This is one of the most well explained and scientifically detailed yet comprehendible presentations (for the public) that I have seen in many years. Much kudos and thanks to Dr. Jayme Dyer on her lucid and engaging presentation. Her down-to-earth communication style -- of not coming off as too technical -- was critical for her balanced communication. It helped explain and tie together opaque areas of cellular biology. I plan to forward this to friends.
Don't know what to say, except amazing. For someone who just wants to know about cells and life, this is magic. The extent of research to pin it down is just supreme.
THANK YOU OMG I’ve been wondering this basic question ‘how the cell parts ‘know’ what to do’ and no one seemed to be able to tell me - no biology professors, no chemistry professors, no one. You are amazing thank you SO much!!!!!
You are not only brilliant you are an amazing science communicator! Thank you for the work you do. Hope you also share with gen public more too. We need more folks like you!
@@YouTooBio Absolutely, you're an amazing presenter and investigator. I'm so grateful people like you have put their talents into this field and expanding our knowledge of the natural world. You all are a blessing to humanity.
About a zillion hours of painstaking research compressed into a half hour lecture. Great job. I'm still curious about the mechanism of directional motion in cells with flagella or cilia.
I think there should be difference between MSD in uniform pheromone and gradient pheromone. For bias random walk, the mean free distance in different concentration of attractant should be different, which is associated to the diffusive coefficient. The MSD only reaches about microns after 20 minutes. The polarity patch nearly stay in the original position. It is due to the ultra-small diffusive constant that hides the difference.
Thank you for posting this interesting topic. I always wondered how cells (white, sperm, neurons, and general tissue) did that. I thought receptors might have something to do with it, but you've now confirmed it. Thank you for being concise and passionate about what you love doing, Dr. Dyer, it shows. Cell biology is such an interesting field; so much that goes on in a cell, never mind with other types of cells! The complexity is exciting. I'll definitely watch more videos in this channel.
Look at how cells think from this prospective your brain is a network of cells . Microtubules are like a computer board and our eyes are the receiptors or no accurately your retinas are receptors
This is great. I really love this channel. She's explaining complex biological behavior and research in very simple terms to make general public understand. I've always wondered how cells are able to know where to move.
The receiptors are eyes or better yet your retas are receptors . How do we cells think without brains . Look at things this way your brain is a collection of cells
Always a fascinating subject. Having viewed ‘the secret life of the cell’ many times and been in awe of the response of the cell to the adenovirus, watch bacteriophages in action, semi grasped the implications of “how cells talk to each other”, how different motor proteins work in different places and the wonder at the connection, complementarity and competition between the world of virus, bacteria and single and unicellular life, my next question is .....given the obvious interconnection between all life (and non life -maybe, e.g. a virus), where, what, is the source of the directive information that enables all of this to occur. I look forward to the next exciting episode. Well done Jayme, fascinating, well presented and I love the passion and the excitement. Cheers. GT
And microtubules and hormones Are like computer board and data disc or transistors. Look at the question of how cells think without brains from this prospective. Your brain is a network of cells. And or eyes are receiptors or more accurately your retas are receiptors
But then how does the cell know how to physically move its body in such a way that it propels itself forward? And how is it being attracted to those chemicals being released by the egg? What makes it attracted to those chemicals? And how is it receiving those chemicals? Like how is it smelling? Because unlike us, they don't have olfactory receptor cells. And then whats generating a nerve impulse that would travel to a brain which it does not even have?
Suspect the dots aren't all connected,(edit: they're connected but i mean it's not know how exactly) this talk was about polarity patches sort of making a moving average of the direction of the gradient. And delivery of vesticles moving it. That helps, but, the patch itself is smaller than the cell and sees less of the gradient, and it's not entirely clear why it moves towards the gradient. (it seems likely a bigger area than just the patch is involved in sensing somehow. Maybe the lines the "walkers" traverse is pulled sideways due to some sequence of things caused by the gradient.) By no means an expert and watched it a little while ago.
