What is celiac disease | Gastrointestinal system diseases | NCLEX-RN | Khan Academy
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- Опубликовано: 17 сен 2015
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I appreciate the content but I would have liked more information on the pathophysiology. I have looked elsewhere (UptoDate, Robins and Osmosis) and would like to share my findings in dot-point form:
-> Gluten ingested
-> Once it reaches the duodenum, it has already been broken up into gliadin and glutenin
-> On the mucus layer that lines the GIT wall, secretory IgA binds to gliadin. Normally, the body should attack this complex, however this does not occur.
-> The complex binds to transferrin receptors on the enterocytes (an increased number of such receptors in those with coeliac) and allows the complex to travel through the cell and into the lamina propria where gliadin is separated from IgA
-> Once in the lamina propria, an enzyme known as 'tissue transglutaminase (tTG)' acts on gliadian and the product is 'deamidated gliadine'.
-> Deamidated gliadine is recognised by and bound to MHC II receptors on macrophages, more specifically, the HLA-DQ2 and/or HLA-DQ8 subtypes.
-> This triggers an immune response which destroys enterocytes, leading to malabsorption, thus symptoms such as anaemia, steatorrhea and diarrhoea
This is a very good explanation and covers almost all important points in pathogenesis of CD!
The only thing you left out was that there are three enzymes involved. tTG2 (gut) tTG3 (skin) and tTG 6 (brain), which is why you get different subtypes. You can have any combination too.
I learned more in 6 minutes than I learned by studying with the book in front of me. Thank you so much!
Very helpful! I needed this type of explanation for my nutrition and diet therapy report! Do keep on making this type of videos! God bless you!
you did a very good job!
that is very good. .continously please
Thanks mate, that helps alot!
Bravo...nailed it....
N!cE W0rk Bro! :)
i learned a lot from tis video
short and to the point!
Hey. Thanks a lot for the video:) May I point something? The neurological symptoms of celiac desiase are not to be forgotten. Fogginess, "slow thinking", depression, flashes and other symptoms similar to ephiletic crises are very important. Don't know if they're commun but they're definetely significant to help diagnosing.
Sheffield University has done some great research if you are still looking for information about the neurological aspects of Celiac Disease. You can find some good recorded classes about it.
Cool video!
Great video very useful
nice
Great video! I have Celiac Disease, I was diagnosed at 16.
Let's say you start a gluten-free diet, are the vili able to heal?
I am 23 and I struggle so much eating a gluten-free diet but I recognize the importance and this video really helped me realize I should probably stick to it 😩
By hosting hookworms I can consume gluten without issue. I'm celiac from a family of celiacs.
Is Celiac disease a type IV hypersensitivity reaction; is it a type II?
Thank you!
why coeliac disease may be complicated by hyposplenism?
U a so good. What's ur credential,btw?
I was diagnosed with the Celiac disease after I had a camera put down when I was like 13, I stuck to the diet for about 3 months and then started eating wheat again because it didn't hurt or change my body in any way, I told the doctor years ago and he said that if it doesn't hurt or cause discomfort in any way, then its okay to keep eating wheat and gluten, I started getting consistent stomach cramps a few weeks ago and if I go without food for about 2 hours I'll start feeling really sick though. Not really sure what to do because I'm a poor uni student and I can't really afford to stop eating gluten, I live on pasta.
Potato and risotto
Love them both, probably a good idea to give afew different diets a go. thanks
if you were diagnosed with CD, then you must avoid gluten, regardless what the doctor says.
We don't know why there is an attack in these disorders but I have a feeling it is the result of generations of Candida Albicans (a fungus we all have in our bodies and beyond) being passed down. Some of us have it worse than others. A grain-yeast free diet is best but hard to live out. Worth it but still hard to eat that clean. I have a serious disorder around donuts (mainly Krispy Kremes:). When I pass by that case and something comes over me. I have found I can eat them without problems in packaged donuts... maybe it is the preservatives? I want to learn how to make bread without yeast with grains like spelt, quinoa, rice, because of a wheat allergy I have had all my life. It causes swelling in my sinuses and eyes.
Celiac disease has a genetic cause, it is not caused by a fungus.
also, try sourdough bread
No discussion of celiac disease is complete without a discussion of how hookworms can put celiac disease into full remission.
That's because there is no real evidence to support it. In Placebo controlled trails, there was very modest benefits that were outweighed by the negative effects of the infection. So there was NO benefit at this time to Celiac Patients. Hookworms do NOT put the disease into remission. Period.
Meeting Dr IGUDIA RUclips channel was the beginning of a new life for me after using his herbs medication in curing my Coeliac disease.
I think I just fart too much & don't have Celiac Disease. 🤷♂️