Maybe Vampires drink blood to get mitelets/mitochondria from the young! Maybe the effects of plasma transfer from young to old (Peter Thiel) was doing this sometimes. Will mitochondria from not your native DNA cause any immune issues?
Taking mitochondrias from my child (I m male) would not work to extract and multipky them in a reactor ... but for the mother it could work ... AND I dont think that there is an ethical problem (but politicians will produce one for shure). For men ... the are only 2 solutions ... first extract from my own blood and select the ones with less damage ... or second ... if the kind of damages differ between the mitichondrias ... it may be possible to replace damaged parts by korrect parts from others ...
Both. The integrated stress response damages them. They release mtdna as a warning signal to the body to fix them. But as we get older the MTdna becomes oxidised and causes overactivation of Sasp, which damages mitochondria further.
A state of ketosis makes new mitochondria, your body can do this by itself. Fasting will encourage cleaning up and recycle old and damaged mitochondria.
@@allenbrost9564 I disagree, at least for most people. For the greater part of our evolution, frequent or regular meals were not the norm and it was situation of feast or famine and we've adapted quite well to survive in times of low food availability. Fasting also promotes autophagy, a process by which old, damaged, and worn out cells are mopped up and removed to be replaced by new healthy ones, including mitochondria.
@@GothicSteven your confounding surviving with thriving. There's no doubt the human body is adaptable and can get by when times are lean, but that comes as a sacrifice at being optimal. Energy is everything and when you don't have it the body doesn't work optimally. You're also confounding a diet of constant garbage versus eating nutritious food. When you fast from garbage undoubtedly this is positive but not the same as always fueling your body with nutrition. Also there is evidence that autography is always happening not just when you fast.
You can accomplish something very similar by bicycling intensely for a few weeks once a year, thereby increasing the number of heathy mitochondria in your leg muscles (your largest muscle mass in your body), and then return to your normal lifestyle, where your muscle cells won't need so many mitochondria and they will bud them off into your blood for the rest of your body to absorb. Just my theory and why you will feel 10 years younger.
This is why fasting/Keto is so important for longevity. It forces mitochondrial biogenesis/fission that increases the amount of mitochondria in your cells.
Tried keto for a few months, lost some weight, but always felt too uncomfortable in my stomach to be okay with exercise. Also gave me the shits on the daily lol. Probably not for picky eaters like me, truth be told. But everyone is different.
@@alexanderrahl7034you have to work through it. Protein and fats with majority of calories/qty as fat. 75/25%. If you get loose cut down fat. If you get constapated add more fat. Carbs are not essential and toxic to the body. Your liver will produce all the blood sugar you need?
Excellent video. The biggest step is to recognize those synthetic and processed things in our food supply that damage the cells and are directly related to all the modern diseases. Then understand how to correct the cellular damage and optimize the mitochondrial function. Most of these things are successful alternative treatments for so-called "terminal" cancers (which is a metabolic disease but not treated as such in general)
OMG!! I'll have to find out if I can volunteer as an advanced glaucoma patient to get a new lease on life!!!! I'd be thrilled. I'd be willing to do it, too. I'm losing eyesight slowly. Thank you for making this video!
My closest friend is 31, and born with X-Linked Hypophosphatemia. A form of rickets in her family. Her body cannot process vitamin D. Her bones are weak, and her legs bowed over the years. I care deeply for her. If a doctor told me tonight, that i could greatly help her condition by providing my blood to her, and thus my mitochondria, i would devote the next 6 months of my life to getting in the best shape of my life, to give the best results
Its like star wars the force jajaja practices like fasting, selfless service to others, using the sauna, and engaging in meditation and yoga have been suggested to positively impact mitochondrial health and function. Fasting, for example, is known to stimulate mitochondrial biogenesis, which is the process by which new mitochondria are formed in the cell, enhancing the cells' ability to produce energy. Similarly, activities like yoga and meditation are associated with reduced stress and improved cellular health, which may indirectly support mitochondrial function by reducing oxidative stress and enhancing overall well-being. While the direct impact of selfless service on mitochondria isn't well-documented in scientific literature, the reduction in psychological stress and the improvement in mental health often associated with altruism could potentially contribute to better cellular health, including that of mitochondria. These practices collectively could be seen as holistic ways to enhance physical and mental health, possibly supporting mitochondrial function and contributing to longevity and better quality of life.
If this ever becomes a viable treatment, it will be very expensive. This will be for the wealthy only. This company is in business not for altruistic reasons, but rather for profit, just like every other company. You'd better believe that this won't be paid for by your health insurance or medicare. You'd be better off making positive changes to your lifestyle and by daily intermittent fasting with periodic longer fasting to enhance the process of autophagy, which helps to clean up old and damaged mitochondria and cells.
Health span is everything. Upper end Zone 2 training is “maximum mitochondrial expression” (maximum fat oxidation/maximum mitochondrial development/maximum metabolic development) and adding some functional resistance training and VO2 max training can achieve health span dramatically.
@@markmetternich7629 I don't understand the delusion with you people that think zone 2 training is optimal. It has zero benefit to the body and it is an even bigger detriment for elderly and aging oneself.
Those are good but you still get accumulated mitochondrial DNA damage with mitochondria your body produces. If this mitochondria produced in the lab, has the ones with DNA errors filtered out, it will be good for the body.
@@user-yl7kl7sl1gScience will never outdo God. We are created perfectly..there is no need for Frankenstein mitochondria…just a healthy lifestyle and positive mindset.😊
@@Holodoll The better understanding we have of the machine that is the human body, the more technologies we can create to repair damage, and improve function.