Jayme Dyer here - if you're interested in seeing me talk more about the intersection between biology concepts and cool recent research, check out my new RUclips Channel!
How many polarity patches are there in a yeast cell? If there are very limited number of polarity patches (or just one), and if they are located in a portion of the plasma membrane that is not close to pheromones, then how does this polarity patch move? Because we know that vesicle trafficking occurs substantially only in regions where yeast receives a lot of pheromone signal, and without vesicles, polarity patch does not move much. Or does it?
Great question! There is only 1 polarity patch in the cell at a time (sometimes there are two, but only for a minute or so, before one "wins" and outcompetes the other.) Vesicle trafficking occurs towards the polarity patch, which means it is always happening where the polarity patch is. So, the patch will always be moving, whether it's on the up-gradient or down-gradient side of the cell. The idea is that the polarity patch moves less when it's on the up-gradient side of the cell, so it will spend the most amount of time on that side, resulting in growth in that direction.
That's a cool explanation! However, after watching the video I was left with even more questions. How do those proteins make actine cables build in their direction? Why does that raft even build up in such a density on a particular pole? Ok, ligands bind to the receptors which probably produce some mediating molecules, but how come a concentration of the polarity proteins is so dramatically different across the cytoplasm? There must be some sort of an inhibiting interaction between different "sides" of a cell, right? What if there are two local gradients on two sides of a cell?
Watching the neutraphil(?) giving chase to the bacteria made me wonder how body justifies spending so much energy (moving the whole neutraphil) just to eliminate one small target.
+tomcmlee yeah i had a similar thought. i can only speculate that neutrophils spend most of their time NOT engaging in this sort of behaviour and only resorting to this behaviour when it is very much needed, in selective areas and for contained periods of time, as controlled by cytokines and other inflammatory mediators.
Perhaps because that one small target will turn into two small targets then four then eight then 16 then 32 if nothing stops it. In this case an ounce of prevention really is worth a pound of cure.
Hope dont mind, Thanks for answering how sperm cell look after egg but not clear why sperm cell want to go die after going inside egg having known this in many ages and doesnt changes phenomenon. 2nd question: why men by nature put so much thrust before ejaculation as per science, what it benefit to women.If you answer will be great for my paper.
She starts as a cell biologist 0:20 and evolving into a geneticist 15:20 in just a record 15 minutes. How many time do we need to wait until she finds out herself as an inorganic chemist?
How do cells think without brains chemical computers. . microtubules are lots computer board. How do cells think without a brain. Look at this prospective your brain is a network of cells. And we do have eyes their receiptors. Or more accurately your retas are receptors
Glad she gives sperm credit instead of going on and on about parthenogenesis. Did you most examples are producing their own sperm From polar bodies. Some examples like Breaded lizards are closer to males
шикарная работа 🔥 в голове правда сразу возникли идеи для фильма катастрофы где допустили ошибку и специальный вирус меняющий ДНК вредоносных клеток/бактерий - мутировал в широком многообразии всех видов клеток и вирусов окружающей среды и начал бесконтрольное заражение доброкачественных клеток. В теории ,как дрожжи, это снизит вероятность размножения (повысит шансы вымирания колоний бактерий) однако это будет фатально для нейронов. если они изменят свой принцип амёбовидного движения это скорее приведёт к смерти. Клетки будут жить, но механизм обмена импульсами будет нарушен. Хотя 🤔 нейроны живут в среде которую они же и создают своей коллективной деятельностью, точнее с помощью управления другими органами и процессами (которые собственно говоря и создают среду для жизни) нарушив этот процесс организации, кто знает к чему это может привести. Но я более чем интуитивно полагаю ни к чему хорошему :'з "Сложно делать открытия. Но в миллион раз сложнее сделать так, что бы это открытие не убило тебя" а касаемо биологии на атомно-молекулярном уровне, влезая в гармоничный суп похожий на результат деятельности инженера-извращенца-криптомана, так и вовсе всё имеющее интеллект и нервную систему :'D Во истину потрясающее и страшное! (наверное это можно назвать одним словом "величественное") 🚬🌚
Why you hate finding something about being male to be proudly of are insecure about having an ego. You know sperm's roles is passing down special Gene expression . The egg is general gene expression
Receptors are my eyes or better yet your retas are receptors. How do we think without brains . Look at things this way your brain is a collection of cells. Microtubules are like a computer bord
Quran "We will show them Our signs in the horizons and within themselves until it becomes clear to them that it is the truth. But is it not sufficient concerning your Lord that He is, over all things, a Witness?" Quran "Travel through the land and observe how He began creation. Then Allah will produce the final creation. Indeed Allah, over all things, is competent." Quran "Recite in the name of your Lord who created - Created man from a clinging substance. Recite, and your Lord is the most Generous - Who taught by the pen - Taught man that which he knew not.
