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I have hematology finals tomorrow and am not even worried as always.After watching your videos,i feel no need to memorize stuffs,just undastnd.!! youre second to none.
a few miles away from Beirut 7 of my professors passed away because of covid-19 including this subject's professor but we still have to move on with our first exam this semester if it was't for this playlist i would've honestly given up and dissociated until the end of finals thank you for the awesome explanation and for your super-human power of simplifying even the most complicated points
You made me like Medicine, the way you simplify the information and the interesting way you conduct the lesson especially when you say "and this is the whole story morning glory" I even started to use it sometimes when I talk 😂 Thanks so much Dr ❤️ All my love from Sudan 🇸🇩
Mcv can be high in myelodysplasia. Because MDS is also a cause of non megaloblastic macrocytic anaemia. So MDS may have low mcv or high mcv. Low mcv- if MDS is a cause of sideroblastic anaemia and High mcv- if MDS is a cause of non megaloblastic macrocytic anaemia
But the question is when is mcv high in sideroblastic type of anemia and not other type like non megaloblastic macrocytic anemia... The stain is prussian stain.
You made me like Medicine, the way you simplify the information and the interesting way you conduct the lesson especially when you say "and this is the whole story morning glory" I even started to use it sometimes when I talk 😂 Thanks so much Dr ❤️
You are so smart, such a great teacher, and you are very funny. thank you!! I've always thought learning should be fun, and your sense of humor absolutely makes learning fun!
lead poisoning is often listed in textbooks as a cause of sideroblastic anemia. It is the author's experience, however, that lead poisoning is not associated with sideroblastic changes [76]. Like sideroblastic anemia, lead poisoning can cause anemia, a low reticulocyte count, and neurologic changes. Like sideroblastic anemia, lead poisoning is associated with disordered heme synthesis. Unlike sideroblastic anemia, lead poisoning typically produces heavy basophilic stippling rather than Pappenheimer bodies in RBCs or ring sideroblasts. Unlike sideroblastic anemia, lead poisoning is associated with elevated blood lead levels.
I am glad to know the nutritional equivalents to the body's absorption placement to help my acquired symptoms with no general defects. I combine my personal experience with food and your technical instructions. Keep posting! Thanks for helping me save my life!
Thank you very much! I love the etymology thing very much as well! IMO sidero- means star, -blast means immature cell It is a type of immature cell that look like a starry sky It is not called siderocyte because siderocyte is a mature RBC that looks like a starry sky Please comment if I am wrong :P
+Lee Romeo I think “Sidero”- here means iron, as we say “hemosiderosis”... blast means: growing, germ, or cell with a nucleus. But thinking of it as a star or constellation helps during studying but I am not sure it’s scientifically accurate. That’s all that I know :)
Congenital forms often present with normocytic or microcytic anemia while acquired forms of sideroblastic anemia are often normocytic or macrocytic. Congenital forms including X-linked SA, autosomal recessive SA, genetic syndromes Acquired forms including acquired clonal SA (which fall under the broader category of myelodysplastic syndromes (MDS)), acquired reversible SA (alcoholism, pyridoxine deficiency, lead poisoning, copper deficiency, excess zinc) Prussian blue stains iron
It's MDS, because in this condition there is JAK 2 gene mutation, this gene codes for a protein called Juan kinase, it's a protein that transmit stimulations from hormones like EPO and thyroxine to the nucleus helping in cell differentiation, thus the cell will get the ability to have new functions like Hb synthesis. Each time the cell gets a new function, it's work-list increases so it will be less interrested by division instead of maturation. In the mutation of Jak2, the cell keeps it's ability of division but lose it's ability for maturattion,this mutation happens so early in the pathway before even pro-erythroblastic state. This mutation can alse affect others blasts from # lineage not only erythroblasts, so the divisions increase and they consume vit B12 so the cells becomes macrocytic instead of being blastic ( having big size). And because there is no maturation of RBC's, there will be no synthesis of Hb components cause there will be no EPO and other hormone stimulus cause there in no jak2. And then the mitochondria surrounding the nucleus charges with Fe and wait for it's clue (enzymes) essential for Hb synthesis, that will never come. So we will have macrocytic sideroblasts. In the case of alcohol yes we can have vit B12 deffeciency (causing macrocytosis) but in opposition we may have sideroblastosis and decrease in Hb synthesis (microcytosis), if both of them meets they can lead to normocytosis.
