I had the side effect of “insatiable appetite” from a mental health med that I must take to be stable and function. So, because of this I’ve been obese for the past 10 years no matter hard I tried, I would take my psych meds and then wake up at night and eat everything. Anyway, first dose of Wegovy and wasn’t hungry for the first time in over a decade, I’ve lost 47 pounds and joined a gym where I started strength training! I feel better than I have in ten years. My a1c is 4.9 and LDL 79. BMI 26!
Seroquel by chance? One dr I had gave me it for sleep. Off label low dose. It caused insane night time hunger. I would wake up 1 hour after falling asleep like clock work...and I'd be starving.
It's so disappointing when I see this daisy chained drug usage. It's like no one cares about solving the underlying issues, they just want to run away from the catalyst and treat symptoms. It's one thing if you have an organ that literally doesn't function, but mental health problems often stem from environmental issues. People will be poor, overworked, fat, depressed, and have no good relationships in their life. They'll then take antidepressants, obesity medication, food stamps, and jump on a dating app... They remain overworked, but humans can deal with a lot of stress, so minimize most of it and you'll be fine right? Then the occasional slight deviation from their medication schedule will lead to an episode that takes them right back to the reality they've been distracting themselves from with drugs, only to quickly cover it up again. Tension builds up and people do their best to bury it. Most do pretty well at that. The point isn't to say we shouldn't ever use a drug if we are in dire need. The point is that we need to pay closer to the overall patterns that are reflecting themselves in human behavior, and seek to solve the problems by fixing the environment, rather than treating symptoms that reinforce the current state of the environment. This can be done on multiple scales. An individual who has a tendency to overeat can remove junk food from their houses and shopping lists -- shop on the outside of the store or buy raw ingredients that force you to make a tray of cookies rather than buying them. Likewise, a society can collectively deem processed food as virtual poison, and take measures to make that reality known to the public. Instead though, all our solutions treat symptoms, and often one side effect will lead to another symptom. And at every turn, there's a guy and his middleman waiting to take money out of your pocket to "fix" your illness. A good portion of the time, the illness was caused by financial stress. Afterall, the correlation of income to crime, obesity, depression, and other diseases of despair are just waiting to start the next revolution, peaceful or otherwise. By accepting the treatments that capitalism comes up with for environmental caused illnesses, again, you reinforce the environment that led to treatments instead of cures. Every time you buy an anti-depressant, you feed the pharmaceuticals profit motive. If you are wealthy, mentally healthy, and emotionally healthy, but just can't stop overeating. Maybe it's because we design food to make you overeat. Maybe it's because you aren't eating food that's meant to be consumed by the human body in a natural environment. If you're wealthy, physically healthy, but you are depressed beyond imagination, maybe it's because some other aspect of your environment is failing you. Maybe it's not healthy or natural to read about the disgusting daily behaviors that 8 billion people living in a sick environments can muster in a single day. Maybe your empathy for other people's pain is trying to tell you something about your environment. But if you take an antidepressant to cover up the purpose of that empathy, what are you left with? Psychopathy? Why solve the catalysts of violence when you can find someone to build prisons and profit from imprisoning violent people? Why solve wealth inequality when you aren't personally effected, and can *probably* ignore it and get by to the end of your life? Why solve global hunger when the accompanying scarcity and strife is waiting to be milked for every dime by the military industrial complex? I don't mean to bash you for taking drugs that have helped you. I just want to point out that the pain you felt without these medications was not there by accident. That pain is an evolved response to environmental factors. If you cover up these natural responses, you inhibit your ability to solve the underlying problems. You may even inhibit your ability to see the problems at all. Your best course of action is to keep taking your medications, but be very conscious of *why* you need them. This goes deeper than simply saying "I was depressed/anxious and overeating." You need to seek out the original catalyst of the mental health issues. You need to understand that you did not solve your problems, you're merely treating them. With that fact comes a great responsibility to be aware of those symptoms as they show themselves in other people. You have experience that others who haven't suffered from the same illnesses don't have. This means you have intuition that helps you recognize symptoms of your mental health problems and food addiction when you see them in other people. You must both help others who you suspect suffer in the same ways, as well as *learn* from the similarities you have with those people. If you recognize a commonality among 95% of people with your particular mental health issues, then you've uncovered a potential catalyst. It's the original catalysts that we as a society need to focus on, otherwise the expectation is that we will all be lining up for our anti-obesity, anti-anxiety, and anti-depressant meds right after we get out of the bread line. In summary, obesity, anxiety, depression, crime, and other diseases of despair are on the rise. Wealth inequality is on the rise. Do not be so eager to treat your own problems if you don't understand why those symptoms are really there. Otherwise, you will find yourself somewhere down the road facing the consequences of someone else's problems. In the same way that you may have been disfunctional before your treatment while others looked down on you, is the same way you may look down at someone else for a different set of problems that stemmed from the same catalyst.
I'm a health psychologist working in bariatrics, non-surgical weight loss, and eating disorders in Jacksonville, FL. In short, I agree with this video completely and it is very well said and put together.
First time watching this guy. Hes spot on. Im so sick of everyone trying to look down on and make fun of bigger people for getting help they need to lose weight. Surgery is no joke and very hard. Everyone thinks its simple and a simple fix all. Its not. With the sleeve i lost 100 pounds. Put back on around 20 after a couple of years. My doctor got me on the shot and along with my sleeve doing really good. I hit my personal goal weight. The docotrs want about 30 more pounds off of me. Since surgery i excerise more, no sodas, pay attention to what i eat. I drink a protein shake daily and use it as a meal replacement. Like my doctor told me. You have to treat this like any addiction. Its a never ending battle.
My aunt was on it and lost 100lbs but built habbits to eat and due to feeling more confident works out daily now, she got off it and obv ate more but paired with her lifestyle changes she made on weygove she has kept the weight off and in fact even continued to lose 25lbs in 6 months post quitting. I love this video as it is super helpful and unbiased
@@scarred10 oh I agree but in reality most rely on the affect because their current poor food habits make them hungrier. If u do it right u don’t have to be on it forever but we both know 99% don’t Hahaha my aunt even said if she ate how she used too even on it her hunger was worse so as soon as she went higher in dose she cut out 80% of crap foods and she said it was night and day. Do that long enough ur body won’t crave food like it used too.
My dad is down 60 lbs on semiglutide. His A1C or whatever it's called is now in normal range, and his doctor just took him off metformin, a diabetic drug. I'm proud of him. He has sulfer burps as his worst side affect.
You not only provide the solid research, you also present it with maturity, wisdom, and compassion, all of which are much needed in the spheres of fitness and sports. 👏🙏🖖
I'm MD from Finland. Here semaglutide is primarly meant for type 2 diabetes patients who are obese or have unsatisfactory response to other diabetes medications. It is also compensated with tax money for those patients so it's easily affordable. However obese patients who don't have diabetes are willing to pay full price and suffer the side effects because it's so efficient. I wish people were that motivated to take all health improving medications I prescribe them.
Wegovy is specifically approved for weight management. It’s the exact same drug as Ozempic. As an MD you should be aware of the updates in these drugs, whether they are available in your country currently or not. Your comment comes off as extremely judgmental and condescending towards obese patients - many/most of whom have struggled for decades with weight loss. Do better, doctor.
I appreciate your pragmatic approach to this (no surprise). As a fitness enthusiast, health care provider, AND type 2 diabetic myself (since childhood), I think I have a reasonable perspective regarding the right types of patients who might need these meds. If they're at their wits-end with trying to lose weight and are clinically obese, it's kind of ridiculous to not try it for them (with guidance regarding other levers they can pull too) and could be the kick start they need to get started down the right path. It's nice to see you have an "in the right person and in the right situation" view on the GLP-1 agonosts!
I fit in that category. I'm hella fat and need to drop like 200 pounds to be considered a healthy weight. I was prescribed Wegovy but the cost for me due to my insurance is way too much, over $1k a month for a few months. Hopefully I can change my plan later this year and my employer will still cover it. I feel like a lot of people aren't trying to change their eating habits while taking semaglutide so they will just gain it back once they are off the medicine.
