Two Main MTHFR Variants Explained: MTHFR C677T and MTHFR A1298C
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- Опубликовано: 16 окт 2024
- Discussing the two main MTHFR variations and our personal experiences with them in my recent podcast with Karalynne Call @just.ingredients.podcast
The two main MTHFR variants are MTHFR C677T and A1298C.
These MTHFR variants are also called MTHFR mutations, MTHFR polymorphisms, MTHFR SNPs.
Want to learn more about the MTHFR gene and 7 other really important ones? Read Dr. Lynch's book, Dirty Genes:
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I have the C677T type, which is homozygous. I had a serous angle closure glaucoma attack and temporarily lost my vision. Studies show that low folate and high homocysteine are implicated in glaucoma. At the time I was just divorced and I was struggling with living situation and was sleep deprived. I got emotionally triggered and it happened. All is well now and I am supporting MTHFR, but would like to do more with Seeking Health supplements.
Thank you.
All the MDs and PhDs on youtube I've seen discussing MTHFR are wrong in their diagrams and the actual pathophysiology. Homocysteine is from methionine in the first place. Converting homocysteine with coenzymes/vitamins back to methionine is not the most practical view for treatment. High B12 is known to increase oxidative stress with methionine and also creates higher histamine levels. The most rational is lower intake of methionine foods from the get go. That way you lower homocysteine from it's starting point. MTHFR "disorder" is not a disorder if supposedly 50% of the population has it. What it simply means is this is genetics of ancestors that did not eat high levels of methionine foods and have to deal with the higher levels of toxic byproducts like homocysteine, that youtbe MDs and PhDs want to recycle which will create further symptoms and a merry-go-round. Reduction of source methionine is correct treatment. It's basically also a good argument that many peoples ancestors came from vegetarian or low meat diets since methionine is higher in animal flesh products.
we would love to see the full interview...
🎯 Key Takeaways for quick navigation:
00:28 *🧬 There are 676 known genetic variations of MTHFR, but only two are commonly discussed.*
01:49 *🤚 Most genetic variations have little impact on gene function, similar to different hand shapes affecting catching ability.*
02:45 *🧬 MTHFR variants alter enzyme shape, affecting methyl folate production; 677 and 1298 are the most discussed.*
04:08 *📉 Variants at position 677 reduce methyl folate production by 60-70% with two thymidines, 20% with one.*
05:02 *🧬 Variant at position 1298 affects SAMe binding, possibly slowing enzyme function by 20%.*
07:21 *🤰 Medical interventions during pregnancy can increase prevalence of MTHFR variants, impacting offspring's health.*
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Wow
Thank you!
Im blown away because I literally have this gene mutation with autism, adhd and a few other diagnoses.
Those disorders are mainly caused by methylation and neurotransmitter issues (in simple terms).
@@Paul-hu1ht Yes
@@Paul-hu1ht and should be natural medical exemptions for all 'shots'
Homozygous MTHFR C677T plus folate transport mutations. Interesting about dying in utero. My mother nearly lost me early in pregnancy (in 1955) and she was confined to her bed for most of the pregnancy. I always thought, given all of the homozygous mutations I have and various health issues, that I wasn't meant to survive. It's been a really difficult life. No one knew that I needed extra nutritional support. And yes, I'm autistic/ADHD as well.
❤❤❤
I have the same mutation and have autism too. I’m blown away.
The motherfu$@er Jean is what it needs to be called. It sucks !
So I got tested and I'm 1298cc. I have two variants . So I'm assuming I got one copy from each parent. Still trying to figure this out n just found this out at age 54. Explains a lot for me though. I do have your book dirty genes.
@@sandikobilansky8766 do you have any siblings? Do you think they have the same variations as you?
Never thought about it this way, although I always wondered about the mathematics of transferring more insufficient variants to the next generation. Thanks Ben!
Homozygous MTHFR C677T plus folate transport mutations. My folate levels were bordering on the levels that can cause megaloblastic anemia. I'd been unable to take folate, even crumbs (tried for a couple of years), without serious side effects. Then I stumbled onto some magnesium I could handle, and when I addressed that issue, suddenly I could take folate and avert that one health crisis. I have to take 400mg daily or I get hangnails very quickly (a sign of a folate deficiency)... missing just 3 in a week will result in this sign. Had them my whole life and could never figure out why my fingers were always painfully peeling like that.
the info you shared about hangnails is very interesting. I did the 23andme swab 10 years ago & then had MTHFR tested thru bloodwork. I have 2 SNPs, one 677 & one 1298. I have had weak fingernails all my life (now 70) & some issues w hangnails. I would be interested in the form of magnesium that you now take as there are at least 10 forms. You mentioned about anemia, well……my hemoglobin & hematocrit are too high but my ferritin is ok??? Any ideas are welcome😊
Interesting, I'm curious to hear which magnesium you are taking and exactly which folate. I guess you take methyl-folate?
