Neurology | Upper Motor Neuron vs Lower Motor Neuron Lesion | UMN vs LMN Lesion

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  • Опубликовано: 28 май 2024
  • Official Ninja Nerd Website: ninjanerd.org
    Ninja Nerds!
    In this lecture Professor Zach Murphy will present on the pathophysiology and characteristics of an upper motor neuron lesion and a lower motor neuron lesion (UMN vs LMN lesion). We hope you enjoy this lecture and be sure to support us below!
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    #ninjanerd #UMNvsLMN #Neurology

Комментарии • 960

  • @imperfectmammal2566
    @imperfectmammal2566 3 года назад +555

    Best teacher to ever exist in this planet!!!!!

    • @rjkmdb
      @rjkmdb 3 года назад +2

      So true

    • @hillsongirl1
      @hillsongirl1 3 года назад +5

      His kids will be blessed, hope he does pass on his DNA

    • @MsElina28
      @MsElina28 3 года назад +2

      Amen!

    • @Foodies28Joy
      @Foodies28Joy 3 года назад

      True❤️😍

    • @prashant23ify
      @prashant23ify 3 года назад +2

      Sir I have a dbout please help me solve it .
      If UMN lesion is present, obviously no signals are passed to lower motor neurons, so there should be less release of acetylcholine ….. so basically umn=lmn … why there’s a difference???

  • @ismaelbarzani6064
    @ismaelbarzani6064 Год назад +42

    You deserve to be named as the father of explaining and teaching

    • @NenehAgan
      @NenehAgan 2 месяца назад +1

      where do we vote🥹

    • @selwynhenriques2614
      @selwynhenriques2614 11 дней назад

      Very useful to understand difference between upper and lower motor neuron lesions ,really appreciate the ton of research you put in to give us such a detailed and simple to understand explanation .

  • @ArundhotiRay
    @ArundhotiRay 2 месяца назад +12

    Throughout the medical life I felt pain whenever I saw the word UMN & LMN because I didn’t understand these complexity. Thank God, I can die in peace now bcz I understand upper & lower motor neuron lesion.
    Thank you ninja nerd, you are the best teacher of this planet.

  • @sabaripaulmajumder5196
    @sabaripaulmajumder5196 3 года назад +173

    Love from INDIA

  • @djay909
    @djay909 3 года назад +259

    How this man keeps going all from his memory without a single hiccup is beyond me 🤯

    • @evilreborn4088
      @evilreborn4088 3 года назад +14

      Practice. He prepares every lecture. Then practice and then shows us the final product.
      He Is seriously good. All concepts getting cleared

    • @drdebocherry
      @drdebocherry 3 года назад +3

      He is the Master of the Universe, as in Queen Song!

    • @ghadderd.3444
      @ghadderd.3444 3 года назад +12

      صلي على محمد لا تحسدينه

    • @BrianHurd
      @BrianHurd 2 года назад +1

      Pretty sure some of the minutia is on a monitor off screen (but I could be wrong!), but 90% he knows. He is a badass.

    • @seemo5681
      @seemo5681 2 года назад

      @@ghadderd.3444 منجد فجعتني ليتها تقول ماشاءالله

  • @mimansa_sah
    @mimansa_sah Год назад +10

    Seriously - 4 hours of uni lectures - distilled into pure gold.

  • @riturajmajumder2055
    @riturajmajumder2055 2 года назад +6

    Zach , you are like one of the best med teacher in the planet currently.

  • @jillybasu8300
    @jillybasu8300 Год назад +34

    You guys are awesome, insanely good, the best teachers! Thanks for a great lecture Zach, it has really helped me understand about assessing for UMN v LMN lesions 🧠🤩🤙🏼

  • @neelamjha7955
    @neelamjha7955 3 года назад +45

    Ahhh!!!!! The most awaited video is here....🤩 Thank you Zach....I respect You and your work a lot...I really do...🤩🍰

  • @thehunchbackgirl
    @thehunchbackgirl 3 года назад +66

    I would travel across the world just to thank you in person, Zach!

