A daily three mile walk is absolutely great for the body. Sometimes I think there is a lot of emphasis on “exercise” over work. I don’t “exercise” on days I mow the yard, weed the garden, clean the house, wash and vacuum the car, scrape and paint the porch floor or many other types of work. There are so many labor saving devices in favor of going to the gym. Not shaming you at all, walking is wonderful, I just wish there was more emphasis on getting the job done over getting exercise. I bet you do both.
Great topic to talk about! Let's remember that by getting enough quality sleep we help the body to slow down glycation. As you say "Glycation...leads to inflammatory state" this is then most likely one of the many ways why lack of sleep disrupts immune function.
Don't forget the adverse effects of toxic LED lighting disrupting deep slow wave sleep and harming the depth of paralysis necessary to throw switches in the brainstem to bring on the repair and replace functions adequately IMHO. Cortisol needs to reduce for this to allow melatonin to help provide better sleep.
@@davidcardinal3654 I believe that one adverse effect of LED light, is that cortisol and adrenalin stay present through the first two hours of sleep that is when you reach deep slow wave sleep. The depth of this sleep allows deeper paralysis to quiet the nonessential energy and activity, to 'clear the decks' to bring in the cleanup crew activity that is important for repair/replace/ and heal. Pineal-derived melatonin is at a level to help in all of this, but LED increases the excitatory hormones so that melatonin is not as effective. That's my understanding, so far. Supplying near infra red light, as was done in incandescent bulbs, modulates the LED 'blue light', but now everything is LED light.
It's important for darkness prior to going to sleep. If you ' must' have light in the late evening, minimize it with weak incandescent bulb light, not computer, phone, or LED. IMHO. Out in daylight we always have the blue light of the sky modulated by the ever-present near infra red in the sunlight.
Great but you forgot #4 for solving this problem: 1. Reduce sugar consumption 2. Exercise 3. Herbs to help 4. Intermittent Fasting ---> Causes autophagy to get rid of 'all the junk glycoproteins' filling the cells.
@@capnceltblood5347 Yes, my point was that it should have been included in the "solutions" section along with mention of intermittent fasting to induce it.
while this is nice, it's enabling sloth and ingratitude, because learning should be experienced, and not just summary and itemized things. Please let people learn to listen to free medical advice and learn concepts
@@Jennifer-gr7hn Agree Jen. But I didn't post my note above to provide cliff notes for the video, rather to point out that it would be nice if he mentioned intermittent fasting as another component of the solution. My comment was actually for Dr. Been himself and for those who watched the whole thing.
Awesome visuals to help us understand what is taking place on a cellular level in our bodies! Thank you for allowing us to learn from you! Adapting graphics to complex methodologies is a game changer!🙏🏻👍🏻❤️
one of the best presentations on the topic, thanks @DrbeenMedicalLectures - the graphics refreshingly clear and simple/supportive of what's being explained
I want to remember to view this video each time I crave reaching for sweetness in my mouth, other than in the fall of the year where we were adapted to try desperately to gain weight, toward better survival through potential harsh low food availability times. And, now since those times don't happen for the vast number of us, sweetness appears dangerous. And, carbohydrate intake to excess just increases sugar in the blood to spike insulin above levels we were evolutionarily expecting by our mid to higher latitude seasonal diets (relying on animal products primarily, and usually lesser amounts of vegetable carbohydrates). IMHO Oh. and if we get back our 'normal prehistoric, outdoor dominance of daylight nutrition, we need less food anyway. Indoor lighting durations and lack of near infrared to balance the LED lights is dangerous by only getting isolated blue-dominant wavelengths that are toxic when by themselves.
@p4h10oso I seriously doubt that, could you cite that? Quality of that food needs to be pointedly considered, as well as quantity. Current diet in western societies appears to be almost unable to sustain health right now. Junk light as well as junk food dominates our intake, and nutrient density decline plus toxicant input needs far better assessment before making your statement above seem adequate?
Is it known if modified sugars like sucralose (which is an almost calorie-free sweetener where some naturally occurring parts of the sugar molecule, called hydroxyl, are swapped out for chlorine) are also amenable to glycation and formation of AGE products causing inflammation?
