Types: 1.Glomerular (primary/secondary) - Increased glomerular capillary permeability to protein 2.Tubular (Decreased tubular reabsorption of proteins in glomerular filtrate) 3.Overflow (Increased production of low-molecular-weight proteins) 4.Orthostatic 5.Isolated Also: Transient/Persistent In multiple myeloma: At the very beginning - overflow; Than tubular - Fanconi syndrome; And may be Secondary glomerulonephropathy at the end-stage chronic kidney disease?
I've spent hours on these videos in this course to learn more about cancer, I when I check my slides after watching they become so much easier to remember, I really appreciate your efforts to make these topics much cooler for us
Really good content!! The only thing I would add it is about treatment. I think it is important to mention as well the monoclonal antibodies (Daratumumab)! Thank you for your amazing lectures!
Please can you do neuroanatomy and physiology! I'm in my final year of med school and still don't understand all the spinal tracts and cns pns anatomy and function. You're explanations could save my life like these haem ones have thanks. Oh also nephrology I find super hard so hoping you're planning on releasing more
I am a Vietnam Vet with past contact to Agent Orange. At age 75 recently I was diagnosed with MGUS. So all the test that you mentioned I expect to be given Your lecture design for medical students was informative and your side comments made me laugh as well Currently my main symptom is constant numbness and tingling of my left hand and arm. So my question to you: could I actually have MGPNS? So far my labs are not to bad. Cheers
I think I only know of renal failure. Renal failure includes multiple myeloma because the bence Jones proteins and light chains produced by the multiple myeloma cells damage the kidneys which will then be unable to prevent proteins from being filtered out. That's what I think
Thanks a lot for the great Video! But why phoresis and immunofix in the urine, if you already did that in the serum? Wouldn't it be smarter to additionally perform light chain quantitation in the serum and protein differentiation in the urine and skip the phoresis +Immunefix in the urine?
Yes, the previous replies are correct. Harrison's Internal Medicine, p 796, says "Patients with multiple myeloma have a decreased anion gap because the M component is cationic, resulting in the retention of chloride."
je suis francophone et j'ai trouvé ta chaîne par hasard et je te trouves génial merci bien docteur mais s'il te plait comment je peux télécharger tes notes et tes schéma sous forme de PDF ?
what program and tools do you use to make these videos? I am a nurse educator that wants to move away from powerpoint lectures towards this style of teaching and learning.
Actually in my mother blood report there is a M spike in gamma region. We are really very scared right now. After that we went to a oncologist. They suggested us to do some more test like xray of skull and multiple myeloma test. We get xray of skull and it looks ok but myeloma test report will come after 4 days.
Because the loss of Na+ causes contraction to the serum due to MM. And, due to hypoalbuminemia ,the serum Cl- , COH-3 must raise to compensate for metabolic acidosis
@@MedicosisPerfectionalis It's a long story etc, but let's not ignore facts like a) studies with such natural things like cannabis are prohibited b) there's no money (for those who can fund studies) in studying something anyone can buy or do while not paying for their patented substances, c) farmaceutical companies are just businesses, they are interested in showing maybe that their (patented) drug (probably an isolated or modified molecule of what is found in nature, in plants) is better than nothing, and if they find that from natural sources the effect is much better you guess if they will publish those results or hide it. Etc. Plus we know that strengthening our immune system can only do good, wether it's multiple myeloma we are talking about or any other disease. And yet this is successfully ignored (things like exercise, diet, bad habits, etc.) and, for some reason, a doctor will skip all that kind of things and think of the treatments only or mainly in terms of farmaceutical, patented, substances. And that's because, believe it or not, medical schools and what they teach are in farmaceutical business' pocket. Just watched Dr. John Bergman's recently new presentation "Medical failure the delusion of diagnosis" - it too concerns the whole current failing medical system picture. If only humans were more open minded and more suspicious of the businesses like farmaceutical business, who knows maybe how we would be a healthy society, and not an ever sicker one, killed by mostly preventable diseases and killed a lot by iatrogenic diseases, like discussed in, for example, Dr. Michael Greger 's presentations on top causes of death. Things like that, my friend.