@@Holodollthanks, I always wondered why would God allow evil and people losing extremities…and if it is ok with you that they receive new man made extremities if it happens.
This is the most comprehensive information I've ever heard on the mitacondria. Thank you so much for this video. My 35 year old daughter has MS. Would she be able to recieve a transfusion from her daughter? And also, does methyline blue preserve mitacondria health? Thank you.
@@sufficetosay As personalized treatments move from novel to the norm in terms of costs and accessibility I think we will finally learn who are "non responders" to certain drugs, meds, vitamins, minerals, treatments etc. Also very importantly those of us who may hyper-reactive to some things like glutens, lectins, etc etc. The specialists of 2morrow ideally will be able to lock down what is needed to optimize you and me however distinct, or unique we may be. Ideally they can also determine what may be genetic or epigentic. Dormant or active...that is A LOT of work to do.
@@fondrees That is part of the problem. There isn't a blood test or anything we can use to see if we are slowing down free radical damage. Scientists have access to them. Some things will give it away like cataracts, crepe skin, and other aging effects. Even if there is a test you could take, it would need to be taken before and after a supplementation regimen with no other changes in lifestyle. I have more confidence in methylene blue and D-limonene which reduces Interleukin-6. NMN sublingually would even be better than PQQ imo.
You should get in contact with Thomas Seyfried at Boston Collage who is doing cancer research, I think that he might be interested in your approach, he talkes a lot of damaged mitochondria as a cause of cancer.
Why can’t our mitochondria be replaced or replenished internally within our bodies by either inducing mitochondrial genesis or replacing older cells or “zombie” like cells? What about the use of PQQ which is suppose to initiate mitochondrial genesis internally? Is the therapy you’re talking about a true quantum leap above what I mentioned?
Aging is concept that represents the SUM of all the adverse effects of the individual biological processes taking place moment to moment in our bodies. That phenomenon is called aging. Aging as a function we have: a = x + 3m^6 + oS - (gN + gS) where x is all the unknown causes of aging, m = mitochondria DNA decline, oS = oxidative stress, gN = good nutrition, and gS = good sleep. Aging is dependent on a host of variables.
It will take advance AI and super advanced diagnostic models to formulate any comprehensive function for any one individual’s aging process. Medicaid probably wont cover this 😅….talk to Bryon Johnson for details!
This seems like the perfect treatment for primary mitochondrial disorders. I have a child we suspect has a defect in complex iii of the electron transport chain. (He has a mtdna variant of unknown significance that encodes that structure). Regards of my personal situation this could the most promising therapy for such conditions. The best intervention we have found is to do all we can to support electron transport chain efficiency. Where can I learn more?
Since DNA from mitochondria is exclusively inherited from the mother, any DNA damage that occurs in the eggs of the mother before pregnancy could be inherited by the child. Would this not lead to mitochondrial DNA damage accumulation with every generation of children? For example, could you could accumulate significant mitochondrial damage over 10 generations, or could 100 generations lead to mitochondrial disease, infertility, and developmental or metabolic disorders? To what extent can this DNA damage be mitigated by intrinsic DNA repair?
I would assume that's correct. However we still have the epigenetics effect. It is strange that it's a maternal inherited trait. So, what do males have to do in regards to inheritance and mitochondria?
Upper level steady state zone two training is “maximum mitochondrial expression” and is the total foundation to all other approaches to develop mitochondrial health and metabolic health.
A second adolescence? A reboot to a new "stage"? Micro dosing implants localized while controlled via a remote. (I've the perfect I/O for this.) Different use cases.
Why don't you donate your blood to your Mom and report the improvements? Also, your son's chart makes it an apples to oranges comparison because he would have his mother's mitochondria, unlike the other 2 charts. Very interesting video, thanks for sharing. Look forward to you helping your Mom with a donation and see what the results are. If it is this simple I'd like to do the same and gi e boost for my Mom.
The proof of concept study of mitochondrial transfustion is interesting however the interpretation is problematic. Sepsis causes severe baseline mitochondrial disruption and dysfunction. Mitochondrial transfusion, assuming there is no immune response to the foreign mitochondria, might restore basal mitochondrial function. This is unrelated to the aging process or recovery of the immune system.
Not only that, but is prolonging the agony of mice the most humane way to test this? I'd imagine sepsis is a pretty unpleasant condition to experience, no matter what species of mammal you are.
Very cool, if this develops as the presenter predicts we may find that a lot of "modern medicine" is treating things too late and in the wrong way. The book Power, Sex, Suicide by Nick Lane is an excellent overview of mitochondria, full of things you probably don't know. I now can't remember the details, but the DNA that enables mitochondrial functions is actually distributed between the mitochondria and the cellular nucleus. So "mitochondrial DNA damage" can happen in either the mitochondria or in the cell's nucleus or both. Science is very cool and this stuff could shape the future in a big way.
Maybe in the future some skin like tissue will be lab grown and sewn onto one's arm and it will produce and release 1000x more antioxidants or age stopping chemicals into one's blood stream?
Maybe this is only promotional... But I would have liked to hear more about where this doesnt work; uncertainty, inconsistencies in the results, if results could be promoted or demoted by another factor not isolated by the experiments, etc. I'm not so sure it's a miracle cure just yet, otherwise we would be hearing more about it... A few years is enough for it to be widely considered by the scientific community at least, no? If anyone can fill in any of these details, that would be great.