  • @spanishlatteMD
    @spanishlatteMD 3 года назад +175

    so happy for you guys for what you have accomplished over the years! been here since 1st yr med school and I still am now that i am a graduating medical student! keep rocking you guys!

    • @obedbagona7402
      @obedbagona7402 2 года назад +1

      Regards to MSU Med! - From ADZU School of Medicine

    • @danielpa8644
      @danielpa8644 2 года назад +1

      In the MASS part of lecture - LMN lesions cause less protein synthesis (more protein degredation) then at 23:30 the muscle responds to a decrease in Acetylcholine by synthesizing more nicotinic receptors. How are new receptors being created when protein degredation is going on with a LMN lesion?

    • @honeybadger1621
      @honeybadger1621 Год назад

      hi,I'm type 1 diabetic 46 years old 15 years have neuropathy. I broken my tibia bone 4 screws and rod in my leg now. my question diabetic people's fracture healing? also neuropathy can made problem for healing process?

    • @sudeeptalapatra3982
      @sudeeptalapatra3982 Год назад +4

      @@danielpa8644 great qs Daniel.!..even when protein synthesis is less due to less Ach cell will try to make new and more nicotinic receptor so as to increase muscle pr synth with whatever protein the cell from the very beginning of UMN lesion and even in late phase it will destroy it's organelles
      To make N.receptors because it is the only means to maintain homeostasis for the muscle cell.

  • @neethu4661
    @neethu4661 Год назад +24

    Being a medical student your videos are such a blessing to me... Thank you sir.. Finally understood it❤

  • @flypnay704
    @flypnay704 3 года назад +60

    Zach & Ninja Nerds, you constantly blow my mind...in that good neuro way! This subject was so terribly taught at my medical school, thank you for making this clear!

  • @SF-es3ff
    @SF-es3ff 3 года назад +4

    So much respect to you, attempting to get into PA school and discovering how hard that can be! Your videos provide an in-depth understanding that I probably couldn’t get elsewhere this easily! May God bless you for all your efforts!

  • @josetrujillo738
    @josetrujillo738 3 года назад +22

    The way you teach is honestly amazing! Thank You Zach! Shout out Kristen! Shout out Rob! Thank You Ninja Nerd Lectures!

  • @britneyidapaulus750
    @britneyidapaulus750 2 года назад +24

    This was aweeeesome😭
    I am basically hours away from facing my end of term internal Med exams and this was so useful 💡, the light to the end of my tunnel 💗

  • @jeffreyrayner5235
    @jeffreyrayner5235 3 года назад +3

    Thank you Zach. I have been recently diagnosed with MND and a fell into a dark space. Your lecture has clarified my case such that I can understand what I may or may not have. This allows me to understand and deal with what could have been a total despair.

  • @fatemahh9459
    @fatemahh9459 3 года назад +4

    Oh my God I have a neurology exam in the morning, you couldn't possibly have had better timing! I might cry with sheer relief and gratitude 🤧 Your videos are the only reason I'm surviving and feeling smart while doing it 😂❤️ Thank you soooooo much! I cannot possibly ever express my gratitude. You are a real inspiration!

  • @tanziasharmin7364
    @tanziasharmin7364 2 года назад +5

    I was waiting for so many years for this video...passed MBBS some years back.. I used to memorize UMN &LMN Lesions.. But this time i wl never forget....Great teacher..! Wonderful way of teaching...

  • @aakashkumarsah8616
    @aakashkumarsah8616 3 года назад +24

    Neurology seemed so tough to me.You made it so easy zach🤗🤗. Thank you ninja nerd team❤🇳🇵

  • @grdainylung5216
    @grdainylung5216 Год назад +3

    Please share this video to freshers in medical school,it's fucking awesome,I have wasted years studying books trying to understand this but you clearly described in simple way.Millions thanks to you.

  • @amirulazam5034
    @amirulazam5034 2 года назад +4

    3 years of doubt and confusion cleared in 1 hour lecture... THANK YOU VERY MUCH..

