I end up doing that A LOT because what I'm working with is very easily destroyed by the heat. I'm very used to doing it, so I've gotten quite quick at setup and operation, but whenever I have someone working with me, I get complaints about how often we setup and take down the short-path distillation rig.
At some times it felt like the video was on repeat 🤣 Add some DCM, distill with water somethingsomething short path vacuum distillation salts salts crystals bleak oily substance. Add some DCM, distill with water somethingsomething short path vacuum distillation salts salts crystals bleak oily substance.
What I'm curious about is the random nitro group, would the compound break down if that nitro group was removed? It's a pretty electronegative group so maybe it has something to do with the resonance of the central ring, but then why isn't another nitro on the aniline attached to the solitary nitrogen? What's special about the hydrazine group that warrants the nitro that isn't necessary for the amine?
As a PhD student working on an organic synthesis project, I appreciate seeing your discussions in this and other videos where a technique didn't work. I would say your videos are an accurate reflection of what chemical synthesis research is like -- find something in the literature, try it, laugh it off when it doesn't work, try other things until something does work, wonder how the literature managed to get a higher yield than I did, muse on how everything is yellow.... Also: I love your sense of humor.
The search for solutions and beeing as much tolerant against frustrations is the most important thing as chemist lol I guess a steam destillation with the catnip would have worked to gain the essential oils
so it's not science. I knew it. It's still alchemy. It should work every time. But wait... some giants had to write those papers, to imagine the reaction path and follow the perfect theory to a pure product. IMO they dont share all the tricks and little details
@@refluxcatalyst7190 The quality of the content on this channel is really superior than any other ochem channels on youtube. It's essentially a lab report of the synthesis of all the reagents, with professionnalism and a really scientific approach. Message to benchtop NMRs : Give this man an NMR already!!!
Absolutely love your videos! The mixture of humour, cleanliness of the graphics, detailed and much appreciated reaction mechanisms, clear step-by-step explanation, and so much more. Truly blessed to have found your channel. For once the RUclips Algorithm actually suggested me an amazing channel. Looking forward to (hopefully) many more chemistry videos :).
Wow all that effort. You certainly gave that short path distillation head a real workout. You must really really really love cats!!! Glad it worked out.
Absolutely mind blowing chemistry, and your video composition is great! Good job dude, you deserve way more hits. No doubt you will get them if you keep it up
Очень качественное видео! Смотрю вас достаточно давно, и мне очень нравится, что вы начали детально рассматривать механизмы проходящих реакций! Получается информативно и полезно!
Oh man, that's a cool synthesis! It spans over so many different aspects of chemical synthesis. Nice use of NHC catalysts and oxidative phenol coupling I must say
Your videos really bring back the magic when I first entered organic synthesis lab in Uni. (I now do research on surface modification of nanoparticles with polymers, and don't need to think about yield, column and distilling anymore)
Oh man I feel ya... Whenever I synthesize a new product and try just filtering and washing, 90% of the time I'll overshoot and lose product on the fritted glass filter 😅
in the diazotization reaction: your yield wasn't as high as the literature because of the foaming ... that's an indicator for the production of nitrogen, so you basically performed a sandmeyer reaction to a certain extent ... replacing the diazo-group with Chlorine from HCl and releasing Nitrogen ...
Doesn't the sand meyer reaction require a Cu(I) salt for it to actually happen? The Cu+ donates 1 electron to the diazonium salt( which has a carbocation resonance form) generating a phenyl radical which then couples with a chlorine atom to form the chloro-arene compound.
@@durshurrikun150 the sandmeyer reaction can just be substitution where molecular nitrogen is the leaving group, I think only specific transformations require Cu(I)
@@Siyuan_Li Ah, so it has both a radical mechanism and a SnAr mechanism. Because when I studied it, my textbook called the sand meyer reaction only the substitution of a diazonium group on an aromatic ring with chlorine, iodine and bromine in the presence of the respective Cu(I) salt. For example, the gentle decomposition of a diazonium salt in water or OH- to produce a phenol or the decomposition of a diazonium tetrafluoroborate to give an a fluoro arene were not classified as a sandmeyer reaction.
