Avery Experiment: DNA as the Transforming Principle

The Avery, MacLeod and McCarty classic experiment helped to prove that DNA is the molecule of heredity. Previously, it was thought that proteins were the most likely biomolecule that transferred inheritance information from parent to offspring.
Avery's experiment built on the foundation of Griffith's earlier work, in which he identified a "transforming principle" that allowed bacteria to acquire characteristics from one another. In the Avery experiment, they first used process of elimination to determine that neither carbohydrates nor lipids were responsible, then tested proteins, RNA and DNA. The scientists knew that bacterial transformation should still take place unless they disabled the transforming principle. They added enzymes such as proteases, RNases and DNases to destroy various components of the bacterial mixture, knowing that most mice would die except the mice who received the injection with the disabled transforming principle.
Guided Notes & Study Guide: Check out the BOGOnotes for this video!
etsy.me/3wlfh3g
0:00-0:38 Introduction
0:38-0:55 Biomolecules
0:55-1:47 Proteins vs. Nucleic Acids
1:48-2:30 Building on Griffith's Experiment on Bacterial Transformation
2:30-3:50 Preliminary Testing
3:50-4:03 The Diva Protein
4:03-4:26 Process of Elimination
4:26-4:57 Avery Experiment Design
4:57-6:24 Avery Experiment Results
6:24-7:12 Conclusions
Sources:
The Original Paper: www.ncbi.nlm.nih.gov/pmc/arti...
en.wikipedia.org/wiki/Avery%E...
openstax.org/books/microbiolo...
thebiotechnotes.com/2019/12/0...
#averyexperiment #bacterialtransformation #moleculeofheredity

[@BOGObiology]

Guided Notes & Study Guide: Check out the BOGOnotes for this video!
etsy.me/3wlfh3g

[@zinaalkharraz7752]

This is literally the most underrated scientific channel ever. Thank you so much for these videos, they help a ton. Keep it up!!

[@BOGObiology]

Thanks, Zina! So happy to hear that! Please share with your classmates, if you feel comfortable doing that. Sending love and best wishes from Boston! -BOGO

[@zinaalkharraz7752]

@@BOGObiology Yes, will do!

[@annantony4488]

This was such an amazing video, it really helped me understand this experiment. Well done, and thank you

[@BOGObiology]

Thanks, Ann! Sending love and best wishes from Boston!

[@lonelysensei8345]

I LOVE THIS CHANNEL. you guys helped me finally understand avery's expiriment! my teacher was SHOOK lmao

[@TrucNguyen-qk2yn]

thank for this video! thank you so much!

[@iraqi3612]

thank you Doctor❤️

[@talhawaheed438]

Nice presentation....

[@dishaganguly8106]

McLeod McCarty and Avery did their experiment invitro... so from where does the mouse comes

[@Art-cq1zy]

What does a 1.67 ratio entail? Don’t ratios usually have two numbers?

[@readmesoon13]

1.67 = 5/3
ratio of 5 to 3

[@elham2821]

Helpful video, do you do zoom tutoring?

[@BOGObiology]

Thanks, Elham! Sorry, no zoom tutoring at the moment. Maybe someday! -BOGO

[@elham2821]

@@BOGObiology No worries, thx tho.

[@THEDONATRON]

Here for Biochemistry class

[@BOGObiology]

Yes, lots of folks are haha. Sending good vibes from Boston! -BOGO

[@slideszi]

Thank you so much!