I believe the modern term is “ glycated proteins”, our ancestors ate protein and fat together when available. Then fasted , then turned to plants and carbohydrates to avoid starvation. Fats and proteins hardly ever were eaten in presence of sugars, that’s the “give”! Context over contents
You mean like brown spots from the sun? I have some on my arms and back.. I suspect it’s from the glycation and when in the sun the spots form.. do you think that carnivore diet and fasting could help remove the spots from the skin?
Reduce or eliminate dietary carbohydrates... This is the simplest and most obvious way to reduce glycation. There is no physiological requirement for dietary carbohydrates.
The room is too hot or cold? Turn up the air conditioning or heat, respectively. The shoes hurt your feet? Take the shoes off. Do you have too much glycation? Reduce eating carbohydrates (glucose, fructose, galactose). It's so simple to comprehend!
I bet excessive advanced glycation end product symptoms look just like Lyme disease, CIRS, MSAS, Undiagnosed Diabetes, and Cancer in the end. I bet they are all Metabolic. A prediabetic person can have all the symptoms and damage occurring as a diabetic, they just don’t get the label. The threshold is purely political because if they had to take responsibility for making the whole country sick heads would role, and the money train would end. The biggest scam is it was purposely done.
I’m struggling with your saying “permanent” - I heard some hope techniques for removing the AGE build up I’ve done mostly in ignorance, whew! I hope to see more about how to remove AGE effectively. I’m doing actions and fear “permanent”. THANK YOU!
usual daily intermittent fasting cannot induce autophagy, only fasting multiple days can. Autophagy installs only after minimum 24-36 hours of water fasting... good to fast at least 3 days in a row from time to time, for higher purposes like anti-glycation.
I mean if you know the answer why not give it? Anyway I’ve been taking Quercetin since Been talked abt it during shut down. I didn’t check to see if it was a herb! Checked today and it is. And kaempferia, genistein was on report. At abt 17:46😊
Paul Saladino will say that you have to increase the carbohydrates even more He will say more honey, that contains fructose and glucose. Fructose will glycate with a factor of 7-10 more than glucose. So be careful with table sugar, honey, glucose, so carbohydrates actually, careful with modern fruits loaded with fructose.
Im not sure what happened for paul but he does live a different lifestyle. Im inclined to see fruit besides a select few as sugar. Maybe we should just be eat glycine instead?
@klondike444 nut we have cave masters who encaved the other by making fructose fermented aka alcohol and other fructose from cane sugar products that sells for what we call the sugar for teas.
Be careful with berberine especially if you take aspirin the combination is too much blood thinning. I noticed bruising appearing from doing normal things I always do.
I exercise a lot, I really enjoy it and I have the time since I'm retired. But, due to the high amount of exercise, my blood sugar fluctuates a lot, giving an A1C of 5.7. I've been LCHF for over 5 years, practice 16 hr IF with 2 meals a day. I just got the Stelo GCM and I'm surprised to see the fluctuations in my blood glucose levels.
@@jpilrose Yes, I watch my fat closely because I'm LMHR, LDL > 350. I still don't know what to think about soft-plaque development over decades with LMHR. I've known Cardiologists that say we all develop soft-plaque and there is a correlation to LDL, although proving causal is subjective. So, yes, I am careful with sat-fat intake. If I was not LMHR, I would not care about sat-fat consumption.
I am also LMHR. What helped me, surprisingly, is re-introducing complex carbs into my diet after years on low carb…lowered my LDL substantially, 50%. This was after that “oreo cookie” paradoxical study, and it makes sense biochemically, but, of course, I would not do oreos, only complex carbs and very carefully. Had to change the whole mindset.
Berberine is found in two similar & related plants: barberry root & Oregon grape root and in an unrelated plant, golden seal. Barberry root tea is really good for diarrhea. The concentrate of barberry root is berberine.