I really like your videos, i am in an entirely different field and i only really have some entry level chemistry knowledge but i like to see the process its satisfying to see it then have it explained and seeing the end result etc, i dont know if im the main target audience but i enjoy it a lot
Meanwhile Nilered's channel: *"Today, I show you how to make Benzoic acid. In the next video I will show you how to make Diethyl ether - I will upload the next video in one year because it takes a long time and hard work to produce this content"*
The mistake u made with the separatory funnel reminded me of what I did last week in my lab xD I was refluxing for a couple hourse and then it toppled because it wasn't tightend properly and I lost most my material.
Absolutely killer video man! Would have been nice to see you try it on more cats or test that you actually had the product but amazing syntheses regardless!
Very nice Video. In general, as a organic chemist phd student, I like your videos on the synthesis of some nice stuff. You can do TLCs of harsh reaction mixture, for example containing sulfuric acid, by doing a small workup in a vial.
Valerian root works even better as a cat attractant. But nepetalactone has another advantage in humans, in that it has a repellant actions towards cockroaches and mosquitoes.
I need a cat repellent please! This is the most complicated synthesis I have seen on youtube. I particularly liked the part around ~17:10 where you used a crap stir plate to stir turd-butylphenol and turd-butanol.
Amazing video and synthesis! I also had a project idea to get some nepetalactone, but I was gonna try to vacuum distill the catnip extract since most of it should be nepetalactones.
I hated chemistry at college. I hated chemistry at university. And I hate chemistry in my current job. But man, I love your videos. Thanks for doing what no chemistry teacher I ever had has done, inspire me to love chemistry!
And he was complaining that extracting the nepetalactone from catnip was too difficult. Steam distillation worked fine for me when I was making some cat attracting juice. I did have to wait for the catmint to grow though. I really like the smell of that stuff too.
Awesome man! Simply awesome! Cheers for the reaction mechanisms, they honestly make it really enjoyable. Also, the equivalents are very helpful as well, they make the reactions more appreciable
New drinking game: take a shot every time he has to do short path vacuum distillation.
I end up doing that A LOT because what I'm working with is very easily destroyed by the heat. I'm very used to doing it, so I've gotten quite quick at setup and operation, but whenever I have someone working with me, I get complaints about how often we setup and take down the short-path distillation rig.
Joke's on you. I don't even know what that means and I'm already drunk. So I won twice.
😎
At some times it felt like the video was on repeat 🤣
Add some DCM, distill with water somethingsomething short path vacuum distillation salts salts crystals bleak oily substance.
Add some DCM, distill with water somethingsomething short path vacuum distillation salts salts crystals bleak oily substance.
That's a pretty good one! It's a fairly regular event which happens just the right amount of times to get you drunk but not wasted.
That catalyst is absolutely wild. I can't imagine the hours of scouting and development to discover it.
What I'm curious about is the random nitro group, would the compound break down if that nitro group was removed? It's a pretty electronegative group so maybe it has something to do with the resonance of the central ring, but then why isn't another nitro on the aniline attached to the solitary nitrogen? What's special about the hydrazine group that warrants the nitro that isn't necessary for the amine?
@@GarryDumblowski bruh
@@Insommer Look, I'm not smart and I'm also not a chemist, if there's something i'm missing then i'm sorry but I'm not gonna find it on my own lmao
As a PhD student working on an organic synthesis project, I appreciate seeing your discussions in this and other videos where a technique didn't work. I would say your videos are an accurate reflection of what chemical synthesis research is like -- find something in the literature, try it, laugh it off when it doesn't work, try other things until something does work, wonder how the literature managed to get a higher yield than I did, muse on how everything is yellow....
Also: I love your sense of humor.
