A MORE Effective Approach To Restore Our NAD Levels??
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- Опубликовано: 14 окт 2024
- Dr Nichola Conlon presents about how to use a whole system approach to restore our youthful NAD production in this interview clip.
Dr. Colon Recent Paper:
A systems-approach to NAD+ restoration
www.sciencedir...
Dr Nichola Conlon is a molecular biologist specialising in the study of cellular ageing. After a career in drug development with a leading biotech firm, Dr Nichola founded Nuchido Laboratories driven by her belief that cutting-edge science should not lie hidden.
Dr Nichola is on a mission to democratise science and is an expert in cellular health, with particular focus on the science of ageing well, helping people to reverse their biological age and improve their healthspan. Dr Nichola’s work to translate recent scientific discoveries into interventions to increase healthspan and vitality recognizes that while great progress has been made in treating age-related ailments, the focus now must be placed on reducing the burden of these diseases as we live longer lives.
Along with leading scientists at Nuchido, Dr Conlon has identified the optimum combination of targets to restore cellular NAD+ production back to youthful levels, leading to the development of a breakthrough NAD+ booster called Nuchido TIME+.
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DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.
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What about NAD injections? what's the opinion?
Fasting is also very effective for restoring NAD levels. Yamanaka factors, too! Some of the many benefits of doing occasional extended fasting: Blood clotting is reduced and blood clots and arterial plaque are reabsorbed into the body. High blood pressure is lowered to normal levels very quickly while fasting. Fribrosis/scarring is reversed over time.
Fasting increases nitric oxide release.
Vitamin D plasma levels are increased as fasting improves metabolic health, and vitamin D in turn increases autophagy.
Telomeres are lengthend and fasting also increases anti-aging Yamanaka factors.
Fasting stimulates phagocytosis, the ingestion of bacteria, plaques and viruses by the immune system. It will also remove any 'foreign material' that is not supposed to be there.
Reflexes and short term memory are increased.
Fasts from 36-96 h actually INCREASE metabolic rate due to norepinephrine release!
Thymus is regenerated, which suppresses aging and renews the immune system. The thymus also plays a vital role in fighting cancer.
Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue! The hunger hormone ghrelin also lowers with extended fasting and rises from dieting.
Blood sugar and insulin are lowered, allowing white blood cells to move more freely throughout the body and do their job. Ideal blood sugar is around 80. Some viruses activate glycolosis (the release of sugar in the body) and clinically it has been shown that decreasing glucose metabolism in the body weakens the influenza virus.
When you move out of MTOR your body shuts down the building blocks of the cell which are used to produce organelles and proteins. This means the mechanisms needed by viruses to replicate are by and large unavailable when you are in a deeply fasted state.
What breaks a fast? Anything with protein or carbohydrates in it will break a fast, though if the amount is tiny you will go back into ketosis very quickly. Most teas and herbs are OK. Most supplements and meds will either break ketosis directly or contain a filler that will. Many medications are dangerous to take while fasting so you may have to talk to your dr. about discontinuing them during a fast.
Does fasting lower testosterone? No, it raises it when the fast is broken by increasing lutenizing hormone. Fasting also increases insulin sensitivity, which helps with muscle building.
Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility, especially in women with PCOS.
The hormone Leptin is an immunomodulator that keeps the body from attacking itself and obesity causes leptin resistance. Fasting very quickly reduces leptin resistance and leptin levels and one day of fasting can cut your leptin levels in half and gets your immune system working properly again!
Does the body preferentially prefer glucose as a fuel? No, except for brief periods of very intense exercise, your body mainly burns fats in the form of free fatty acids. Your brain also prefers to burn ketones at a rate of around 2.5 to 1 when they are available in equal quantity to glucose.
Deep ketosis virtually eliminates chronic inflammation in the body. This can offset the life threatening symptoms of viral pneumonia which effectively kills you through inflammation. This also creates BHB ketones in your body, which help your immune system and anti-oxidative system, especially in the brain. When not in ketosis, the brain can only burn carbohydrate, which produces a great deal of damaging ROS the brain has to deal with.
It increases mitochondrial function and repairs mitichondrial DNA, leading to improved ATP production and oxygen efficiency and thereby making cells better able to fight off infection. Increased mitochondrial function also has the added benefit of increasing your metabolism and cancer prevention!
When you fast, this stimulates apoptosis in senescent or genetically damaged cells, which destroys them. Senescent cells are responsible for many of the effects of aging and are a root cause of the development of cancer.
Fasting also releases BDNF and NGF in the blood which stimulates new nerve and brain cell growth. This can help a great deal with diseases like MS, peripheral neuropathy and Alzheimers.
In fact, the biochemical regulator of BDNF production is beta-hydroxybutyrate, which is the same ketone the body produces to nourish the brain while fasting.
Fasting also increases telomere length, negating some of the effects of aging at a cellular level.
