of these videos recently where the patients actually live.
The old ones used to depress me SO much. Glad there are some happier endings.
The zuck appeared at 6:23-6-24 on a single frame. I barely caught it at 0.25 speed. What a meme lord lmao.
facts
METAVERSE!
same here lmao, i had to know what it was
Finally, I'm not alone
Loved it😂
As a chemist in the pharmaceutical industry, when preparing aromatic amines by reduction of a nitro group, it's drilled into our heads to look out for the hydroxylamine and nitroso (+ other) intermediates, as these absolutely cannot be present in the API due to being known mutagens. I've not taken biology since I was in high school so I've never really thought about why they are so problematic, so this was an interesting case study for me on why exactly they're so bad!
Anything that will oxidize sulfide groups is especially going to be a problem but reduction of carbohydrates and radicalization lipids is a concern too. Proteins are the most studied in terms of ROS interactions as it can cause cross-linking which will miss-fold the entire protein. People are often surprised how damage to just a single residue can be significant but one you study how ternary structure forms, it makes sense. Just a single regular substitution can have significant effects on protein properties. And with a more sophisticated understanding of lipid signaling, it is understood that ROS are major culprits of inflammation.
Hey! I know some of those words… from orgo class 😅
Your job sounds awesome
Your brain on chemistry
You are now manually breathing
Appreciate the chemistry lesson. Thank You.
I love hearing when they make a full recovery.
As someone who entirely gave up on chemistry after one semester, I really appreciate how easy to understand you make the chemical aspects of these. Thank you!
Chem definitely isn't for everyone, but a basic understanding is very useful! Gen chem is tough because you get everything thrown at you. For bio you use organic which I find a lot more interesting than inorganic for the most part which you don't go into until later on.
I know how you feel. In high school, chemistry used to make me want to cry. I hate crying. Who wants to be that girl crying over their homework?? Plus, I already cried every single time I had to work on math. So instead I was fucking furious. I couldn't ask questions because I knew my attitude would make it sound like I was about to fight my teacher. I don't miss those days. Sure, I could eat three brownies without seeing them on the scale a week later, but I had to look at both math and chemistry on a regular basis.
so real I only passed bc I had a crush on my teacher but hey law turned out to be my path you'll find urs
@@eric6cartman9this is really sweet but I’m an adult with a graduate degree too. I just never made it passed high school chemistry lol
Wow. What a story. Glad you have a good metabolism
Hearing that the person made a full recovery always puts a smile on my face. That’s the main part I always listen for in every video lol
he made a full recovering but still is blue like a navi ;)
Yeah that coconut one was a huge let down.
Sus Coconut water enters chat
"With the treatment, YC was able to make *A* recovery..."
I’ve learned and understood more chemistry from these videos than I ever learned in school.
Educational as always thanks for the knowledge Dr Chubby ': D
Watching the whole science behind what's going wrong with the body, explained so very well and without any judgement for the decisions the patients made it's just the best. Thank you Dr Bernard for your amazing contribution to RUclips. I'm already waiting for the next video, till then, be well!
it must be difficult at times... some of these people do such ridiculously stupid things.
@@aliveandwellinisrael2507 we're all capable of doing such things.
I just gotta say its fucking wild that Blue dye is the cure. Like it's just one of those poetic solutions that has a slight tinge of irony in this situation.
@@SergyMilitaryRankings Natural selection and stupidity is a bad combo. That is what 80 percent of this channel is about. I find it amazing that more of the cases don't end horribly.
@@oldtimergaming9514 that's not what natural selection is lol
I look forward to your videos. I was (retired now) a research chemist in a manufacturing industry and worked on several projects in multiple fields over 4 decades, but I never worked on anything involving the life sciences. Your videos are always a great learning experience on an intellectual as well as a practical level and are presented with great clarity. Thank you.
You seem like a great lad. I am very weak in chemistry myself so I just wanted to give some honors, it's a really difficult field and we need more people like you because it's a core field that can truly change the world, and even basically runs the entire world as we know it.
this is a good channel for both science and story telling
I can actually learn from your channel, it's a godsend!
It's nice to have an instance of friends who notice something's wrong AND bring the thing that might be causing it, I'm sure it helped immensely in this instance. Also, was not aware you aren't supposed to swallow that spray. Good thing I've only used it a handful of times, and only at the recommended dosage.
Me either. I learned something
Yeah I have used this before when I had strep as a kid, and thankfully even as a kid I didn’t overdo it. I would spit it out a bit sometimes but definitely have also swallowed a tiny bit
It quite literally says to spit it out and not swallow it. Please be sure to carefully read the labels on *any* medication you're taking.