I'm no scientist, and my opinion may not hold much weight, but I believe the initial decline in mitochondria is driven by a kind of biological clock that gradually downregulates cellular processes in each species. Once this metaphorical clock starts to decline, it damages mitochondria, setting off a feedback loop where the compromised mitochondria, in turn, accelerate damage to the body. Take the bowhead whale, for instance-these creatures can live for 200 years and have a vastly larger biomass than humans, meaning more cells and more mitochondria, all derived from their mother's mitochondria. So, why do their mitochondria remain stable for so much longer? Given the far greater number of mitochondrial divisions and replications over such a long lifespan, it’s surprising they live so much longer without the same decline we see in humans. I understand that many scientists are sceptical of the biological clock theory of ageing, but I sometimes wonder if there might be something to it.
Can we stop balding and grow hair again with this research? Though balding doesn't kill a person physically but psychologically lots of humans are suffering.
So, It seems to me last night I listened to an almost exact presentation on the Reverse Aging Revolution channel about NAD+, and today I read about NMNH. Has NAD+ been dropped by your channel as important for longetivity? If so, why are you still promoting Nuchido Time. What happened to DR Nicole Conlon who was the researcher on Nuchido Time? Last video I watched with her she had her study reviewed and was waiting to have it published, but now she is gone and you appear. What's the story dude?
If your Mitochondria are EXACTLY the same as your mothers are ... cant you find a way to extract and implant them for a longer life? Clearly this would be diffucult ... but to have a copy screams for this solution.
You may want to investigate the different strains of mitochondria. I suspect there are super mitochondria in different nations, races and age brackets You may also want to consider cross species mitochondria which could work like exosome transplants.
Longevity is still scattered and fragmented. I think huge strides can be made in 10-20 years, but only if major governments prioritizes it. Probably it will have to be the US and it should be a moon landing or Manhattan project level of coordinated commitment and resources. AI will of course be a big part of it. If that doesn't happen, anyone who is over 30 now are unlikely to benefit much from longevity science.
@@norbertnagy5514 I have a book about Rho-diola Rho-sea where are scientifically facts about anticancer effects and actions for mitochondrias multiplication in muscles ceela are prover. That book is in russian language.
Your body gets better at making clotting factors to replace the ones you lost. This can become dangerous if you adapt to it for too long. Don't be too regular about it.
@@elinope4745can you go into a little more detail about this. I have been donating off and on for years. Always wondered what donating over the long term was doing to me. Recently they have been touring it as an anti aging hack. Sort of like cleaning out the sludge from your blood.
Well, if you have painfree and quality of life til you die, then you've won the game called life. BUT it seems most people think living as long as possible is more important than quality of life, because people in general live with diseases and are bedridden etc the last 10 to 30 years, or earlier, of their lives. That's not living, that's dying slowly in agony where you wish for death much sooner. If I can keep my health (I'm 43 btw and healthy because I do certain things) til I die, I'm happy. But if I get sick and my life quality goes down due to bad advice, and ofc manipulation and brainwashing, I would want to die early. Don't 100% trust your doctor when it comes to their medical practice which is VERY narrow, or most of what mainstream media says and keep an open mind where you will find stuff that can and will help you treat disease and other ailments, and make your life a lot better and healthier. Most people are sick due to bad advice and manipulation, the lack of good information, not the other way around.
if you don't use the patients mitochondria then are you bypassing hereditary evolutionary and eliminating variation from the gene pool. Though older recipients may not be strong reproducers.
You forgot to begin your lecture with three key points: "This is all theoretical", "It does not exist", "The FDA might take a look at this in 20 years". If only we were a moue...
He claims mitochondrial transplant it is already used in surgeries and rare diseases, so there is already human use in some fashion. He claims his technology can be in human trials next year. Time will tell, there are hiccups/roadblocks more often than not.
NMN is precursor to NAD. I'm on NMN since 18months ago. Now put the powder under my tongue. Lately increase to 500mg/day. Energy level is amazing at 69yrs. Lately been playing 2-3 hours of tennis, single or double. My hair is turning black. Stop dyeing my hair since 8months ago. I have steak of very black hair on the top front of my head. Wonder when I'll have a full head of black hair again.
Living longer or enjoying life ,food, and alcoholic pleasure ,not in a greedy way ,die at 90 with gods knows what other issues or die sooner having lived .Every year, i see plenty of people way younger than me die and some seemed way too healthy .Mitochondria would have meant nothing .
He doesn't even understand half his own research. Adding new mitochondria to the body boosts pyruvate production. Pyruvate can convert into ethyl pyruvate, which is one of the most effective blood cleansers. I need to become a longevity influencer to sort out all these studies. They tunnelvision, they don't research related studies.
Hoh so that why the women the Eggs are form this early in the life development of a woman and not later. So the mitochondria are not to far descendants of the ones of the mother eggs
Older people have a lot to offer the world, and birth rates are rapidly going down in most Countries. If someone is very healthy at age 95, that's less taxing on "society" than a chronically ill 45 year old.
And man will never land on the moon, let alone fly. That’s just crazy talk. Truthfully, most humans have such fantastically pitiful an stunningly dim imaginations. Most live in a crisis of imagination. Often “believing” the wrong bullshit, simply because they refuse to challenge their established belief systems, which feel sacred to them. Not to mention that their wildest imaginations can’t even keep up with current developments. Dim bulbs.
And man will never land on the moon, let alone fly. That’s just crazy talk. Truthfully, most humans have such fantastically pitiful an stunningly dim imaginations. Most live in a crisis of imagination. Often “believing” the wrong bullshit, simply because they refuse to challenge their established belief systems, which feel sacred to them. Not to mention that their wildest imaginations can’t even keep up with current developments. Dim bulbs.