A fasting mimicking diet for 3-5 days in a row also provides many of the same benefits as water fasting. FMD usually has 200-800 calories, under 18 g of protein and extremely low carbs.
Exogenous ketones can aid with fasting, making it easier in healthy people and allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia.
Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors or certain forms of hypoglycemia generally cannot fast at all. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis. Those with Addison's disease may also be unable to fast without liberal use of exogenous ketones, depending on severity. If you experience extreme symptoms of some kind, especially dizziness then simply break the fast and seek advice.
Resources:
-7
www.ncbi.nlm.nih.gov/gene/25712
www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/
n.neurology.org/content/88/16_Supplement/P3.090
www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits
medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html
www.ncbi.nlm.nih.gov/pubmed/23876457
repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations
www.cell.com/cell/fulltext/S0092-8674(19)30849-9
www.ncbi.nlm.nih.gov/pubmed/25686106
www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/
www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/
www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf
www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext
pubmed.ncbi.nlm.nih.gov/20921964/
www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/
faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10
www.biorxiv.org/node/93305.full
pubmed.ncbi.nlm.nih.gov/6859089/
pubmed.ncbi.nlm.nih.gov/21410865/
pubmed.ncbi.nlm.nih.gov/28235195/
www.nejm.org/doi/full/10.1056/NEJMc2001176
pubmed.ncbi.nlm.nih.gov/23408502/
www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518306051%3Fshowall%3Dtrue
www.clinicaltrials.gov/ct2/show/NCT04375657
pubmed.ncbi.nlm.nih.gov/7714088/
www.ncbi.nlm.nih.gov/pmc/articles/PMC8470960/
www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/
www.sciencedirect.com/science/article/pii/S1931312809002832
www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/
www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/
www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/
www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/
www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart
pubmed.ncbi.nlm.nih.gov/20102774/
www.sciencedirect.com/science/article/pii/S0005272806000223
www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/
www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/
www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224
pubmed.ncbi.nlm.nih.gov/31890243/
www.ncbi.nlm.nih.gov/pubmed/10232622
academic.oup.com/ajcn/article/81/1/69/4607679
pubmed.ncbi.nlm.nih.gov/25909219/
www.nejm.org/doi/full/10.1056/NEJMoa012908
pubmed.ncbi.nlm.nih.gov/15522942/
pubmed.ncbi.nlm.nih.gov/31877297/
pubmed.ncbi.nlm.nih.gov/23707514/
clinical.diabetesjournals.org/content/36/3/217
pubmed.ncbi.nlm.nih.gov/27569118/
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www.ncbi.nlm.nih.gov/pubmed/10859646
europepmc.org/article/MED/22402737?javascript_support=no
onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x
pubmed.ncbi.nlm.nih.gov/29727683/
This list compiled over years of research by the user known as Pottenger's Human on youtube but feel free to copy and paste this anywhere you like, no accreditation needed!
My channel which will always contain an updated version of this list of fasting benefits on the community tab. I also have playlists on fasting and health topics.
This works best if fasting is combined with complete rest. It is the complete rest which allows this to happen. Otherwise you burn muscle
Wow. What complete and excellent information. Thanks a lot. ❤
@@subodhpethe3999 Thank you for saying so!
Excellent article.. one problem, how is big pharma going to make money if everyone fasts... they are even developing a fasting mimicking tablet. They can't lose money.😅
Does this imply that a keto diet is best? I could never go keto as I enjoy a balanced diet and am a long distance swimmer (I need calories). Can you go into ‘ketosis’ after just one 36 hour fast? That’s about the longest I would ever voluntarily go. I’m a 64 year old woman, btw, just for perspective!
Fascinating.
I'm aged, have always been a physically active adult. I am dismayed at how quickly my energy fades in spite of eating a healthful diet, and being fit. If I had time, I'd be hitting the gym, riding bicycle. I've a huge landscaping project started... hard work.
I run out of juice at about 2pm. I have to rest, nap, whatever.
I am taking NMN, and it doesn't seem to help at all. This video explains why. Thanks.
I've a lot of work to do, I'm a musician, craftsman, metal worker. I cannot waste time napping.
I'll be looking up this product.
I take a lot of supplements. I know they are not drugs, take time to work, and work slowly, at best, if noticeable at all. I'm in much better shape than my peers... many have passed from lifestyle choices, others too tired to get off the couch.
Again, great video. Thank you.
Nicotinamide + Apigenin + ALA + Rutin + Vitamin C + Zink. Great combination. Still I would keep a place for NMN. PS: I add B6 because it improves NAD+ synthesis from Tryptophan.
Just niacinamide is better then nmn, the nmn scam is fucking insaine!
Please add Niacin or Nicotinic acid too.. Bear the flush. Start with a low dose .
You will thank me for that.
What is NMN?