Like all fat people that have tried to lose weight, have lost weight, only some lose as much as they want. I guess it's a battle and by the time they get the weight off they are mentally done and can no longer control the urges. If the fight was easy, they should not so mentally destroyed and could go on a plan to build the muscle back and keep the fat off. Nobody really talks about what to do when the fat has been lost and the program to go on, to fix the metabolic adaptation. To me it's about lifting weights and training super hard, but not too long or often. If that is less excercise than you were doing during fat loss, you don't need to eat more straight away, but gradually eat more as metabolism increases. If you are building muscle at a reasonably fast rate, metabolic adaptation will be reversed in under 2 months. I finished a diet 6 weeks ago, because my blood pressure had got too low, now I am finding it hard to eat enough.
Agree with your view. Some people just think they found a magic pill. I’m sure they are still hitting the fast food drive thru, hitting the bars but not hitting the gym.
"Try" it? It works but as soon as you quit the weight comes back. It's a lifetime commitment because people can't eat better and exercise more. Improve your discipline, improve your life.
It's designed to change the eating habits. It teaches that eat not enough you wont loose a thing, you need to eat. If you eat "bad foods" you get punished by feeling sick, and explosive toilet time. Or the polar opposite.....If you eat high protein low fat, you feel fine and it also shows on the scales. You typically will go through one or several periods of platau so they tend to look to diet/exercise changes to work out why, for the price people want it to work. For this reason I feel the cost should be high. It keeps people accountable and on track.
Great take Layne! My Doc has me on Ozempic, 6 weeks in. We decided to use it to help me get to a weight for surgery on my knee. Really hard to work out more if you have a wrecked knee and simple mechanics like walking are a challenge. Since day one, I have worked with my PT and nutritionist on the "reversing" off the drug. The lifestyle change is really important. It's disappointing that many chase stuff like this as a wonder "drug" and do nothing to change their habits for longer term success.
I have about 150lbs to lose and a prime candidate for this. But you’re right, insurance doesn’t cover it although I’m classified “pre-diabetic” and obese. My search continues however I’ve hired a coach for 12 months to assist with establishing good habits to lose weight and maintain it.
Great to hear you talk about this subject. I struggle with weight but the side effect that wasn’t mentioned and scares me away is the gastrointestinal paralysis
I love your nuanced take on this that considers both the scientific data and the personal aspect regarding mental, emotional, cultural, economic, and societal factors surrounding obesity, satiety, and appetite. Also you never get hung up on the aesthetics or societal implications of someone's weight. It's always based around the factors like diabetes, heart disease, etc. That being fat doesn't make you a bad person.
I'm on Ozempic for a high fasting blood sugar and high A1C. It's not only helped me with my fasting BS, went from 131 to 98, but helped me drop 15lbs. I hope to keep going with the weight loss and I hope, to get off it someday.
Semaglitide and Terzapitide were being sold by research chemical companies for a good bit before the patent hit. Was being sold for about 1/10th of the price. Works amazing. Big pharma loves the profits though
Appreciate the insight. I'm on Mounjaro, and have been for about 4 months now. Re-gained all my weight after gastric sleeve - mostly because of lack of discipline. I also suffer from chronic depression in that my dopamine response is very inhibited. The reason why I mention this, is because junk food (for me) triggers that dopamine response that my body craves, and it's extremely difficult, especially in deep depressive episodes to resist the urge to eat bad food or drink alcohol. Enter Mounjaro. Thanks to this medication the urge to consume bad food is nearly zero. I've lost 30 pounds and this has given me the energy and determination to go back to the gym again. I'm so thankful for this medicine and really do think it's critical for those like me that need help resisting the brain chemistry that promotes bad habits and junk food addiction. Would really like to hear your thoughts on insulin resistance as well. Cheers!
@@youngkimmy40 A friend was getting it for $25...and was sent a letter - SURPRISE - won't be $25 anymore...up to $1200 or whatever the full price is, so she has to stop. Sucks.
Thanks again for another nuanced look at a topic, Layne. Today I have finally reached my "maintenance" threshold goal after losing 140 lbs over the last 14 - 18 months. Gonna rewatch your videos on fat-loss and maintenance to make sure I don't mess things up.
This was a great summary but with one omission. The weight lost with these drugs is a much higher percentage of lean mass vs fat when compared to a standard lifestyle, exercise, and diet regime. Also there is a tic up in heart rate. So the pros and cons need to be weighed carefully, particularly with adolescents. Long term studies need to be done to assure of no long term negative effects. That said, the scales tip in favor of those with difficulty in managing severe metabolic syndrome. Key is to be informed.
I’m an ER physician and my hospital system just started giving this out for weight loss within the past year. I have seen several people in the ER for intractable nausea and vomiting with pretty severe abdominal pain. Granted I get filtered people with the worst responses, just something to keep in mind. Side effects can be pretty bad.
@IblisTheMage I'm a paramedic and people go to the ER because a tree leaf fell on them. You learn how ridiculous people can be in the Healthcare system.
@@Nerdybdirty First time I read it, I read "because a tree fell on them", ok that makes sense... then I read "tree leaf"... wut?????? 😀 😀 😀. When I was a kid, going to the ER meant stiches, arm in a sling, or a gypsum casket... 😀, And for sure a tetanus vaccine, no matter when the last one was 😀
Thank you for being so open minded and understanding. This drug is a game changer and is very helpful to anyone who has been struggling with obesity for years. It’s not the ultimate solution but emphasizing personal responsibility is vital.
I was waiting for this because my doctor said no to me as far as weight loss drugs go. She told me drugs don’t change habits . She told me I need to reset my brain and work on my diet. I want to lose 25-30 lbs . Plus I’m on Prozac. She said I simply don’t need it . I used adipex years ago lost the weight, and regained it all back plus more. I had no plan post weight loss. Thank you for sharing your knowledge
You should thank your doctor. She is giving you good advice. Wait to see the outcomes of this drug in 10 yrs. Side effects of gastroparesis. Serotonin is made in the gut so its production is down regulated increasing the risk of suicidal ideation. Focus on eating whole foods and exercise.
Thanks Layne. My father is obese and is one of those old school guys who IS NOT going to workout and eat right. I’m going to tell him to talk to his doctor about this.
Well said, I spoke with a friend who started taking ozempic or something similar and I said the exact same thing, injections without changes to lifestyle (this person doesn't work out and eats junk food) and you'll relapse, good to hear from a reliable source that this is generally safe.
@@sufiblade IMHO lifestyle modification must be at least a part of the treatment regimen, in some cases - the only one. But in others, when it's tried and not effective, ozempic or other meds can be used.
I was listening to the Mind Pump guys be quite disparaging about it, but they do come from a hyper-masculine, chest beating area of the fitness industry where nuance is often lost on them. Thank you Layne, for coming in with a balanced, sensitive approach to this hugely important shift in the fitness/health world. I myself have been obese, underweight, a healthy weight and now, trying to lose that last 14lbs that love to sit there, laughing at me. I couldn't afford to buy Ozempic, but even if I could, I probably wouldn't touch the stuff - a calorie deficit and lifting weights works for me, but I have crazy self-control when I put my mind to it. Most people don't have the level of self-control I do, so shouting 'get a trainer' or 'eat less move more' isn't going to solve the issue. One massive, perhaps insurmountable issue is the systemic problems Western society has with its food. Highly palatable processed food, I believe, is hugely responsible for the obesity epidemic. Until 'big food' get on board, we'll always be looking for 'big pharma' to provide the answers (at a cost).
Thank you thank you thank you for this. You are one of my most trusted resource in science based approaches to sustainable weight loss and was very interested to hear your take. Maybe I’m biased because I agree with this, but glad to hear your thoughts all the same. 😊
My appetite is insane. The amount of food I can put away is disgusting. Since I’ve started GLP-1 (Sema), I routine eat at or lower than 2,000 calories. Sema has worked miracles for me. Not trying to promote it and definitely speak to your doctor about it but it is a POWERFUL appetite suppressant.
The reason health insurance is reluctant to pay for drugs like this for weight loss is bc A) the weight loss is temporary/tied to continued use of said drugs (which are expensive to begin with) and B) there is no guarantee that your current health insurance company will be the beneficiary of the health benefits/reduced long-term costs associated with the weight loss, as people change jobs and/or insurance companies all the time.
