Mutation in Folate Metabolism Causes Epigenetic Instability & Transgenerational Effects

Erica Watson and colleagues find that genetic deficiency in folate metabolism in maternal grandparents affects development of their wild-type grandprogeny, even if the mothers are also wild-type.

[@dawndid5972]

Thank you for this informative video on folate metabolism and mutations. So glad science had probed further to find these epigenetic effects on normal expression and development.

[@sabrina-terresinterieures]

Difficult for me (french) to understand but seems verry interessant!
Can you tell me if this mutation can make problem in umbilical cord like a unique artery in this one?
And a placenta who can't be delivered after the birth ?

[@AtarahDerek]

I tested compound het MTHFR. If one of my MTHFR genes is switched off, does that mean it wouldn't show up in my results?

[@lfbarella]

Very interesting results.