The microbial cause of recurrent obesity and weight regain | Dr. Eran Elinav

Many people who lose weight regain the lost weight often with additional pounds in a cycle known as recurrent (or "yo-yo") obesity. Research from Dr. Elinav's lab suggests that metabolic parameters normalize with weight loss, but characteristics of the microbiome remain unchanged. In other words, the microbiome holds a memory of past obesity that promotes weight regain. Preclinical studies indicate that repeated weight cycling shifts gut microbes to a configuration with an altered ability to metabolize flavonoids - compounds that usually help promote the burning of excess energy by adipose tissue. In this clip, Dr. Eran Elinav discusses the microbiome-related dynamics of weight regain and why some people have difficulty maintaining weight loss.
Watch the full interview here:
• Dr. Eran Elinav on Mic...
#microbiome

[@ILOVE2FeelGOOD]

Absolutely fanatic information. Learnt a LOT!
THANK YOU SO MUCH 💜

[@igiveupfine]

incredible that stomach bacteria had such an impairment on the rats health, even after they returned to a healthy weight. even after the rest of the rats bodies returned to "normal health markers", it impaired nutrition absorption and left them so pre-disposed to becoming obese again. and they became so worse overweight each time too.
edit: a few times i was on TRT and i thought it was helpful in being able to lose weight. i thought this because earlier in the week (during my weekly dose), while i had a VERY high amount of testosterone in my blood, my stomach just seemed different. it's like i was just less hungry. i wondered if it had a downstream effect on what my stomach chemistry was like.
ah, but he even said, after the "formerly fat mice" went back to their normal size, and all health markers returned to normal, their gut biomes were still "damaged" from being fat.

[@MyEpiphanies89]

I wonder if some sort of anti-microbial enema would help

[@igiveupfine]

@@MyEpiphanies89 i am completely out of my league/expertise here, but i wonder if this has any other milder similarities here to any other stomach problems like chrons diseases. much milder in nature of course, but still mildly similar in any way.

[@kathiewhite1852]

I respect your work. But how can this help me now. My family has been obese as long as we can remember. We were always dieting and lose 30 gain 40 lose 40 gain 50. Every diet known. We need help. This is problem all over the US.

[@KenOtwell]

Would a wide-spectrum probiotic help here?

[@ken3marcus]

It would be interesting to see the same study where after losing weight, the mice were split into groups and some went low fat, some went high protein / higher fat. Then compare that microbiome. What works well for me is a meat with green veggies in cheese wraps.

[@victorlopez3024]

Are these doctors MDs ?

[@KenOtwell]

Why would you ask? Medical Doctors have very little exposure to the latest research in nutrition or biology. They focus on time-tested methods that are AMA approved, which means nothing that's been learned in the last 10 years at least.

[@victorlopez3024]

@@KenOtwell Thank you for replying to my question so quickly .
I often ask if a person is a medical doctor so I know where they are coming from so I can better ev
aluate the information they are putting out. It seems like a reasonable question to me. I'm also interested in what school granted their degree. Maybe because I was raised in Palo Alto.
I certainty meant no disrespect. I'm well aware there are different schools of thought on the subject of health. I have been given great health advice by non medical doctors and bad medical advice by MDs.

[@FoundMyFitnessClips]

Dr. Elinav is an MD PhD. Dr. Patrick is a PhD. First 30 seconds of full interview usually clarifies those sort of details (incl. what institute the guest is affiliated with, if any, etc.)