Myelodysplastic Syndrome (MDS) - a precursor to Acute Myeloid Leukemia (AML) ?! - Hematology Series

Myelodysplastic Syndrome (MDS) - Between Normal & Acute Leukemia (AML) - Hematology Series.
Myelodysplastic syndrome (MDS) is an intermediate state between normal and acute myeloid leukemia (AML).
The MDS patient is usually an elderly person with anemia, leukopenia, and thrombocytopenia (pancytopenia).
Myelodysplastic syndrome is a stem cell disorder characterized by ineffective hematopoiesis.
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MEDICOSIS PERFECTIONALIS
In brief, Myelodysplastic syndrome (MDS) is a stem cell disorder characterized by ineffective hematopoiesis, pancytopenia and bone marrow dysplasia...There is a risk of malignant transformation into AML. If you like my videos, please consider leaving a tip at www.paypal.me/perfectionalis/
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[@deemam.3334]

Never enjoyed studying hematology till i found your channel, thanks! It hella makes sense now

[@MedicosisPerfectionalis]

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After watching many of these videos, my brain size increased by 50%. This is definitely a very good prognosis!

[@MedicosisPerfectionalis]

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I agreee by brain size has increased

[@MedicosisPerfectionalis]

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[@reaganssali1438]

You’re making hematology look easy. Thank u so much❤

[@MedicosisPerfectionalis]

My pleasure 😇

[@fourdayhomestead2839]

Watching to understand my grandsons labs. Thank you for jogging my memory from collage classes.

[@delevoyeguillaume9126]

I'm doing a machine learning project on data from HSCT. My hematology courses were 5 years ago I had forgotten nearly everything. Now all my old memories come back thanks to your videos... Thank you ! It could be really perfect if you'd think some day of changing the batteries of the smoke detector that we hear every minute or so :D Otherwise these are really, really cool videos thanks

[@MedicosisPerfectionalis]

Haha 😂
You’re very welcome 😊

[@saadkhan2255]

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Didn't skip ads for you sir! Thank you!
Harrisons has been difficult for a student like me with visual memory..

[@MedicosisPerfectionalis]

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I appreciate you!

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[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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قبل ايام كنت اشعر ان أمراض الدم شئ لن افهمه لان الطبيب البروفيسور الذي يكثر الكلام بلا فائدة جعلني اكره امراض الدم ولكن الان اشعر بمعلومات قيمة جدا … شكرا جزيلا 🎉❤

[@MedicosisPerfectionalis]

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This video really helped me for my PhD interview! Thanks a lot. Great job. I am really interested in haemato-oncology so your videos are really helpful!

[@MedicosisPerfectionalis]

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This’s amazing, unbelievably good , Please please please make videos on CHF management, you make things look way easier and help me understand, big chubby thanks 🙏

[@MedicosisPerfectionalis]

My pleasure 😇

[@prabalmajumder5179]

Sir all your lectures are just awsome...please elaborate the findings of DYSPLASIA in peripheral smear microscopy ..thanks

[@kerriann8836]

“Low retic count, because your bone marrow is a loser” 😂👌🏼

[@MedicosisPerfectionalis]

Kerri Ann Hehe 😁
Just a joke!

[@safari4342]

Great vid. I found your other haematology vids very useful.

[@MedicosisPerfectionalis]

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i keep watching ur hematology playlist for my exam, thanks for good summary!

[@MedicosisPerfectionalis]

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Saved millions of medical students worldwide!!

[@MedicosisPerfectionalis]

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I can relate

[@sarahabdelkarim9284]

you answered all my questions :) thank you very much

[@MedicosisPerfectionalis]

You’re welcome 😊

[@Shantanu.Shandilya]

Amazing explanation! Thanks for clearing up every possible doubt.

[@MedicosisPerfectionalis]

Glad it was helpful!

[@asmahanijamaludin4465]

thank you for the great video, my 4 yrs daughter was diagnosed with MDS with monosomy 7 recently and this video helps me a lot!

[@MedicosisPerfectionalis]

I am sorry to hear that about your daughter...How is her health now?

[@asmahanijamaludin4465]

@@MedicosisPerfectionalisthank you for reply, she is doin great, will undergo a Haplo - HSCT in June this year.

[@MedicosisPerfectionalis]

I wish you the best!

[@waqasawan4771]

Great work thanks for that much effort it was always confuse in MDS topic before i watch this video but now u cleared my concept ...