I like this new videos you are posting, thank you. I would like to see the whole interview.
My 3x4 genetics report says I have 1298A>C result AC. So no idea if that is different that what you are discussing. I wish there was a standard for these terms/variants. Same for in your book and you say GST/GPX and yet I have GSTM1 snips, GSTP1, GSTO2, GPX1, GSTP1. All very confusing unfortunately and also understandably.
Dr. Ben Lynch, I have both C677T and A1298C like you. Trying to to work out what's going on with my health and what I'll need to do!
Same. I am wondering what % reduction we have with this combination?
Same...I've heard we only process 20% of B Vitamins from anything we eat or supplement
So what does it mean if I have MTHFD1 G1958A/T105C haplotype >> AND
Just found out my daughter has hyperhomocysteinemia according her genome, C677T homozygous. So my question is why would a low protein low meat diet be recommended? I’ve read that meat will raise her methionine, but it also the source of the B vitamins she needs. What kind of protein is ok then?
All the MDs and PhDs on youtube discussing MTHFR are wrong in their diagrams and the actual pathophysiology. Homocysteine is from methionine in the first place. Converting homocysteine with coenzymes/vitamins back to methionine is not the most practical view for treatment. High B12 is known to increase oxidative stress with methionine and also creates higher histamine levels. The most rational is lower intake of methionine foods from the get go. That way you lower homocysteine from it's starting point. MTHFR "disorder" is not a disorder if supposedly 50% of the population has it. What it simply means is this is genetics of ancestors that did not eat high levels of methionine foods and have to deal with the higher levels of toxic byproducts like homocysteine, that youtbe MDs and PhDs want to recycle which will create further symptoms and a merry-go-round. Reduction of source methionine is correct treatment. It's basically also a good argument that many peoples ancestors came from vegetarian or low meat diets since methionine is higher in animal flesh products.
How do I know if I have one or two or either? My 698 variant is TT and my 1298 is AA.
I believe having AA alleles for 1298 would be typical. So you don't have the variant for 1298. As for 698, I'm not sure.
hi dr ben do you think the mthfr gene is more predominate in european people rather than hispanic or other ethinic people thanks
I tell you as Italian & Sicilian, it's all over the family & we're super healthy and active, but have a looooot of health issues that are serious. We're Mediterranean.
@@Jennifer-gr7hnyou meaning that your nutrition decreasing the risk of this mutation ???
Dr Lynch, ur Awesome, thanks for continuing education of this, especially as I’m Just discovering it ! As I research this, and figure out finances for supplements and test,, I’d also like to know your thoughts on the Methylene Blue micro dosing, per say, that is also very interesting, and how it may or not be connected. Thank You Sir !
My test says I have A1298C (rs1801131) as TT which it says is good.
MTHFR C677T (rs1801133) as AA which it says is poor.
So this is the version with the most reduced ability?
DR BEN, I’ve been taking methyl folate and feel great with it. I just wanted to know if it’s normal that I get hungrier since I’ve started consuming it. Thanks!! I can’t find any info on that
Yes that's normal as folate supports mitochondrial function thereby giving you more energy which requires more fuel - ie food. :) Keep in mind that at some point you may start getting methylfolate side effects - and then ease off of it. It's a great nutrient. Just needs to be used, paused and then used again and know when to use and when to pause. www.seekinghealth.com/blogs/education/methylfolate-side-effects-here-s-what-to-be-aware-of
should mean your metabolism is going up which is good
Umm... Would the left hand be considered the standard blueprint in use?
Dr. Lynch, is it theoretically possible that high estrogen due to the MTHFR polymorphism causes Pubertas precox, thanks, Dr. dent med Goran Bras?
not familiar - haven't looked into it
I have the E429A per genetic testing but i don't see too much info online when i try to research it. My genetic testing does indicate I can take Methl B vitamins to counteract.
