NAD+, aging & fertility - Prof Charles Brenner
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- Опубликовано: 31 июл 2024
- In this video I speak with Prof Charles Brenner, Alfred E Mann Family Foundation Chair of Diabetes and Cancer Metabolism, Beckman Research Institute, City of Hoper. He has contributed to the field of NAD metabolism and is passionate about demystifying aging research. I hope you enjoy our conversation.
Find Charles on Twitter - / charlesmbrenner
Find Charles publications on his website: brennerlab.net/
Find me on Twitter - / eleanorsheekey
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Timestamps:
Intro - 00:00
NAD Metabolism - 01:00
NR discovery - 08:30
Measuring NAD - 22:00
NAD dysfunction and decline - 25:30
NMN - 33:00
Circadian rhythm - 36:00
Aging - 41:00
Fertility - 50:30
Industry vs. academia - 57:00
Unanswered questions - 1:00:00
Advice - 1:02:00
References:
Sirtuins are Not Conserved Longevity Genes - doi.org/10.1093/lifemeta/loac025
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed. 
Наука
I hope you enjoy our conversation!
tldr?
Go do that PostDoc!
What a knowledgeable and decent human being. Thanks so much for this. It was really instructive.
Enjoyed this interview! It's helped me appreciate the complexity and deeper questions about this field. It's easy to get caught up in hype and I appreciate Dr. Brenner's consideration of alternative hypotheses and emphasis on evidence and inquiry.
Long time fan of your channel. Thanks for posting this content.
Fantastic discussion, thanks both of you
Have you looked into the study that showed that nicotine (pure, not from tobacco) can stimulate/activate NAMPT and the NAD+ salvage pathway? The title of the study is: "Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity."
Beauty and brains! Than you again .
Haemophilus influenzae needs v-factor (NAD) and x-factor (hæmoglobin) to grow. We grow this potential patogenic bacteria to diagnose pneumonia or miningitis.
Great conversation! I took NR for athletic performance.
I think Brenner on his scepticism is indeed what the field need. We clearly see some people going out of their way selling supplements and not actually looking at the bigger picture. Remember even in mice the gains were not that big. Though for healthspan there is something to say.
Also the warning here is clear.. when using NMN liposomal it is suggested this can be significantly problematic. Now wehn we ingest NMN or NR it frankly does not make a huge difference where it seems both are being broken down in digestion before absorption. This will not lead into big difference in outcomes.
BTW he just offered Sheeky a post doc
Hi Eleanor! Loved it, but I understood about 10%. I'd love to hear your interpretation for layman specifically around NR/ NMN / Sarm1 interaction. Thanks again!
Yes, please!
Is there a supplement to support ivf in females in terms of increasing egg quality and quantity ?
If the SIRT enzymes are not connected to longevity, then we don't have to worry about nicotinamide inhibiting them. That implies NAM could be used instead of NMN/MR as a viable NAD supplement with little cost.
It would have been good if you had asked Charles what he thinks about the results that show how NR withdrawal leads to undesirable consequences and exacerbates aging phenotypes (doi: 10.1038/s41514-021-00078-3). Also, how confident he is in the accuracy of the data produced by the labs ChromaDex has a CRADA with? Well, hopefully next time. :)
The next sentence in the discussion section of that paper is "Thus, once a deficient system [i.e. compromised hematopoietic systems (NAD+ depleted system)'] is exposed to NAD+ supplementation, to maintain the benefits we have demonstrated, the regimen may need to be sustained long-term." But is that such a surprising result?
Ok, the NR is coming back out the cupboard 😂
Very interesting…But I’ll have to watch this in steps…Dr. Sinclair, suggests that NA is less effective in boosting NAD+ than NMN or NR, because it lacks the building blocks to to so. Are there any studies or is there any evidence that shows that NA can be equally effective, provided that the other pieces can be provided separately, eg, TMG and Phosphate?
Dr Sinclair has investments in NMN takes a disappointingly self serving stance. NMN is barely found in foods and we went though billions of years of evolution doing fine on NA and NAM. NA doesn’t deplete phosphate groups and neither does NR.
If you take NR early in the morning, you prime the body to be in the mood to make NAD+, thus if you take nac a few hours later your body is more likely to us nac to make NAD. Just a theory of mine.
@@TheBiffsterLife The "evolution" argument is a real fallacy here. We are talking about the best outcomes for modern man. Meaning the lessons from history are why the systems were formed the way they were and how to exploit them into getting the outcomes we need.