Always iffy with yellow chemistry
The search for solutions and beeing as much tolerant against frustrations is the most important thing as chemist lol
I guess a steam destillation with the catnip would have worked to gain the essential oils
Everybody knows that all yellow chemistry is alchemy
I AGREE! It is no where as easy as on paper
so it's not science. I knew it. It's still alchemy. It should work every time.
But wait... some giants had to write those papers, to imagine the reaction path and follow the perfect theory to a pure product. IMO they dont share all the tricks and little details
Regular people attracting cats: Pspspspspspspsps!
Chemists attracting cats: *CHEMICAL WARFARE TIME!*
The chemicals do the "Pspspspspspspsps"
That’s cheating! I use chicken. 😂
🤘
- Mum can we watch Nile Red?
- We have Nile Red at home.
Nile Red at home... but the home is a posh countryside estate:
- Mum can we watch Nile Red?
- Psh! How about a chemist who can actually distill a product properly!
Stop being so catty 😹
This is miles ahead of any content anyone else on chemistry youtube is doing.
Do you need more chemistry channels? This is pretty identical to what many others are doing - it's FAR from "miles ahead."
Here's some other channel recommendations: explosions&fire/extractions&ire, NileRed, thylabs, nurdrage, chemplayer, doug's lab, probably a bunch more
@@refluxcatalyst7190 The quality of the content on this channel is really superior than any other ochem channels on youtube.
It's essentially a lab report of the synthesis of all the reagents, with professionnalism and a really scientific approach.
Message to benchtop NMRs : Give this man an NMR already!!!
nile red
How do you measure?
Neil does nice video too. And quite a few others.
Strange enough, my cat seemed to be attracted to this video alone. She came to check it out quite immediately 😅
she understands human languages, she is too powerful
My cat "Haz you Cat-Viagra?" :D
So… this is basically Breaking Bad for cats?
this is 'Baiting Cat'
Thanks
Needless to say, I admire your purrsistence.
I had no clue what I was looking at but you made catnip juice which is kind of cool. I left you at like good content!
this has very extractions&ire energy and I'm absolutely here for it
sadly tom no longer likes animals after he got kicked out of his shed by a bunch of possums
not enough failure to be "very" similar to E&I tbh
nah, not enough tar
@@cvspvr loool
Nah, not enough tar and too clean setups, Tom's lab looks like a post-apocalyptic drug lab
The first cat at the end reacted exactly the way every cat I've ever tried to offer catnip reacted
Absolutely love your videos! The mixture of humour, cleanliness of the graphics, detailed and much appreciated reaction mechanisms, clear step-by-step explanation, and so much more. Truly blessed to have found your channel. For once the RUclips Algorithm actually suggested me an amazing channel. Looking forward to (hopefully) many more chemistry videos :).
The detailed and well illustrated synth-theory is great and educational.
Wow all that effort. You certainly gave that short path distillation head a real workout. You must really really really love cats!!! Glad it worked out.
I really apreciate you putting the reaction mechanism and molecular structure. Thank you.
Thanks! Awesome videos 📹 👌 👨🔬
That is another achievement far beyond the average RUclips chemistry. Damn, you are good, man! Love your channel. 😻
While other RUclipsrs are sniffing Menthyl Acetate (Menthol), here cats are flipping out on cat-Viagra. hehe
This guy makes me feel so damn lazy. Doing all this and filming it too is a crazy investment of time. Thank you so much and keep it up!
You deserve way more subs with the content you put out
Same could be said about you honestly
Absolutely mind blowing chemistry, and your video composition is great! Good job dude, you deserve way more hits. No doubt you will get them if you keep it up
Очень качественное видео! Смотрю вас достаточно давно, и мне очень нравится, что вы начали детально рассматривать механизмы проходящих реакций! Получается информативно и полезно!
Takes 89 days to make the catalyst, but doesn't want to take 5 days to remake the nepetalactone.
In all seriousness though, excellent presentation.