@@MedicosisPerfectionalis In that case I'm waiting to see evidence that show that patented drugs compared to hundreds and hundreds of natural medicines (herbs, spices, plants, etc.), to lifestyle changes etc, still have best results out of all. You don't have it? What does that say? Well, only that there are no such studies (returning to my point why we don't have such studies), and not that the patented substances have best effects. Be well.
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📝 Notes and Cases: www.medicosisperfectionalis.com/
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Types:
1.Glomerular (primary/secondary) - Increased glomerular capillary permeability to protein
2.Tubular (Decreased tubular reabsorption of proteins in glomerular filtrate)
3.Overflow (Increased production of low-molecular-weight proteins)
4.Orthostatic
5.Isolated
Also: Transient/Persistent
In multiple myeloma:
At the very beginning - overflow;
Than tubular - Fanconi syndrome;
And may be Secondary glomerulonephropathy at the end-stage chronic kidney disease?
I've spent hours on these videos in this course to learn more about cancer, I when I check my slides after watching they become so much easier to remember, I really appreciate your efforts to make these topics much cooler for us
My pleasure 😇
Many thanks from Botswana, if I could I'd send you an elephant man. you've made a huge difference.
Thank you so much 😊
just send him cash
@@bilalaldulaimy3954 are you willing to buy an elephant?
Really informative . Thanks a lot 👍🏼
Really good content!! The only thing I would add it is about treatment. I think it is important to mention as well the monoclonal antibodies (Daratumumab)!
Thank you for your amazing lectures!
Awesome 👏
Thank you so much
BEST BEST BESTTT EXPLANATION EVERR
Thank you 🙏
I loved 15000 times....❤
Thank you!
Please can you do neuroanatomy and physiology! I'm in my final year of med school and still don't understand all the spinal tracts and cns pns anatomy and function. You're explanations could save my life like these haem ones have thanks. Oh also nephrology I find super hard so hoping you're planning on releasing more
I agree! i'm having trouble with the same topics
I agree too, I‘m also last year student and have a lot of trouble with these tracts and stuff
I will try my best!
loved ur lecture sir..thnk u so much
dr najeeb is a fentestic tchr but his videos r too time consuming..
I am a Vietnam Vet with past contact to Agent Orange.
At age 75 recently I was diagnosed with MGUS. So all the test that you mentioned I expect to be given
Your lecture design for medical students was informative and your side comments made me laugh as well
Currently my main symptom is constant numbness and tingling of my left hand and arm. So my question to you: could I actually have MGPNS? So far my labs are not to bad. Cheers
I think I only know of renal failure.
Renal failure includes multiple myeloma because the bence Jones proteins and light chains produced by the multiple myeloma cells damage the kidneys which will then be unable to prevent proteins from being filtered out. That's what I think
SubhanAllah your lecture is very good
Thanks a lot
YOU RE THE BEST EVER .. THANK U
Thanks a ton!
Nicely done
Thank you 🙏
Extradural mass may cause herniated nucleus purposes pressing on other nerve roots
Thanks a lot for the great Video!
But why phoresis and immunofix in the urine, if you already did that in the serum? Wouldn't it be smarter to additionally perform light chain quantitation in the serum and protein differentiation in the urine and skip the phoresis +Immunefix in the urine?
Thoughts on Free Light Chain testing?
Bundle of thanks ❤
My pleasure! ❤️
Are there any surgery videos on the chanel ?
I have a surgery course on my website: medicosisperfectionalis@gmail.com/
What is b2M? Explain it to me please DrM and what is its role or function?
What type of electrophoresis is used? Gel or capillary?
I don’t know 🤷♂️
Thanks , May Allah bless you
Thanks...You too!
Why uremia in case of MM do not cause HAGMA ? Does the decrease of Albumin exceed the increase of uremia & hyperlipidemia ?
i have no words to appreciate you Sir ..how simply u explained this especially M spikes this was sort of Osm ... i felt in love with u...
Thankyuu
You're welcome, but what does "Osm" mean? 🤷♀️
@@MedicosisPerfectionalis I think Osmosis videos..
Or, it could be an abbreviation of “Awesome” 🤷♀️
Hi, thanks for this video! I don't understand why anion gap is low in MM - can someone please clarify?
The M component is cationic which results in retention of Cl- and a reduced AG
Exactly! In myeloma it is the marked increased in cationic protein (IgG or other paraprotein) in plasma that causes the reduced AG.