Not good for me because my face become red flush 😢
I keep asking this with little to no answer or articles: is Liposomal NAD+ as effective as NMN? Not Liposomal NMN, but Liposomal NAD+ directly?
Excellent explaanation. Really liked the analogy of the factory. Thank you.
Taking a whole approach:
1. Take NAD precursors: NMN, NR, nicotinamide, etc.
2. Take cd38 inhibitor: apigenin.
3. Take NAD recycling enzymes: NAMPT.
*Apigenin
so...taking NMN in the morning, with apigenin, the latter making you tired, would be a somewhat contraintutive thing?...
@@erlandwoldolsen5091 Agree. One should be taken in the morning, the other should be taken in the evening.
you got it wrong. their product does NOT contain the enzyme NAMPT. One should not mess up the metabolism by taking enzymes directly.
Next, the point is that NMN, NR are nt as effective, for several reasons. Here it is about NAM
You forgot r-ALA, and zinc
...hot air babbler
Parsley powder also has luteolic with apigenin like effects. She never mentions it, yet that's exactly what she's promoting essentially.
bla bla bla
@@monnoo8221 I guess you knew all that.
This is the first I've seen explaining this process!
Very helpful!
They want to take NMN and maybe NR off the market as a supplement. These are both precursors to NAD.
If these are naturally occurring, they should remain as supplements.
If David Sinclair wants to market his crystallized form of NMN as a drug, that should remain a separate issue.
People will not be able to access something like this if it is prescription-based, and be able to enhance their own health.
Ya anything good or useful to us has to go . .like the stuff that starts with iv a few yrs ago. They've made it clear they don't care or want us to be well
Good one
Very interesting! Good to know you have a product that is an option! I have been taking mnm since Feb and not noticing and energy or strength increase ( just back ..ballet dancer) So tweaking what i have .. Fingers crossed!! ♥️🕊🙏🏻💪
👍👍Love your explanation! Remind me to take some dry parsley with my meal!🙏🙏💖💖
science never changes. knowledge changes
There is 140mg/100g apigenin (fresh weight) in parsley juice. Hostetler GL, Riedl KM, Schwartz SJ.
It would be nice if the company Nuchida could post their clinical findings. This is nice to have a mix of products but i am skeptical about the outcomes vs other products. Especially their product prices are quite high. thanks
yeah seems it is cheaper to take NMN, The whole sell story have one flaw if you stop taking their 65Eu supplement the factory stops right. Same thing as taking NMN.
@@mats8038 Yup, living on a budget, retired, is quite something. I feel blessed if I can afford sardines, blueberries and broccoli. The more I watch, the more supplements I jot down in my spiral notebook. Quite a tall stack of spirals now. Think I'll be adding parsley to my salads more often.
Hi, you can read the full clinical trial results on our website.
if you mix the ingredients by yourself, you end up with the same amunt. Consider that their product is high dosed, so you can calculate to take only 2 caps per day. and then it is quite affordable
Great info on NAD and how to get to work and recycled properly. Thank you.
So glad you enjoyed the video!
I was taking NAD for awhile..thenI started reading reports of it being dangerous to take for long period of time. I switched to taking Nicotinamide (also recommended by a RUclipsr). But I also take several other suplements since Im vegan (Vit D3 K2 Vitamin C and B12). Im 71, no serious illnesses and regularly get told I like mid 40's or 50's. Guess I'll keep doing what Im doing😅
Thanks for your post. I heard about cancer with NAD so I am nervous too. Is there no risk with NMN? Have you noticed a difference? I learned we want the Methylated version of all Vits. including B6 and B12 should be sublingual too. Some people have a MTHFR gene so only sublingual will work so that is what I do. I also really hope you are taking Magnesium Glycinate before bed. It is essential for most. I have been taking it for many years.
Try to avoid synthetic forms of vitamins made from petrochemicals. Read the labels. One trick I use is to compare to a really expensive premium brand. This way you can see what should be in it- and more importantly, what fillers and things should not be in it. Read the new book called YOUNG FOREVER- Dr. Hyman. It is excellent. At 71 seems you are doing many things right. Good for you. Also, do check your blood sugar levels twice, 2 days a week. This can help you adjust your diet to lower your sugar/carbs.
I tried being a vegan- love the idea behind it but it did not work for me. I quickly got deficient in many things and felt terrible. Sad to say, I am no longer vegan. I really wish I could be. Even as a non-vegan I have trouble gaining weight. I did lose my gallbladder- not sure if that has anything to do with it but maybe. I probably do not digest fats too well- that is what it helps with.
@@MOAB-UT Hi, there is no evidence that NAD+ causes cancer, in fact NAD+ levels and cancer risk are negatively correlated throughout life. Cancer risk rises as NAD+ levels decrease with age, both exponentially. What experiments do show is that NAD+ production can be targeted as an Achilles heel in cancer cells. If you cut off the NAD+ supply cancer cells die. The same applies to glucose and oxygen. Cancer cells are heavily dependent on a supply of critical molecules and removing the supply locally kills cancer cells, but this does not mean glucose, oxygen or NAD+ cause cancer, nor is it a sensible approach to restrict any of these critical molecules.