I took Wegovy 18 months ago and lost 35 pounds (15% of BMI) I did not change a THING but then put most of it back on over the last year. I am going back on now but I am recording my food and plan to get a personal trainer. Hoping this will help me change this time.
I have been on Rybelsus for 4 months, and the control of hunger has been amazing. I have lost a total of 60 pounds. I would like to lose as much weight as I am able to lose safely. My health, energy, and my ability to work out have all improved. I am 59 years old and i feel so much better. I would like to get as lean as possible. Food tastes great, but i have found I eat much less on Rybelsus. I feel satisfied, and stepping on that scale losing another 2 pounds is highly motivating.
I was able to get my Wegovy approved based on conditions related to Metabolic Syndrome (BP, Obesity, Cholesterol, Family History) so insurance coverage is improving somewhat. I am very focused on the “after” and now that I’m within 15lbs of my goal weight, am looking forward to slowly reverse dieting over the next year and weaning myself off of the drug.
I've seen some doctors comment that their anecdotal experience in watching patients is that it helps patients who eat because they're hungry all the time, and has minimal effect on patients who eat out of habit (e.g. boredom, to deal with emotional issues, etc.).
Another great video. I was thinking the same thing, for someone that in clinically overweight, it could prove to be a great tool while they focus on building the habits. One of my biggest worry would be, some people not getting in enough nutritious foods while taking it and then neglecting the habit of eating nutritious food, simply because they are just not hungry enough.
Gastric sleeve teaches nothing, this does. If you dont eat it stops working, some even gain weight. If you eat bad foods, it causes discomfort from feeling nauseas to it being rejected and vomited up, or very bad toilet experiences. But if you eat high protein low fat it will show in your energy levels, you feel "normal" and continue to loose weight which is only supposed to be a kg a week. Slow and steady and consistent is the goal. It also requires that you drink more (well to the standard recommended amounts) People not only loose the craving for sweet or salty foods as the insulin is more stable but it tends to make people enjoy or like the taste of things like coffee, alcohol cigarettes even medical and recreational drugs like weed and lots of people find that they use less medicines that are used in non scheduled treatment aka less use of valium, xanax is used to combat peaks in anxiety etc. Some people talk of it helping them stay sober off narcotics and stimulants. Its quite pavlovian to begin with and the 'education' comes in a physically form. Kinda how alot of over eating or bad foods and dopamine form habits before, Now you get punishment, and are not loosing like everyone else on the treatment. I do believe the community and group support pages are absolutely necessary for the encouragement and advice and suggestions and ideas. Most will experience plateaus and this causes people to look into their diets and exercise habits as its too expensive to just take and wait until it ends. When correctly used it should be done with a reverse of the introduction dosing process. So a weekly or incremental decrease so that the body and you can adjust and change your habits accordingly. To relearn the hunger curs and sensations and what helps to keep them at bay.
I’ve added semaglutide to my nutrition and training planning 4 weeks ago and was wondering - “what would Dr. Norton say about this?” I’ve read your book 2x listened to many many many videos. I’m impressed yet once again how you don’t “sell out” you could have easily pushed this aside and made it sound like it’s a waste of time. Appreciate you much. Eat less move more works - kinda👊🏼
I've become somewhat of a naturalist. Never thought I would be one, but here I am. Humans want to be healthy, at least the lizard brain prefers it. This means humans don't want to be obese. But it also means humans want to be mobile, they want to eat healthy, they want healthy relationships, a healthy economy etc. I believe all of these things work in sync with each other. In other words, if your environment is working for you, you will work for you... If your environment is healthy, you will be healthy. However, when your environment is not working for you, for example, an economy that forces you to work 60 hours to get by, you're not going to want to put in the effort to fix obesity for example. I'm tired of people saying "95% of diets fail," as evidence to take the easy path of weight loss surgery or medication. The reality is that the struggle you endure to become the 5% is dependent on you fixing the environment, both mental and physical, and by extension, all the other issues that present themselves in your environment. If you just treat one symptom of the poor environment, then not only do you not solve the underlying issues, but you become dependent on the very environment that created the weight loss pill. That environment is filled with greedy pharmaceutical companies that want nothing but to put you on another drug for life. Using a statistic to write yourself off just manifests your expectations before you've even given it a fair shot. In fact, I would argue the statistics itself removes the fairness from your attempts altogether, unless you truly and honestly believe the statistics don't apply to you. This is a very hard thing to do, and I very few can achieve it. I'm a naturalist because I believe in solving underlying problems. What happens when supply chains get disrupted or your insurance stops covering weight loss medication? What happens when some unforseen side effect hits you 2 decades later?
Absolutely! I believe discipline involves a variety of behaviors that are not always generalized across settings and events. It’s never too late to expand our learning repertoires. These medications might bring people into closer contact with those positive results which reinforce good health behaviors, thus making it more likely folks will follow through with nutrition plans (I.e., it seems possible these meds can help promote/increase good discipline, if played right).
I'm glad it's a prescription drugs. I hated that I needed caffeine to curb hunger towards the later weeks of a cut, and the feeling of knowing you can accomplish weight loss through determination and will power alone is something everyone should experience at least once in their lives. I hope this drug won't take away from that.
Finally a take I can agree with. There seems to be a ton of fear mongering surrounding GLP-1 agonists. Not everyone can just "eat less". This helps those people.
This is great advice. Not everyone can grind and we all have areas where we are less disciplined. This should only be prescribed as a kick start to weight loss to motivate people. We have to implement the healthy habits in order to be successful in the long term. However, I find that most people just want to take it as a shortcut so they don’t have to work too hard. They love their highly palatable food and will go back to eating large quantities of it when they stop the drug…
Great video. Prevention will be less expensive than treating all of the conditions that result from obesity. I am looking at whether I want to try Ozempic. I'll talk to my doctor and we'll decide together. If I do go on it, it's going to be as an adjunct to what I'm already doing to lose weight. I'm working on changing my eating habits and some help along would be good.
The modification of behavior is super important. I have a family member who literally lost zero pounds on the drug for a year, because she did not change a single behavior. And now she's saying the medicine doesn't work. So, I feel above all habitual additions to life, exercise is so important, even if it's just for the health of the brain.
I'm pre diabetic...58 years old. Been obese and dieting all my life. I stay hungry...I can't understand. My Dr prescribed this medication to help but my insurance does not cover it! This is the problem...especially when I would benefit from this medication. It sucks. I pretty much have to have full blown diabetes to get covered. I'm still eating healthy and losing slowly but it's a struggle. I just want to get to a healthy weight for once before I die. Taking one day at a time. Thank you for your info!
Thank you for saying this! The drug helps you eat less. It's not what makes you lose weight. Eating less calories, making better food choices and exercise is what really does it. It has calmed my food brain so I'm not thinking about food all the time. And of course weight will come back when you stop it and go back to your "normal" way of eating.
You are supposed to stay on it for life,not come off since its for people who've failed on conventional methods.Exercise does very little to lose weight,its how many calories you eat and the drug reduces that.
I'm an aging athlete tacked on with Treatment Resistant Depression who's always had a monster appetite. Like, I can eat 4000 cals a day and not blink twice. That wasn't a problem when I burned that amount. Now that I physically and mentally can't burn my appetites worth of calories I think this is something worth looking into as I've skyrocketed body fat.
Yes, I agree, excellent discussion. But you forgot to mention tirzepatide, under the brand name Mounjaro (and now Zepbound). It's currently the most powerful diabetic and weight loss medication out there because it combines GLP-1 (semaglutide) with GIP. The average weight loss was about 22 percent. But of course, diet and exercise are necessary to obtain these benefits, as all the trials showed. Even on Ozempic-Wegovy or Mounjaro, one would need to learn how to eat smaller portions. That's the only way to avoid plateaus or weight regain..
I've qualified for ozempic for weight loss. In Canada, disability will cover the cost. My Dr will be prescribing it once my sleep related anxiety has been resolved. Thank you for the positive video!
Great timing for this vid, heard a lot about this drug recently and was wondering how it worked, what the side effects were, etc. Sounds like it could be a game-changer for a lot of people in the battle against diabesity.