And man will never land on the moon, let alone fly. That’s just crazy talk. Truthfully, most humans have such fantastically pitiful an stunningly dim imaginations. Most live in a crisis of imagination. Often “believing” the wrong bullshit, simply because they refuse to challenge their established belief systems, which feel sacred to them. Not to mention that their wildest imaginations can’t even keep up with current developments. Dim bulbs.
yes, pharmaceuticals, processed food industries, pension system... would go bankrupt if everybody lived to 100 disease free and plenty of health. There is no profit for institutions and government in healthy aging
Whatever side of the debate you are on it remains an undeniable truth that WE can and DO "evolve" every minute of every day. Then we hit a peak and devolve...or break down be it our society, morals, values or ethics. Aging plays a HUGE part in this. Today there are extremely few WW1 or WW2 veterans , as they go so does their memories of those conflicts...we are just about to make the same mistakes that were made in their era. If they we able to live to 125 they'd be sounding the alarm.
@@TruthIsHardToTake i mean with our current knowledge the universe itself very well could be created by a godlike entity but humans specifically created by god and that there is no evolution or the earth being only a few thousand years old is pure bs
@@TruthIsHardToTake and btw truthishardtotake is pretty egoistic name i dont think the bible teaches to be like that. You could very named youself like "TheTruthSayer" lol
He said different ethnic groups not races ! what , doesn't he know there are all these different races on planet earth THE HUMAN RACE is the only race on this planet of different species
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Is this expected to reverse involution of the thymus?
Can tissue nano transfection TNT be used for mitochondria transplantation or transformation or possibly revitalization?
Maybe Vampires drink blood to get mitelets/mitochondria from the young! Maybe the effects of plasma transfer from young to old (Peter Thiel) was doing this sometimes. Will mitochondria from not your native DNA cause any immune issues?
Taking mitochondrias from my child (I m male) would not work to extract and multipky them in a reactor ... but for the mother it could work ... AND I dont think that there is an ethical problem (but politicians will produce one for shure).
For men ... the are only 2 solutions ... first extract from my own blood and select the ones with less damage ... or second ... if the kind of damages differ between the mitichondrias ... it may be possible to replace damaged parts by korrect parts from others ...
The essential question: are damaged mitochondria the cause of aging, or the consequence of aging?
Both...
Both
Both and... both...🤷♂️
Both. The integrated stress response damages them. They release mtdna as a warning signal to the body to fix them.
But as we get older the MTdna becomes oxidised and causes overactivation of Sasp, which damages mitochondria further.
It’s a feedback loop. Over time, eventually something will damage the mitochondria, due to poor lifestyle choices
A state of ketosis makes new mitochondria, your body can do this by itself. Fasting will encourage cleaning up and recycle old and damaged mitochondria.
If something can reverse graying hair it can reverse aging too
Maybe. Maybe fasting causes undue stress on your system.
Autophagy
@@allenbrost9564 I disagree, at least for most people. For the greater part of our evolution, frequent or regular meals were not the norm and it was situation of feast or famine and we've adapted quite well to survive in times of low food availability. Fasting also promotes autophagy, a process by which old, damaged, and worn out cells are mopped up and removed to be replaced by new healthy ones, including mitochondria.
@@GothicSteven your confounding surviving with thriving. There's no doubt the human body is adaptable and can get by when times are lean, but that comes as a sacrifice at being optimal. Energy is everything and when you don't have it the body doesn't work optimally. You're also confounding a diet of constant garbage versus eating nutritious food. When you fast from garbage undoubtedly this is positive but not the same as always fueling your body with nutrition. Also there is evidence that autography is always happening not just when you fast.
longevity therapy is getting rapidly advanced this few years! I wish my mother can use this in her life time.
I wish it too.
For your mother, and for all of us ❤
me too
You can accomplish something very similar by bicycling intensely for a few weeks once a year, thereby increasing the number of heathy mitochondria in your leg muscles (your largest muscle mass in your body), and then return to your normal lifestyle, where your muscle cells won't need so many mitochondria and they will bud them off into your blood for the rest of your body to absorb. Just my theory and why you will feel 10 years younger.
🙏
to są fakty a nie przypuszczenia trening wytrzymałościowy wytwarza dużo nowych mitochondriów
Few weeks ?
Just hard an hour a day for a few weeks straight ?
This is why fasting/Keto is so important for longevity. It forces mitochondrial biogenesis/fission that increases the amount of mitochondria in your cells.
Tried keto for a few months, lost some weight, but always felt too uncomfortable in my stomach to be okay with exercise.
Also gave me the shits on the daily lol.
Probably not for picky eaters like me, truth be told. But everyone is different.
@@alexanderrahl7034 full blown fasting is much easier
fasting breaks down the body, try building muscles while fasting, the risk of tendon rupture or something is much higher@@rogerdavies8586
@@alexanderrahl7034you have to work through it. Protein and fats with majority of calories/qty as fat. 75/25%. If you get loose cut down fat. If you get constapated add more fat. Carbs are not essential and toxic to the body. Your liver will produce all the blood sugar you need?
@@alexanderrahl7034 fasting and not keto is great for longevity!! keto carni vegan are all fad diets...
