@@kristeenbarker After 4 years of med school, 3 years of IM residency, and now nearly 2 years of Rheum fellowship, I've FINALLY been able to wrap my head around immunology concepts because of you and your videos!😍 I don't just 'get' the concepts, I *UNDERSTAND* them, and can apply them (which you know, is just a bit important 😅). The way you explain and visualize things works so well for my neurodivergent brain - I'm beyond excited. I'm so happy to have made your day, because for real, you've made my fuckin' month (and very likely more)!! I look so forward to whatever other videos you make! :)
Are the HLA class 2 antigens present on HLA class 2 presenting cells heterogeneous for the possible combinations of each inherited allele within the same cell, or does each HLA class 2 presenting cell only present one variant ( ie: allelic exclusion or clonal expression for a given clone of B cells or a given histiocyte or dendritic cell) ?? My question is the same for HLA class 1 cells (?).
Amazing explanation! Hence, in chronic autoimmune diseases, are the autoantibodies produced by plasma cells or memory B cells? Does this depends on the type of disease?
Niccolo, this is such a fascinating question. As i was researching this, i understood the B cells (at last) then I started to question how rituximab even works because it doesn't target plasma cells after all - and so there's something more to this - I'm hoping to get to the bottom of this question at some stage but please let me know if you find clarity before i do! :) Immunology = a journey!
@@kristeenbarker Kristeen what a wonderful reply! I will definitely let you know and I thought about the same thing given that, as you said, Rituximab does not work on plasma cells. I am on an impossible mission of curing my own multisistemic autoimmune (in part) diseases (MECFS, POTS and Autonomic SFN). I am sure there is a lot of work to be advanced in research. 😊May I ask you, given my ignorance, do B cells become eventually plasma cell? And if so, how long does the whole process take? I am sure the answer will be not straightforward. 😅 Thanks again!
@@niccolowrld they say patients are experts in their own condition, and i very much hope your journey leads you to cure. So some b cells become plasma cells, some remain as memory cells and can become plasma cells later. in terms of timeline, i'm not sure exactly - will be slower the first time the B cell sees the foreign particle, and it will switch from IgM antibodies to IgG antibodies along the way, so it's sort of days-weeks initially. Memory B cell can spring into action much faster (the rationale for vaccination) - hope that helps and again my best wishes for your health. Kristeen
oooofffft waht a question! =Admittedly i have never done a deep a dive into the different classes of IgA - defintely let me know if you solve this mystery!
@@kristeenbarker Can the innate immune system, throgh the NK Cell, iverpowering the immoglobin class switching? Which chronic infection can interfere with the cd19 production ?
your a life saver wow i thought this topic was difficult until i found your videos.
Aw Mohamed thank you so much for watching. You have no idea how much it means to me, knowing that this helped your studies :) my best wishes Kristeen
i absolutely love this video. Thank you so much
this is amazingly in-depth! although as a teenager it's hard to take in all this, this process is far more complicated than I imagined!
Isn't the human body incredible! thanks so much for stopping by. :)
Great video! Thanks
Wonderful thanks very much
Excellent synopsis
The best video yet
Yay so excited u enjoyed it!!!
Your enthusiasm is infectious (pun so intended)! Fantastic videos! :)
Thank you so much Melissa, I'm so excited you are enjoying the series. This made my day! :)
@@kristeenbarker After 4 years of med school, 3 years of IM residency, and now nearly 2 years of Rheum fellowship, I've FINALLY been able to wrap my head around immunology concepts because of you and your videos!😍 I don't just 'get' the concepts, I *UNDERSTAND* them, and can apply them (which you know, is just a bit important 😅). The way you explain and visualize things works so well for my neurodivergent brain - I'm beyond excited. I'm so happy to have made your day, because for real, you've made my fuckin' month (and very likely more)!! I look so forward to whatever other videos you make! :)
Thanks for this video, as. B-cell depleated patient, this was super helpful.
@@elizabethnewell3133 I'm so pleased you found it helpful. My best wishes for your health and wellbeing
what is the function of plasma cell during an immune response
That is Epic
Thank you so much Ameen, I'm so glad you enjoyed it :)
Are the HLA class 2 antigens present on HLA class 2 presenting cells heterogeneous for the possible combinations of each inherited allele within the same cell, or does each HLA class 2 presenting cell only present one variant ( ie: allelic exclusion or clonal expression for a given clone of B cells or a given histiocyte or dendritic cell) ??
My question is the same for HLA class 1 cells (?).
Amazing explanation! Hence, in chronic autoimmune diseases, are the autoantibodies produced by plasma cells or memory B cells? Does this depends on the type of disease?
Niccolo, this is such a fascinating question. As i was researching this, i understood the B cells (at last) then I started to question how rituximab even works because it doesn't target plasma cells after all - and so there's something more to this - I'm hoping to get to the bottom of this question at some stage but please let me know if you find clarity before i do! :) Immunology = a journey!
@@kristeenbarker Kristeen what a wonderful reply! I will definitely let you know and I thought about the same thing given that, as you said, Rituximab does not work on plasma cells. I am on an impossible mission of curing my own multisistemic autoimmune (in part) diseases (MECFS, POTS and Autonomic SFN). I am sure there is a lot of work to be advanced in research. 😊May I ask you, given my ignorance, do B cells become eventually plasma cell? And if so, how long does the whole process take? I am sure the answer will be not straightforward. 😅 Thanks again!
@@niccolowrld they say patients are experts in their own condition, and i very much hope your journey leads you to cure. So some b cells become plasma cells, some remain as memory cells and can become plasma cells later. in terms of timeline, i'm not sure exactly - will be slower the first time the B cell sees the foreign particle, and it will switch from IgM antibodies to IgG antibodies along the way, so it's sort of days-weeks initially. Memory B cell can spring into action much faster (the rationale for vaccination) - hope that helps and again my best wishes for your health. Kristeen
Then iga2 or iga6 are produced by B1 or B2?
oooofffft waht a question! =Admittedly i have never done a deep a dive into the different classes of IgA - defintely let me know if you solve this mystery!
@@kristeenbarker Can the innate immune system, throgh the NK Cell, iverpowering the immoglobin class switching?
Which chronic infection can interfere with the cd19 production ?