My genetic testing also revealed I tested high for severe combined immunodeficiency disease. The reason I did this testing on my own was because of my family history of cryptogentnic Liver disease and autoimmune diseases. I lost my mom, aunt, uncle, grandmother to this Liver disease without any answers. I was sick a lot as a kid with multiple uti's, sicknesses, lung infections. Fast forward I've been diagnosed with stage 2 liver fibrosis and 5 autoimmune diseases. My uncle has crohns and other issues but is still alive on my mom's side. The problem is I can't get any of my Dr's to do the genetic testing or even listen to the fact that I did.
I have the double mutation for C677T, but normal homocysteine.. I've treated the low folate and b12. I still feel lousy after working with a dr for three years.
If your homocysteine is fine and you're supplementing with methylfolate, you are going to feel lousy. MTHFR is not something to 'fix' - it's something to be aware of.
may be some other reason you feel crap
Can you take TMG Betaine if you have either one of these genes?
you dont supplement based on SNPs - you supplement based on need. SNPs identify vulnerabilities - they don't dictate them.
The answer is yes you can. Track homocysteine with blood tests. Aim for about 7 or 8. Also methyl B vitamins help as well especially B12.
@@chrismyers9951 thank you 😊
I am homozygous for 3667, I tried TMG and it helps with anxiety. I started getting some ringing in the ears.
@@chrismyers9951 methylcobalamine
Why would supplementation during pregnancy make someone more susceptible to genetic variations?
He is saying that the supplementations are what is allowing the babies to survive to term, but because they already have the variations they will struggle with the downsides of them through life. They would have otherwise most likely not survived to term without the supplementation support.
@@tinad6812My neighbor had never heard of MTHFR……her daughter had 10 miscarriages & finally had 2 kiddos that are now teenagers.
Hey Doc, have you ever weighed in on using creatine to bring down homocystine levels? Asking for a friend.
In theory, it should work but I don't have evidence. If one already has sufficient creatine levels, then taking more won't help. Phosphatidylcholine may help instead as that also is a big homocysteine producer during the production of it. I'd look into Homocysteine Nutrients or Optimal PC.
@@DrBenLynchIs Creatine measured in a standard blood panel? My homocysteine runs high (currently around 15). I have taken Homocystex Plus off and on for several years but can’t get it down to around 7. Looking for answers.
Have you tried TMG?
Why not just take DMG or TMG both methyl donors to process folate if you have the mutation? DMG has 2 methyl donors, TMG has 3. DMG has even been documented to help with autism. Research DMG's history it's an interesting supplement.
Not everyone can tolerate them - they are hard core. Remember, it’s about the sum total of SNPs, not just any one in particular
All the MDs and PhDs on youtube I've seen discussing MTHFR are wrong in their diagrams and the actual pathophysiology. Homocysteine is from methionine in the first place. Converting homocysteine with coenzymes/vitamins back to methionine is not the most practical view for treatment. High B12 is known to increase oxidative stress with methionine and also creates higher histamine levels. The most rational is lower intake of methionine foods from the get go. That way you lower homocysteine from it's starting point. MTHFR "disorder" is not a disorder if supposedly 50% of the population has it. What it simply means is this is genetics of ancestors that did not eat high levels of methionine foods and have to deal with the higher levels of toxic byproducts like homocysteine, that youtbe MDs and PhDs want to recycle which will create further symptoms and a merry-go-round. Reduction of source methionine is correct treatment. It's basically also a good argument that many peoples ancestors came from vegetarian or low meat diets since methionine is higher in animal flesh products.
Dr Ben, i like you and i watch all your videos, please help me. My son has rs1801133AA... What do you know about that???
That is the MTHFR C677T genetic variation. It's more commonly known to have the T as the variant allele but sometimes the labs use the A which is confusing. You'll need to confirm but I suspect your son has the MTHFR C677T homozygous genetic variation which means he has a reduced ability to make methylfolate. Thus, he needs to be mindful about this. Read Dirty Genes. That's the best support.
I have both of those mutations which to you make me genetically inferior. I’m also first in family to graduate from college (and it was a top 5 college in global ranking) 6’2, financially independent before age 40, own house on beach in CA, married, two kids; work at a “FAANG” tech company, etc. Yes have struggles but much more successful than my relatives with no health struggles. Went autoimmune paleo 15 years ago, cold plunge tank next to my home office, sauna on side of house and red light therapy have all helped the journey. Also morality, you’re probably right we don’t detox well and that includes bad karmic actions. A spiritual journey also helps.
wow-that was new to me - kind of Darwins theory how the population going to get more and more sick by every generation etc
*promo sm*
what does that mean?