As part of our clinical trial we did safety tests and found Nuchido TIME+ was safe and well tolerated, with no toxic effects on liver function.
@@MOAB-UT Have you tried supplementing with taurine or TUDCA? It helps promote bile flow, so should help with fat digestion.
@@chidude Thanks and no. I think it has more to do with being used as an amino acid but only during times when your body is stressed. For digestion I've taken a digestive enzyme in the past because I lack a gallbladder. But thanks for offering your thoughts. I also eat plenty of meat so I think I get enough from natural sources which is usually better. Nutrition has also been my hobby for the last decade.
A great video, very informative.
Love your analogies! Perfect!
I started using 500 mg nmn per day since 30 days ago and it literly changed my life. I have more energy, my brain fog is gone. Also i was always tired in the morning and lit up in the evening. Now i stay up at 7 am and i go to bed at 11pm. I don't need to eat that much and especially the energy is so great now. My girlfriend can't believe it..
How old are you? Did you have any health issues? You taking resveratrol too?
Hey What brand do you use?
@@haveaniceday7950 I use TMG with NMN. It belongs to a methyl group, required for many crucial processes.
Methylation is a critical biochemical process that occurs in the cell when a methyl group (consisting of one carbon atom and three hydrogen atoms) is transferred from one molecule to another to help that molecule perform its function.
In a nutshell, because of the methylation cycle, methyl groups are required for many crucial processes in our bodies such as producing neurotransmitters and antioxidants, epigenetics (how DNA expresses itself), regulating cardiovascular and nervous system activity, energy production, and heavy metal detoxification. Our bodies have a reserve of methyl groups that it uses whenever it requires methylation for cellular processes and functions.
When NMN is converted into NAD+, nicotinamide (NAM) is formed. High levels of nicotinamide are not good for our bodies and in order for our bodies to get rid of nicotinamide it needs to be methylated into N-methyl nicotinamide that is excreted in our urine.
There is concern that NMN depletes methyl groups within our bodies and, therefore, as a precaution, it’s thought to be important to take TMG (an amino acid known as betaine) to donate methyl groups especially if you have been taking NMN for a long period.
In the podcast below with Dr. Mercola, Dr. David Sinclair mentioned that he takes TMG as a precaution to prevent this from happening because, at the moment, the research is not clear.
@@justinbraveheart26 thank for the reply. Yes I know all this.
Did you have health issues? How old are you? So no resveratrol with it?
Me too. I have been taking it for 60 days now. I also take NAC and glycine which gives an immediate energy boost and reduces inflammation. My wife also says I look younger. Now she is stealing my pills.
Of all Mental Health is Most Important... !
Thank you. This was very informative.
Thank you soooo much! This's a well explanatory informative video. Now, I know why NAD didn't work. I remember telling my mum I'd by for her, too if I feel anything in positive way after finishing pure NAD filled bottle. And, yes Niacin makes a positive difference (when I take in high dose)
Hangi ilaçları kullanıyorsun?
Same I bought NAD & still have a whole bottle of it and we get nothing - now I know why. The biggest problem is the outrageous cost of their supplements. Who can even afford this?! We aren't poor, but this is just impossible for 2 ppl with pets. I'm tempted to suckon parsley leaves & take ALA, C, chamomile tea & pepper separately lol This is a hard pass!
@@cinystarr4657 look out for the rutin and troxrutin. These are plant compounds which help to activate\enhance availability of NAMPT. you get it alone as homeopathic preparation, or you can find it in skin of peach, or in the plant she describes. r-ALA is very helpful as well.
In sum their product is outstanding, and i did a lot of research. If you try to mix compounds from your own sources yu end up paying much more.
That said, you probably do not need 3x2 pills per day. for me 1..2 is already enough, it is very effective
I am taking niacin
@@petermalmgren1207 is not precisely the same. Niacin is converted into NAD+, while NAM is created FROM NAD+. The latter is relying on a proper salvage pathway cycle, hence the preferable intervention, while niacin can disturb a range of feedback mechanisms when taken in higher dose. Admittedly it is a bit cheaper. Both approaches share the need to co-supplement with TMG
any link to the full video ?
Thank you. I would rather think that addressing the roor cause would be lowering the inflammation. I don't like parsley. Will have to from today :)
Any comments on this from PubMed:
"A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+"
That is, is D-Ribose a possible component in your mix?
My first scan of that report was pretty inconclusive. I don't think they sepatated the effect of the two substances, so I couldnt say if all effect was from Nicotinamide or not.
And it was just a short pre-study.
Furtermore, I wonder if D-Ribose is just one molecule, or a family.