What does "they become macrocytic and not blastic"mean? Is it Because if the vit b12 gets over due to excess usage even the blasts won't be produced and whatever cells are already in circulation would be macrocytic.bcz now even the blasts can't be made
@@luffy101n2 No myelodysplasia is different from aplasia, the first one there will be blasts but few ones cause there is a lack of vit B12 not total absence, so there will be divisions that give big cells and those cells because they are big they remain few this is why we have anemia but in the case of Aplasia there is no Blasts at all. 0 bone marrow.
Chronic alcohol use may lead to macrocytic but sideroblastic anemia. Iron can be visualised with prussian blue stain. Am I right? Thank you for the video
Erythrocyte protoporphyrin - The erythrocyte protoporphyrin (PP) measurement has not been systematically examined in the majority of sideroblastic anemia types and has limited value in diagnosis. RBC PP values have been established in a few forms: ●In X-linked sideroblastic anemia (XLSA) and with defects in SLC25A38, the erythrocyte PP level is uniformly low because heme synthesis and hence protoporphyrin production are reduced ●In XLSA with ataxia (XLSA/A), erythrocyte PP is increased (mainly as zinc protoporphyrin) [9,10] ●In MDS disorders with ring sideroblasts, erythrocyte PP is characteristically increased up to 300 mcg/dL (normal: 20 to 80 mcg/dL)
Iron stain is prussian blue. In acquired type MCV is high Ex. MDS ......... AND I HAVE A QUESTION TOO, WHY YOU DONOT COMMENT ON RETICULOCYTE? IN SIDEROBLASTIC ANAEMIA THERE IS INEFFECTIVE ERYTHOPOIESIS SO THERE WILL BE RETICULOCYTOPENIA IN RELATIONS TO ANAEMIA.
MCV can be high ie macrocytic in acquired forms eg MDS, medication s eg isoniazid, chemotherapy etc, and also in alcohol abuse. Stain with Prussian blue
ANSWER: MCV is expected to be high in cases of Myelodysplastic Syndrome. Stain used for sideroblastic anemia are New Methylene Blue and Wright Stain. Correct me if I'm wrong. I'm grateful to you sir, thank you so much. P.S. more info in MDS pls. :)
I finally know what the heck Sideroblastic anemia is, thank you! Also MCV would be high in MDS And a personal request, can you make a video for MDS vs Aplastic Anemia, I know you have one video for each but it would be very helpful to make a comparison video to highlight the differences and similarities between the two conditions.
@@mty6391 Sorry its been nine 9 months but I dont really know what caused it sorry. i've had it since I was born and I cannot remember an actual reason for it. Im sorry
@@MedicosisPerfectionalis I’m IM resident , and I found your videos very useful to me clinically and for Exams , I feel gratefully when I see some persons love to make other people learn like them and make the complex things easier, ALLAH love this people, Thank you again🙏
Is it that the MCV would be high in the sideroblastic anemias caused by a myelodysplastic syndrome, having an underlying megaloblastic process as well? You can see stainable bone marrow iron by staining with the Prussian Blue stain.
💉 📜 50 hematology cases are waiting, as well as the answer to today's question...Go to www.patreon.com/medicosis/
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Mds
mds
In alcoholism, MCV is increased because of macrocytosis
Prussian blue(Perl's reaction) is used for staining the sideroblast rings
Thank you
By all means you are the very best in this subject, no one makes it simpler and clearer than you! So glad that I met you!
+Lee Romeo Me too! That’s so kind of you...I don’t deserve all of that! I am just a regular student trying to make something big!
Thanks again.
I have hematology finals tomorrow and am not even worried as always.After watching your videos,i feel no need to memorize stuffs,just undastnd.!! youre second to none.
Thanks, bro, good luck!
Do you wanna see more Biochemistry videos?
Yes please
Sure!
Yes please
Yesss
yaa
The most extraordinary training I've ever seen .sideroblastic anemia was so hard for me to understand
Thank you sooo much
My pleasure 😇
a few miles away from Beirut
7 of my professors passed away because of covid-19 including this subject's professor but we still have to move on with our first exam this semester
if it was't for this playlist i would've honestly given up and dissociated until the end of finals
thank you for the awesome explanation and for your super-human power of simplifying even the most complicated points
I didn’t do anything!
Thank you so much for watching!
And I am so sorry to hear what you’ve been through...It must’ve been hard.
my heart goes out to you.
it is almost humiliating how we bitch and moan about our easier lives
really makes me introspect
Omg!
You made me like Medicine, the way you simplify the information and the interesting way you conduct the lesson especially when you say "and this is the whole story morning glory" I even started to use it sometimes when I talk 😂
Thanks so much Dr ❤️
All my love from Sudan 🇸🇩
I appreciate you!
Saving millions of lives with the health professionals you teach👏🏾👏🏾👏🏾👏🏾💐💐💐Thankyou kind sir!