Excellent video. The biggest step is to recognize those synthetic and processed things in our food supply that damage the cells and are directly related to all the modern diseases. Then understand how to correct the cellular damage and optimize the mitochondrial function. Most of these things are successful alternative treatments for so-called "terminal" cancers (which is a metabolic disease but not treated as such in general)
if we cant stop greying of hair then we cant stop aging
OMG!! I'll have to find out if I can volunteer as an advanced glaucoma patient to get a new lease on life!!!! I'd be thrilled. I'd be willing to do it, too. I'm losing eyesight slowly. Thank you for making this video!
My closest friend is 31, and born with X-Linked Hypophosphatemia. A form of rickets in her family. Her body cannot process vitamin D. Her bones are weak, and her legs bowed over the years.
I care deeply for her. If a doctor told me tonight, that i could greatly help her condition by providing my blood to her, and thus my mitochondria, i would devote the next 6 months of my life to getting in the best shape of my life, to give the best results
just do fasting
Its like star wars the force jajaja practices like fasting, selfless service to others, using the sauna, and engaging in meditation and yoga have been suggested to positively impact mitochondrial health and function. Fasting, for example, is known to stimulate mitochondrial biogenesis, which is the process by which new mitochondria are formed in the cell, enhancing the cells' ability to produce energy. Similarly, activities like yoga and meditation are associated with reduced stress and improved cellular health, which may indirectly support mitochondrial function by reducing oxidative stress and enhancing overall well-being. While the direct impact of selfless service on mitochondria isn't well-documented in scientific literature, the reduction in psychological stress and the improvement in mental health often associated with altruism could potentially contribute to better cellular health, including that of mitochondria. These practices collectively could be seen as holistic ways to enhance physical and mental health, possibly supporting mitochondrial function and contributing to longevity and better quality of life.
But remember what he said, and its typically true, you get to 80 or 90 and no matter what you've done you start running on fumes.......
If this ever becomes a viable treatment, it will be very expensive. This will be for the wealthy only. This company is in business not for altruistic reasons, but rather for profit, just like every other company. You'd better believe that this won't be paid for by your health insurance or medicare. You'd be better off making positive changes to your lifestyle and by daily intermittent fasting with periodic longer fasting to enhance the process of autophagy, which helps to clean up old and damaged mitochondria and cells.
Everyone has their priorities. Is it important to you?
Yep,... back to basics
Health span is everything. Upper end Zone 2 training is “maximum mitochondrial expression” (maximum fat oxidation/maximum mitochondrial development/maximum metabolic development) and adding some functional resistance training and VO2 max training can achieve health span dramatically.
False
@@Christian-tw3sp And what is “false”?
@@markmetternich7629 the nonsense you just spouted
@@Christian-tw3sp and what does not make sense to you?
@@markmetternich7629 I don't understand the delusion with you people that think zone 2 training is optimal. It has zero benefit to the body and it is an even bigger detriment for elderly and aging oneself.
Where does mitochondria get it's reproductive or renewing stimulus or energy from, and what causes that to decline?
It's called fasting and HIIT
Those are good but you still get accumulated mitochondrial DNA damage with mitochondria your body produces. If this mitochondria produced in the lab, has the ones with DNA errors filtered out, it will be good for the body.
HIIT or IHHT? IHHT does quality control of the mitochondria.
@@user-yl7kl7sl1gScience will never outdo God. We are created perfectly..there is no need for Frankenstein mitochondria…just a healthy lifestyle and positive mindset.😊
@@Holodoll The better understanding we have of the machine that is the human body, the more technologies we can create to repair damage, and improve function.
@@Holodollthanks, I always wondered why would God allow evil and people losing extremities…and if it is ok with you that they receive new man made extremities if it happens.
Fascinating! It will be great our life battery can be recharged all the time so we can continue living in a healthy state, no age-related diseases!
This is the most comprehensive information I've ever heard on the mitacondria. Thank you so much for this video.
My 35 year old daughter has MS. Would she be able to recieve a transfusion from her daughter? And also, does methyline blue preserve mitacondria health?
Thank you.
I've had ME/ cfs since I was a kid in 1978. I could use this right now!
I'm so sorry...me also for nearly 30 years, but I think I'm on the upswing. I'm so sorry....
Genetics = loaded gun
ENVIRONMENT pulls the trigger
ie Rx drugs, air/water/food/nnEMF pollution, household chemicals, lifestyle + + + +
u need cell permability , c15 omega 9
Have you heard of Dr Sarah Myhill and Craig Robinson's new book on CFS/ME, long-covid and mitochondrial function?
have you tried lots of broccoli and some cashews? "Anacardic acid, a compound found in cashew shells, promotes the repair of myelin"
pyrroloquinoline quinone.. PQQ. You're welcome.
I took pqq for years and got zilch out of it...
@@sufficetosay As personalized treatments move from novel to the norm in terms of costs and accessibility I think we will finally learn who are "non responders" to certain drugs, meds, vitamins, minerals, treatments etc.
Also very importantly those of us who may hyper-reactive to some things like glutens, lectins, etc etc.
The specialists of 2morrow ideally will be able to lock down what is needed to optimize you and me however distinct, or unique we may be. Ideally they can also determine what may be genetic or epigentic. Dormant or active...that is A LOT of work to do.
It helps, but it isn't a fix it all solution.
How can u tell, u may end up living longer based on the time u supplemented pQQ@@sufficetosay
@@fondrees That is part of the problem. There isn't a blood test or anything we can use to see if we are slowing down free radical damage. Scientists have access to them. Some things will give it away like cataracts, crepe skin, and other aging effects. Even if there is a test you could take, it would need to be taken before and after a supplementation regimen with no other changes in lifestyle. I have more confidence in methylene blue and D-limonene which reduces Interleukin-6. NMN sublingually would even be better than PQQ imo.