They seems to think it does something, though.
Love this
I get amazing results from NMN, I doubt if changing NAD production methods will give me the same results.
thank you for your public announcement that you do not understand anything... Life extension supplements should be forbidden for dumb people
You know, as a person who watches little television, youtube being the exception, it seems like it's turning into one big TV commercial. This is the reason i quit watching TV:(
Thank you I absolutely agree with you.. You just can't believe what it's true or what is just false information.
@@robert-js1ur So true. And let's not talk about the clickbait. "Elon Musk takes off by himself to Mars kinda BS:) You know it's not true.
I did it with NMN and Resveratrol and Fisetin
Try activated charcoal 36-44% lifespan increase in rats administered 10 days out the month softens arteries cleans toxins out the blood and kidneys
Please update and post again on your channel.
My wife & I take most of the supplements mentioned...she used to always be very cold but now is hardly ever cold ( in our 70s)
Which company do you take?
UR WIFE NEEDS SOME MILK
@@MEF7 Use donotage they’re third party tested and I use it myself
Could this be a regime change? Just like that? I'll be keeping a close eye on it. Still cannot imagine leaving out my NMN.
Is there a regime, or did u mean regimen? Regimes are very scary...those nasty dictators n all.
I just started taking NMN from Wonderfeel 900 mg twice per day and I’ve noticed my energy level has increased. This is the product from Dr. Bergman from Harvard University. I’ll keep taking it see what happens,
Thanks for the informative video. I love how you pronounce "better" with only the initial consonant ("be'e'").
Does this account for the possibility that an increase in NAD+ might also enhance the growth of cancer tumors? There's a cost involved with increasing NAD+ (according to other doctors in this field) and I'm not sure the public are aware of it.
NAD+ levels and cancer risk are actually strongly negatively correlated throughout life. Cancer risk rises as NAD+ levels decrease with age, both exponentially. There is no evidence that NAD+ causes cancer. What experiments do show is that NAD+ production can be targeted as an Achilles heel in cancer cells. If you cut off the NAD+ supply cancer cells die. The same applies to glucose and oxygen. Cancer cells are heavily dependent on a supply of critical molecules and removing the supply locally kills cancer cells. This is one of many alterations in a cancer cell that evolve to confer a survival advantage. Which is why taking NAD+ supplements isn't recommended for those with active cancers.
It kind of make sense to me, as I don't like taking many pills. if I need to take all the supplements she mentioned, nicotinamide, apigenin, ALA, rutin, quercetin, vitamin C, zinc.... Seems all goods ingredients, but there will be many pills. BTW, I read somewhere it also contain green tea EGCG in, no??
All excellent ingredients for generating expensive piss.
Nuchido TIME+ does contain EGCG for its ability to inhibit excretion of Nicotinamide (NAM), as our formulation restores the cells ability to recycle NAM back into fresh NAD+. The recommended serving of Nuchido TIME+ is 3 capsules twice a day, as this was the serving used in our clinical trial and we know is effective.
Thanks for this informative video but the ALA R form is more effective we learned & go for it. Thanks again🙏✨💫💯💊💊
Great information 🔥
What about this article that link the nampt with more agresive cancer
Have you seen the study that says that microdosing pure nicotine can stimulate/activate NAMPT? I know nicotine has very negative associations from tobacco, but in its pure form it looks really interesting. I've been taking sublingual 1mg, four or five times a week and it doesn't seem addictive at all.
Do I order BOTH, the Apigenin capsules and the Nuchido Time supplement and combine them ? Or does the Nuchido Time have 500 mg of Pure Apigenin in it ? it's two different websites.
Hi, Nuchido TIME+ does contain apigenin, so you can take just Nuchido TIME+ as a comprehensive supplement to restore NAD+ levels.
ihihihihihi 500mg of apigenin ... note that the saying "dosis facit venenum" is 500 y old :)))
apigenin is blocking CD38.. an that has a role in the body. It can be blocked fro overshoot, but blocking it completely would result in a death by a blocked immune system
Thanks buddy, good video.
Any GMP clean company name & have an idea on benefits on this supplement if anyone knows a name will be appreciated.
Thank you
Also, would R-Alpha Lipoic acid be used?
Where is this product?
Great content
I eat chole kulcha and smell my farts as anti aging
6:20 CD38 doing nothing but draining NAD, "unnecessarily" , while also being part of an inflammatory response, doesn't make any sense. Instead of inhibiting this enzyme, couldn't we somehow help it deal with the excess Ca++ it tries to remove?
DC38 is an enzyme used by the immune system for pathogen fighting, so you don't want to lower its level directly. Fasting for example, kills off the pathogens so less cd38 is triggered, but trying to fight cd38 like some of these yt channels suggest is not going to be helpful but harmful.
@@LTPottenger thanks for the reply, but I'm not sure what to think of the word "pathogen". A pathogen is usually defined as a microorganism. Something else must be going on.