Yes, the previous replies are correct. Harrison's Internal Medicine, p 796, says "Patients with multiple myeloma have a decreased anion gap because the M component is cationic, resulting in the retention of chloride."
thank u guys! u really help me with this :x
Because Na++ must be lost to maintain the electroneutrality hence hypotention along with proteinuria
je suis francophone et j'ai trouvé ta chaîne par hasard et je te trouves génial merci bien docteur mais s'il te plait comment je peux télécharger tes notes et tes schéma sous forme de PDF ?
Elkorso Sanaa Avec Plaisir: www.medicosisperfectionalis.com/ or www.patreon.com/medicosis/
@@MedicosisPerfectionalis est ce que c'est gratuit ?
Non
@@MedicosisPerfectionalis ok dommage mais merci bien pour tout
Lifesaver!
Thanks 🙏
what do you mean by "2 were I grew up", is it a reference I'm not getting?
he probably meant 2 where i grew up as in he was referring that his medschool had rounded it off to 2. i guess thats it
Nice service
Thanks 🙏
what program and tools do you use to make these videos? I am a nurse educator that wants to move away from powerpoint lectures towards this style of teaching and learning.
Thank you 🙏
Please send me an email: medicosisperfectionalis@gmail.com
Where's the Ans?
Thanx🌹
My pleasure 😇
maltipal mylomia disease is primary ,secondary the patient made compilet blood count and ather anylises 🌹🌹
Sir does M band detected in gamma region confirms multiple myeloma? Or it is just an indication??
Actually in my mother blood report there is a M spike in gamma region. We are really very scared right now. After that we went to a oncologist. They suggested us to do some more test like xray of skull and multiple myeloma test. We get xray of skull and it looks ok but myeloma test report will come after 4 days.
why is serum anion gap decreased in MM?
Because the loss of Na+ causes contraction to the serum due to MM. And, due to hypoalbuminemia ,the serum Cl- , COH-3 must raise to compensate for metabolic acidosis
H-E-L-P-F-U-L👍
Thank you so much 😊
😞
❤🏆
Coucou !
???
@@MedicosisPerfectionalis That's "Hello" in French.
Was hoping to hear natural ways to treat it, no luck, big pharma needs to get bigger eh?
Do you have any scientific evidence that natural ways are capable of treating multiple myeloma in a manner that’s statistically significant?
@@MedicosisPerfectionalis
It's a long story etc, but let's not ignore facts like a) studies with such natural things like cannabis are prohibited b) there's no money (for those who can fund studies) in studying something anyone can buy or do while not paying for their patented substances, c) farmaceutical companies are just businesses, they are interested in showing maybe that their (patented) drug (probably an isolated or modified molecule of what is found in nature, in plants) is better than nothing, and if they find that from natural sources the effect is much better you guess if they will publish those results or hide it. Etc.
Plus we know that strengthening our immune system can only do good, wether it's multiple myeloma we are talking about or any other disease. And yet this is successfully ignored (things like exercise, diet, bad habits, etc.) and, for some reason, a doctor will skip all that kind of things and think of the treatments only or mainly in terms of farmaceutical, patented, substances. And that's because, believe it or not, medical schools and what they teach are in farmaceutical business' pocket.
Just watched Dr. John Bergman's recently new presentation "Medical failure the delusion of diagnosis" - it too concerns the whole current failing medical system picture.
If only humans were more open minded and more suspicious of the businesses like farmaceutical business, who knows maybe how we would be a healthy society, and not an ever sicker one, killed by mostly preventable diseases and killed a lot by iatrogenic diseases, like discussed in, for example, Dr. Michael Greger 's presentations on top causes of death.
Things like that, my friend.
Still waiting to see your evidence.
@@MedicosisPerfectionalis
In that case I'm waiting to see evidence that show that patented drugs compared to hundreds and hundreds of natural medicines (herbs, spices, plants, etc.), to lifestyle changes etc, still have best results out of all.
You don't have it? What does that say? Well, only that there are no such studies (returning to my point why we don't have such studies), and not that the patented substances have best effects.
Be well.
Maybe Iodine, Vitamin C, Aspirin, Chlorophyll, NAC. What do you think ?