One of the best videos I've seen on the subject. Seems to cover major questions and provide good answers without going into deep or excessive details ... a good summary for most people on the subject. Another thing not usually covered is effect of stress of being hungry by reducing calorie intake, on hormones such as stress hormones, which after a lengthy time, might be considered chronic stress, and the effect on a person's general health that is trying to lose weight for health purposes with a low success rate.
I lost 30lbs in 3 months and got skinny fat. I gained it all back in like 3 weeks. I think it’s great for people who are really heavy and need a boost. Not so much for bodybuilding. That’s my take on it. Great vid Layne.
Sounds like your dose was way too high. It's not good for anyone, heavy or otherwise, to lose >5% of their bodyweight in a few months. Muscle loss is almost guaranteed at that point
Hey, I really liked your collaboration with Jeff Nippard and so I came over to check you out. Leaving a comment for the algorithm and to let you know I love these analyses/mythbusting videos so you've got a new sub.
Working on a podcast about this stuff/theme as we speak, glad to find another voice in the world that sees it the same way: medications can be effective, but without lifestyle/mindset modification, its a bandaid on a bullethole. Cheers!
Really like your comments about discipline. Everyone lacks discipline is some aspect of life; for some people, it's in their food intake. Great video, thanks for discussing.
Thank you for this. I'm almost 5 months in. I've just now lost 20 lbs. I seriously could not have done it without a calorie deficit and walk 7 kms a day. Nice to hear about it being in this format. 😊
The problem with appetite suppressants is that most people don’t overeat because they feel hungry. Most people overeat calories because they eat calorie dense / nutrient poor foods, and mindlessly eat out of habit and boredom.
Thanks for the video. I really don't understand insurance companies policies. Would they rather pay the 12 grand a year for this drug or the 100k+ hospital bills from heart attacks etc
I'm 3 points away from being diagnosed with hoshimotos. I eat strict keto but more carnivore, 10 carbs or less a day, I track my food, ketones, blood sugar, etc... I gained 40 lbs back on keto in 4 years. I have a sedentary job, but I exercise. I could not lose weight at all. My MD prescribed mounjaro but my ins won't cover without a PA. I have no other health conditions. I am currently on compounded semaglutide from a med spa. I l Lost 7 lbs in 3 weeks. No side effects. Just mild appetite suppression. I wish the brand was covered for me. I'm doing everything I possibly can to get the weight off.
Ozempic helped me overcome my food obsession, but I’ve seen plenty of patients on it and actually gain, because their lifestyle is what caused their weight gain. They did 0 changes to their diet, so for many they often think it’s a wonder drug
The point is you need no lifestyle changes,you just wont have the desire to eat as much due to its action on your brain.Thats why it's for life in most cases.
I’ve lost close on 200 pounds over the last decade, starting when I was diagnosed type 2. There have been ups and downs, literally. I’m now at a point where I’m around 245 pounds and I’m stuck. I’ve dipped down under 240 a few times, sure, and since I’m bodybuilding I know that I’m gaining some muscle, but it still feels like the slowest recomp in history. If I was to be “lean”, I would likely be around 200-210. One doctor said 190, but I’m 6’3” with a large structure. I did get on trt 5 months ago because I was below the low threshold. It’s helping some with the recomp, but I just can’t lose the weight. I spoke with my doctor briefly about ozempic, since my A1c still tends to be high even though I’m low carb/keto (in order to avoid more meds). At the time my knowledge of the drug suggested that it was horrible for bodybuilding and that it was, essentially, lifetime therapy. I’m wondering now if I should revisit this topic. I’m just tired of fighting with a body that hates being under 250 pounds…
you are eating wrong, Eating 2 much fat, and probably 2 much calories or 2 little calories Track calories, reduce fat intake Only eat healthy food Drink 3-4l of water daily If you want fast results eat under 20 grams of fat a day, and do daily cardio for atleast 40min-1h You'll be 200 in no time
Yeah, you make a good point. We are in a tough spot these days with junk foods everywhere & modern convenience technologies making sedentary lifestyle that much more the default. While I may not like it, we may have to accept some of these interventions as “ necessary evils” in our current world. Obviously convincing everyone to become active, go to the gym, and eat better is not realistic in this environment.
8:51 Constipation is more common than diarrhea in my experience. Also the NNH from observation data is about 300 over 3 yr for thyroid cancer but the signal to noise ratio is very weak, probably residual confounding.
@@BestLifeMD look up number needed to harm - article is entitled “GLP-1 Receptor Agonists and the Risk of Thyroid Cancer” - I just revisited it, it’s a 0.4% absolute increased risk which is a number needed to harm of 250, ie you need to treat 250 w/ GLP1a for 3 years to incur one additional case of thyroid cancer, the effect size is very small, signal to noise is low, this is an artifact of residual confounding in my opinion.
Is it too early to tell what's going to happen to everybody once they stop taking it? Are there any potential long-term side effects for those who stay on it indefinitely so as not to regain weight loss? And once again, the public is more concerned with weight loss, vice body fat reduction and increasing healthy fitness lifestyle markers for the long term. Great info as always...thank you!
Finally a real good video about these drugs. I was working out everyday and dieting, yet I couldnt lose weight because im obese and have eating disorder. But with these drugs, im losing alot of weight for the first time in my life! And all my eating disorders are gone and I feel amazing.
I believe this can help a lot of people (probably more then it harms) and some people will be able to keep the weight off while getting off the drug. But there will be consequences and abuse, one obvious one is what happens when the bodybuilding community gets their hands on this, unfortunately a lot of people that have no business using this drug will and a lot of people will be reliant on it when they didn't have to be.
Really glad to see your end conclusion. Though I understand ideas of personal responsibility. It simply seems to be best for the overall good and at the end of the day for insurance costs etc. to use it when it MAKES SENSE to do so. Great video.
I had the side effect of “insatiable appetite” from a mental health med that I must take to be stable and function. So, because of this I’ve been obese for the past 10 years no matter hard I tried, I would take my psych meds and then wake up at night and eat everything. Anyway, first dose of Wegovy and wasn’t hungry for the first time in over a decade, I’ve lost 47 pounds and joined a gym where I started strength training! I feel better than I have in ten years. My a1c is 4.9 and LDL 79. BMI 26!
Awesome!! Great to hear that, all the best in your journey
Wtg man ❤
Seroquel by chance? One dr I had gave me it for sleep. Off label low dose. It caused insane night time hunger. I would wake up 1 hour after falling asleep like clock work...and I'd be starving.
Congratulations. Keep it up
It's so disappointing when I see this daisy chained drug usage. It's like no one cares about solving the underlying issues, they just want to run away from the catalyst and treat symptoms. It's one thing if you have an organ that literally doesn't function, but mental health problems often stem from environmental issues.
People will be poor, overworked, fat, depressed, and have no good relationships in their life. They'll then take antidepressants, obesity medication, food stamps, and jump on a dating app... They remain overworked, but humans can deal with a lot of stress, so minimize most of it and you'll be fine right? Then the occasional slight deviation from their medication schedule will lead to an episode that takes them right back to the reality they've been distracting themselves from with drugs, only to quickly cover it up again. Tension builds up and people do their best to bury it. Most do pretty well at that.
The point isn't to say we shouldn't ever use a drug if we are in dire need. The point is that we need to pay closer to the overall patterns that are reflecting themselves in human behavior, and seek to solve the problems by fixing the environment, rather than treating symptoms that reinforce the current state of the environment.
This can be done on multiple scales. An individual who has a tendency to overeat can remove junk food from their houses and shopping lists -- shop on the outside of the store or buy raw ingredients that force you to make a tray of cookies rather than buying them. Likewise, a society can collectively deem processed food as virtual poison, and take measures to make that reality known to the public.
Instead though, all our solutions treat symptoms, and often one side effect will lead to another symptom. And at every turn, there's a guy and his middleman waiting to take money out of your pocket to "fix" your illness. A good portion of the time, the illness was caused by financial stress. Afterall, the correlation of income to crime, obesity, depression, and other diseases of despair are just waiting to start the next revolution, peaceful or otherwise. By accepting the treatments that capitalism comes up with for environmental caused illnesses, again, you reinforce the environment that led to treatments instead of cures. Every time you buy an anti-depressant, you feed the pharmaceuticals profit motive.