  • @hsmith1180
    @hsmith1180 3 года назад +1

    you get a lot of love in these comments and it's well deserved. I rely on these vids so much to supplement my "scholarly readings" because you break it down into much more comprehensible language. I'm not exactly sure how you do it but you make it so much easier to grasp. I watch bits over and over to make sure I have the idea correct. You are a legend

  • @evelynperez2486
    @evelynperez2486 3 года назад +6

    I just wanted to say that I freakin love your videos! You truly helped me pass advanced anatomy in my grad program! You have a gift of teaching things very clearly something some professors do not know how to do!!!!

  • @amelonlord654
    @amelonlord654 3 года назад +6

    Liked it and enjoyed it, definitely. I am so thankful, I was always very interested in neurology but found it quite complicated. You make all the complicated concepts seem understandable. I coudn't ask for anything more. And you even tell everything with such a spark that makes me want to binge watch your neurology playlist! Who would've thought..

  • @sudeeptalapatra3982
    @sudeeptalapatra3982 Год назад +3

    understanding Mechanism behind all these hyper reflexia and hyper Tonia makes it easy to memorise.... also gives an enjoyment 9f understanding the actual concepts behind...Kudos to your team sir for gifting such an amazing lecture.❤️

  • @granitklippa
    @granitklippa 2 года назад

    Best teacher ever! My wife has recently been diagnosed with Progressive Bulbar Palsy and this video really helps me understand the symptoms. I am a Nurse anesthetist by training, but never really paid attention to this topic in the past. Thank you for posting, keep it coming

  • @TheChartreusePenguin
    @TheChartreusePenguin 7 месяцев назад +3

    I don't know how I'd get through medical school without you Zach! Thank you so much for teaching and sharing your knowledge - I literally don't know how to thank you enough

  • @manishaprja
    @manishaprja 3 года назад +3

    Thank you so much for this. Best teacher! No one taught this in so simplified form in medical school. It helped me a lot.

  • @lifeingreatmoment5654
    @lifeingreatmoment5654 3 года назад +8

    The best teacher I am eagerly waiting for him twice in every week

  • @daniaizzah4335
    @daniaizzah4335 Год назад +2

    last year med student here and your videos are god-sent!! thanks Prof! Many loves from malaysiaaa

  • @mosab_emad
    @mosab_emad 2 года назад +2

    I swear this is the best lecture I have see in RUclips ,, Sincere love and respect Doctor ,, YOU ARE AMAZING!!

  • @kyongvincent4385
    @kyongvincent4385 3 года назад +3

    Love his lectures. How he can remember that much info. Genius

  • @scottwilson7633
    @scottwilson7633 Год назад +13

    Thank you for what you guys do. I've been using your videos all through undergrad and now in medical school, and I can honestly say that you are one of the main reasons I (and likely many others) have been able to make it this far. Ninja nerd will have a big donation coming their way after residency!

  • @setarehabdoli3115
    @setarehabdoli3115 Год назад +2

    You are literally amazing,for years as a postgraduate specialist I was struggling for this topic,,,,,if there is a magician,its you❤

  • @cleopaschisanga5355
    @cleopaschisanga5355 Год назад +2

    You deserve tones of awards... This makes so much sense when examining CVA patients thanks so much ninja nerd🙏❤️

  • @VERA-jo3ev
    @VERA-jo3ev Год назад +14

    THIS IS LIFESAVING, i have a neuro class in 2 hours and this just was PERFECT!

  • @guarkenchiman4427
    @guarkenchiman4427 2 года назад +3

    His spirit challenges every mind to thirst more for knowledge. Thank you for your energy and time

  • @melissamonreal9486
    @melissamonreal9486 2 года назад +2

    BLESS YOU!! You explained UMN vs. LMN in the first 5 min of this video better than my grad school professor did in a full semester. Thank you!!

  • @sheliapdd758
    @sheliapdd758 3 года назад +1

    Really help me to understand neurology class clearly. Thank you Zach. You did it great!