One thing, avoid Mitochondria damage as much as possible.
Isn't PQQ a mitogenesis agent, much simpler?
Taurine helps against AMD of the retina?
Where does mitochondrial uncoupling fit in. I thought various foods (such as MCT oil) or supplements created more mitochondria.
Also the body tends to replicate the more healthy mitochondrya if he got everythings it need for the process like glycine, q10 etc.
You should get in contact with Thomas Seyfried at Boston Collage who is doing cancer research, I think that he might be interested in your approach, he talkes a lot of damaged mitochondria as a cause of cancer.
I’m interested in seeing what this does when injected into the uterus. Considering it’s the fastest aging organ.
Do older mothers pass on damaged mitochondria ? Is egg mitochondria preserved due to lack of division ?
I wondered that, too.
Golden! Nice video to up your knowledge!
What’s about mitochondria peptides like mots-c?
So, didn't see any how-to recommendations, just waxing scientific.
Why can’t our mitochondria be replaced or replenished internally within our bodies by either inducing mitochondrial genesis or replacing older cells or “zombie” like cells? What about the use of PQQ which is suppose to initiate mitochondrial genesis internally? Is the therapy you’re talking about a true quantum leap above what I mentioned?
Fantastic research Kai..!🫡👍
Aging is concept that represents the SUM of all the adverse effects of the individual biological processes taking place moment to moment in our bodies. That phenomenon is called aging. Aging as a function we have: a = x + 3m^6 + oS - (gN + gS) where x is all the unknown causes of aging, m = mitochondria DNA decline, oS = oxidative stress, gN = good nutrition, and gS = good sleep. Aging is dependent on a host of variables.
It will take advance AI and super advanced diagnostic models to formulate any comprehensive function for any one individual’s aging process. Medicaid probably wont cover this 😅….talk to Bryon Johnson for details!
Accessible for everyone, they said.
But at what cost?
This seems like the perfect treatment for primary mitochondrial disorders. I have a child we suspect has a defect in complex iii of the electron transport chain. (He has a mtdna variant of unknown significance that encodes that structure). Regards of my personal situation this could the most promising therapy for such conditions. The best intervention we have found is to do all we can to support electron transport chain efficiency. Where can I learn more?
When will this be available?
Didn't you hear it, he said they are already doing it.
Only the wealthy will be able to do this.😢
Since DNA from mitochondria is exclusively inherited from the mother, any DNA damage that occurs in the eggs of the mother before pregnancy could be inherited by the child. Would this not lead to mitochondrial DNA damage accumulation with every generation of children? For example, could you could accumulate significant mitochondrial damage over 10 generations, or could 100 generations lead to mitochondrial disease, infertility, and developmental or metabolic disorders? To what extent can this DNA damage be mitigated by intrinsic DNA repair?
I would assume that's correct. However we still have the epigenetics effect.
It is strange that it's a maternal inherited trait. So, what do males have to do in regards to inheritance and mitochondria?
There must be a mechanism of repair or we would be extinct. Maybe that mechanism is in us and can be unlocked.
Upper level steady state zone two training is “maximum mitochondrial expression” and is the total foundation to all other approaches to develop mitochondrial health and metabolic health.
I hope this helps cure dry eye disease
Look up red light therapy and dry eyes. Lots of positive info right now. Good luck 👍
How do I sign up for 2025 test
How are the mitochindria change from bloodstrean into and out of the cells ...
A second adolescence? A reboot to a new "stage"?
Micro dosing implants localized while controlled via a remote. (I've the perfect I/O for this.) Different use cases.
Prolonged dry fasting. Promotes mitochondria biogenesis. Accurate or nah?
"If you're running away to escape a leopard..." Is this guy for real?
He doesn't have to run faster than the leopard, just faster than you thinking it's hopeless!
Why don't you donate your blood to your Mom and report the improvements? Also, your son's chart makes it an apples to oranges comparison because he would have his mother's mitochondria, unlike the other 2 charts.
Very interesting video, thanks for sharing. Look forward to you helping your Mom with a donation and see what the results are. If it is this simple I'd like to do the same and gi e boost for my Mom.
The proof of concept study of mitochondrial transfustion is interesting however the interpretation is problematic. Sepsis causes severe baseline mitochondrial disruption and dysfunction. Mitochondrial transfusion, assuming there is no immune response to the foreign mitochondria, might restore basal mitochondrial function. This is unrelated to the aging process or recovery of the immune system.
Not only that, but is prolonging the agony of mice the most humane way to test this? I'd imagine sepsis is a pretty unpleasant condition to experience, no matter what species of mammal you are.
Very cool, if this develops as the presenter predicts we may find that a lot of "modern medicine" is treating things too late and in the wrong way.
The book Power, Sex, Suicide by Nick Lane is an excellent overview of mitochondria, full of things you probably don't know. I now can't remember the details, but the DNA that enables mitochondrial functions is actually distributed between the mitochondria and the cellular nucleus. So "mitochondrial DNA damage" can happen in either the mitochondria or in the cell's nucleus or both.
Science is very cool and this stuff could shape the future in a big way.
Are there studies that we can volunteer for?
Maybe in the future some skin like tissue will be lab grown and sewn onto one's arm and it will produce and release 1000x more antioxidants or age stopping chemicals into one's blood stream?
LUV!!
So, If I donate platelets to sick patient he will get beter?
I think these treatments will only be available for the Elite.
Just fast... It's free
first is a luxury later is everywhere and better than ever....