This is one of the most well explained and scientifically detailed yet comprehendible presentations (for the public) that I have seen in many years. Much kudos and thanks to Dr. Jayme Dyer on her lucid and engaging presentation. Her down-to-earth communication style -- of not coming off as too technical -- was critical for her balanced communication.
It helped explain and tie together opaque areas of cellular biology. I plan to forward this to friends.
Superb! I wish there was even more resources to fund these amazing investigators.
One of the best talks in this high quality series.
Excellent delivery and explanation from Jayme. Thanks
How cells think if don't have brains. But just think you brain is a collection of cells. I'm a white blood cell and got chemical eyes
Don't know what to say, except amazing. For someone who just wants to know about cells and life, this is magic. The extent of research to pin it down is just supreme.
THANK YOU OMG I’ve been wondering this basic question ‘how the cell parts ‘know’ what to do’ and no one seemed to be able to tell me - no biology professors, no chemistry professors, no one. You are amazing thank you SO much!!!!!
How cells think if we ain't got brains? Look at it this way your brain is a collection of cells
You are not only brilliant you are an amazing science communicator! Thank you for the work you do. Hope you also share with gen public more too. We need more folks like you!
Thanks! Jayme Dyer here - I've started my own RUclips Channel to meld biology education with cool recent research check it out!
@@YouTooBio Absolutely, you're an amazing presenter and investigator. I'm so grateful people like you have put their talents into this field and expanding our knowledge of the natural world. You all are a blessing to humanity.
I fulfilled my day's 'learn something new' task! Awesome explanations, and clever science. Thank you!
About a zillion hours of painstaking research compressed into a half hour lecture. Great job.
I'm still curious about the mechanism of directional motion in cells with flagella or cilia.
I think there should be difference between MSD in uniform pheromone and gradient pheromone. For bias random walk, the mean free distance in different concentration of attractant should be different, which is associated to the diffusive coefficient. The MSD only reaches about microns after 20 minutes. The polarity patch nearly stay in the original position. It is due to the ultra-small diffusive constant that hides the difference.
Thank you for posting this interesting topic. I always wondered how cells (white, sperm, neurons, and general tissue) did that. I thought receptors might have something to do with it, but you've now confirmed it. Thank you for being concise and passionate about what you love doing, Dr. Dyer, it shows. Cell biology is such an interesting field; so much that goes on in a cell, never mind with other types of cells! The complexity is exciting. I'll definitely watch more videos in this channel.
Look at how cells think from this prospective your brain is a network of cells . Microtubules are like a computer board and our eyes are the receiptors or no accurately your retinas are receptors
This is great. I really love this channel. She's explaining complex biological behavior and research in very simple terms to make general public understand. I've always wondered how cells are able to know where to move.
The receiptors are eyes or better yet your retas are receptors . How do we cells think without brains . Look at things this way your brain is a collection of cells
Always a fascinating subject. Having viewed ‘the secret life of the cell’ many times and been in awe of the response of the cell to the adenovirus, watch bacteriophages in action, semi grasped the implications of “how cells talk to each other”, how different motor proteins work in different places and the wonder at the connection, complementarity and competition between the world of virus, bacteria and single and unicellular life, my next question is .....given the obvious interconnection between all life (and non life -maybe, e.g. a virus), where, what, is the source of the directive information that enables all of this to occur. I look forward to the next exciting episode. Well done Jayme, fascinating, well presented and I love the passion and the excitement. Cheers. GT
great presentation! really engaging and fully explained with communicative illustration XD
Outstanding presentation.