  • @jyotisamanta4997
    @jyotisamanta4997 3 года назад +3

    Kudos and all the best wishes. This solved my never solving confusions ❤️

  • @arijoybhattacharjee6039
    @arijoybhattacharjee6039 3 года назад +5

    I love you Teacher ❤️... From India 🇮🇳

  • @judithumeadi2704
    @judithumeadi2704 2 года назад +1

    Great revision session. Excellent teacher, delivered at just the right pace. Easy to understand and follow. Thank you!

  • @tylerp8062
    @tylerp8062 3 года назад +2

    Perfect timing. Great job guys you really help bring it all together at the same time hitting the small things people like to test about.

  • @sandrak4032
    @sandrak4032 3 года назад +3

    Amazing! I understood so many things in depth that I had been taught couple years ago

  • @mrindian5908
    @mrindian5908 2 года назад +3

    Thank you for the most woderful lecture with brilliant simplification of a complicated topic. I have one doubt - the inhibitory tracts from Medullary reticulo spinal nuclei are descending ipsilateral where as excitatory cortico spinal tracts are coming from opposite side of brain, so how these inhibotory tracts are damaged to produce hyperreflexia in UML when the UML lesion is actually on the opposite side of the brain. Pl clarify, thank you.

  • @musicbeachdance
    @musicbeachdance 3 года назад

    Saving my entire existence in Neuro thank you for explaining the findings for fasciculations!! So easy to follow!

  • @rwuthenow
    @rwuthenow 2 года назад

    That was amazing. Just basically taught about 400 pages of exam prep. Thanks for doing this. You have really exemplary teaching skills. I wish I could half as good a job.

  • @ifrahakbar2283
    @ifrahakbar2283 2 года назад +3

    One word for you: KING!

  • @Iminoamino
    @Iminoamino 3 года назад +14

    Being a medical student the respect and love I have for this person is inexplicable! Thank you

  • @H-ton-R-tonSN7893
    @H-ton-R-tonSN7893 3 месяца назад

    You're absolutely an amazing instructor, who feeds the whole world with knowledge through social media..

  • @andydonham8612
    @andydonham8612 Год назад +1

    Should be mandatory viewing for new PLS and ALS patients. Cleared so much up about the affliction. Thanks so much.

  • @marianapereira5370
    @marianapereira5370 3 года назад +3

    Amazing lecture as always! When are you guys releasing the video about the physical exam? Btw love your videos, been watching them since my first year in medschool and I'm in my fifth now, and it's a lot thanks tou you! Keep up the great work!!

  • @alih6953
    @alih6953 3 года назад +8

    Zach you are helping millions of people. I am praying for you and your family so that God grants you with health and wealth. Thanks

  • @garycovington7925
    @garycovington7925 Год назад +1

    As someone diagnosed with PLS (Primary Lateral Sclerosis, UMN) over 29 years ago and heavily involved with PLS email groups then Facebook PLS groups (1400+ members) for around 25 years that's the best explanation I've yet seen! Thank you! 👍
    The only thing I have issues with is the explanation of fasciculations as being LMN. Almost every one of the 1400+ PLSers in our Facebook group, including myself, have fasciculations yet I'm sure after 31 years from first symptoms I have PLS with UMN symptoms only. The connection between fasciculations and fibrillations measurable on EMG seems tenuous because most of us with serious fasciculations have had EMGs which show no LMN involvement.

  • @obaidkhan2278
    @obaidkhan2278 3 года назад +3

    Pure class of love 😍😍❤️❤️❤️❤️

  • @malihahoque5460
    @malihahoque5460 3 года назад +19

    The way you connect physiology with medicine ; damn I'm in love !

  • @EmmArwen
    @EmmArwen Год назад

    oh my god! i can not stop watching your neurology classes. i am a resident 5 th year in the neurology department. It is fascinating me after seeing you explain this staff!