@@drnicholaconlon7735 Hi, I really appreciate you chiming in on this. I am still reading and I'm happy to see that you embrace "complexity" in the linked article. My half-way educated guess would be that there's something aging the ER and/or there's something off with magnesium signaling/availability, leading to CD38 going rogue. Magnesium ions act as cofactors for several enzymes involved in calcium signaling, including those that synthesize and degrade calcium messengers such as cyclic ADP-ribose (cADPR) and inositol 1,4,5-trisphosphate (IP3). With SPCA transporters using ATP hydrolysis to pump magnesium ions against their concentration gradient from the cytosol into the lumen of the ER, it would seem that a decline in MT health could be behind all this. Is there anything you are aware of that makes this hypothesis unlikely? Many thanks!
I think she may be was referring to altered CD38 enzymatic activity, like in autoimmune disease, not antipathogenic action.
Dr. Eric Verdin talks about how fighting gut pathogens comes to suck up huge amounts of NAD through the cd38 enzyme as we age. But we also need it for other things like repairing the cells.
Where can i read about all this
Might I suggest the use of Boron to assist in absorption.
Any opinions on these 'liposomal' NAD+ delivery 'systems'?
Hi, while liposomal delivery systems get NAD+ into the blood, NAD+ is needed inside of cells to exert its beneficial effects. NAD+ itself is a very large molecule which struggles to enter cells whole. They also do not fix the root causes of NAD+ decline, they are like putting a plaster on the problem. The best approach to boost NAD+ levels are to fix the reasons why NAD+ declines and restore the cells natural ability to make and recycle NAD+, which is how Nuchido TIME+ works.
@@nuchido2094so you are basically saying the scientists who studied and created nad plus don’t actually know what they are doing but you do..give me a break..
Would IV NAD therapy be helpful?
The first time i took NAD pils I felt the effect 100000000 % I thought it was some kind of psychedelic drug butt I had a lot of energy I could run all day without getting tired
Stop to lie
That's called a placebo effect
@@thierryvidal63 I know my physical limitations there is a specific number of kilometers that I can run or a specific number of push-ups that I can do , with NAD I far exceeded my physical limit
EUGEN+ YOU LIKE DOGGYSTYLE?
@@jenu2959 I believe you same with me
Can anyone help me understand? Do I have to TEST before taking NAD and is NAD+ better? Should I also take NMN? I have been hearing there may be a cancer connection with NAD though? Any insights would be appreciated. Pretty healthy- eat well, run, lift, etc. I just want to optimize but not get cancer obviously. I learned about it in the new book Young Forever- Hyman which is really good.
Hi, you don't have to test your NAD+ levels in advance. Common symptoms of NAD+ deficiency are decreased physical and mental energy, brain fog, disrupted sleep, reduced ability to recover from illness and loss of strength. You can learn more about NAD+ on our website, but there is no evidence that NAD+ causes cancer.
@@nuchido2094 Thank you. Good to know.
I would say, the activation of the AMPK pathway through r-ALA is an opponent of cancerogenic processes.
However, if you messed up your metabolism by eating to much sugar, or high GI carbs, snacking all the time and such provoking a conitnuus hyperinsuiinemic state, and never doing a 20+ hours fast, THEN you should NOT pour a pure energy booster into the system.
afaik, the cancerogenic hypothesis came from in vitro experiments. Also note, that many tests are made with mice and rats, and those have a natural tendency to die from cancer in old age. ...unless us, IFF... see above
@@monnoo8221 Thanks for your comment.
I think you are suggesting that AMPK activation via stressors (hormesis) like exercise is a good thing- right? If so, I agree.
Even more than just sugar, I think the real issue is inflammation. When we consume seed oils, processed foods, fail to exercise, stress out and lack sleep, our bodies are primed for trouble. Then consuming sugar is pouring fuel on an existing fire. There are some younger athletes I follow like Mikey Musumeci. He is a machine- virtually unbeatable. His diet is absolute garbage consisteing mostly of heavy carbs Pizza and Pasta. He is proud of that. Yet why is he so dominant? I guess it can take a while to catch up and he is very active so he gets away with it...for now. There are many factors to the health and wellness puzzle. In addition to running and working out, I have started to eat 3 cloves of raw garlic and raw red onion with Avocado and EVOO daily. I put them on an Outer Isle Cauliflower round (instead of bread.) Only two net carbs. You can grab them at Costco.
@@MOAB-UT agree, 👍. Just about onions and garlic, I would be careful... Because they are so powerful, they can be toxic as well , recommend cycling 3+2 or 3+3 weeks
Joel greene has great info on this
Does anyone else get blurry vision from taking nmn?
EEEWWW
what brand are you taking?
Thank you, very clear presentation.
The salvage pathway "simply doesn't work as well". Now, those are words even non-scientists should refrain from using.