You are amazing. Seriously! Wow!
Fantastic video! Very easy to understand.
Not a um or a eer in the whole presentation, beautifully explained in a great talk, thanks.
Very interesting topic. Jayme did a very good job explaining the cells motion.
How do cells think without brains but look at things this way your brain is a collection of cells
Excellent presentation! What a great teacher!
Interesting article and good presentation - thanks for sharing this!
And microtubules and hormones Are like computer board and data disc or transistors. Look at the question of how cells think without brains from this prospective. Your brain is a network of cells. And or eyes are receiptors or more accurately your retas are receiptors
Great teacher
thanks for uploading.
Thanks for sharing.
Excellent video. She is a brilliant scientist.
Clear explanation, 😊
Good god, you and your team are brilliant! Thank you for contributing to our society and knowledge.
But then how does the cell know how to physically move its body in such a way that it propels itself forward? And how is it being attracted to those chemicals being released by the egg? What makes it attracted to those chemicals? And how is it receiving those chemicals? Like how is it smelling? Because unlike us, they don't have olfactory receptor cells. And then whats generating a nerve impulse that would travel to a brain which it does not even have?
Suspect the dots aren't all connected,(edit: they're connected but i mean it's not know how exactly) this talk was about polarity patches sort of making a moving average of the direction of the gradient. And delivery of vesticles moving it.
That helps, but, the patch itself is smaller than the cell and sees less of the gradient, and it's not entirely clear why it moves towards the gradient. (it seems likely a bigger area than just the patch is involved in sensing somehow. Maybe the lines the "walkers" traverse is pulled sideways due to some sequence of things caused by the gradient.)
By no means an expert and watched it a little while ago.
This was fascinating, thank you.
Great findings and great presentation!
Jayme Dyer here - if you're interested in seeing me talk more about the intersection between biology concepts and cool recent research, check out my new RUclips Channel!
How many polarity patches are there in a yeast cell? If there are very limited number of polarity patches (or just one), and if they are located in a portion of the plasma membrane that is not close to pheromones, then how does this polarity patch move? Because we know that vesicle trafficking occurs substantially only in regions where yeast receives a lot of pheromone signal, and without vesicles, polarity patch does not move much. Or does it?
Great question! There is only 1 polarity patch in the cell at a time (sometimes there are two, but only for a minute or so, before one "wins" and outcompetes the other.) Vesicle trafficking occurs towards the polarity patch, which means it is always happening where the polarity patch is. So, the patch will always be moving, whether it's on the up-gradient or down-gradient side of the cell. The idea is that the polarity patch moves less when it's on the up-gradient side of the cell, so it will spend the most amount of time on that side, resulting in growth in that direction.
I love this! she is great and passionate.
She's.. A... Genius!!! Mind blown!!!
That's a cool explanation!
However, after watching the video I was left with even more questions.
How do those proteins make actine cables build in their direction? Why does that raft even build up in such a density on a particular pole? Ok, ligands bind to the receptors which probably produce some mediating molecules, but how come a concentration of the polarity proteins is so dramatically different across the cytoplasm? There must be some sort of an inhibiting interaction between different "sides" of a cell, right? What if there are two local gradients on two sides of a cell?
Great great talk! Thank you so much
However I still wonder: How are vesicles targeted to the membrane region where they are “needed”?
Great explanation! Thanks!
Mind blown.🤯💥
Watching the neutraphil(?) giving chase to the bacteria made me wonder how body justifies spending so much energy (moving the whole neutraphil) just to eliminate one small target.
+tomcmlee yeah i had a similar thought. i can only speculate that neutrophils spend most of their time NOT engaging in this sort of behaviour and only resorting to this behaviour when it is very much needed, in selective areas and for contained periods of time, as controlled by cytokines and other inflammatory mediators.