  • @DOT368ER
    @DOT368ER 2 года назад

    Best to explain MND! My dad passed away from ALS a few years back started with the bulbar. I’m having symptoms of LMN with fascinations. This definitely give knowledge to determine what one has!

  • @User-to7nb
    @User-to7nb 3 года назад +12

    Just here to leave a like and a comment for the algorithm

  • @akatodemyrus6077
    @akatodemyrus6077 3 года назад +10

    I wish I could draw like him...

  • @mileyuli
    @mileyuli 3 года назад

    I am so beyond thankful for this video! I couldn't understand the differences between them and was struggling and this was so so clear!
    Thank you so much you guys are life savers!

  • @joymutheu7737
    @joymutheu7737 Год назад +1

    You really explain in depth ❤️..most times we don't stop to ask why some things in medicine happen the way they do but you explain it all❤️😍

  • @balavantbhaipatel1969
    @balavantbhaipatel1969 3 года назад +8

    My teacher is back.....whoooo

  • @prasannabharathi2019
    @prasannabharathi2019 3 года назад +5

    You make the topic more interesting by saying the word "beautiful " again and again 😍😌😍

  • @Desert-123
    @Desert-123 10 дней назад

    This is the best video on the internet . Thanks for being short and so comprehensive !❤

  • @zahraaammar2708
    @zahraaammar2708 3 года назад +1

    the best teacher and the best channel ever , you literally are saving lives !

  • @SameerShaikhAdventures
    @SameerShaikhAdventures 3 года назад +6

    FIRST ONE TO COMMENT. HUGE FAN OF YOU SIR. LOVE FROM PAKISTAN❤ do reply to me 🤒😂
    Stay Blessed❤

  • @qamaruddinkhan3847
    @qamaruddinkhan3847 2 года назад +2

    Best teacher for understanding concepts 💞 kindly at the end of every lecture, cover the whole board so that we can take screen shot as well for memory

  • @haleeyzkhair4121
    @haleeyzkhair4121 3 года назад +2

    I have waited all day for this. Thank you Zach you are the best of all.!!!!

  • @mowsumisara1411
    @mowsumisara1411 3 года назад

    Everytime i finished any lecture by you i feel like uff i love your teaching techniques...also i think its your teachings that makes me love mediacal science...thank you a very very much...😊😊😊

  • @kelechi2352
    @kelechi2352 3 года назад +1

    what a time to be alive.. I am blessed to have found this channel

  • @365bmmusic
    @365bmmusic Год назад

    You are really good at what you do. I have been struggling to understand this stuff for years so you have really filled the gaps in my knowledge, so thank you Ninja Nerd, keep creating and explaining, looking forward to watching more of your videos

  • @eman-ne2ng
    @eman-ne2ng Год назад

    42:33 that smile on your face made me smile, Zach. You love to teach and it shows, always! Appreciate everything you do :)

  • @lollolez7147
    @lollolez7147 3 месяца назад

    Can't express how thankful I am, Appreciate the time you spend to teach us in such an efficient easy, and fun way.

  • @humanbeing3177
    @humanbeing3177 3 месяца назад

    What an extraordinary lecture you have prepared and made it available for free for real. I am so thankful to you.

  • @hannahunt1175
    @hannahunt1175 3 года назад +1

    Your enthusiasm is infectious

  • @RailingMedia
    @RailingMedia Год назад +1

    I'm doing an elective, only a first year unit, and I have close to 5,000 words in notes from various sources on ALS. In absolutely none of them (and I'm talking books devoted to ALS) do they describe it anywhere near as clearly or sequentially as this video. What an amazing teacher, you're now bookmarked next to 2-minute neuroscience videos... I'll be seeing you along the rest of my psychology degree pathway :D
    Now to find suitable academic texts to reference for the knowledge that you shared in this video.

  • @neliakalenga2462
    @neliakalenga2462 2 года назад

    Literally the best teacher anyone could ask for! My Med school life saver!

