If we manage to rejuvenate/replenish the stem cells then would it be possible to "fix" the ECM by chemically breaking down the tissue for the body to heal?
Thanks for your kind words! Jean brought a lot of valuable insights to the debate, and I respect his work immensely. The goal of such discussions is to make all of us think more deeply and improve our approaches. Again thanks for watching and sharing your thoughts!
I don't think partial reprogramming claims to repair all aging damage, such as telomere length, ECM cross links, mitochondria. Those are parallel research efforts addressing those. Stem cell partial reprogramming to build a replacement organ that is immune compatible is (was?) being researched at Turn Bio. Perhaps that could be a bridge between the two approaches.
Indeed, partial reprogramming primarily aims to rejuvenate cells by upregulating more youthful gene expression, which aims to prevent damage from accumulating in the first place. That said, given that tissue histology of mice treated by partial reprogramming looks better than those of control mice, partial reprogramming could also have beneficial effects on the ECM.
Papers released previously showed partial preprogramming improved all of the “hallmarks of ageing” other than telomere length. Seems clear that there will be interactions between all of the hallmarks
@@YuriDeigin It makes sense that the ECM would be effected by reprogramming, if cells start spitting out the correct proteins that would at least slow damage on that front.
Iv'e just started to watch......I hope the 'replacement' being discussed is FULL replacement i.e. everything excluding the connectome information bearing parts of brain ultrastructure p.s. audio is terrible!
how does partial reprogramming address the issue of calcium plaque in the arteries won’t the calcium plaque still be there and heart attack still occur as no drug can remove calcium plaque yet?
My original answer seems to have disappeared, not sure what's going on with RUclips comments. Basically, the main goal of partial reprogramming is to PREVENT damage from building up by upregulating more youthful gene expression in cells and the organs they comprise. So while partial reprogramming doesn't directly remove cholesterol or calcified plaques from arteries, it would likely slow down or prevent plaque buildup.
If we manage to rejuvenate/replenish the stem cells then would it be possible to "fix" the ECM by chemically breaking down the tissue for the body to heal?
Very important debate that should be discussed on a much larger scale! Bravo gents!
@@BrentNally thank you! Our field could definitely use more debates
Can't watch it - too much background noise!
I thought Jean was resistant to hearing Yuri’s actual argument which was more complex but also more compelling. Yuri wins imho
Thanks for your kind words! Jean brought a lot of valuable insights to the debate, and I respect his work immensely. The goal of such discussions is to make all of us think more deeply and improve our approaches.
Again thanks for watching and sharing your thoughts!
I don't think partial reprogramming claims to repair all aging damage, such as telomere length, ECM cross links, mitochondria. Those are parallel research efforts addressing those. Stem cell partial reprogramming to build a replacement organ that is immune compatible is (was?) being researched at Turn Bio. Perhaps that could be a bridge between the two approaches.
Indeed, partial reprogramming primarily aims to rejuvenate cells by upregulating more youthful gene expression, which aims to prevent damage from accumulating in the first place. That said, given that tissue histology of mice treated by partial reprogramming looks better than those of control mice, partial reprogramming could also have beneficial effects on the ECM.
Papers released previously showed partial preprogramming improved all of the “hallmarks of ageing” other than telomere length.
Seems clear that there will be interactions between all of the hallmarks
I made this point recently too
@@YuriDeigin It makes sense that the ECM would be effected by reprogramming, if cells start spitting out the correct proteins that would at least slow damage on that front.
Hebert being VERY sensible and conservative...
Iv'e just started to watch......I hope the 'replacement' being discussed is FULL replacement i.e. everything excluding the connectome information bearing parts of brain ultrastructure p.s. audio is terrible!
Sorry, the audio gets better after the first few minutes once AC is turned off
how does partial reprogramming address the issue of calcium plaque in the arteries won’t the calcium plaque still be there and heart attack still occur as no drug can remove calcium plaque yet?
Not sure but it seems to...to some extent anyway
@@Theodorus5 it does indeed
that’s awesome
My original answer seems to have disappeared, not sure what's going on with RUclips comments.
Basically, the main goal of partial reprogramming is to PREVENT damage from building up by upregulating more youthful gene expression in cells and the organs they comprise. So while partial reprogramming doesn't directly remove cholesterol or calcified plaques from arteries, it would likely slow down or prevent plaque buildup.
So it's not age reversal