Perhaps because that one small target will turn into two small targets then four then eight then 16 then 32 if nothing stops it. In this case an ounce of prevention really is worth a pound of cure.
And how do they avoid two going after the same one."Hey, I saw that one first. Get your own bacteria, buddy!"
thanks for the video!
She is great
Mind blowing
the ith thpeaking in a very interethting manner. But Great I could learn thomething about thellth in thith video
Thank you. 💜👍🏻
Hope dont mind, Thanks for answering how sperm cell look after egg but not clear why sperm cell want to go die after going inside egg having known this in many ages and doesnt changes phenomenon.
2nd question: why men by nature put so much thrust before ejaculation as per science, what it benefit to women.If you answer will be great for my paper.
The Origin of Life is Chemical Synthesis.Marine algae(green seaweed):Cellulose is a cell
I told my sixth graders that the Macrophages were smelling bacteria farts.
She starts as a cell biologist 0:20 and evolving into a geneticist 15:20 in just a record 15 minutes. How many time do we need to wait until she finds out herself as an inorganic chemist?
How do cells think without brains chemical computers. . microtubules are lots computer board. How do cells think without a brain. Look at this prospective your brain is a network of cells. And we do have eyes their receiptors. Or more accurately your retas are receptors
Gradient tracking.. a crucial skill for driverless cells
your quite an interesting teacher
Glad she gives sperm credit instead of going on and on about parthenogenesis. Did you most examples are producing their own sperm From polar bodies. Some examples like Breaded lizards are closer to males
nice
So sweet
I think i fell in love
Next up: how cells talk without mouths.
шикарная работа 🔥
в голове правда сразу возникли идеи для фильма катастрофы где допустили ошибку и специальный вирус меняющий ДНК вредоносных клеток/бактерий - мутировал в широком многообразии всех видов клеток и вирусов окружающей среды и начал бесконтрольное заражение доброкачественных клеток.
В теории ,как дрожжи, это снизит вероятность размножения (повысит шансы вымирания колоний бактерий)
однако это будет фатально для нейронов. если они изменят свой принцип амёбовидного движения это скорее приведёт к смерти. Клетки будут жить, но механизм обмена импульсами будет нарушен. Хотя 🤔 нейроны живут в среде которую они же и создают своей коллективной деятельностью, точнее с помощью управления другими органами и процессами (которые собственно говоря и создают среду для жизни)
нарушив этот процесс организации, кто знает к чему это может привести. Но я более чем интуитивно полагаю ни к чему хорошему :'з
"Сложно делать открытия. Но в миллион раз сложнее сделать так, что бы это открытие не убило тебя" а касаемо биологии на атомно-молекулярном уровне, влезая в гармоничный суп похожий на результат деятельности инженера-извращенца-криптомана, так и вовсе всё имеющее интеллект и нервную систему :'D
Во истину потрясающее и страшное! (наверное это можно назвать одним словом "величественное") 🚬🌚
👍🏼
Imagine one of the genetic mutations of a sperm cell is to not go after eggs....task failed successfully.
nice work indeed,if she didn't start the video by say that sperm is really good and keep pointing it out i mean..
Why you hate finding something about being male to be proudly of are insecure about having an ego. You know sperm's roles is passing down special Gene expression . The egg is general gene expression
i have hispanic blood cells homes
Receptors are my eyes or better yet your retas are receptors. How do we think without brains . Look at things this way your brain is a collection of cells. Microtubules are like a computer bord
Quran "We will show them Our signs in the horizons and within themselves until it becomes clear to them that it is the truth. But is it not sufficient concerning your Lord that He is, over all things, a Witness?"
Quran "Travel through the land and observe how He began creation. Then Allah will produce the final creation. Indeed Allah, over all things, is competent."
Quran "Recite in the name of your Lord who created - Created man from a clinging substance. Recite, and your Lord is the most Generous - Who taught by the pen - Taught man that which he knew not.