Non Steroidal Anti-Inflammatory Drug | NSAIDs (Part- 02) = Physiology of Inflammation | Inflammation

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Prostaglandins are a family of chemicals that are produced by the cells of the body and have several important functions. They promote inflammation that is necessary for healing, but also results in pain, and fever; support the blood clotting function of platelets, and protect the lining of the stomach from the damaging effects of acid. Prostaglandins are produced within the body's cells by the enzyme cyclooxygenase (COX). There are two COX enzymes, COX-1 and COX-2. Both enzymes produce prostaglandins that promote inflammation, pain, and fever. However, only COX-1 produces prostaglandins that support platelets and protect the stomach. Nonsteroidal anti-inflammatory drugs (NSAIDs) block the COX enzymes and reduce prostaglandins throughout the body. As a consequence, ongoing inflammation, pain, and fever are reduced. Since the prostaglandins that protect the stomach and support platelets and blood clotting also are reduced, NSAIDs can cause ulcers in the stomach and promote bleeding.
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Sir ek confusion hai jaisa ki apne 1st lecture me bataya ki inflammation postaglandins se cause hota hai aur is lecture me process of inflammation me selatin aur integrin se inflammation cause ho rha h postaglandins ka role hi nahi h. So please clear the confusion with little bit of explanation thank you

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