Thank you so much!
I am honored and humbled!
Mcv can be high in myelodysplasia. Because MDS is also a cause of non megaloblastic macrocytic anaemia. So MDS may have low mcv or high mcv.
Low mcv- if MDS is a cause of sideroblastic anaemia and
High mcv- if MDS is a cause of non megaloblastic macrocytic anaemia
what about the alcoholism?It too can cause high MCV
@@thisumamarasinghe8171 it will lead to non megaloblastic anemia
But the question is when is mcv high in sideroblastic type of anemia and not other type like non megaloblastic macrocytic anemia...
The stain is prussian stain.
@@favromcomscenes3903 ok
"I know. I am boring" 😂😂😂😂 Thanks for explaining this topic. Very easy to understand now.
Thank you so much 😊
U r a doctor from another planet
Thanks 😊
8:45 acquired sideroblastic anemia. Prussian blue staining for iron
You made me like Medicine, the way you simplify the information and the interesting way you conduct the lesson especially when you say "and this is the whole story morning glory" I even started to use it sometimes when I talk 😂
Thanks so much Dr ❤️
Haha 😂
You’re very welcome, Sir!
Now let us know the answer doc ☺️
You are so smart, such a great teacher, and you are very funny. thank you!! I've always thought learning should be fun, and your sense of humor absolutely makes learning fun!
May Allah bless you!
Love from Bangladesh 🇧🇩
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“I know I’m boring” BUT no you aren’t!! I love your videos:)
Thank you so much 😊
Amazing series on anemia..conceptual approach and so simplified..thank you so much🤗 helped a lot in preparation of the topic🤗
Awesome 👏
Because of yours other videos
I was able to answer our demonstrator's question which other students were unable to answer!!
I am so glad 😃
Much thanks and love 💕 A pharmacist from 🇩🇿 is saying Hi
bless your soul. Saved my grades !
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I am so happy right now 😃
lead poisoning is often listed in textbooks as a cause of sideroblastic anemia. It is the author's experience, however, that lead poisoning is not associated with sideroblastic changes [76]. Like sideroblastic anemia, lead poisoning can cause anemia, a low reticulocyte count, and neurologic changes. Like sideroblastic anemia, lead poisoning is associated with disordered heme synthesis. Unlike sideroblastic anemia, lead poisoning typically produces heavy basophilic stippling rather than Pappenheimer bodies in RBCs or ring sideroblasts. Unlike sideroblastic anemia, lead poisoning is associated with elevated blood lead levels.
Acquired sideroblastic anaemia is frequently associated with myelodysplastic syndrome (macrocytic anaemia). high MCV.
I am from India. Thank you so much for your explanation☺️
My pleasure 😇
Can you please help me by sharing?
@@MedicosisPerfectionalis yes sure!😊
Prussian blue staining (Perls’ reaction)
Is it really??? As i forget it??
الحمد لله انى لقيت القناة دي 😊
🙏
Actually you're our real professor
Thanks a ton!
I am honored!
Can you please help me by sharing?
mcv is high in MDS, and the stain used for staining iron is prussian blue
Excellent!
You're better than alot of doctors 💕
I screened ur slides.. I'm happy cz I understood them easily
Great...That’s amazing!
I am glad to know the nutritional equivalents to the body's absorption placement to help my acquired symptoms with no general defects. I combine my personal experience with food and your technical instructions. Keep posting! Thanks for helping me save my life!
You’re not boring but Great! Thanks a lot for this video so helpful
Thanks a million!
Your connection to the information is wonderfull
Thanks, bro
Prussian Blue- Fe stain
+x Correct
Prussian blue iron stain
Right!
Are you internist? Dude im amazed by how much information you hold in your brain...love your videos
Thank you so much 😊
I am not an internist!
Thank you very much! I love the etymology thing very much as well!
IMO sidero- means star, -blast means immature cell
It is a type of immature cell that look like a starry sky
It is not called siderocyte because siderocyte is a mature RBC that looks like a starry sky
Please comment if I am wrong :P
+Lee Romeo I think “Sidero”- here means iron, as we say “hemosiderosis”... blast means: growing, germ, or cell with a nucleus. But thinking of it as a star or constellation helps during studying but I am not sure it’s scientifically accurate.
That’s all that I know :)
Congenital forms often present with normocytic or microcytic anemia while acquired forms of sideroblastic anemia are often normocytic or macrocytic.