Most importantly, make sure the carbs are still the major macro component of the menu BUT it needs to be in the form of whole food, resistant starch and fibers and the slow release of carbs in between of fibers - gut bacteria turns fibers into saturated fatty acids to be honest - so these carbs end up as a fat instead, in part, but a healthy type of short chain fats, and some healthy C15 longer ones to stabilize the cells. If you make it keto or high protein, then chronic health issues follow, slowly. The gut gets destroyed and all sorts of long terms problems that could take some years to develop (iron buildup, acidosis products, raised cortisol etc).
@@Izzy-cu9do The totality of scientific literature supports it. It's the nature. No virtual "wrongs" can change this. The biochemistry is universal all over the universe.
@@musaire Post the scientific studies links please. Those that are NOT funded by the seed oil, sugar, cereal cartels, the WEF, Harvard, or Bill Gates Foundation just to name a few.. Otherwise you are talking nonsense. Links????Proof?? No gibberish from you is going to ever be considered truth unless you post the links to the scientific studies WITH the funding sources. Otherwise you will just be embarrassing yourself further. End of story.
@@musaireyes, science is full of bogus studies that were driven by ideology or were outright bought by ultra processed food companies. Some is even driven by religion (7th day adventist nutrition "science"). Don't fall for it.
As far as I paid attention, there was no mention of autophagy. But I also thought of it as the remover of non-functional components in our bodies. Is there evidence autophagy removes glycated proteins?
AGEs are much higher in animal products and nuts, than in fruits, beans and grains. The best way to minimize AGEs in our foods is to eat fruit or boil beans and grains. If you eat a chicken you are also eating all the AGEs that formed in that animal's body throughout it's entire rather brief lifetime.
![Advanced Glycation End-Products (AGEs) EXPLAINED [Part 1]](http://i.ytimg.com/vi/zhnulhhGxpU/mqdefault.jpg)
![Hunxho - Ball Forever [Official Video]](http://i.ytimg.com/vi/nki9ZTF9Uls/mqdefault.jpg)
Great information for anyone. Encouragement for continuing my 3 mile walks.
A daily three mile walk is absolutely great for the body. Sometimes I think there is a lot of emphasis on “exercise” over work. I don’t “exercise” on days I mow the yard, weed the garden, clean the house, wash and vacuum the car, scrape and paint the porch floor or many other types of work. There are so many labor saving devices in favor of going to the gym. Not shaming you at all, walking is wonderful, I just wish there was more emphasis on getting the job done over getting exercise. I bet you do both.
Great topic to talk about! Let's remember that by getting enough quality sleep we help the body to slow down glycation. As you say "Glycation...leads to inflammatory state" this is then most likely one of the many ways why lack of sleep disrupts immune function.
Don't forget the adverse effects of toxic LED lighting disrupting deep slow wave sleep and harming the depth of paralysis necessary to throw switches in the brainstem to bring on the repair and replace functions adequately IMHO. Cortisol needs to reduce for this to allow melatonin to help provide better sleep.
@@raykinney9907by paralysis you mean the body staying paralyzed? Is my sleep paralysis related to my poor sleep lol?
@@davidcardinal3654 I believe that one adverse effect of LED light, is that cortisol and adrenalin stay present through the first two hours of sleep that is when you reach deep slow wave sleep. The depth of this sleep allows deeper paralysis to quiet the nonessential energy and activity, to 'clear the decks' to bring in the cleanup crew activity that is important for repair/replace/ and heal. Pineal-derived melatonin is at a level to help in all of this, but LED increases the excitatory hormones so that melatonin is not as effective. That's my understanding, so far. Supplying near infra red light, as was done in incandescent bulbs, modulates the LED 'blue light', but now everything is LED light.
It's important for darkness prior to going to sleep. If you ' must' have light in the late evening, minimize it with weak incandescent bulb light, not computer, phone, or LED. IMHO. Out in daylight we always have the blue light of the sky modulated by the ever-present near infra red in the sunlight.
Great but you forgot #4 for solving this problem:
1. Reduce sugar consumption
2. Exercise
3. Herbs to help
4. Intermittent Fasting ---> Causes autophagy to get rid of 'all the junk glycoproteins' filling the cells.
He did mention Autophagy...