If you are wealthy, mentally healthy, and emotionally healthy, but just can't stop overeating. Maybe it's because we design food to make you overeat. Maybe it's because you aren't eating food that's meant to be consumed by the human body in a natural environment.
If you're wealthy, physically healthy, but you are depressed beyond imagination, maybe it's because some other aspect of your environment is failing you. Maybe it's not healthy or natural to read about the disgusting daily behaviors that 8 billion people living in a sick environments can muster in a single day. Maybe your empathy for other people's pain is trying to tell you something about your environment. But if you take an antidepressant to cover up the purpose of that empathy, what are you left with? Psychopathy?
Why solve the catalysts of violence when you can find someone to build prisons and profit from imprisoning violent people?
Why solve wealth inequality when you aren't personally effected, and can *probably* ignore it and get by to the end of your life?
Why solve global hunger when the accompanying scarcity and strife is waiting to be milked for every dime by the military industrial complex?
I don't mean to bash you for taking drugs that have helped you. I just want to point out that the pain you felt without these medications was not there by accident. That pain is an evolved response to environmental factors. If you cover up these natural responses, you inhibit your ability to solve the underlying problems. You may even inhibit your ability to see the problems at all.
Your best course of action is to keep taking your medications, but be very conscious of *why* you need them. This goes deeper than simply saying "I was depressed/anxious and overeating." You need to seek out the original catalyst of the mental health issues. You need to understand that you did not solve your problems, you're merely treating them. With that fact comes a great responsibility to be aware of those symptoms as they show themselves in other people. You have experience that others who haven't suffered from the same illnesses don't have. This means you have intuition that helps you recognize symptoms of your mental health problems and food addiction when you see them in other people. You must both help others who you suspect suffer in the same ways, as well as *learn* from the similarities you have with those people. If you recognize a commonality among 95% of people with your particular mental health issues, then you've uncovered a potential catalyst. It's the original catalysts that we as a society need to focus on, otherwise the expectation is that we will all be lining up for our anti-obesity, anti-anxiety, and anti-depressant meds right after we get out of the bread line.
In summary, obesity, anxiety, depression, crime, and other diseases of despair are on the rise. Wealth inequality is on the rise. Do not be so eager to treat your own problems if you don't understand why those symptoms are really there. Otherwise, you will find yourself somewhere down the road facing the consequences of someone else's problems. In the same way that you may have been disfunctional before your treatment while others looked down on you, is the same way you may look down at someone else for a different set of problems that stemmed from the same catalyst.
I'm a health psychologist working in bariatrics, non-surgical weight loss, and eating disorders in Jacksonville, FL. In short, I agree with this video completely and it is very well said and put together.
Wow interesting, do you deal with binge eating disorders? I'm on liraglutide and it does nothing to stop my food desire 🙈
First time watching this guy. Hes spot on. Im so sick of everyone trying to look down on and make fun of bigger people for getting help they need to lose weight. Surgery is no joke and very hard. Everyone thinks its simple and a simple fix all. Its not. With the sleeve i lost 100 pounds. Put back on around 20 after a couple of years. My doctor got me on the shot and along with my sleeve doing really good. I hit my personal goal weight. The docotrs want about 30 more pounds off of me. Since surgery i excerise more, no sodas, pay attention to what i eat. I drink a protein shake daily and use it as a meal replacement. Like my doctor told me. You have to treat this like any addiction. Its a never ending battle.
My aunt was on it and lost 100lbs but built habbits to eat and due to feeling more confident works out daily now, she got off it and obv ate more but paired with her lifestyle changes she made on weygove she has kept the weight off and in fact even continued to lose 25lbs in 6 months post quitting. I love this video as it is super helpful and unbiased
That's fantastic. Hope she can maintain that for years...permanently!
That's great but most need to be on it for life because they totally rely on its effect
@@scarred10 oh I agree but in reality most rely on the affect because their current poor food habits make them hungrier. If u do it right u don’t have to be on it forever but we both know 99% don’t Hahaha my aunt even said if she ate how she used too even on it her hunger was worse so as soon as she went higher in dose she cut out 80% of crap foods and she said it was night and day. Do that long enough ur body won’t crave food like it used too.
My dad is down 60 lbs on semiglutide. His A1C or whatever it's called is now in normal range, and his doctor just took him off metformin, a diabetic drug. I'm proud of him.
He has sulfer burps as his worst side affect.
You not only provide the solid research, you also present it with maturity, wisdom, and compassion, all of which are much needed in the spheres of fitness and sports. 👏🙏🖖
Spot on.
I love your non judgmental open minded practical take on the use of this drug for obesity! Always a pleasure to hear your opinion.
This is the best health/fitness channel on RUclips. Finally one I can trust, thank you.
I'm MD from Finland. Here semaglutide is primarly meant for type 2 diabetes patients who are obese or have unsatisfactory response to other diabetes medications. It is also compensated with tax money for those patients so it's easily affordable.
However obese patients who don't have diabetes are willing to pay full price and suffer the side effects because it's so efficient. I wish people were that motivated to take all health improving medications I prescribe them.
Another doctor who shills for big pharma.
Wegovy is specifically approved for weight management. It’s the exact same drug as Ozempic. As an MD you should be aware of the updates in these drugs, whether they are available in your country currently or not.
Your comment comes off as extremely judgmental and condescending towards obese patients - many/most of whom have struggled for decades with weight loss. Do better, doctor.
I appreciate your pragmatic approach to this (no surprise). As a fitness enthusiast, health care provider, AND type 2 diabetic myself (since childhood), I think I have a reasonable perspective regarding the right types of patients who might need these meds. If they're at their wits-end with trying to lose weight and are clinically obese, it's kind of ridiculous to not try it for them (with guidance regarding other levers they can pull too) and could be the kick start they need to get started down the right path.
It's nice to see you have an "in the right person and in the right situation" view on the GLP-1 agonosts!
I fit in that category. I'm hella fat and need to drop like 200 pounds to be considered a healthy weight. I was prescribed Wegovy but the cost for me due to my insurance is way too much, over $1k a month for a few months. Hopefully I can change my plan later this year and my employer will still cover it. I feel like a lot of people aren't trying to change their eating habits while taking semaglutide so they will just gain it back once they are off the medicine.
Like all fat people that have tried to lose weight, have lost weight, only some lose as much as they want. I guess it's a battle and by the time they get the weight off they are mentally done and can no longer control the urges. If the fight was easy, they should not so mentally destroyed and could go on a plan to build the muscle back and keep the fat off. Nobody really talks about what to do when the fat has been lost and the program to go on, to fix the metabolic adaptation. To me it's about lifting weights and training super hard, but not too long or often. If that is less excercise than you were doing during fat loss, you don't need to eat more straight away, but gradually eat more as metabolism increases. If you are building muscle at a reasonably fast rate, metabolic adaptation will be reversed in under 2 months. I finished a diet 6 weeks ago, because my blood pressure had got too low, now I am finding it hard to eat enough.
Agree with your view.
Some people just think they found a magic pill. I’m sure they are still hitting the fast food drive thru, hitting the bars but not hitting the gym.
"Try" it? It works but as soon as you quit the weight comes back. It's a lifetime commitment because people can't eat better and exercise more. Improve your discipline, improve your life.
It's designed to change the eating habits. It teaches that eat not enough you wont loose a thing, you need to eat. If you eat "bad foods" you get punished by feeling sick, and explosive toilet time. Or the polar opposite.....If you eat high protein low fat, you feel fine and it also shows on the scales. You typically will go through one or several periods of platau so they tend to look to diet/exercise changes to work out why, for the price people want it to work.
For this reason I feel the cost should be high. It keeps people accountable and on track.
Great take Layne! My Doc has me on Ozempic, 6 weeks in. We decided to use it to help me get to a weight for surgery on my knee. Really hard to work out more if you have a wrecked knee and simple mechanics like walking are a challenge. Since day one, I have worked with my PT and nutritionist on the "reversing" off the drug. The lifestyle change is really important. It's disappointing that many chase stuff like this as a wonder "drug" and do nothing to change their habits for longer term success.