@@agnieszkapeesz9830I'm going to look into this. Is intermittent fasting enough or do you have to do it longer.
Yes, most likely. They don't want resources being depleted by "Useless Eaters." Especially immortal ones.
Bunch of mitochondrial vampires. Hide your kids.
Maybe this is only promotional... But I would have liked to hear more about where this doesnt work; uncertainty, inconsistencies in the results, if results could be promoted or demoted by another factor not isolated by the experiments, etc. I'm not so sure it's a miracle cure just yet, otherwise we would be hearing more about it... A few years is enough for it to be widely considered by the scientific community at least, no? If anyone can fill in any of these details, that would be great.
I'm no scientist, and my opinion may not hold much weight, but I believe the initial decline in mitochondria is driven by a kind of biological clock that gradually downregulates cellular processes in each species. Once this metaphorical clock starts to decline, it damages mitochondria, setting off a feedback loop where the compromised mitochondria, in turn, accelerate damage to the body.
Take the bowhead whale, for instance-these creatures can live for 200 years and have a vastly larger biomass than humans, meaning more cells and more mitochondria, all derived from their mother's mitochondria.
So, why do their mitochondria remain stable for so much longer? Given the far greater number of mitochondrial divisions and replications over such a long lifespan, it’s surprising they live so much longer without the same decline we see in humans.
I understand that many scientists are sceptical of the biological clock theory of ageing, but I sometimes wonder if there might be something to it.
Where's the technical specifications? Open source? For Everyone? Let's see the goods.
Can mitogenisis happen in a can cell?
Can we stop balding and grow hair again with this research? Though balding doesn't kill a person physically but psychologically lots of humans are suffering.
So, It seems to me last night I listened to an almost exact presentation on the Reverse Aging Revolution channel about NAD+, and today I read about NMNH. Has NAD+ been dropped by your channel as important for longetivity? If so, why are you still promoting Nuchido Time. What happened to DR Nicole Conlon who was the researcher on Nuchido Time? Last video I watched with her she had her study reviewed and was waiting to have it published, but now she is gone and you appear. What's the story dude?
I fast 10-12 days on just water. It that length of time bad for these bacterias
Cant I train my leg mucles for not declining?
Interesting.
But how long it keeps its positive effects?!
A sort of Frankenstein idea comes to mind. Genetically engineer mitochondria to enhance functionality, then transplant them.
12:25 Question are Mitochondria types related to blood types?
Smplistic point of view about agening. Is obvious this is not one factor process
WHERE DO I SIGN UP? I am willing to pay good money for this!
Me too. I could pay USD500 if we can split it over a few years
If your Mitochondria are EXACTLY the same as your mothers are ... cant you find a way to extract and implant them for a longer life?
Clearly this would be diffucult ... but to have a copy screams for this solution.
How does redox signaling molecules play into this?
Who is this person talking. He sounds like RFK jr
You may want to investigate the different strains of mitochondria. I suspect there are super mitochondria in different nations, races and age brackets You may also want to consider cross species mitochondria which could work like exosome transplants.
Longevity is still scattered and fragmented. I think huge strides can be made in 10-20 years, but only if major governments prioritizes it. Probably it will have to be the US and it should be a moon landing or Manhattan project level of coordinated commitment and resources. AI will of course be a big part of it.
If that doesn't happen, anyone who is over 30 now are unlikely to benefit much from longevity science.
There is one plants root that has scietifically proven ability to produce new motochondrias! I use it.
@ok-ih5nv
Rhodiola Risea
@@AndroidSon Rho di ola ri se a for some reason your reply disappeared
@@norbertnagy5514
I have a book about Rho-diola Rho-sea where are scientifically facts about anticancer effects and actions for mitochondrias multiplication in muscles ceela are prover. That book is in russian language.
@@norbertnagy5514
Rosea
Haven’t heard of this plant. Pls share!
What happens when I donate regularly platelets?
Your body gets better at making clotting factors to replace the ones you lost. This can become dangerous if you adapt to it for too long. Don't be too regular about it.
@@elinope4745can you go into a little more detail about this. I have been donating off and on for years. Always wondered what donating over the long term was doing to me. Recently they have been touring it as an anti aging hack. Sort of like cleaning out the sludge from your blood.
Well, if you have painfree and quality of life til you die, then you've won the game called life.
BUT it seems most people think living as long as possible is more important than quality of life, because people in general live with diseases and are bedridden etc the last 10 to 30 years, or earlier, of their lives. That's not living, that's dying slowly in agony where you wish for death much sooner.
If I can keep my health (I'm 43 btw and healthy because I do certain things) til I die, I'm happy. But if I get sick and my life quality goes down due to bad advice, and ofc manipulation and brainwashing, I would want to die early. Don't 100% trust your doctor when it comes to their medical practice which is VERY narrow, or most of what mainstream media says and keep an open mind where you will find stuff that can and will help you treat disease and other ailments, and make your life a lot better and healthier.
Most people are sick due to bad advice and manipulation, the lack of good information, not the other way around.
Im not a evolutionary but love the science
Me too, Adam and Eve is where its at but I adore new scientific health information
Am 63÷ went to London eye clinic for a thouROUGH
check up came out surprised ; Zero prob with my eyes: AM ON ZERO MEDICATTION
if you don't use the patients mitochondria then are you bypassing hereditary evolutionary and eliminating variation from the gene pool. Though older recipients may not be strong reproducers.
Bro sounds like science trump lmao 13:34
Over population? Economics of having funds for living longer. Could easily be a human disaster.
