Extending lifespan by rejuvenating mitochondrial membrane potential - Dr Brandon Berry
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- Опубликовано: 10 июл 2024
- In this video i spoke with Dr Brandon Berry, a current Post-Doctoral fellow at the University of Washington, where he is developing and using tools to understand the function of mitochondria and their link with diseases and aging. Here, we discuss these interests further and the results from his latest publication one tool, termed 'mitochondria-ON', extended worm lifespan. 'Mitochondria-ON' rejuvenates the mitochondrial membrane potential when exposed to light and all-trans-retinal using optogenetics.
Find Brandon on Twitter - / mitobrandon
Research papers - Berry, B.J., Vodičková, A., Müller-Eigner, A. et al. Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan. Nat Aging (2022). doi.org/10.1038/s43587-022-00...
Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance www.embopress.org/doi/full/10...
Berry, B.J., Kaeberlein, M. An energetics perspective on geroscience: mitochondrial protonmotive force and aging. GeroScience 43, 1591-1604 (2021). doi.org/10.1007/s11357-021-00...
Find me on Twitter - / eleanorsheekey
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TIMESTAMPS
Intro - 00:00
Mitochondria and proton motive force - 01:10
Optogenetic tools manipulate membrane potential - 08:45
Lifespan studies - 17:55
Consequences of recharging - 30:00
Cellular senescence - 36:30
Academia & advice - 38:30
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "www.freepik.com/free-photos-v..."Background vector created by freepik - www.freepik.com 
Наука
Mitochondria! Thanks Brandon for coming on the show!
What about PQQ (PQQ Pyrroloquinoline Quinone) --- how does it work to support mitochondria?
Methylen Blue would be interesting to discuss (mitochondria versus NO)..
Would you be willing to include a slightly dumbed down recap/take aways at the end of these videos for some practical ways to incorporate the info learned? I would love that! Thank you for this consideration.
None of this has practical implications until proven to be clinically relevant in trials
Unless you're a scientist, of course!
You (or Brandon) mentioned Co-Q10 ... I was just learning about MitoQ, which supposedly boosts Co-Q10 INSIDE MITOCHONDRIA, which apparently does not happen with regular Co-Q10. Some research seems to suggest that this can help with energy production in the mitochondria, presumably a good thing for the cell and for the organism. I'm curious what you think about this (MitoQ) as a potential longevity tool. Thanks for a great interview!
Super interesting! I love following the REAL cutting edge of science! Keep on informing! :)
Did you test the effect of far infrared on the health of mitochondria?
It is now know that far infrared is used by mitochondria to make melatonin that scoop up the oxidative stress inside of mitochondria.
Our melatonin done inside the brain is merely the backup plan for the night, the main source is inside each mitochondria but need infrared to be produced correctly.
Are you sure far? I had thought NIR was more effective here.
Awesome interview, thank you!
Fantastic, informative video!
Thank you so much, I love your material, I use it in the AP Biology class I teach all the time. It can be difficult to get high school kids to read primary research however, they will listen to your videos. It really gets them excited and also gets them to start thinking like a scientist.
well done!!
Great combining optogenetics with mitochondria research. I’ll try and follow this researcher. Thx for the interview.
Interesting talk!
very interesting, thanks for this interview.
One pint which stroke me most is when Brandon mentioned the contrast of 2 phenomena. First, mitochondria are highly preserved, and second, they loose membrane potential already in early adulthood. Yet, offspring organisms spawned in later adulthood start with fully capable mitochondria. this clearly points to causation outside of mitochondria, in both ways, poisoning and restring reconfiguration. ...ultimately it comes down to a deterioration of the genetic outsourcing model, and the communication\transport between the host cell and the mitochondria.
My guess would be that the effect of the outsourced genes deteriorates, either by lower activity or simply by a loss of transport capacity towards the little guys. And I also think that the electrochemical differential in the cytosol and around mitochondria is rather important here.
It would be really valuable if you could post these interviews as podcasts on Spotify 🙌🏻
Thanks, this was great; And I'm only 3 minutes in.
Awesome content.
Please increase the quality of production (audio in particular) to increase your reach.
It's his audio that isn't good.
Yes, HIS audio is rather weak, but at least clear…
Very imteresting. Vaguely recall that lipid composition of mito membrane changes with aging so would make sense that membrane potential would change based on this alone. Not sure if dietary interventions have been tested to explore partially rejuvinating the membrane. Brandons techniques could probably test this.
I'm not so much thinking on the line of anti-aging. I'm more thinking on the line of overcoming ME/CFS, and I have a potential hypothesis that mitochondria autophagy maybe might possibly be a potential key to overcome ME/CFS. I'm looking into such supplements as Huperzine-A, berberine, glutathione, D-Ribose, methylene blue, etc.