So sting "it was hardly found in food" means the complexity of applications in the field just went over your head. Rapamycin wasn't ingested either.. does that mean we need to write it off because it was not "found in foods"..
Stop commenting about people having conflcit of interest when you do not even understand the baseline of how interest relate to this field in the first place.
@@unholyquail4560 please educate us wise man. Rapa works in mice because is antitumorgeric and mice have a different geneset such that they are far more prone to cancer than people. Unfortunately for longevity hipsters like you, it is also a strong immunosuppressant. No sensible person should take rapa without any proof it works in humans.
So, around what age should one start taking NAD supplements? I was thinking of testing my levels but even with this information, I don’t know when is best to start. I’m currently taking fisetin. Also, what happens if we suddenly stop taking NAD supplements? Are there any side effects? I’ve seen that there are a few companies testing NAD supplements on people so far but I don’t find any clear answer…
Certainly by age 40. That's when your levels really drop off. I've started and stopped NAD supplements several times and experienced no side effects. It sure has helped my sore back and joints however, and my stamina. (I'm going to be 44 in a week!)
What is the consequence of stopping NR, that is the question. Does the body become dependent on supplementation and can no longer make it's own NR?
BEST TOPIC YOUVE EXPLORED SO FAR!
YOU KEEP KNOCKIN IT OUTTA DA PARK!!!
😉😁👍💪
I’m a fan of the channel, but this interview was not an easy listen. BTW, did you know that Brenner is a paid consultant for ChromaDex, which holds the only license to manufacture NR? He also is co-founder and Chief Scientific Adviser of ProHealthspan, which sells NR supplements under the trade name Tru NIAGEN®. I happen to take NR, and believe strongly in its benefits, but I think his financial interest in NAD+ precursors should probably be noted for your audience. (If I missed the disclaimer, my apologies - I still like your channel.
His commercial ties were discussed in the interview.
Your cartoon is funny 😅😄! nice hair!😂
Do you mind not showing the Windows logo, I use Linux.🐧
She's using Microsoft surface studio 😊
lol u will live. Not everyone need to cd and bash all the time
Pretty sure I understood about 1% of this...
For long life span look at the Korean eueunchs life span was 14 too 19 years longer then any citizen at that time period
Yeah but at what cost? Oh yeah the whole eunuch thang. I can not fathom an extra 14 to 19 years sounds like a prison sentence without D’s. nuts
So, are we transducing light at the frequency of the electron into matter?
Listen to Dr Nicholas Conlon instead
Found the conversation a little unfocused and the combination of too many sidetracks and superfluous detail makes it hard to follow the whole interview
It appears Dr Brenner allocates about 300 of his 1000 IQ points to making his thoughts clear to ordinary folk. Would suggest it wouldn’t hurt to increase the allocation somewhat.
Weird coincidence, I was just looking for an NAD video and this popped up in my notifications.
Unfortunately probably not weird but big data at work
Maybe but I start my PhD tomorrow and my first link project is measuring NAD+ metabolism in muscle after NMN and NR supplementation. So it’s apt, and it was literally just as I went to refresh, this video was uploaded.
The last time I saw this fellow (on another channel) he was very MEAN
Maybe he was having a bad day, or fell to Sheekey charm.
He and Dr Sinclair are like oil and water 😁
I also would describe his conduct on the last longevity-related interview I saw him in as "mean" -- though, he did later participate in an audio-only follow-up interview to that interview on Twitter, in which he was much better behaved, at least.
@@WickedHole He's a brilliant man, but he is smug and interrupts people, he can be pretty mean, especially in the discussion he had with Dr Aubrey on RUclips.
@@adriancandelario2902 Yes, I was referring to that interview. There is a follow-up to it on Twitter in which Brenner conducts himself much more respectfully. Evidently, he can, in fact, stop himself from interrupting when he puts in the effort.
Melatonin and Nocturin regulates the Nad hydrogen and phosphate shuttle that drives the circadian oscillations.
These guys are studying things we knew 10 years ago.
Slow release all day, let melatonin and nocturnin regulate it.
Avoid too much blue light, get enough sleep.
In practical terms? Is there slow release NR out in the market, or what method for spreading levels over many hours, divided doses?
@@eugeniebreida1583 Someone should make slow release vitamin C + non vitamer B vitamins + NRH + NO2 + H2S.
I'm doing something a little more revolutionary, but it's slow going due to lack of capital.
speed gap between these two is remarkable. This conversation therefore lacks a kind of connection.