@@capnceltblood5347 Yes, my point was that it should have been included in the "solutions" section along with mention of intermittent fasting to induce it.
while this is nice, it's enabling sloth and ingratitude, because learning should be experienced, and not just summary and itemized things. Please let people learn to listen to free medical advice and learn concepts
@@Jennifer-gr7hn Agree Jen. But I didn't post my note above to provide cliff notes for the video, rather to point out that it would be nice if he mentioned intermittent fasting as another component of the solution. My comment was actually for Dr. Been himself and for those who watched the whole thing.
Thank you. It leaves us a list for after we read too and that is helpful for forgetful people @jackfroste
Awesome visuals to help us understand what is taking place on a cellular level in our bodies!
Thank you for allowing us to learn from you! Adapting graphics to complex methodologies is a game changer!🙏🏻👍🏻❤️
💯🙏🏻
Great lecture. Mechanism simply explained. Thank you!
Another excellent explanation, we can't thank you enough dearest Mobeen 🙏❤ Greetings from the UK 🇬🇧
Good evening everyone!
Fantastic lecture! Dr. Been you are a true gift to humanity 🥰
Liking-in with a hello to @Drbeen Medical Lectures and all KoolBeens!
Hello!
never do keto long term.
Keto is not the solution. Look at my comment above somewhere.
@@musaire keto-flex / Dr Dale Bredesen, The End of Alzheimer’s book ❤️🩹
one of the best presentations on the topic, thanks @DrbeenMedicalLectures - the graphics refreshingly clear and simple/supportive of what's being explained
This was very valuable data, thank you for your time and energy into this!
Insightful and beautiful work. 🙏💕
Hello Dr Been & All Cool Beens.
Hello Dr. Been & Fellow Koolbeens. 🌎
Great lecture to prevent aging too fast.
more importantly, health. We will all die
You cannot exercise your way out of a bad diet. Carbohydrate restriction is necessary.
yes, others have said this and it's true -- a lot of bulimic lifestyles out there who need help since it's a trauma, anxiety thing.
GREAT ANIMATION
Excellant presentation...Very informative ...Thanks Doc...👍🏻👍🏻
Fantastic. Thanks Doc.
Valuable information: thank you.
Good information!
I want to remember to view this video each time I crave reaching for sweetness in my mouth, other than in the fall of the year where we were adapted to try desperately to gain weight, toward better survival through potential harsh low food availability times. And, now since those times don't happen for the vast number of us, sweetness appears dangerous. And, carbohydrate intake to excess just increases sugar in the blood to spike insulin above levels we were evolutionarily expecting by our mid to higher latitude seasonal diets (relying on animal products primarily, and usually lesser amounts of vegetable carbohydrates). IMHO Oh. and if we get back our 'normal prehistoric, outdoor dominance of daylight nutrition, we need less food anyway. Indoor lighting durations and lack of near infrared to balance the LED lights is dangerous by only getting isolated blue-dominant wavelengths that are toxic when by themselves.
@p4h10oso I seriously doubt that, could you cite that? Quality of that food needs to be pointedly considered, as well as quantity. Current diet in western societies appears to be almost unable to sustain health right now. Junk light as well as junk food dominates our intake, and nutrient density decline plus toxicant input needs far better assessment before making your statement above seem adequate?
How great you are!!!!! thank you so much
Is it known if modified sugars like sucralose (which is an almost calorie-free sweetener where some naturally occurring parts of the sugar molecule, called hydroxyl, are swapped out for chlorine) are also amenable to glycation and formation of AGE products causing inflammation?
I heard that these sugar replacements create the problem that the body will learn that food tasting sweet has no sugar.
Practically doesn't matter. Don't eat artificial sweeteners.
I believe the modern term is “ glycated proteins”, our ancestors ate protein and fat together when available. Then fasted , then turned to plants and carbohydrates to avoid starvation. Fats and proteins hardly ever were eaten in presence of sugars, that’s the “give”! Context over contents
No process to remove glycation products? When I moved to carnivore diet, my dark areas on my old skin slowly disappeared.
