Many say that obesity leads to high CRP, but no one seems to know what the expected CRP would be in obese individuals. Just something I’ve noticed as I’ve tried to understand my own hsCRP numbers, perpetually high around 30-50, but my weight loss clinic says that isn’t what they see consistently in patients with obesity. I also don’t have any signs of autoimmune diseases, so it’s remained a mystery, which is why I wanted to know what the norms were for people with obesity. Would be cool if research might give us an expected range for people by BMI.
If adipose tissue dysfunction leads to higher pO2, as opposed to hypoxia, in humans (but the opposite in animals) due to a speculated pathological lower metabolic rate of adipocytes, then it is possible that relatively low or high pO2 is just a consequence of adipose tissue function or dysfunction, but not the cause of insulin and inflammation pathologies. It is also possible, that higher p02 due to pathological lower adipocyte metabolism, is just a temporary phenomenon, which explains the higher risk of already obese but healthy individuals to suffer insulin resistance, inflammation, and other secondary diseases. Differentials with animals may be due to some sort of evolutionary obesity adaptation, but obesity in general is a relatively new condition in humans since the industrial revolution, and widely spread only in the latter 20th century.
how do you explain the obesity and insulin resistance in patients with obstructive sleep apnoea? They also have periods of hypoxia esp at night. confusing
Many say that obesity leads to high CRP, but no one seems to know what the expected CRP would be in obese individuals. Just something I’ve noticed as I’ve tried to understand my own hsCRP numbers, perpetually high around 30-50, but my weight loss clinic says that isn’t what they see consistently in patients with obesity. I also don’t have any signs of autoimmune diseases, so it’s remained a mystery, which is why I wanted to know what the norms were for people with obesity. Would be cool if research might give us an expected range for people by BMI.
Many say that obesity leads to high CRP, but no one seems to know what the expected CRP would be in obese individuals. Just something I’ve noticed as I’ve tried to understand my own hsCRP numbers, perpetually high around 30-50, but my weight loss clinic says that isn’t what they see consistently in patients with obesity. I also don’t have any signs of autoimmune diseases, so it’s remained a mystery, which is why I wanted to know what the norms were for people with obesity. Would be cool if research might give us an expected range for people by BMI.
If adipose tissue dysfunction leads to higher pO2, as opposed to hypoxia, in humans (but the opposite in animals) due to a speculated pathological lower metabolic rate of adipocytes, then it is possible that relatively low or high pO2 is just a consequence of adipose tissue function or dysfunction, but not the cause of insulin and inflammation pathologies. It is also possible, that higher p02 due to pathological lower adipocyte metabolism, is just a temporary phenomenon, which explains the higher risk of already obese but healthy individuals to suffer insulin resistance, inflammation, and other secondary diseases.
Differentials with animals may be due to some sort of evolutionary obesity adaptation, but obesity in general is a relatively new condition in humans since the industrial revolution, and widely spread only in the latter 20th century.
这个视频对我的帮助非常大❤❤❤
Very informative
how do you explain the obesity and insulin resistance in patients with obstructive sleep apnoea? They also have periods of hypoxia esp at night. confusing
There has been some writing addressing this. it's even theorized that the apnea might be a protective mechanism (or an attempt at one)
11:04 The one on the left is metabolically healthy though?
Many say that obesity leads to high CRP, but no one seems to know what the expected CRP would be in obese individuals. Just something I’ve noticed as I’ve tried to understand my own hsCRP numbers, perpetually high around 30-50, but my weight loss clinic says that isn’t what they see consistently in patients with obesity. I also don’t have any signs of autoimmune diseases, so it’s remained a mystery, which is why I wanted to know what the norms were for people with obesity. Would be cool if research might give us an expected range for people by BMI.