[@MedicosisPerfectionalis]

Thank you 🙏

[@farheenmalik1342]

Excellent! thoroughly enjoyed it!

[@MedicosisPerfectionalis]

I am so delighted to hear that...Thanks:)

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very good content - I subscribed to your channel.
thanks for your work

[@MedicosisPerfectionalis]

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[@MedicosisPerfectionalis]

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so very helpful ,simple and rich content !! I don't understand why you don't have so much views !!

[@MedicosisPerfectionalis]

Thanks a ton, dear, for your kind words! Please share my videos when you have time...Thanks!

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[@MedicosisPerfectionalis]

Thanks:)

[@seanmock1135]

I have myeloid Dysplastic/AML...just trying to learn all I can. Thanks...my third cancer...papillary adenocarcinoma thyroid was 1st, the dermatofibroidsarcoma protuberance and now this. I also had a brain tumor...

[@MedicosisPerfectionalis]

Wow!
I am so sorry to hear that!
Keep fighting, and never give up.

[@rajeshwarpaulgaming3338]

Hey.. How are you now? I am also suffering from mds... I m 28. Can you suggest me the best possible treatment...

[@geradmahega1570]

Thank you for good explanation on MDS and other vids

[@MedicosisPerfectionalis]

You’re welcome 😇

[@edwinchesi1294]

Woow, so educative, thanks alot.... Was hard understanding MDS but now it's so simple

[@MedicosisPerfectionalis]

Thank you 🙏

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Superb one.. Appreciating your noble efforts

[@MedicosisPerfectionalis]

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Super simple explanation in short video ..Huge thanks .. cheers 🥂

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[@MedicosisPerfectionalis]

My pleasure 😇

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Plz explain what is difference and clinical importance between large and nu cleated rbc n in which disease it occur..

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give this man a medal... unbelievably easy

[@MedicosisPerfectionalis]

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Thank you

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[@MedicosisPerfectionalis]

Thank you!

[@udarapandikorala6777]

nicely done. thanks for making this

[@MedicosisPerfectionalis]

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[@RohanKayani]

Thank you so much. I was so confused between myeloproliferative, mylodysplastic, and aplastic anemia. You explained all of them brilliantly. Thank you so much!

[@MedicosisPerfectionalis]

My pleasure 😇

[@Sky-sr2bf]

what is the cause of monocytosis here ?? n thank you so much

[@placo10100]

Hello and thank you for this most informative video my mother was recently diagnosed with MDS she is currently 15 to 20% blast with a left shift can you say what life expectancy under these conditions and best treatment she is in her eighties

[@MedicosisPerfectionalis]

Hey...Thanks for the question...I am so sorry that your mother and you are going through this...Unfortunately, I cannot do that based on this information, only her doctor who knows all her history, physical exam, labs, biopsies and radiology imaging can make that decision....Regarding her age, its harder, but again, the pros and cons of treatment should be discussed with her physician...Sorry I couldn’t help...Also, if she doesn’t like her doctor, both of you can seek a second opinion...Take care!

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Please make cardiology videos
Your videos saved my life

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Amazing lecturing skills!

[@MedicosisPerfectionalis]

Thank you so much!

[@THX-2208]

I have a friend who was on the haematology ward with me. We both went through pretty intense Chemotherapy together and have become really good friends. I was rejected for a stem cell transplant because I became so poorly on the treatment and was very close to death a few times but thankfully my friend got though his treatment and had a stem cell transplant but unfortunately just over a year later he has told me he has been diagnosed with Myelodysplastic Syndrome and I don't know what this means. I was hoping someone here could explain what are his options. He had lymphoblastic leukaemia while on the ward and I don't understand how he could have gotten this after a stem cell transplant. Thank you so much

[@rajeshwarpaulgaming3338]

Hey.. How is your friend now... I am also suffering from mds.. Fully depended on blood transfusion

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best tutorial ever

[@khamikos1]

THANKS SIR. THAT WAS GREAT.

[@MedicosisPerfectionalis]

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[@srinivasaraosirasapalli5104]

veru nice sir.can you make video on pelger heut anomaly and pseudo pelger heut anomaly?

[@MedicosisPerfectionalis]

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You make it so enjoyable. I’m the one with ET

[@MedicosisPerfectionalis]

You mean essential thrombocytosis?

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Excellent
Last case open my mind❤❤
شكرا

[@MedicosisPerfectionalis]

You're welcome!

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This is quite Helpful Prof thank you

[@MedicosisPerfectionalis]

My pleasure!