Congenital forms including X-linked SA, autosomal recessive SA, genetic syndromes
Acquired forms including acquired clonal SA (which fall under the broader category of myelodysplastic syndromes (MDS)), acquired reversible SA (alcoholism, pyridoxine deficiency, lead poisoning, copper deficiency, excess zinc)
Prussian blue stains iron
I am from Iraq
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You just maked me professionalis
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I absolute love your lectures, it’s concise and I like your humour 😂 makes it fun so I don’t fall asleep half way through!
Thank you 🙏
It's MDS, because in this condition there is JAK 2 gene mutation, this gene codes for a protein called Juan kinase, it's a protein that transmit stimulations from hormones like EPO and thyroxine to the nucleus helping in cell differentiation, thus the cell will get the ability to have new functions like Hb synthesis. Each time the cell gets a new function, it's work-list increases so it will be less interrested by division instead of maturation.
In the mutation of Jak2, the cell keeps it's ability of division but lose it's ability for maturattion,this mutation happens so early in the pathway before even pro-erythroblastic state.
This mutation can alse affect others blasts from # lineage not only erythroblasts, so the divisions increase and they consume vit B12 so the cells becomes macrocytic instead of being blastic ( having big size).
And because there is no maturation of RBC's, there will be no synthesis of Hb components cause there will be no EPO and other hormone stimulus cause there in no jak2. And then the mitochondria surrounding the nucleus charges with Fe and wait for it's clue (enzymes) essential for Hb synthesis, that will never come. So we will have macrocytic sideroblasts.
In the case of alcohol yes we can have vit B12 deffeciency (causing macrocytosis) but in opposition we may have sideroblastosis and decrease in Hb synthesis (microcytosis), if both of them meets they can lead to normocytosis.
Woahh amazing 👏
What does "they become macrocytic and not blastic"mean? Is it Because if the vit b12 gets over due to excess usage even the blasts won't be produced and whatever cells are already in circulation would be macrocytic.bcz now even the blasts can't be made
@@luffy101n2 No myelodysplasia is different from aplasia, the first one there will be blasts but few ones cause there is a lack of vit B12 not total absence, so there will be divisions that give big cells and those cells because they are big they remain few this is why we have anemia but in the case of Aplasia there is no Blasts at all. 0 bone marrow.
u r not boring!! u r hilarious & i lov ur channel so much!
❤️❤️
thanks alot Sir.....it's wash off all my difficulties related to it✨
.... "I know am boring"
I just love this crazy genius...
Thank you ☺️
the mcv will be high in sidrobalstic anemia .. in case of MDL .. myeloid leukemia ..
and the stain that used to stain iron stores is Perls stain .
Chronic alcohol use may lead to macrocytic but sideroblastic anemia. Iron can be visualised with prussian blue stain. Am I right? Thank you for the video
MCV is normal in sideroblastic Anaemia that is X-linked.
The stain used is Prussian blue stain
You are the legend in this topic ❤️
Thank you 🙏
"I know am boring"
Not at all, you are amazing 🌸
Thank you dear for always encouraging me :)
You are shitting me right
Erythrocyte protoporphyrin - The erythrocyte protoporphyrin (PP) measurement has not been systematically examined in the majority of sideroblastic anemia types and has limited value in diagnosis. RBC PP values have been established in a few forms:
●In X-linked sideroblastic anemia (XLSA) and with defects in SLC25A38, the erythrocyte PP level is uniformly low because heme synthesis and hence protoporphyrin production are reduced
●In XLSA with ataxia (XLSA/A), erythrocyte PP is increased (mainly as zinc protoporphyrin) [9,10]
●In MDS disorders with ring sideroblasts, erythrocyte PP is characteristically increased up to 300 mcg/dL (normal: 20 to 80 mcg/dL)
Thank you 🤩
You’re welcome!
Man, this looks so easy when i am on your videos I felt like i am hematologist lol🥰
Thank you 😊
Iron stain is prussian blue.
In acquired type MCV is high Ex. MDS
.........
AND I HAVE A QUESTION TOO, WHY YOU DONOT COMMENT ON RETICULOCYTE?
IN SIDEROBLASTIC ANAEMIA THERE IS INEFFECTIVE ERYTHOPOIESIS SO THERE WILL BE RETICULOCYTOPENIA IN RELATIONS TO ANAEMIA.
MCV can be high ie macrocytic in acquired forms eg MDS, medication s eg isoniazid, chemotherapy etc, and also in alcohol abuse. Stain with Prussian blue
macrocytic in sideroblastic anemia is seen in the acquired form
I love your teaching very much. Thanks, I learn a lot. :)
+reachtt That’s why Medicosis exists! Thanks for your great words! My pleasure!
Awesome presentation... Will never forget sideroblastic anemia.. thank you.