You mean like brown spots from the sun? I have some on my arms and back.. I suspect it’s from the glycation and when in the sun the spots form.. do you think that carnivore diet and fasting could help remove the spots from the skin?
Reduce or eliminate dietary carbohydrates... This is the simplest and most obvious way to reduce glycation. There is no physiological requirement for dietary carbohydrates.
stop with the misinformation. simple carbohydrates cause glycation.
yes exactly. who ever invented the idea of a 'balanced diet' ?
Lol.
The room is too hot or cold? Turn up the air conditioning or heat, respectively.
The shoes hurt your feet? Take the shoes off.
Do you have too much glycation? Reduce eating carbohydrates (glucose, fructose, galactose).
It's so simple to comprehend!
I bet excessive advanced glycation end product symptoms look just like Lyme disease, CIRS, MSAS, Undiagnosed Diabetes, and Cancer in the end. I bet they are all Metabolic.
A prediabetic person can have all the symptoms and damage occurring as a diabetic, they just don’t get the label. The threshold is purely political because if they had to take responsibility for making the whole country sick heads would role, and the money train would end. The biggest scam is it was purposely done.
Excellent. Informs me about other things.
May not be allot of glucose but they are diabetic? Carbohydrate consumption is always contra-indicated in humans.
I’m struggling with your saying “permanent” - I heard some hope techniques for removing the AGE build up I’ve done mostly in ignorance, whew! I hope to see more about how to remove AGE effectively. I’m doing actions and fear “permanent”. THANK YOU!
Dr Been, are you thinking of joining the medical practice in Vegas connected with Billy Crone? I swore I heard your name mentioned recently
Great topic! You didn't seem to go in to how autophagy (i.e. form intermittent fasting) might help ? Or am I wrong and it would never help?
usual daily intermittent fasting cannot induce autophagy, only fasting multiple days can. Autophagy installs only after minimum 24-36 hours of water fasting... good to fast at least 3 days in a row from time to time, for higher purposes like anti-glycation.
Did I miss something, as many times herbs are referred to, but never actually mentioned. Does anyone know which herbs? Thank you.
Listen again and be attentive 😊
I mean if you know the answer why not give it? Anyway I’ve been taking Quercetin since Been talked abt it during shut down. I didn’t check to see if it was a herb! Checked today and it is. And kaempferia, genistein was on report. At abt 17:46😊
Cloves,Parsley,Chives,Turmeric,Anise are just a few to reduce AGE's.
Paul Saladino will say that you have to increase the carbohydrates even more He will say more honey, that contains fructose and glucose. Fructose will glycate with a factor of 7-10 more than glucose. So be careful with table sugar, honey, glucose, so carbohydrates actually, careful with modern fruits loaded with fructose.
Im not sure what happened for paul but he does live a different lifestyle. Im inclined to see fruit besides a select few as sugar. Maybe we should just be eat glycine instead?
Table sugar shouldn't be a thing.
@@klondike444 It is because it is 50 percent fructose.
And don't juice your fruits also.. eat on empty stomach after fasting maybe good idea.
@klondike444 nut we have cave masters who encaved the other by making fructose fermented aka alcohol and other fructose from cane sugar products that sells for what we call the sugar for teas.
Ketones, fat soluble vitamins, less Ros, water, vitamin D, Nac, micronutrient.
Thank you!
Carbohydrates = Glucose
all things break down to glucose...in time.
@@Jennifer-gr7hn Even lawnmowers? 🤔
Some slower or not even get there, so less damage. What about ketones?
@@Jennifer-gr7hn No. Fatty meat breaks down to fatty acids and amino acids
@@alexmarques2398 Fiber is an indigestible carbohydrate. Though our stomach cant turn it into glucose, it provides almost no nutrition to humans.
What do you think of chromium and Berberine?
chromium deficiency = large contributor to developing diabetes in the first place. And Berb = nature's metformin :)
Be careful with berberine especially if you take aspirin the combination is too much blood thinning. I noticed bruising appearing from doing normal things I always do.