Oh man, that's a cool synthesis! It spans over so many different aspects of chemical synthesis. Nice use of NHC catalysts and oxidative phenol coupling I must say
I love that you go through making rocket fuel to make catnip :-) chemistry is really fascinating!
EDIT: 20:12 : And Aspirin too??? Wow!!!
Honestly, that seems like how cats react to it so it makes sense 😜😂😂
Very impressive
Chemistry is beautifull, to be able to make something like this out of pure whim and a lot of effort is just done splendidly, thank you for the video.
18:26 Recrystallization, always my favorite part when it happens :-) I know it hurts your yield but it's always beautiful to watch hahaha!
Your videos really bring back the magic when I first entered organic synthesis lab in Uni. (I now do research on surface modification of nanoparticles with polymers, and don't need to think about yield, column and distilling anymore)
Holy smokes, must have been a tremendous effort. Awesome video!
What a massive project, kudos to you for following it through!
Breaking Cat
pretty neat stuff
This is some serious OG chemistry. Awesome!
This is high quality chemistry cinematography
i am a simple internet person. i see “nepeta” prefix a word, and then i just start thinking about trolls
my condolences (yeah 😔)
Could you explain?
Get trolled snowkie
hello
@@radRadiolarian you.
man, this was so complex, you literally built the entire molecule like legos, cool
I like that the video gets quieter and quieter over time.
Oh man I feel ya... Whenever I synthesize a new product and try just filtering and washing, 90% of the time I'll overshoot and lose product on the fritted glass filter 😅
in the diazotization reaction: your yield wasn't as high as the literature because of the foaming ... that's an indicator for the production of nitrogen, so you basically performed a sandmeyer reaction to a certain extent ... replacing the diazo-group with Chlorine from HCl and releasing Nitrogen ...
that's damn right, i remember studying that reaction at high school
Doesn't the sand meyer reaction require a Cu(I) salt for it to actually happen?
The Cu+ donates 1 electron to the diazonium salt( which has a carbocation resonance form) generating a phenyl radical which then couples with a chlorine atom to form the chloro-arene compound.
@@durshurrikun150 the sandmeyer reaction can just be substitution where molecular nitrogen is the leaving group, I think only specific transformations require Cu(I)
@@Siyuan_Li Ah, so it has both a radical mechanism and a SnAr mechanism.
Because when I studied it, my textbook called the sand meyer reaction only the substitution of a diazonium group on an aromatic ring with chlorine, iodine and bromine in the presence of the respective Cu(I) salt.
For example, the gentle decomposition of a diazonium salt in water or OH- to produce a phenol or the decomposition of a diazonium tetrafluoroborate to give an a fluoro arene were not classified as a sandmeyer reaction.
Chemiolis uploaded. Thank God I needed daily dose of column chromatography
Each video gets better, keep it up! You are the best :)
Yes they often use hexane etc to remove after being refluxed with ethanol. It is tough to separate I tried I was uncessful. Glad you made it.
Interesting. Had noticed that cats get a "high" when they sniff my hand. They start rubbing against my hand, rolling around, licking me and meowing.
7:40 uuuh, forbidden eggnogg
Going from giving your cats weed to giving your cats dabs.
Nice vid! As a student i love the explained mechanim backgrounds :)
13:30 YOU LITERALLY GIVE ME A HEART ATTACK 😥😥😥😥😥
me too
"Literally." 🤔
Are you feeling better now?
How is your head?
rip
yooo i had this idea and you did it!! great job man keep up the cool content👍
Definately needs more patreons for more equipment
These videos are like high quality wine
“Because this cheap stir plate is crap”
Lol, I felt that XD
A catylist for cats 🐈 😂 wow what a complex prosses hats off 👏 👌
Diazonium salt: please, I beg you, just let me become nitrogen gas!