My pleasure 😇
MCV is raised in acquired type .. Perls' prussian blue stian .. Thans ^^
in b6 deficiency then?
Mcv often raised in acquired type.
Excellent!
Also in MDS.
ANSWER: MCV is expected to be high in cases of Myelodysplastic Syndrome. Stain used for sideroblastic anemia are New Methylene Blue and Wright Stain. Correct me if I'm wrong. I'm grateful to you sir, thank you so much. P.S. more info in MDS pls. :)
I think the stain is Perls Prussia Blue
Mcv is high in alcohol chronic
NO, you are not boring❤️
Thank you so much 😊
Your videos are so helpful! Thank you for making them !
+EnchantedBanana101 Wow! Thank you for watching them. I really appreciate you taking time and writing me a great comment. Wish you all the best!
Your fantastic! Stop saying your boring.
Thanks 🙏
Purrsion blue
bundle of thanks from Afghanistan 🙂
You’re welcome 😊
Anemia is microcytic in congenital causes of SA
And macrocytic in acquired causes
MCV is high in sideroblastic anemia in myelodysplastic syndrome
In acquired ones
As Alcoholism, Myelodysplastic syndrome
Thank you very much ..an amaaazing series
My pleasure 😇
Nucleus persistence > mRNA > protein > inc cytoplasm > Inc cell size > High MCV
In MDS, MCV increases!
Excellent!
MCV is high in acquired sideroblastic anemia
...The moment I found myself shouting "Perl's stain" to my screen.
very nice so easy, wow i wish college professors can teach the same way
YOU ARE BEST😍😍😍😍😍😍😍
Thank you 🙏
Mcv is going to be high if it’s an acquired clonal cause in Myelodysplastic syndrome
Excellent
, As always excellent and well presented information. Thank you.
+Basheer Oudah Thank you for watching
you are amazing .. thank u for making it easy .
You’re very welcome 😊
I finally know what the heck Sideroblastic anemia is, thank you!
Also MCV would be high in MDS
And a personal request, can you make a video for MDS vs Aplastic Anemia, I know you have one video for each but it would be very helpful to make a comparison video to highlight the differences and similarities between the two conditions.
Thank you so much 😊
I actually have sideroblastic anemia :) I go to the hospital all the time for blood transfusions
what is the cause
@@mty6391 Im not actually sure, I'll have to get back to you
@@mty6391 Sorry its been nine 9 months but I dont really know what caused it sorry. i've had it since I was born and I cannot remember an actual reason for it. Im sorry
🩸 Hematology Playlist: ruclips.net/p/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU&si=tomFsUjAgOKhOJVq
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very helpful
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Your videos are sooo helpul thanx
Cause alcohol cause it's associaed with B12 deficiency
Thanks a lot, but I didn’t understand the second half of your comment. Can you elaborate?
MCV high with Sideroblastic Anaemia = MDS
Prussian blue stain of RBC in marrow shows ringed sideroblasts.
It could be myelodysplastic anemic or alcohol excess which can cause macrocytic without megaloblastic anemia
Yor are amazing
MCV ⬆️ in B6 deficiency
MCV is high in MDS.
Thank you 🙏
Nice explanation
Thanks:)
perls prussian blue staining is used in fe staining of bone marrow specimen
Great...But what does “perls” mean?
Stain for iron is pearl stain or Prussian blue.
Thank you! I think it’s “Perls”, not “pearls”.
as always.. you are the best , 💙
Thank you 😊
Perfect lectures
Thank you 🙏
Prussian blue stain for visualization.
Qotd- heavy alcoholism?
you are very awesome -from Egypt
Thank you 🙏
7:50 Prussian blue stain
Excellent!
@@MedicosisPerfectionalis 😊
High MCV- MDS.
For see the sideroblast in BM- Perl's stain to be done.
Purssian blue stain
Sideroblastic anemia with MDS would give a high MCV
Excellent
@@MedicosisPerfectionalis thank you for your videos!
In sideroblastic anemia:
Low MCV in congenital type
High MCV in acquired type
Hey
Thank you a lot
My pleasure 😇
@@MedicosisPerfectionalis I’m IM resident , and I found your videos very useful to me clinically and for Exams , I feel gratefully when I see some persons love to make other people learn like them and make the complex things easier, ALLAH love this people, Thank you again🙏
In alcoholism mcv can be raised
Is it that the MCV would be high in the sideroblastic anemias caused by a myelodysplastic syndrome, having an underlying megaloblastic process as well?
You can see stainable bone marrow iron by staining with the Prussian Blue stain.
In acquired form of sideroblastic anemia MCV might goes up or normal. In MDS it goes high.