A few years back we'd say, "efficient cellular respiration, simply doesn't work as well with age", which led to sketching the importance of NAD in age reversal.
"Diminishing NAD salvage pathway", should be the answerable issue. Otherwise, desperately pumping the freshest air in a flat tire, simply may not work.
Instead, looking into how the original blocks - which do create life - could be ad infinitum optimized, might offer a clue. Answer hovers over "not destroying", and "creating". Be happy.
Are u talking about Kynurenine pathway?
That's a very condescending way to put it.
Quando eu era criança eu chorava muito quando eu ia de ônibus pra Bahia só de imaginar que eu ia ficar velha eu me desesperava e até hoje eu tenho pavor do envelhecimento aqui no Brasil em São Paulo.
What about SIRT6?
Pretty expensive product. Why does it cost so much when none of the ingredients are all that expensive?
Nuchido TIME+ is based on years of preclinical and clinical research. Conducting this level of testing is very time consuming and costly. There is also no legal requirement for a supplement to be tested in humans before being sold, which is why most supplements have no data to support their claims.
Furthermore, we invest heavily in the manufacturing, quality control testing and ingredients in Nuchido TIME+. For example, Nuchido TIME+ only contains R-ALA, this is the form of ALA which can enter cells and have beneficial effects. It is much more expensive that S-ALA, the synthetic form which has no effect on cells and is commonly found in many other supplements.
We appreciate that Nuchido TIME+ is a long-term investment in your cellular health which is why we offer a subscription which provides a built-in saving.
Weißt jemand ob SIRT6 Activator Jod enthält oder nicht.
Bitte um die Antwort.
Love it 🔥
You say that CD38 drains NAD out of the cells "unnecessarily." but is that actually true? CD38 is an important part of the immune system and perhaps it needs more NAD to function or be added for a NECESSARY immune response, particular in older individuals who have an involuted thymus and therefore fewer T cells, each of which may need more CD38 to be placed on it's cell membrane.
As you say CD38 does have an important role in immune function, however during aging expression of CD38 increases greatly. This wastes large quantities of NAD+ (CD38 is actually the largest mammalian consumer of NAD+ wasting around 100 molecules of NAD+ for every reaction is performs) and promotes further chronic inflammation and cellular senescence. CD38 also exerts dominance over other beneficial NAD+ consumers such as the sirtuins meaning these critical pathways are left without sufficient NAD+. In this manner extremely high levels of CD38 are not beneficial. Studies have shown that inhibiting CD38 even slightly can boost NAD+ levels, which is why Nuchido TIME+ contains apigenin.
Yes, CD38 is very important for the immune system. However, we are not trying to eliminate CD38 entirely. Our goal is to inhibit to lower levels to allow for optimal functioning and NAD+ sparing for other processes ie Sirtuins, PARPS, etc.
CD38 is upregulated due to infection and inflammation. In aged bodies, chronic infections aka parasitic infections by bacteria, fungi increases strongly BECAUSE you don't have enough energy. In aged bodies, inflammation is triggered by senescent cells. So, regarding fungi, which very often is candida, berberine is good, regarding senescent cells high dose fisetin + quercetin every 3..4 weeks helps, an in between LOW dose fisetine, or quercetine, or resveratrol.
that's the background for enhancing NAD then, by repairing the salvage pathway for nad+ production.
After some months then, the metabolic machinery will run smoothly again, kicking ut infections, and senescent cells, like a breeze...
For me, the effect kicked in after 4 weeks or so, on half the recommended dosis
Dr Nichola Conlon talks about addressing the route causes of declining NAD+ yet her suggested solution is supplements to boost the NAMPT level, provide NAD+ precursors, and reduce the NAD+ destroying enzyme, CD38. While not doubting the efficacy of this combination, I can't see how it addresses the route causes. After all, we don't need these supplements when we're younger.
Wouldn't addressing the route causes mean improving the health and increasing the number of mitochondria, where the Krebs cycle takes place, and reducing the number of CD38 excreting cells, if there are too many of them? Ginger, for example, has been shown to increase mitochondrial size and mitochondrial biogenesis and can be purchased very cheaply and conveniently as ground ginger. Ashwagandha has also been shown to improve mitochondrial health and function.
Hi, studies have demonstrated that the reasons NAD+ levels decline with age are because of 1) decreased production - the salvage pathway is the largest source of cellular NAD+ and the enzyme which powers it called NAMPT declines with age 2) increased consumption - increased levels of inflammation and DNA damage cause increased expression of CD38 and PARPs which waste large quantities of NAD+, leaving other beneficial pathways without sufficient NAD+. Nuchido TIME+ works to restore the cells natural ability to make and recycle NAD+ by activating the salvage pathway and inhibiting CD38. Increased NAD+ levels are known to benefit mitochondrial function by activating sirtuins. We have written blogs on our website which go into more detail about how Nuchido TIME+ fixes the root causes of NAD+ decline and supports mitochondrial function.