Chemists: lol nah dawg, I don't think so
this guy is awesome
I really like your videos, i am in an entirely different field and i only really have some entry level chemistry knowledge but i like to see the process its satisfying to see it then have it explained and seeing the end result etc, i dont know if im the main target audience but i enjoy it a lot
alright guys, take 1 shot of HPLC grade Ethanol for every "short path vaccuum distillation"
it's strange seeing "nepeta" in normal contexts
"My pride didn't let me abandon the project" Words to live by!
Why I didn't know about your channel until now?! Great everything, thanks.
"Ermmm Oopsss..." *gets cancer*
Meanwhile Nilered's channel:
*"Today, I show you how to make Benzoic acid. In the next video I will show you how to make Diethyl ether - I will upload the next video in one year because it takes a long time and hard work to produce this content"*
The mistake u made with the separatory funnel reminded me of what I did last week in my lab xD I was refluxing for a couple hourse and then it toppled because it wasn't tightend properly and I lost most my material.
Absolutely killer video man! Would have been nice to see you try it on more cats or test that you actually had the product but amazing syntheses regardless!
Very nice Video. In general, as a organic chemist phd student, I like your videos on the synthesis of some nice stuff.
You can do TLCs of harsh reaction mixture, for example containing sulfuric acid, by doing a small workup in a vial.
Valerian root works even better as a cat attractant. But nepetalactone has another advantage in humans, in that it has a repellant actions towards cockroaches and mosquitoes.
I need a cat repellent please! This is the most complicated synthesis I have seen on youtube. I particularly liked the part around ~17:10 where you used a crap stir plate to stir turd-butylphenol and turd-butanol.
My head was spinning before the 10 minute mark. OMG was this complicated!
Your neighbors must love you with all the SO2 you're making..
Amazing video and synthesis! I also had a project idea to get some nepetalactone, but I was gonna try to vacuum distill the catnip extract since most of it should be nepetalactones.
Whoever discovered this chemical missed a great opportunity to call it Nepetacatalactone.
Cats AND Chemistry - The perfect YT video :)
loved the test at the end😂😂
Very cute cats you've got there 😻
And interesting synthesis.
I don't need this... Or catnip... My cats go crazy smelling my shoes 😂
Besides the few oopsies, which happen cause we all make mistakes, it’s pretty cool you pulled of such a long synthesis
The best video in the Internet
So not only are we making insect repellant, but it also attracts cats? You sir, are a magician!
“So I attached the short path distillation column” for the win
I’m not used to watching someone on chemistry RUclips who actually knows what they’re doing
This is so easy, I wonder why more people don't make this at home.
I would love to see a trimethyl aniline synthesis
This makes me excited to start my career in organic chemistry!
We got cat crack before gta6
You got me at « i love cats »
I hated chemistry at college. I hated chemistry at university. And I hate chemistry in my current job. But man, I love your videos. Thanks for doing what no chemistry teacher I ever had has done, inspire me to love chemistry!
This content is so high quality wow
Breaking bad in an alternate reality where cats are the dominant species.
Whisker white: "I am in the empire business...
The Catnip empire"
You gave me a heart attack at 13:30
This video deserves cat-ass trophy.
This is so informative!!! Fantastic video; I love this kind of content!🌻🌼🐝
after Nile red this channel is doing great
And he was complaining that extracting the nepetalactone from catnip was too difficult. Steam distillation worked fine for me when I was making some cat attracting juice. I did have to wait for the catmint to grow though. I really like the smell of that stuff too.
Now THIS is the kind of chemistry I can get behind
NMR, NMR, NMR, ole ole ole, NMR is what we need!
Awesome man! Simply awesome! Cheers for the reaction mechanisms, they honestly make it really enjoyable. Also, the equivalents are very helpful as well, they make the reactions more appreciable
I want to buy cat cologne please.
So... He made Meowijuana dabs?
Cute cats
From that intro, it felt you didn't love cats, you love-love cats!!! 🤨
jokings aside, loved the video and subscribed!!! 😊
Hey, how about a lab tour?
Gud gawds what a process! Thumbs up for effort, daym!