Great lectures. I learned a lot. To contribute to your riddle of nucleation, I think it‘s useful to take a few steps backwards to get a better sight. A theoretical abstraction, that makes sense on many, many stages of development is the so called „absolution“. An absolution occurs, when a ressource becomes ubiquitous. In our case it‘s the ubiquity of oxygen. This special ubiquity made it possible for an archaeon to incorporate a bacterium, that was able to use oxygen for generating an additional amount of ATP, allowing the cell not only growing in a Thiomargarita mode, but into the third dimension. The 1:1 relation of ATP production and outer cell surface was no more. Before the mitochondrial revolution, Myxobacteria developed a quite different way to solve this issue not by internalising auxiliary troops, but by externalising duties to their conspecifics in a distributed organism. So they were able to build up the largest genomes in the bacterial world. Myxobacteria also developed very special ways of social motility.
Dear Dr. Theriot: Your presentation is like riding a magic carpet through the cytoplasm, speculating and wondering about the causes of such differences in cells. Imagining is what leads to creative and innovative new theories. Good luck to you and your work. Now.... about the flowers... do you need my address now or when I discover the special nucleotide bacterial motors?
Fascinating, thanks again. I think prokaryotes choose not to make Type B structures because they are just too dangerous to mix with your chromosomes. Think about the pulling forces exerted by microtubule shrinking, or the pushing forces exerted by nucleated F-actin polymerization. Or the forces exerted by processive motor protein walks. Long DNA molecules are fragile you know... if you had these things running around the bacterial cytosol, kiss the genome goodbye! Eukaryotes must have first evolved the nucleus, then gone to town with cytoskeleton. Then got big. This explanation is supported by the fact(?) that MreB and FtsZ filaments are always just running along under the plasma membrane. Maybe anchored to it? Test, make C crescentus mutant MreB that polymerizes normally but does not care where. Predict genomic instability!
The breath of knowledge and the clarity of logic are amazing. Thank you for the great lecture.
This was such an entertaining and informative lecture, your passion really shines through. Thank you!
This series of lectures are informative and thought-provoking. Thank you!
Amazingly great and fascinating lecture, maybe the best I've seen so far (out of hundreds)!
Dr. Theriot, You're terrific. I thoroughly appreciate your lectures.
Did not realize these discoveries were so recent
Great lectures. I learned a lot. To contribute to your riddle of nucleation, I think it‘s useful to take a few steps backwards to get a better sight. A theoretical abstraction, that makes sense on many, many stages of development is the so called „absolution“. An absolution occurs, when a ressource becomes ubiquitous. In our case it‘s the ubiquity of oxygen. This special ubiquity made it possible for an archaeon to incorporate a bacterium, that was able to use oxygen for generating an additional amount of ATP, allowing the cell not only growing in a Thiomargarita mode, but into the third dimension. The 1:1 relation of ATP production and outer cell surface was no more. Before the mitochondrial revolution, Myxobacteria developed a quite different way to solve this issue not by internalising auxiliary troops, but by externalising duties to their conspecifics in a distributed organism. So they were able to build up the largest genomes in the bacterial world. Myxobacteria also developed very special ways of social motility.
Did the bacteria in minute 29:17 pay windows to use its patented logo. If not they should get a good lawyer. ;)
Dear Dr. Theriot: Your presentation is like riding a magic carpet through the cytoplasm, speculating and wondering about the causes of such differences in cells. Imagining is what leads to creative and innovative new theories. Good luck to you and your work. Now.... about the flowers... do you need my address now or when I discover the special nucleotide bacterial motors?
Great stuff! Thank you!
Fascinating, thanks again. I think prokaryotes choose not to make Type B structures because they are just too dangerous to mix with your chromosomes. Think about the pulling forces exerted by microtubule shrinking, or the pushing forces exerted by nucleated F-actin polymerization. Or the forces exerted by processive motor protein walks. Long DNA molecules are fragile you know... if you had these things running around the bacterial cytosol, kiss the genome goodbye! Eukaryotes must have first evolved the nucleus, then gone to town with cytoskeleton. Then got big.
This explanation is supported by the fact(?) that MreB and FtsZ filaments are always just running along under the plasma membrane. Maybe anchored to it? Test, make C crescentus mutant MreB that polymerizes normally but does not care where. Predict genomic instability!
I'd still want to keep an eye on them, I mean they just look like they're up to no good, hunched tubular lurkers.
What - that's it ? No season 2 ?!
Don't leave me like this
Don't break my heart
It took me 40 years to find you . . . and now you're gone ?!!!
Are you thinking of: ruclips.net/video/wQID2zmeWTQ/видео.html ?
I think they try and very rarely do be semi multicelular thing and then get eaten, They're late is their problem
Perspicuous, Coherent, Compelling . . . say - you wanna go get a cup of coffee or something ?
What three people disliked this?