10:09 talks about R-ALA
Liposomal NAD+ is protected from digestive breakdown and absorption is better.
While liposomal delivery systems get NAD+ into the blood, NAD+ is needed inside of cells to exert its beneficial effects. NAD+ itself is a very large molecule which struggles to enter cells whole. They also do not fix the root causes of NAD+ decline, they are like putting a plaster on the problem. The best approach to boost NAD+ levels are to fix the reasons why NAD+ declines and restore the cells natural ability to make and recycle NAD+. Nuchido TIME+ is bioavailable and has beneficial impacts inside of cells.
@@nuchido2094 yeah that’s why ya dont take NAD+ and instead take the precursor.
What are the quantities of the different ingredients?
You can view the ingredients list on our website.
Interesting
I have glaucoma im 36 what should take
So parsley powder
So all the NAD I bought is useless?? Damn it? What about GlyNad?!
.... but if thats true what u said, the inflammation is the cause of everything, or before that, the immune system. Wouldnt it b better to either restore the immune system or get rid of these inflammations for example by just using curcumin?
I theorize that we are so inflamed because we eat too many plants.
Switching to a meat based diet drastically reduced my inflammation.
Cucumin can be highly inflammatory to alot of people.
@@trentbusta1.... well, sometimes its good to enforce certain inflammatory pathways, or better, to support them. Inflammation is a good thing if it works properly.
I just like to watch her talk and she's pretty
Good info!
TY.
Women taking HRT should use caution in using apigenin. Study posted below.
I can’t see the link to the study, can you plz put article’s name
Oh no, I take HRT. Where is the study please? I don’t see it.
@@user-on7zd8yi8g if you Google epigenin and women on HRT, you will see several studies on the topic.
_Who_ taught the cells to recycle NAD?
OK, so I'm very new to this 😂 you guys might as well be speaking Latin. 😂 I've got some learning to do.
Does she have a book
Hello Dr Conlon does not have a book, but she has appeared on many podcasts which you can listen to including Dave Asprey, Dr Kara Fitzgerald and many more.
Does NADH help?
No, too much NADH can be detrimental
💨 it!
So if i eat tabouli every day i wont age?
Nuchido,is too expensive.I will use another way to boost NAD.
Your'e going to get RICH !!! 🙂
She deserves to be for helping us get around the greedy, greedy David Sinclair.
What IS NAD?????
NAD+ is a natural molecule found within every cell of your body. It is estimated to be involved in over 500 reactions and without it you would be dead in 30 seconds.
Scientific interest in NAD+ has grown significantly during the last few years after the discovery of its crucial role in the aging process. The reason NAD+ is linked to aging is because your cellular NAD+ levels decline exponentially as you age.
When you are young you have really high levels, but these decrease by around 50% every 20 years. This decrease in NAD+ levels has been found to correlate with the signs of aging.
Nuchido TIME+ is a supplement clinically proven to boost NAD+ levels and support cellular health. You can learn more on our website.
Why did you put filter on your face ?
Pelo mesmo motivo de todas as outras pessoas que usam filtro 🤷🏻♂️
I don't think it's the channel owner
It's a AI robot
What is NAD?
Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism. Found in all living cells, NAD is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine nucleobase and the other nicotinamide.
It's something that declines like mad, with 50% loss every 20 years.
@@nootri can I take niacin
THANKS PRINCESS
She's so pretty that I have trouble concentrating on what she's saying.
Somehow… eating NAD’s seems a bit unappetizing. 😮
I meant ALA R form💊
Have a four legged ruminant animal steak and add salt and pepper. #MetabolicMind
#ProteinLeverageHyphothesis
FACT
Perfect
Stop taking nmn why Pain in left chest and blood thickening
What to do: 5:28
It is cost prohibitive.
Nothing about fasting and trainging? She start with talking about fixing the root causes. Then she lists several other ingredient that does the same thing... if you search a little you can get this compounds from diet. Fasting and training also boost this nad production so these supplements are overrated if you use all the factors naturally.
It's easier to take a pill, drug, or supplement than do something about it.
Dr Conlon talks on many platforms about the multitude of lifestyle habits that can positively impact NAD+ levels. Of course lifestyle is essential for any health optimization routine, but for some supplements can also be a valuable tool.
VIT b2 B6
How much of each?
oh, the kynurenine pathway?
@@nootri what is kyenuine pathway
@@markaguilera493 I dunno ... I'm not a doctor.
This is funny. Just look it up, it's why b2 and b6 matter.
Joe for the best? 60% increase with Niacin for pennies.
@goodenergy11 What does "Joe for the best" mean?
What a headwrecker
Your senero doesn't work, can not stop old age
get vaccinated
She looks 20 yo
Very nice lady with a pretty cute face