Agenda for IH and Narcolepsy Research with Emmanuel Mignor, MD, PhD

Dr. Emmanuel Mignot takes us on an overview of the latest research on idiopathic hypersomnia and narcolepsy, along with discussing what he sees as the future agenda for research.
Dr. Mignot is Craig Reynolds Professor of Sleep Medicine at Stanford University. He discovered that human narcolepsy is caused by the autoimmune loss of ~70,000 hypothalamic neurons secreting the wake-promoting peptide hypocretin/orexin. Dr. Mignot has received numerous awards, including the 2023 Breakthrough Prize. He is a member of the National Academies of Sciences and Medicine.
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[@ProBloggerWorld]

Emmanuel Mignot deserves to Nobel Prize. He changed our understanding of the brain 🧠 by identifying Orexin as an important neurotransmitter that influences sleep, eating, wakefulness.

[@teew7168]

I feel confused. With orexin having to be measured in a CSF sample (not in plasma), I would think it hard to imagine the idea of a protein in the blood that could be measured to diagnose NT1, NT2, or IH. Or, do I misunderstand that if orexin were to be sought by plasma proteomics, it would not be found?