Love the balance you bring. Thanks for not joining the bully culture in this space.
I have about 150lbs to lose and a prime candidate for this. But you’re right, insurance doesn’t cover it although I’m classified “pre-diabetic” and obese. My search continues however I’ve hired a coach for 12 months to assist with establishing good habits to lose weight and maintain it.
Thank you for covering this. People need to understand this is in addition to diet and exercise.
Great to hear you talk about this subject. I struggle with weight but the side effect that wasn’t mentioned and scares me away is the gastrointestinal paralysis
Appreciate the push to reserve this for specific folks because there is a shortage.
I love your nuanced take on this that considers both the scientific data and the personal aspect regarding mental, emotional, cultural, economic, and societal factors surrounding obesity, satiety, and appetite. Also you never get hung up on the aesthetics or societal implications of someone's weight. It's always based around the factors like diabetes, heart disease, etc. That being fat doesn't make you a bad person.
I'm on Ozempic for a high fasting blood sugar and high A1C. It's not only helped me with my fasting BS, went from 131 to 98, but helped me drop 15lbs. I hope to keep going with the weight loss and I hope, to get off it someday.
I did that just by eating keto, no drugs involved.
Semaglitide and Terzapitide were being sold by research chemical companies for a good bit before the patent hit. Was being sold for about 1/10th of the price. Works amazing. Big pharma loves the profits though
Appreciate the insight. I'm on Mounjaro, and have been for about 4 months now. Re-gained all my weight after gastric sleeve - mostly because of lack of discipline. I also suffer from chronic depression in that my dopamine response is very inhibited. The reason why I mention this, is because junk food (for me) triggers that dopamine response that my body craves, and it's extremely difficult, especially in deep depressive episodes to resist the urge to eat bad food or drink alcohol. Enter Mounjaro. Thanks to this medication the urge to consume bad food is nearly zero. I've lost 30 pounds and this has given me the energy and determination to go back to the gym again. I'm so thankful for this medicine and really do think it's critical for those like me that need help resisting the brain chemistry that promotes bad habits and junk food addiction. Would really like to hear your thoughts on insulin resistance as well. Cheers!
I was on mounjaro and it worked great until I couldn’t afford it anymore.
@Autumn Dempsey yes. Doctor prescription.
@@youngkimmy40 A friend was getting it for $25...and was sent a letter - SURPRISE - won't be $25 anymore...up to $1200 or whatever the full price is, so she has to stop. Sucks.
@@DanK123 yep! Same.
What dose are you taking?
Thanks again for another nuanced look at a topic, Layne.
Today I have finally reached my "maintenance" threshold goal after losing 140 lbs over the last 14 - 18 months. Gonna rewatch your videos on fat-loss and maintenance to make sure I don't mess things up.
Congrats!
THANK YOU for continuing to spread GOOD evidenced-based information. This is a wonderful video. Alllll about the compassion!!!
This was a great summary but with one omission. The weight lost with these drugs is a much higher percentage of lean mass vs fat when compared to a standard lifestyle, exercise, and diet regime. Also there is a tic up in heart rate. So the pros and cons need to be weighed carefully, particularly with adolescents. Long term studies need to be done to assure of no long term negative effects. That said, the scales tip in favor of those with difficulty in managing severe metabolic syndrome. Key is to be informed.
I’m an ER physician and my hospital system just started giving this out for weight loss within the past year. I have seen several people in the ER for intractable nausea and vomiting with pretty severe abdominal pain. Granted I get filtered people with the worst responses, just something to keep in mind. Side effects can be pretty bad.
People go to the ER for nausea? I am getting to old for this world 😁.
@IblisTheMage I'm a paramedic and people go to the ER because a tree leaf fell on them. You learn how ridiculous people can be in the Healthcare system.
@@Nerdybdirty First time I read it, I read "because a tree fell on them", ok that makes sense... then I read "tree leaf"... wut?????? 😀 😀 😀.
When I was a kid, going to the ER meant stiches, arm in a sling, or a gypsum casket... 😀, And for sure a tetanus vaccine, no matter when the last one was 😀
And they get a PCP referral to us in GI for the same, along with gastroparesis. We see it at least twice a week on new referral patients.
Then just reduce the dose or change drugs no med suits everyone.
Thank you for being so open minded and understanding. This drug is a game changer and is very helpful to anyone who has been struggling with obesity for years. It’s not the ultimate solution but emphasizing personal responsibility is vital.
I was waiting for this because my doctor said no to me as far as weight loss drugs go. She told me drugs don’t change habits . She told me I need to reset my brain and work on my diet. I want to lose 25-30 lbs . Plus I’m on Prozac. She said I simply don’t need it . I used adipex years ago lost the weight, and regained it all back plus more. I had no plan post weight loss. Thank you for sharing your knowledge
You should thank your doctor. She is giving you good advice. Wait to see the outcomes of this drug in 10 yrs. Side effects of gastroparesis. Serotonin is made in the gut so its production is down regulated increasing the risk of suicidal ideation. Focus on eating whole foods and exercise.
Interesting take on discpline being relevant in all areas of life, not just fitness and health
Thanks Layne. My father is obese and is one of those old school guys who IS NOT going to workout and eat right. I’m going to tell him to talk to his doctor about this.
Very respectable video Layne. I was expecting a different tone from you in this video but was pleasantly surprised.
Well said, I spoke with a friend who started taking ozempic or something similar and I said the exact same thing, injections without changes to lifestyle (this person doesn't work out and eats junk food) and you'll relapse, good to hear from a reliable source that this is generally safe.
Finally a fitness channel that doesn’t dumb stuff down and appreciates and explains the underlying biochemistry.
Ozempic has its place and time, it's a great drug, but it definitely should be reserved for the cases when lifestyle modification fails completely.
Could you provide such an example where lifestyle modification fails?
@@sufiblade Millions of people who try to follow a proper diet and quickly return to unhealthy eating, sleep, and sedentary lifestyle.
@@DrSamsHealth I see. I thought you were implying cases where lifestyle modification just doesn't work, such as some PCOS women
@@sufiblade IMHO lifestyle modification must be at least a part of the treatment regimen, in some cases - the only one. But in others, when it's tried and not effective, ozempic or other meds can be used.
Well said, Layne. Let’s have a little more compassion for people’s struggles. We all have different strengths and weaknesses.
I was listening to the Mind Pump guys be quite disparaging about it, but they do come from a hyper-masculine, chest beating area of the fitness industry where nuance is often lost on them. Thank you Layne, for coming in with a balanced, sensitive approach to this hugely important shift in the fitness/health world.
I myself have been obese, underweight, a healthy weight and now, trying to lose that last 14lbs that love to sit there, laughing at me. I couldn't afford to buy Ozempic, but even if I could, I probably wouldn't touch the stuff - a calorie deficit and lifting weights works for me, but I have crazy self-control when I put my mind to it. Most people don't have the level of self-control I do, so shouting 'get a trainer' or 'eat less move more' isn't going to solve the issue.
One massive, perhaps insurmountable issue is the systemic problems Western society has with its food. Highly palatable processed food, I believe, is hugely responsible for the obesity epidemic. Until 'big food' get on board, we'll always be looking for 'big pharma' to provide the answers (at a cost).
Those mind pump guys aren't hyper masculine, their kind of fruity
Thank you thank you thank you for this. You are one of my most trusted resource in science based approaches to sustainable weight loss and was very interested to hear your take. Maybe I’m biased because I agree with this, but glad to hear your thoughts all the same. 😊
It’s funny I had been watching your videos for ages and I can’t tell how you had been evolving over the years. Loved your take on this one
Appreciate the compassionate view on this
My appetite is insane. The amount of food I can put away is disgusting. Since I’ve started GLP-1 (Sema), I routine eat at or lower than 2,000 calories. Sema has worked miracles for me. Not trying to promote it and definitely speak to your doctor about it but it is a POWERFUL appetite suppressant.
The reason health insurance is reluctant to pay for drugs like this for weight loss is bc A) the weight loss is temporary/tied to continued use of said drugs (which are expensive to begin with) and B) there is no guarantee that your current health insurance company will be the beneficiary of the health benefits/reduced long-term costs associated with the weight loss, as people change jobs and/or insurance companies all the time.