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[@MedicosisPerfectionalis]

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Your videos are like watching an interesting movie. Thank u.

[@MedicosisPerfectionalis]

Thank you 😊

[@amineaboutalib]

what about mixed MDS/myeloproliferative disorders?

[@dr.elaineluther6562]

Ringered sideroblasts occur only in the bone marrow. They are not seen in peripheral blood smear.

[@patrick_okora]

Thanks so much.
This makes so much sense.
Why haven't I been paying my school fees to you???? 😭☹️

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Thank you for the very informative info on MDS.

[@MedicosisPerfectionalis]

I appreciate you!

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Great job

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You are very welcome!

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[@MedicosisPerfectionalis]

My pleasure!

[@vinodkumar-sz1lj]

My mother MCV 88.6 , was diagnosed MDS EB 2 . Not getting relief after 7th session of chemo ( 7*7) around 50 days Azacitidine but still 15% blast cell. Please suggest age 68

[@Hawk89gt]

My father (75) was just diagnosed with MDS, this was a very good video. Thank You.

[@MedicosisPerfectionalis]

You’re very welcome!
How is your father’s health?

[@omarbadr8187]

For the Question
Why not CML?

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[@MedicosisPerfectionalis]

Thank you!

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[@MedicosisPerfectionalis]

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Seems like I am addicted to this channel
Love and respect ♥️♥️🇵🇰

[@MedicosisPerfectionalis]

Mubassir Khan Thank you so much :)

[@nyile012]

Thank you thank you thank you thank you !!!!!!!
Just need to confirm something
MDS (myeloddysplasia syndrome ) and MPD (myeloproloferative disoder) are TWO different things / diseases
MDS is when bone marrow is making abnormal cells ( dysplasia) and they DONt go out bone therefore cytopenia
Where as
MPD neoplastic proliferation of mature / myeloid lineage cell and the cells do go out of bone marrow and causes CML/PV/ET/ and MF..( based on which cell predominately produced )
So am I right ??

[@MedicosisPerfectionalis]

Yes, you are!

[@nyile012]

THANK YOU!

[@MedicosisPerfectionalis]

You’re most welcome!

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[@MedicosisPerfectionalis]

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Thank you so much 😊

[@andytse5281]

For MDS, it could be hypocellular too right?

[@srinivasaraosirasapalli5104]

thank you sir

[@MedicosisPerfectionalis]

My pleasure 😇

[@eshraqashoor3237]

Thank you very much ☺

[@MedicosisPerfectionalis]

My pleasure!

[@juansanchez6382]

Any links to getting mds with laser tattoo removal?

[@safari4342]

are you going to upload any videos on Hodgkins and non Hodgkins lymphoma?

[@MedicosisPerfectionalis]

Yes, of course...Stay tuned.

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You are really amazing Sir!

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Thanks 🙏

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I love your videos!! and love you too
Really, are very useful, thanks so much!!

[@MedicosisPerfectionalis]

I am so happy to hear that! Please let me know if you have any questions!

[@hamzagujjar8427]

In MDS, bone marrow could be hypercellular, hpyocellular, or normocellular

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Your lectures are amazing ❤️❤️ Please if you could make videos on Hepatopathology it would be helpful 🙏🏻🙏🏻

[@MedicosisPerfectionalis]

I have a playlist called “hepatology”.

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@@MedicosisPerfectionalis yeah I checked it later and now if feel stupid 🤣

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شكرا يسطا بحبك

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[@MedicosisPerfectionalis]

My pleasure 😇
Can you please help me by sharing?

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@@MedicosisPerfectionalis ofcourse 😍

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That was sooo perfect 🤩

[@MedicosisPerfectionalis]

Thank you 🙏

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that was amazing

[@MedicosisPerfectionalis]

Thank you so much!

[@heradio1000]

Thanks for your video. Why is 5q deletion favorable in mds, yet unfavorable in aml? Is this correct?

[@MedicosisPerfectionalis]

You’re correct regarding the fact...However, I have no idea why that is the case. It’s just the way it is. But, that’s a great question!

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it is treatable with Lenalidomide (Revlimid)

[@abbieguerta9071]

Thank you!!!!!!

[@MedicosisPerfectionalis]

My pleasure 😇

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Good video.
The classification has been updated in 2022 though.

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Thanks

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There can be cytopenias in myeloproloferative disorders. Like myelofibrosis latter stage, full of cytopenias bro

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Which app does he use to make these awesome videos?

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[@MedicosisPerfectionalis]

My pleasure 😇