@@dc8836 to be fair, it's been several years since I used it but I've learned that lesson since
I’ve used it often, and I’m sure I accidentally ingested some, but it obviously takes quite a bit to take you down, like poor RJ.
I always look forward to your videos and they are always so random. You honestly never know what your stories are going to contain and exactly how dumb people can be, it's actually frightening.
Edit: thanks for all the likes!
They walk among us 🤪
@@Gg-ij7li delusional cultist
@@Gg-ij7li hes been coming back "soon" since the start of christianity, same with all the world ending events that never happened
honestly , it's much more frightening when people do NOT do dumb things but still end up in his videos. Like, the coconut water case
@@nin3se The one where a guy took a product that needs to be refrigerated, decided to leave it on his kitchen counter for months instead and then drank it? 🤨I honestly think that's one of the stupidest ones on this channel
edit: It came up in my sidebar again so I rewatched it and it turns out he actually said it had been on the counter for "at least a month". But like, still. Even stored properly in the fridge I'd expect they're only good for a few days. Maybe you actually found that video particularly scary because the guy died even though he barely swallowed any of it? That's an understandable response. And I don't want to give the impression that I'm celebrating his death in any way. But the labelling on food, medicines, and anything else that goes on or in your body is there for a reason. Ignoring that information can be harmful; doing so to such an extreme and senseless degree is bound to end in tragedy.
the subliminal pictures are awesome! showing a Meta-Mark Zuckerburg after saying the word but and the double entendre! GENIUS!!
Wow i normally hate these kinds of videos that present medical issues about other people but they are so useful when done here.
I'm so impressed about how you went into such detail in this complex medical case! I haven't thought about the reactivity of iron since my college years, 40 years ago, and you made the chemistry easy to follow.
Major kudos to the patient's friends for taking the situation seriously. Who knew the misuse of throat spray could be so dangerous?
😉 Yeah! I can Still see the Chemistry "In MY Head" But I Couldn't Put It on PAPER! That was "YEAR 12 High School" in Australia 1990! 30 years Ago
Yeah, I was kinda surprised he delved into full-on orbital diagrams, considering how dumbed-down the explanations tend to be in these videos
I was too really surprised how he showed the orbital diagrams, normally i assume he would explain compex stuff, but i was able to relate to it all that i learned recently in school
he's got a more indepth channel where his video is catered towards med school students if you're interested. I'm not premed/med but I was a biochem undergrad so it was pretty interesting. Worth a watch.
I'm glad he made a full recovery, listening to the dire symptoms he was exhibiting I was beginning to worry that his story wouldn't have a happy ending.
It truly sucks to hear "a recovery" or "at autopsy" in these videos.
He once mentioned in one of the case that the one he presented includes the treatment possible for the case to be saved where full recovery could be assured. Meaning, the actual case didn't make it. So, there is a probability that other cases are also scripted to include treatments available, but in real life, some didn't make it due to lack of first aid, awareness nor quick response.
God damn genius, title talks about his brain but you show pictures of his hands. You win the internet!
Solid!
Top KEK!
Peace be with you.
Growing up in the 1980s, mom would get out the spray bottle of Chloraseptic when we had strep or sore throat. Every time that I do organic extractions of DNA in the lab, that smell of phenol takes me back to that simpler time of Chloraseptic and chicken soup
I am just old enough to remember that when I would go to older relatives' homes as a kid, they would have old containers of "carbolated" everything, like Vaseline.
We really went crazy with the phenol in previous decades and before quaternary ammonium disinfectants. Lysol had a very distinctive smell of phenol, and I gather it was one of the more common methods for people wishing to do harm to themselves.
Reading the old usage suggestions for Lysol is shocking if you look at them today. I will leave it as an exercise for the reader.
One issue with Phenol-based anesthetics, is that they can injure the very tissues that you are trying to numb.
If used carefully, this can be minimized, but the Benzocaine-based products are generally safer(but, indeed can be quite hazardous if abused).
Nope nope nope nope nope that's an instant trauma trigger for me get that shit away from me!
@@SarafinaSummers sorry about that. Should have included a trigger warning. It was pretty gross come to think of it
@@giantfatberg Oh no, friend. You didn't need to put a trigger warning on a damne thing. I'm just a cry baby with no ovaries to speak of. 😂😜🤣 I hope your day is bright, beautiful, and full of good cheer, health, prosperity, peace, love, joy, mirth, kindness, beauty, tenderness, and light that you can stuff into it! 💜💚🌲 ; 💚💜. Please know that you are a valid, beautiful and amazing person, just as you are. Take care of yourself. You deserve it!