It would be great if Brandon would take a look at ME/CFS. Perhaps the reason we have so little understanding of this disease is because there's something missing in our understanding of mitochondrial metabolism.
ketogenic diet is the best way to improve mitophagy and clear out defective mitochondria
Good discussion, but I wish we would have heard a discussion that contrasts more the benefits of higher a membrane potential with pro-longevity benefits driven by inhibition of ATP synthase. How can we reconcile these two differences?
mitochondrial is the key, if we could reduce oxidative stress to a minimum, life span could up to 200%
Walk slowly for 20-30 minutes after each meal. This will reduce oxy damage from first link in Electron Transport Chain after meals! IMHO
@@soaring9406 supply and demand balance...
Potassium Chlorid before and After meal as well as valin
@ammalealaura8923 Can you please recommend any articles on taking potassium Chloride and Valin? Or did you mean valine? Thanks
@@johnm6866 sorry my English is bad
I have no article and
I tried it and it works to stable my bloodsugar and yes I meant valine I am 42 and everybody thinks I am in my 20 so that’s why I know it works well 🏆🍀🎁
Unfortunately is very difficult for me to understand you.
What is the practical application of this research to human lifespan? Take more NMN? PQQ? Fasting? Infrared Light? more Lipids?
Infrared light and grounding.
And Potassium Chlorid After and before every meal and walking and valin Vitamin k infrared
As a guy who is probably average in the intelligence department, I still find these discussions fascinating
hello eleonor . I dont know what protocol you are using, but its working. look like 20 years old. I envy you.
lol, I know its just genetics plus healthy life, but congratulations.
I'm still waiting you to get rich before I get too much old.
People should check out Cracking the Aging Code by Josh Mitteldorf and Dorian Sagan. It's a look at the evolution of aging and why aging is adaptive for both the individual and the larger collective.
Are you familiar with Dr. Jack Kruse? Would love to see you interview him, he's all about mitochondria from a biophysics perspective.
is redox potential gradients among mitochondria related to membrane potential?
Great video but I'm sick of mice mice mice and worms. People over 70 like myself are facing certain death unless the aging process is stopped and or reversed. What about humans?
What about methylene blue? I've heard it's great for your mitochondria.
It's great for a lot of things.
Interesting discussion! (plebe here, w/health issues wherein a bit more applicable concepts woven in would be a fine bonus, as MD’s are a decade or two in the dark. Have hypoxia esp in furthest extremities…)
do you think we will see people of 70 going back to look like in their 20's ?
I think a holistic approach would give better results although it would be much harder.
Is there any testing on taking ATP as a supplement?
A related topic I may look into for a video is creatine
your body makes 100 +/- lb of ATP per day. Just optimize the system.
The title makes me think that it sounds similar to the science of good nutrition. The mitochondria membrane gets wrecked when you have intake of polyunsaturated fats, like from cooking oils that are not coconut oil, avocado oil and legitimate extra virgin olive oil. Also, from most processed food, lol.
What about red light 650 to 800nm
According to Dr Gerald Pollack the water itself is able to create an electrical gradient over hydrophilic surfaces, proteins are, dependent on light abortion . Maybe this experiments with light should consider this fact. Consider water does not absorb all frequencies of light.
What's good for mitochondria then
Potassium Chlorid After and before every meal and valin
subtitles, please
Hi there, is your brother called Patrick?
Yes! I know who you are. I was friends with your brother. I am intrigued that we are both RUclipsrs in the health space online. I would love to collaborate with you some time, if possible?
590 nm is orange, not yellow/green.
yellow/orange , def not green . . .
Coenzyme A!!!!!!!!
im searching for nt factor phospholipids that are not made out of soy. if anyone knows a brand please let me know.
lecithin is in soy but is not soy
Sunflower seeds
Could you put more copies to over charge it?
Doesn't ubiquinol help for the mitochondrial membrane potential?
Study:
"The proton pumping mechanism of the bc1 complex"
Vitamin k has almost the same form than q10
@@Schutzmassnahmen Interesting.
I just read the abstract of a study saying that vitamin K2 has the same kind of effect on mitochondria as Q10.
Any idea on how close that kind of effect is to what Dr. Berry is trying to achieve?
@@Battery-kf4vu for me it is Clear What i want to achive as Long as i can being Young and Healthy from inside First and than it will Show at the outside !
Fasting !before and After every meal Potassium Chlorid! valin !milk thistle !astraxanthin !Vitamin k !But Not just k2 !walking ! For atp Mangan Kupfer Zinc
Sorry for my english i am german i Know you can Not see
He reminds me of a young Ethan Hawke
COENZYME A!!! ASK THE SALK INSTITUTE!!!
Great interview and point about NAD. Worth checking out @nuchido and work of @drnicolaconlon