Thank you.
Thank you
I exercise a lot, I really enjoy it and I have the time since I'm retired. But, due to the high amount of exercise, my blood sugar fluctuates a lot, giving an A1C of 5.7. I've been LCHF for over 5 years, practice 16 hr IF with 2 meals a day. I just got the Stelo GCM and I'm surprised to see the fluctuations in my blood glucose levels.
Most likely, you are getting too much protein and not enough fat. High protein food will cause a spike unless absorption is slowed by the fat.
@@jpilrose Yes, I watch my fat closely because I'm LMHR, LDL > 350. I still don't know what to think about soft-plaque development over decades with LMHR. I've known Cardiologists that say we all develop soft-plaque and there is a correlation to LDL, although proving causal is subjective. So, yes, I am careful with sat-fat intake. If I was not LMHR, I would not care about sat-fat consumption.
I am also LMHR. What helped me, surprisingly, is re-introducing complex carbs into my diet after years on low carb…lowered my LDL substantially, 50%. This was after that “oreo cookie” paradoxical study, and it makes sense biochemically, but, of course, I would not do oreos, only complex carbs and very carefully. Had to change the whole mindset.
How about n-acetyl cysteine? This could also help.
I have read that melatonin is capable of cleaving AGEs. I also wonder whether plasmapheresis might be designed to remove AGEs from circulating blood.
Does the same thing happen with fructose?
7 times worse
I couldn’t understand the name of this herbs plz? 🙏
Hello
TTFD or Benfitiamine?
L-Carnosine
Do you mean l carnitine?
@@RepentfollowJesus
No. Not L-Carnitine.
Rather, it's L- Carnosine.
Berberine?
Berberine is found in two similar & related plants: barberry root & Oregon grape root and in an unrelated plant, golden seal.
Barberry root tea is really good for diarrhea. The concentrate of barberry root is berberine.
Most importantly, make sure the carbs are still the major macro component of the menu BUT it needs to be in the form of whole food, resistant starch and fibers and the slow release of carbs in between of fibers -
gut bacteria turns fibers into saturated fatty acids to be honest - so these carbs end up as a fat instead, in part, but a healthy type of short chain fats, and some healthy C15 longer ones to stabilize the cells.
If you make it keto or high protein, then chronic health issues follow, slowly. The gut gets destroyed and all sorts of long terms problems that could take some years to develop (iron buildup, acidosis products, raised cortisol etc).
Wrong.
@@Izzy-cu9do The totality of scientific literature supports it. It's the nature. No virtual "wrongs" can change this. The biochemistry is universal all over the universe.
@@musaire Post the scientific studies links please. Those that are NOT funded by the seed oil, sugar, cereal cartels, the WEF, Harvard, or Bill Gates Foundation just to name a few.. Otherwise you are talking nonsense. Links????Proof?? No gibberish from you is going to ever be considered truth unless you post the links to the scientific studies WITH the funding sources. Otherwise you will just be embarrassing yourself further. End of story.
@@musaireyes, science is full of bogus studies that were driven by ideology or were outright bought by ultra processed food companies. Some is even driven by religion (7th day adventist nutrition "science"). Don't fall for it.
So, again, autophagy is the key... 🔑
As far as I paid attention, there was no mention of autophagy.
But I also thought of it as the remover of non-functional components in our bodies.
Is there evidence autophagy removes glycated proteins?
@@janboevink230 He did refer to autophagy as a way of removing the damaged cell.
Not, not at all.
use chapters
Sugar and carbs = Villains. Exercise and autophagy = Heroes. 😂😅
stop with the misinformation. simple carbohydrates cause glycation.
AGEs are much higher in animal products and nuts, than in fruits, beans and grains. The best way to minimize AGEs in our foods is to eat fruit or boil beans and grains. If you eat a chicken you are also eating all the AGEs that formed in that animal's body throughout it's entire rather brief lifetime.
No video
Try again
Limit pizza to three meals per week.
Pizza is unhealthy give me a break!
Great ❤❤❤topic