As someone who has neither medical nor chemical expertise I enjoy watching your videos massively! The amount of information you pack into such a short video is mindblowing!
That title really reeled me in. It's an emotional rollercoaster in and of itself.
Could an exchange transfusion be used in this case or similarly to the herbicide Gatorade case or would the replacement rate not be fast enough to counteract the spread of these blood cell killers?
Just wanna say that I’ve always had a hard time understanding chemistry, and I’m a nursing student. Referring to elements as “stable” vs “unstable” and calling the rings energy levels has been SUPER helpful
If you are referring to the rings in the molecules they are not really themselves "energy levels" they are more stable because the electrons are delocalised across the ring which resists reactions. If you see a ring (aromatic) you can mostly assume a higher stability.
its actually more correct to think of them as energy levels than rings. The concept of electrons orbiting the nucleus in rings is from a veryyyy outdated model from Bohr. Today we know that electrons exist in orbitals around the nucleus, and these orbitals are basically clouds where the electron probably is located. Different orbitals have different energy levels, so based off of the electron orbitals an atom has, we can predict how certains things will react together.
@@tsweetland7299 i think it's worth it to call it rings or orbitals during high school. learning the simpler explanations when i was 14~15 helped me conceptualise energy levels when i was 16~18. by uni, i agree that the terminology to switch and become more accurate.
with that said, i think this channel belongs to the first category, like an introductory level for casual viewers, and he's always meticulous about detail enough to explain his case but also keep it simple enough for randos who dont know about the medical field, hence why he went for the "ring" approach
Good lord, the 3 Amigos! I didn't come here to fight! Y'all chanting the science like I'm about to have a bossfight here
Ok, on an atomic level the rings you talk about are "shells" or "orbitals", which are simply a 2d representation of where a specific amount of electrons can be at any point and time. Each shell farther from the nucleus, more electrons can exist in that shell.
On the molecular level, the rings refer to aromatics, which is a ring of carbon often having some alkenes in it. Benzene is a good example of this, it is made of 3 alkanes, and 3 alkenes.
Fun Fact: The best way to fight spiciness is using buttermilk, ice-cream and yoghurt or lassi. Using water sometimes actually worsens the pain.
Worst thing to do is to numb the pain at tongue or throat level as it can cause high damage further in the digestive tract like ulcers since the amount of spicy food consumed might go unchecked.
I love spicy food. I can't imagine wanting to ingest an anesthetic just to eat spicier food than I could handle. It's the entire point of eating spicy food... To feel that burn!
@@brianwright9514 True, just tried ghost pepper instant ramen from daebak and I loved the way taste changed from sweet in the beginning to 10k+ Scoville spicy and the way it gave my brain a mini meditative state for 10 minutes, unforgettable experience.
@@brianwright9514 You usually do that when peer pressured into doing stupid things like inhaling Carolina reapers...then if they have any humanity, pressure said peers right back by making them call ER
Sorry for the oddly specific and cynical take
@@dr.python OMG 😂😂😂
POV: You see me eating an individual sized spicy pirogi pizza like a caveman between sipping some Fireball. 🤣(r e a l l y _ l o n g _ w h e e z e down the drag strip).
Those doctors were smart, find out the reason under time pressure, that’s amazing work
You are a very good instructor and storyteller.
I wanted to thank you. Your videos are partially responisble for my doctor praising me last week. My main takeaway from your videos is that it is in my best interrest to give my doctor as much information as possible. My doctor started me on thyroid medication a few months ago and told me to take note of any changes I noticed. So I did, I sent her an excel sheet with a calender, everything I noticed was there with date and if relevant even time of day. I somewhat regularly take my bloodpressure at home just to know what my normal is, I bought a pulsoximeter when my dad (high risk) had covid to monitor him at home. When the doctor initially asked me to take my bloodpressure for 2 weeks every day she got a printed out calender with date, time and context on it for every messurement, sometimes multiples a day when I was feeling off.
In regards to this video: I'll have to watch it a few more times to completely understand it. Partially because english is my 3rd language, partially because I don't have the background to understand it easily. You do a great job with your videos!
Wow! Your English is really good for being your 3rd language. My 3rd is German and I can pretty much order falafel, say hello/goodbye and ask what time it is. I absolutely don’t know the German word for things like thyroid, blood pressure etc.
Lil excessive don't u think?