  • @Mercyforthewicked
    @Mercyforthewicked Год назад

    amazing and easy to understand video! my professors mentioned the results of the lesions but not why so i left with questions, but this makes it so easy to comprehend

  • @adeyemialexandra209
    @adeyemialexandra209 Год назад

    Sir, you are blessed with intelligence and the gift of teaching. Thank you for breaking down these hard topics

  • @easymedicine3677
    @easymedicine3677 3 года назад

    i cannot express my gratitude , you really made physiology so simple for me thank you so much

  • @atlantic7949
    @atlantic7949 2 года назад +1

    I have tried to understand why UMN lesion causes hyperreflexia, not even my teacher explained this in the lecture in our neurology block. But, I am glad we have you. TBH, We all need to fund this guy to open his medical school.

  • @saveetapurswani5316
    @saveetapurswani5316 3 года назад +1

    OMGGG I was waiting for this lecture and its here. you explain in the best possible way, cant thankyou enough sir, god bless youu

  • @vinayakkapatral4246
    @vinayakkapatral4246 3 года назад

    My Zach doze for the day!
    I was reluctant to see neurology classes but .... now I am hooked!
    Zachcellent!

  • @heatherjean5674
    @heatherjean5674 3 года назад

    You are so talented at making difficult concepts more understandable. Your videos are an absolutely Godsend!!!

  • @siddhantpradhan1419
    @siddhantpradhan1419 3 года назад

    This video is just gold
    I don't think anything is more precious than this
    Thanks Sir for all the effort , this lecture is so very helpful.
    I searched a month looking for this concept in all the places I could .
    Thank u sir
    Lots of ♥️ and respect .

  • @Honey-nv9dp
    @Honey-nv9dp 2 года назад

    I'm thankful to Ninja nerd for the most simplified yet difficult concepts. Thank you for making med school make sense 💖

  • @mashudurebeccamulangaphuma8649
    @mashudurebeccamulangaphuma8649 2 года назад

    Thank you so much. I spent 4hrs trying to understand my lecturer's notes on UMN and LMN. Should have came straight to ninja nerd. You made things easy for me

  • @bulbul10188
    @bulbul10188 4 месяца назад

    Things and books just made sense after a long while. Thank you so so much for this video. I really appreciate your enthusiasm, clarity of concepts and efforts Professor. 😄

  • @iApatheia
    @iApatheia 3 года назад

    Very timely for my Neuroscience class! Thank you @Ninja Nerd Lectures!

  • @keshavbansal7395
    @keshavbansal7395 2 года назад

    life saver man. this is literally amazing.
    i have a seminar presentation today on this topic.
    thanks to you it seems to easy

  • @tabitha2540
    @tabitha2540 11 месяцев назад

    Amazing teacher! Your enthousiasm is contagious to understand this. You are brilliant as a teacher. Thank you soo much.

  • @LeFishe42069
    @LeFishe42069 2 года назад

    i am appreciative of your efforts, due to these videos, i have decided to pursue a degree in the medical field, in particular neuroscience, i think without this resource i would have remained aimless in life, and i attribute my newly ignited passion to you.

  • @simplyy.lylaa7
    @simplyy.lylaa7 2 года назад +2

    Wow, you should honestly be a teacher! This is amazing!!!

  • @carriehope8152
    @carriehope8152 3 года назад

    I have been struggling learning this, you made it so clear. Thank you!!

  • @azmathunnisa9513
    @azmathunnisa9513 2 года назад

    You have my heart sir... totally in love with the way you teach.. thank you soooooo much for this beautiful outstanding explanation. Huge respect to you and your work. Hats offf

  • @dwarf0606
    @dwarf0606 Год назад

    Learning to be a canine chiropractor, and you’re video’s helped me sooo much. Thank you! 😃

  • @ngulabs8300
    @ngulabs8300 2 года назад

    Wow, very impressed with the way everything was explained. Great job!!!

  • @tamannaprety3563
    @tamannaprety3563 2 года назад

    This video is so much helpful to clear concept about UMN & LMN lesions...
    Absolutely brilliant presentation...