I took Wegovy 18 months ago and lost 35 pounds (15% of BMI) I did not change a THING but then put most of it back on over the last year. I am going back on now but I am recording my food and plan to get a personal trainer. Hoping this will help me change this time.
I have been on Rybelsus for 4 months, and the control of hunger has been amazing. I have lost a total of 60 pounds. I would like to lose as much weight as I am able to lose safely. My health, energy, and my ability to work out have all improved. I am 59 years old and i feel so much better. I would like to get as lean as possible. Food tastes great, but i have found I eat much less on Rybelsus. I feel satisfied, and stepping on that scale losing another 2 pounds is highly motivating.
I was able to get my Wegovy approved based on conditions related to Metabolic Syndrome (BP, Obesity, Cholesterol, Family History) so insurance coverage is improving somewhat. I am very focused on the “after” and now that I’m within 15lbs of my goal weight, am looking forward to slowly reverse dieting over the next year and weaning myself off of the drug.
I've seen some doctors comment that their anecdotal experience in watching patients is that it helps patients who eat because they're hungry all the time, and has minimal effect on patients who eat out of habit (e.g. boredom, to deal with emotional issues, etc.).
Another great video. I was thinking the same thing, for someone that in clinically overweight, it could prove to be a great tool while they focus on building the habits. One of my biggest worry would be, some people not getting in enough nutritious foods while taking it and then neglecting the habit of eating nutritious food, simply because they are just not hungry enough.
Gastric sleeve teaches nothing, this does. If you dont eat it stops working, some even gain weight.
If you eat bad foods, it causes discomfort from feeling nauseas to it being rejected and vomited up, or very bad toilet experiences.
But if you eat high protein low fat it will show in your energy levels, you feel "normal" and continue to loose weight which is only supposed to be a kg a week. Slow and steady and consistent is the goal.
It also requires that you drink more (well to the standard recommended amounts)
People not only loose the craving for sweet or salty foods as the insulin is more stable but it tends to make people enjoy or like the taste of things like coffee, alcohol cigarettes even medical and recreational drugs like weed and lots of people find that they use less medicines that are used in non scheduled treatment aka less use of valium, xanax is used to combat peaks in anxiety etc.
Some people talk of it helping them stay sober off narcotics and stimulants.
Its quite pavlovian to begin with and the 'education' comes in a physically form.
Kinda how alot of over eating or bad foods and dopamine form habits before,
Now you get punishment, and are not loosing like everyone else on the treatment.
I do believe the community and group support pages are absolutely necessary for the encouragement and advice and suggestions and ideas.
Most will experience plateaus and this causes people to look into their diets and exercise habits as its too expensive to just take and wait until it ends.
When correctly used it should be done with a reverse of the introduction dosing process. So a weekly or incremental decrease so that the body and you can adjust and change your habits accordingly. To relearn the hunger curs and sensations and what helps to keep them at bay.
*less enjoy the taste and flavours....
@@missjustice2730sleeve does work
I’ve added semaglutide to my nutrition and training planning 4 weeks ago and was wondering - “what would Dr. Norton say about this?” I’ve read your book 2x listened to many many many videos. I’m impressed yet once again how you don’t “sell out” you could have easily pushed this aside and made it sound like it’s a waste of time. Appreciate you much. Eat less move more works - kinda👊🏼
I've become somewhat of a naturalist. Never thought I would be one, but here I am. Humans want to be healthy, at least the lizard brain prefers it. This means humans don't want to be obese. But it also means humans want to be mobile, they want to eat healthy, they want healthy relationships, a healthy economy etc. I believe all of these things work in sync with each other. In other words, if your environment is working for you, you will work for you... If your environment is healthy, you will be healthy.
However, when your environment is not working for you, for example, an economy that forces you to work 60 hours to get by, you're not going to want to put in the effort to fix obesity for example. I'm tired of people saying "95% of diets fail," as evidence to take the easy path of weight loss surgery or medication. The reality is that the struggle you endure to become the 5% is dependent on you fixing the environment, both mental and physical, and by extension, all the other issues that present themselves in your environment. If you just treat one symptom of the poor environment, then not only do you not solve the underlying issues, but you become dependent on the very environment that created the weight loss pill. That environment is filled with greedy pharmaceutical companies that want nothing but to put you on another drug for life.
Using a statistic to write yourself off just manifests your expectations before you've even given it a fair shot. In fact, I would argue the statistics itself removes the fairness from your attempts altogether, unless you truly and honestly believe the statistics don't apply to you. This is a very hard thing to do, and I very few can achieve it. I'm a naturalist because I believe in solving underlying problems. What happens when supply chains get disrupted or your insurance stops covering weight loss medication? What happens when some unforseen side effect hits you 2 decades later?
Absolutely! I believe discipline involves a variety of behaviors that are not always generalized across settings and events. It’s never too late to expand our learning repertoires. These medications might bring people into closer contact with those positive results which reinforce good health behaviors, thus making it more likely folks will follow through with nutrition plans (I.e., it seems possible these meds can help promote/increase good discipline, if played right).
Love you, Layne. Your takes are always very thoughtful.
I'm glad it's a prescription drugs. I hated that I needed caffeine to curb hunger towards the later weeks of a cut, and the feeling of knowing you can accomplish weight loss through determination and will power alone is something everyone should experience at least once in their lives. I hope this drug won't take away from that.
The best, most objective and practical summation of Ozempic's pros and cons I've viewed to date. Thank you!
Finally a take I can agree with. There seems to be a ton of fear mongering surrounding GLP-1 agonists. Not everyone can just "eat less". This helps those people.
Everyone can eat less but it takes more mental work like fighting addiction everyone can stop cold turkey but withdrawal is hellish!
One of the best videos you’ve created. Appreciate you!
This is great advice. Not everyone can grind and we all have areas where we are less disciplined. This should only be prescribed as a kick start to weight loss to motivate people. We have to implement the healthy habits in order to be successful in the long term. However, I find that most people just want to take it as a shortcut so they don’t have to work too hard. They love their highly palatable food and will go back to eating large quantities of it when they stop the drug…
Great video. Prevention will be less expensive than treating all of the conditions that result from obesity.
I am looking at whether I want to try Ozempic. I'll talk to my doctor and we'll decide together. If I do go on it, it's going to be as an adjunct to what I'm already doing to lose weight. I'm working on changing my eating habits and some help along would be good.
The modification of behavior is super important. I have a family member who literally lost zero pounds on the drug for a year, because she did not change a single behavior. And now she's saying the medicine doesn't work. So, I feel above all habitual additions to life, exercise is so important, even if it's just for the health of the brain.
I'm pre diabetic...58 years old. Been obese and dieting all my life. I stay hungry...I can't understand. My Dr prescribed this medication to help but my insurance does not cover it! This is the problem...especially when I would benefit from this medication. It sucks. I pretty much have to have full blown diabetes to get covered. I'm still eating healthy and losing slowly but it's a struggle. I just want to get to a healthy weight for once before I die. Taking one day at a time. Thank you for your info!
Thank you for saying this! The drug helps you eat less. It's not what makes you lose weight. Eating less calories, making better food choices and exercise is what really does it. It has calmed my food brain so I'm not thinking about food all the time. And of course weight will come back when you stop it and go back to your "normal" way of eating.
You are supposed to stay on it for life,not come off since its for people who've failed on conventional methods.Exercise does very little to lose weight,its how many calories you eat and the drug reduces that.
Really appreciate your compassion on this, Layne
I'm an aging athlete tacked on with Treatment Resistant Depression who's always had a monster appetite. Like, I can eat 4000 cals a day and not blink twice. That wasn't a problem when I burned that amount. Now that I physically and mentally can't burn my appetites worth of calories I think this is something worth looking into as I've skyrocketed body fat.
Yes, I agree, excellent discussion. But you forgot to mention tirzepatide, under the brand name Mounjaro (and now Zepbound). It's currently the most powerful diabetic and weight loss medication out there because it combines GLP-1 (semaglutide) with GIP. The average weight loss was about 22 percent. But of course, diet and exercise are necessary to obtain these benefits, as all the trials showed. Even on Ozempic-Wegovy or Mounjaro, one would need to learn how to eat smaller portions. That's the only way to avoid plateaus or weight regain..