@Milla Cerne Hey there! The German word for thyroid gland is "Schilddrüse", the word for blood pressure is "Blutdruck". While the latter is exactly the same just in German words, thyroid gland in German means Schilddrüse (most direct translation: "shield gland"). I can't find any reason as to why it has shield in the name other than assume that the butterfly-like shape was originally also described as some form of shield-ish shape. I will update this once I've been able to ask the professor I'm working with :)
@@nickkohlmannthat’s really cool! I’m doing spanish so I’m just replying so I can increase my vocabulary with German, I know it’s doesn’t make sense but I always like knowing more languages. I wish I could know all languages but sadly I’ll have to stop cuz of exams.
@@nickkohlmann hi fellow German.
Dude throat numbing spray is my life saver. Seriously. I often suffer tonsillitis. Infact whenever I get sick with a cold I tend to get it and the symptoms are horrendous to the point of being in pain every time I swallow, and feeling like I have the flu. Stuck in bed. The only thing that made me feel worse was covid. I rely on this stuff to make me function cus I get sore throats so often. And I have no idea why.
Some people have irritable tonsils, resulting in a state of semi-permanent inflammation. If I were you I'd go to the doc and explain this to them. They just might remove them and solve your problem altogether. I will warn though, tonsillectomies when older are fucking awful and you will drop a lot of weight from just not eating during the recovery.
"if you dont need to put in your body, dont put in your body" pearls of wisdom towards the end !
For those of you who must know, the image at 06:14 is a Metaverse picture of Zuckerberg in front of the Eiffel Tower.
I really appreciate the focus on pharmacokinetics in this episode. It’s always interesting to learn about the mechanisms behind drug toxicity.
Holy shit!
Dustforce OST in background! ❤❤❤
Hilarious choice, but the music is incredibly good, good tracks you picked as well, btw 😂
its always strange to hear of methalyne blue in a medical situation since its most common form is as an anti-fungal medication for the aquarium hobby/trade! I am often working with it to keep fish healthy as well as prevent fish eggs from getting fungal diseases!
I use this spray for its intended purpose. I recently purchased a different brand. It has a minty flavoring that if you spray too much, it becomes uncomfortably minty "hot," preventing one from using too much.
Kudos to whoever designed this formula. More than two sprays, you pay.
15:15 "Could be used on other sensitive parts of the body" *Chubbyemu winks*
Do we have the same problems with lidocaine? When I had a gastroscopy, my physician gave me a lidocaine solution which he directed me to _swallow,_ in order to numb my throat. Also, I have a bottle of 5% lidocaine solution. I use it to control sphenopalatine ganglion pain by holding my head back and putting a lidocaine soaked q-tip way up in one or both nostrils (sometimes the pain is only on one side or the other). I've also found the stuff good for dealing with a sore throat however I neither spray it nor swallow it. I mix about 2 ml of the stuff with about 5 ml of water (so I have roughly a 2% solution) and then I gargle it, trying not so swallow too much of it if any. I wonder if this is too risky.
This is better then most college courses i have taken. Subbed.
6:24 the image that comes up for just like .2 seconds is amazing.
-edit did anyone else notice the hidden pic.
Yoooo i was looking for this comment😂
LOL can't see many people mentioning it. Had to slow it down to be able to pause on it.
I have found the comment. I humbly claim my spot among the few. Let us convene on the next solstice.
Can we take a moment to appreciate the youtube chapter titles like "haha spray go glug glug"?
Wow. Talk about a chemistry refresher 😬
I had tonsilitis once and my mother gave me candy with the active ingredient benzocaine. Ever since I've always though of it as some safe anesthetic since they placed in candy, I figured then it shouldnt be incredibly dangerous. I wonder if back then I had been more squirmy and had sneaked those candies in like I do halls, if I couldve ended up with a case of methemoglobinemia.
something so wonderful about being cast as “food enjoyer”, loving these acting segments
Right? "You don't want stomach pain for dinner? What's wrong with you?"
It always lifts my mood when I hear "a FULL recovery" in these videos! ^_^
Really informative.
I was actually learning something and then a youtube ad popped up and after the ad i was unable to make sense of what you were saying… that’s unfortunate because i was really enjoying this video
I remember watching these videos when I had absolutely no clue what was happening, now that I finished my anatomy and physiology courses I can watch these videos in the background and understand everything, I feel so accomplished.
Even with. Year 9 science level education (periodic table elections and all that I can understand what’s going on
That's awesome, congrats.
@@UtiNo6 thank you brother 🙏🏽
@@nitro_gladiator_6965 nice 💪🏽 stay educated
Welcome to the council!