You forgot to begin your lecture with three key points: "This is all theoretical", "It does not exist", "The FDA might take a look at this in 20 years". If only we were a moue...
He claims mitochondrial transplant it is already used in surgeries and rare diseases, so there is already human use in some fashion. He claims his technology can be in human trials next year. Time will tell, there are hiccups/roadblocks more often than not.
Rather go with PEMF therapy as it's non invasive
NAD levels
NMN is precursor to NAD.
I'm on NMN since 18months ago. Now put the powder under my tongue. Lately increase to 500mg/day.
Energy level is amazing at 69yrs. Lately been playing 2-3 hours of tennis, single or double.
My hair is turning black. Stop dyeing my hair since 8months ago. I have steak of very black hair on the top front of my head.
Wonder when I'll have a full head of black hair again.
@@MsBay129 Very encouraging, when do you take it?
@@sufficetosayMorning and before sleep. I put powder under the tongue. 200-300mg each time.
@@MsBay129 thx, i'll try that. Taking it internally didn't do much for me. Have you tried methylene blue?
@@sufficetosay. 🤔. Nope
Living longer or enjoying life ,food, and alcoholic pleasure ,not in a greedy way ,die at 90 with gods knows what other issues or die sooner having lived .Every year, i see plenty of people way younger than me die and some seemed way too healthy .Mitochondria would have meant nothing .
Please hurry
Kissiger or Queen you choose😢
Grow it or Harvest slippery slope young man
Sign me up
no you are ficused on finding mitochondiria injection to sell it otherwise you would tell bount natural ways to multiply them
God made evolution as well. The bible was coppied from 600,000 year old txt. Sooooooooo
A carnivore diet works just as well without all that palaver.
He doesn't even understand half his own research.
Adding new mitochondria to the body boosts pyruvate production. Pyruvate can convert into ethyl pyruvate, which is one of the most effective blood cleansers.
I need to become a longevity influencer to sort out all these studies.
They tunnelvision, they don't research related studies.
I agree, I have seen that with multiple longevity research, it's mind blowing how they don't seem to talk to one another..🙄🤦♂️
Sounds like you have the knowledge necessary to become an influencer. Share your knowledge my friend! Hope others and make some money!
If you could, you would.
@@michelangelobuonarroti916 I don't like the limelight.
Someone may need to interviene in this unscientific sector, though.
Nadh
Q10
PQQ
Infection 😒
Immunologic system 😒
Hoodia
Hoh so that why the women the
Eggs are form this early in the life development of a woman and not later. So the mitochondria are not to far descendants of the ones of the mother eggs
Yo just take melatonin
People living longer? Society can't have THAT! Young productive citizens is the goal!
Older people have a lot to offer the world, and birth rates are rapidly going down in most Countries. If someone is very healthy at age 95, that's less taxing on "society" than a chronically ill 45 year old.
And man will never land on the moon, let alone fly. That’s just crazy talk. Truthfully, most humans have such fantastically pitiful an stunningly dim imaginations. Most live in a crisis of imagination. Often “believing” the wrong bullshit, simply because they refuse to challenge their established belief systems, which feel sacred to them. Not to mention that their wildest imaginations can’t even keep up with current developments. Dim bulbs.
And man will never land on the moon, let alone fly. That’s just crazy talk. Truthfully, most humans have such fantastically pitiful an stunningly dim imaginations. Most live in a crisis of imagination. Often “believing” the wrong bullshit, simply because they refuse to challenge their established belief systems, which feel sacred to them. Not to mention that their wildest imaginations can’t even keep up with current developments. Dim bulbs.
And man will never land on the moon, let alone fly. That’s just crazy talk. Truthfully, most humans have such fantastically pitiful an stunningly dim imaginations. Most live in a crisis of imagination. Often “believing” the wrong bullshit, simply because they refuse to challenge their established belief systems, which feel sacred to them. Not to mention that their wildest imaginations can’t even keep up with current developments. Dim bulbs.
yes, pharmaceuticals, processed food industries, pension system... would go bankrupt if everybody lived to 100 disease free and plenty of health. There is no profit for institutions and government in healthy aging
utter nonsense !
Lmfao a bioreactor
How does an intelligent mind possibly think that that was not created ridiculous
Almost seemed like he realized how ridiculous it sounded mid-sentence.
Good information. BUT! We were created by God, NOT evolution. You should know that.
God created evolution.
Whatever side of the debate you are on it remains an undeniable truth that WE can and DO "evolve" every minute of every day. Then we hit a peak and devolve...or break down be it our society, morals, values or ethics.
Aging plays a HUGE part in this. Today there are extremely few WW1 or WW2 veterans , as they go so does their memories of those conflicts...we are just about to make the same mistakes that were made in their era.
If they we able to live to 125 they'd be sounding the alarm.
Evolution is the very face of God. Stop separating creator from creation. Show respect to the totality.
@@TruthIsHardToTake i mean with our current knowledge the universe itself very well could be created by a godlike entity but humans specifically created by god and that there is no evolution or the earth being only a few thousand years old is pure bs
@@TruthIsHardToTake and btw truthishardtotake is pretty egoistic name i dont think the bible teaches to be like that. You could very named youself like "TheTruthSayer" lol
He said different ethnic groups not races ! what , doesn't he know there are all these different races on planet earth THE HUMAN RACE is the only race on this planet of different species
A good powerhouse,if perfect mithondria can be armoured by our good scientist we need to achived that , no reject just produced perfect beings!,,,😊😊😊😊😊