The fact that you can actually pronounce all of these is brilliant
I've qualified for ozempic for weight loss. In Canada, disability will cover the cost. My Dr will be prescribing it once my sleep related anxiety has been resolved. Thank you for the positive video!
You could just exercise and quit eating more calories than you burn...
Great timing for this vid, heard a lot about this drug recently and was wondering how it worked, what the side effects were, etc. Sounds like it could be a game-changer for a lot of people in the battle against diabesity.
Wow I am surprised from his take. I’m glad. Dude is such a blessing.
Thanks for info! Will you make content on the other peptides like CJC-1295 and Ipamorelin?
One of the best videos I've seen on the subject. Seems to cover major questions and provide good answers without going into deep or excessive details ... a good summary for most people on the subject. Another thing not usually covered is effect of stress of being hungry by reducing calorie intake, on hormones such as stress hormones, which after a lengthy time, might be considered chronic stress, and the effect on a person's general health that is trying to lose weight for health purposes with a low success rate.
I lost 30lbs in 3 months and got skinny fat. I gained it all back in like 3 weeks. I think it’s great for people who are really heavy and need a boost. Not so much for bodybuilding. That’s my take on it. Great vid Layne.
What's skinny fat? And no, definitely not for bodybuilding. You should just go protein heavy.
Sounds like your dose was way too high. It's not good for anyone, heavy or otherwise, to lose >5% of their bodyweight in a few months. Muscle loss is almost guaranteed at that point
How about the effects on exercise? Ozempic slowed me down, my legs feel like logs and couldn’t do a normal run
Hey, I really liked your collaboration with Jeff Nippard and so I came over to check you out. Leaving a comment for the algorithm and to let you know I love these analyses/mythbusting videos so you've got a new sub.
You are right layne, Everybody is built differently there is no single method that can cure all people.
Working on a podcast about this stuff/theme as we speak, glad to find another voice in the world that sees it the same way: medications can be effective, but without lifestyle/mindset modification, its a bandaid on a bullethole. Cheers!
Always a great perspective on things Layne 👍🏻
It’s the way I asked this as a question on Instagram and it’s now a video. Nice bro!
WoW! Those final words were prophetical! Also new to my ears from Layne tbh
Really like your comments about discipline. Everyone lacks discipline is some aspect of life; for some people, it's in their food intake. Great video, thanks for discussing.
Thank you for this. I'm almost 5 months in.
I've just now lost 20 lbs.
I seriously could not have done it without a calorie deficit and walk 7 kms a day.
Nice to hear about it being in this format. 😊
The problem with appetite suppressants is that most people don’t overeat because they feel hungry. Most people overeat calories because they eat calorie dense / nutrient poor foods, and mindlessly eat out of habit and boredom.
Yep tell someone they can only snack on a bag of baby carrots. Problem solved
Thanks for the video. I really don't understand insurance companies policies. Would they rather pay the 12 grand a year for this drug or the 100k+ hospital bills from heart attacks etc
They rarely play hospitals especially if people are on government insurance
In the UK a months supply is £200 so it is cheap enough to self fund.
I'm 3 points away from being diagnosed with hoshimotos. I eat strict keto but more carnivore, 10 carbs or less a day, I track my food, ketones, blood sugar, etc... I gained 40 lbs back on keto in 4 years.
I have a sedentary job, but I exercise. I could not lose weight at all. My MD prescribed mounjaro but my ins won't cover without a PA. I have no other health conditions. I am currently on compounded semaglutide from a med spa. I l
Lost 7 lbs in 3 weeks. No side effects. Just mild appetite suppression. I wish the brand was covered for me. I'm doing everything I possibly can to get the weight off.
second half of video was really great! Really thoughtful, loved it. Really good job Layne.
Thank you for sharing the most up to date science and above all, being kind.
Love this analysis and especially the bit regarding discipline being a struggle for everyone in one area or another!
Thank you for explaining that satiety signals are based in SCIENCE and not a matter of just will-power.
Really enjoyed your latest appearance with the mindpump boys! Not an easy thing to out talk Sal😆 but you definitely did!!
11:17 Thanks for your empathy. Very refreshing for your industry.
You have made me feel better about my loved one using this now
Dr Israetel and Dr Norton should discuss the use of semaglutide during a cut. It would make for an interesting discussion.
You and Nippard are the only reason I have any faith left in the fitness industry.
Ozempic helped me overcome my food obsession, but I’ve seen plenty of patients on it and actually gain, because their lifestyle is what caused their weight gain. They did 0 changes to their diet, so for many they often think it’s a wonder drug
The point is you need no lifestyle changes,you just wont have the desire to eat as much due to its action on your brain.Thats why it's for life in most cases.
as a physician, I can say that these are the most exciting drugs to come a long in a very long time.
I’ve lost close on 200 pounds over the last decade, starting when I was diagnosed type 2. There have been ups and downs, literally. I’m now at a point where I’m around 245 pounds and I’m stuck. I’ve dipped down under 240 a few times, sure, and since I’m bodybuilding I know that I’m gaining some muscle, but it still feels like the slowest recomp in history. If I was to be “lean”, I would likely be around 200-210. One doctor said 190, but I’m 6’3” with a large structure. I did get on trt 5 months ago because I was below the low threshold. It’s helping some with the recomp, but I just can’t lose the weight. I spoke with my doctor briefly about ozempic, since my A1c still tends to be high even though I’m low carb/keto (in order to avoid more meds). At the time my knowledge of the drug suggested that it was horrible for bodybuilding and that it was, essentially, lifetime therapy.
I’m wondering now if I should revisit this topic.
I’m just tired of fighting with a body that hates being under 250 pounds…
calories.
you are eating wrong,
Eating 2 much fat, and probably 2 much calories or 2 little calories
Track calories, reduce fat intake
Only eat healthy food
Drink 3-4l of water daily
If you want fast results eat under 20 grams of fat a day, and do daily cardio for atleast 40min-1h
You'll be 200 in no time
Yeah, you make a good point. We are in a tough spot these days with junk foods everywhere & modern convenience technologies making sedentary lifestyle that much more the default. While I may not like it, we may have to accept some of these interventions as “ necessary evils” in our current world. Obviously convincing everyone to become active, go to the gym, and eat better is not realistic in this environment.
8:51 Constipation is more common than diarrhea in my experience. Also the NNH from observation data is about 300 over 3 yr for thyroid cancer but the signal to noise ratio is very weak, probably residual confounding.
@@BestLifeMD look up number needed to harm - article is entitled “GLP-1 Receptor Agonists and the Risk of Thyroid Cancer” - I just revisited it, it’s a 0.4% absolute increased risk which is a number needed to harm of 250, ie you need to treat 250 w/ GLP1a for 3 years to incur one additional case of thyroid cancer, the effect size is very small, signal to noise is low, this is an artifact of residual confounding in my opinion.
Is it too early to tell what's going to happen to everybody once they stop taking it? Are there any potential long-term side effects for those who stay on it indefinitely so as not to regain weight loss? And once again, the public is more concerned with weight loss, vice body fat reduction and increasing healthy fitness lifestyle markers for the long term. Great info as always...thank you!
You arent supposed to ever stop,just like taking insulin for diabetes
Just started mounjaro it's about 150-200 gbp month but ill probably save a bit on food and takeaway.
Finally a real good video about these drugs. I was working out everyday and dieting, yet I couldnt lose weight because im obese and have eating disorder. But with these drugs, im losing alot of weight for the first time in my life! And all my eating disorders are gone and I feel amazing.
Great to see this channel nearing 300k subs. Well done Layne. Useful info, simply put, as ever.
I believe this can help a lot of people (probably more then it harms) and some people will be able to keep the weight off while getting off the drug. But there will be consequences and abuse, one obvious one is what happens when the bodybuilding community gets their hands on this, unfortunately a lot of people that have no business using this drug will and a lot of people will be reliant on it when they didn't have to be.
Really glad to see your end conclusion. Though I understand ideas of personal responsibility. It simply seems to be best for the overall good and at the end of the day for insurance costs etc. to use it when it MAKES SENSE to do so. Great video.