Correct me if I'm wrong, shouldn't the reactant in the reduction reaction of FAD be FAD instead of FAD+? Is the + not correct? Because otherwise the reaction doesn't make sense
I think the error comes from the original molecule charge. The FAD+ should actually be just FAD, without the +. Then it just accepts two neutral H atoms basically (One proton and one electron from each)
I had the exact same question the first time I learned this. I think it has to do with the differences in their redox potential. High energy hydrides can be released for large amounts of energy with NADH but this is not always the ideal scenario. In some instances less energy is required for a particular metabolic step so FADH2 can be used to release an amount of energy which more precisely fits the needs of that step. If we only used NADH then we would be releasing more energy than is necessary at times. If anyone has a more precise answer feel free to elaborate or correct me.
I love your videos they help me revise concepts going into post grad. However, can you please discuss the role that magnesium plays in this? It doesn’t seem to be clear in any teachings anywhere!
Could you help me explain this? Actually how many H+ that NAD+ accepts? I also read there is anothet equation : NAD + 2H+ + 2e --> NADH + H I'm confused 🙏
The incoming high energy "package" consists of three things: H+ and TWO electrons. The first electron is used to reduce the original NAD+ molecule to NAD. The second electron is used to reduce the H+ to H. Now the NAD and H can join to make the product (NADH). All electrons have been accounted for.
You taught me more in 9 Mins than my chem professor in a whole quarter
I'm from Spain but I understood everything well. Great video my friend I had dudes about this but they are now resolved
Correct me if I'm wrong, shouldn't the reactant in the reduction reaction of FAD be FAD instead of FAD+? Is the + not correct? Because otherwise the reaction doesn't make sense
YOU ARE RIGHT
The reaction FAD+ + 2H+ +2e- ===== FADH2 seems wrong. The net reaction comes out to be FAD(+)H2.
I think you are correct. My biochem text has the reaction as FAD + H+ + H: = FADH2, where H+ is a proton and H: is a hydride ion.
You're soooooo beautiful Damian
I think the error comes from the original molecule charge. The FAD+ should actually be just FAD, without the +.
Then it just accepts two neutral H atoms basically (One proton and one electron from each)
rookie question incoming: why do we need FAD+ and FADH2 if we have NAD+ and NADH?
I had the exact same question the first time I learned this. I think it has to do with the differences in their redox potential. High energy hydrides can be released for large amounts of energy with NADH but this is not always the ideal scenario. In some instances less energy is required for a particular metabolic step so FADH2 can be used to release an amount of energy which more precisely fits the needs of that step. If we only used NADH then we would be releasing more energy than is necessary at times. If anyone has a more precise answer feel free to elaborate or correct me.
FAD can transfer single electrons (or two electrons), NAD+ can only transfer 2 electrons
Finally, a lecture on nad that makes sense and that you keep track of. Great video
Jeff thanks! :)
Man you explain better than my professor of biochemistry ! lol
I love your videos they help me revise concepts going into post grad. However, can you please discuss the role that magnesium plays in this? It doesn’t seem to be clear in any teachings anywhere!
So much better explained than any german video
Nice explanation
Great video! Inspire and educate! God bless the multiverse!
Thanks, the speech was direct and easy to grasp.
Thank you ak lectures !
this guy is the real mvp man!
FADH2 is synthesized in protein complex one?? Is that an error?
Naa in Complex 2, where no hydrogen ions are pumped (the only complex that doesn't pump hydrogen ions out of the 5)
My question is
Nad and fad always binding to apoenzyme. OR can be exist in free form without binding to apoenzyme
thanks for all the great videos. u made biochem easy!!
You are a great person 👏👏👏👏
Amazing class!!!
Should I be taking NAD like Niagen Nicotinamide Riboside or NDAH? Which one is better to take?
So if NAD supplementation makes sense does FAD supplementation make sense also?
Thank you sir. But, are they not coenzymes?...(organic non-protein part)
Everything makes sense to me now, thank you! :)
Excellent lecture!
Thanks
You're welcome Phil!
great video
This is Golden!
Hasib Haidary lol thanks! :)
Thank you so much ❤️❤️❤️❤️❤️
Could you help me explain this? Actually how many H+ that NAD+ accepts? I also read there is anothet equation :
NAD + 2H+ + 2e --> NADH + H
I'm confused 🙏
Please make more videos for vitamin metabolism!
thank you
Fairly certain that NAD+ is a coenzyme
so is this witnessed in human subjects, is it verifiable?
Where are you from.... I can't place the accent?
Very good explanation indeed :)
Souvik Das thank you!
Thank you sir!
lol who is this person!!!! so easy to understand!
thanks a lot Sir
"and when we PAHMP EM"
What's your age, man? Great explanations btw
FAD needs boron as a cofactor
amazing
Sir pls make a video on fMN nd NADP+
helpful thanks
Is FAD+ and NAD+ cofactors? I thought it was coenzymes.
Coenzymes are cofactors
thanks so much!!
You're Sabina :)
did anybody else get ASMR feels from watching this?
very useful . thanks :)
Livian Kasiraja You're welcome Livian!
I don't understand how reduction of NAD to NADH 😭
The incoming high energy "package" consists of three things: H+ and TWO electrons.
The first electron is used to reduce the original NAD+ molecule to NAD.
The second electron is used to reduce the H+ to H.
Now the NAD and H can join to make the product (NADH). All electrons have been accounted for.
Progress.
wicked man!!!
ليش ماكو ترجمة عربي -،-
Bro relax please
Where are you from.... I can't place the accent?