Download my free MTHFR symptoms and treatment guide. www.drjanellesinclair.com/mthfr Have you tested your MTHFR genetic SNPs? What did you find? Did it help your health?
Dr Janelle Sinclair how can I contact you? I have major anxiety can’t breath and I have many labs test and genesight test for MTHFR. Can you help me please
One of the most informative videos I've seen on how to compensate for MTHFR mutations in a LONG time. Great information, particularly about how to start taking supplements, the order in which you should begin your regimen, what type of negative side effects you can expect to see, and what you should do if you experience them. Bookmarking and sharing!
Thank you 🙏 I wish doctors here understood MTHFR and even know a small tid about it. I was polydrugged because of this mutation and injured by the medications I was put on never addressing the root cause. I’m trying my hardest to learn this but it’s so hard by myself. I’m also histamine intolerant so it makes it hard to eat the right foods. Please do a video on low histamine foods that are high folate. I really wish there was a cookbook for MTHFR with histamine intolerance. Thank you
Dr that hydroxo b12 with folinic acid you recommended is seriously sold out and the comments from previous purchasers says it’s frequently sold out. How can you maintain stability with a protocol this way? Hoping other brands are equally as efficacious. Btw I feel so inspired by your videos. Our lives have taken an abrupt dive because my daughter hit an all time anxiety-related high resulting in Tourette’s and the roller coaster of emotional crashes has been robbing her of her happiness. Thank you for your generosity in sharing this info on RUclips.
Thank you very much for this video, one of the useful on the internet. The only thing I did not understand is whay or how the hidroxicobalamin can help improve Methylation?
It’s the first video where someone mentioned b12 methycobalamin could be an issue. I have been taking it on suggestions of multiple ND. I stopped taking it for a few days bc I ran out and felt so much better. Thank you for these suggestions and info!!!
Hi I’ve been loving your videos. Can you please do a video on B12 supplements for helping depression. I’ve tried to look online but dosing information is very hard to find. Thank you for the videos!
How does one get tested for that? I am an expat in Korea, and I never heard of the mutation until a few days ago. And no doctor has brought up the idea. I have bad IBS, histamine problems, symptoms of pyloruria (spelling, though no one ever tested me).
Hi I respect you so much. Do you know how to increase dopamine safety for AKATHISIA and dystonia? I tried lithium orotate 5mg and it made akathisia worse. Myself and others have been injured by pharmaceuticals. Please if you could help this will save a lot of lives there’s really no treatment for it except smoking pot and I’m tired of smoking pot depressed and fighting bad intrusive thoughts because of torture.
Thank you for reinforcing the benefits of red meat fish and eggs for MTHFR. So many naturopaths and Drs think vegetarian diets are a healthier alternative
Wow what a helpful video. I just found out I am homozygous and feeling a bit anxious as as soon as I started supplementing, I suffer from crippling migraines.
@@DrJanelleSinclair Hey, thank you so much for the suggestion. Do you have an Instagram page? I’m wondering if there’s any possible way to do a consultation with you? Of course I would pay your fees. Please let me know. I don’t need medical advice. Just more like a paid friend who can walk me through this whole thing lol please let me know
@@kaoruyamazaki5724 I am available for consultations. My website is www.drjanellesinclair.com/consulting you can book in an appointment via the website. When you book in please add the upgrade option for me to analyse your test results. I can therefore give you recommendations on your genetic vulnerabilities, not just mthfr.
I'm heterozygous for dhfr, mthd1, and MTHFR C677T. Since these are all enzymes that convert folic acid into the active form of folate, doesn't this mean that I have a significantly reduced ability to complete this process? I am helped immensly by the bioactive form of folate, so I'm trying to figure out why, as someone who is only heterozygous for MTHFR C677T would benefit so much. Is there a funnel down process in methylation where if you are heterozygous at the dhfr stage, your ability to convert folic acid is limited at each stage due to enzymes working at half their abilty?
Because you are heterozygous for mthfr c677t it does mean your ability to process folate is decreased by 25%. I'm not surprised that methylfolate can be of benefit for you.
We just received our order of hydroxyl B12 and folinic acid....Only to read on the package that you cannot take it with gabapentin. Is this because it will reduce the effectiveness of gabapentin? Or is it because there is a negative drug interaction between the two?
What do you mean by not tolerating it? I just started taking both Methyl (b12 and folate) I feel drowsy but still awake which is weird. I heard if I take glycine helps. How do you feel if you overmethylate?
Thank you for this video! I have compound heterozygous MTHFR polymorphisms (C677T and A1298C). I bought a supplement called 'B-Healthy' because it has methylated folate and methylated B12 but felt worse on it! Now I know why and what to try! I have weakened COMT, compound heterozygous (V158M and H62H). I'm so excited to try hydroxy B12 as I've felt so lost since trying methylated B12 and folate and feeling worse. I have one question, is there a reason why someone could take magnesium and feel manic instead of relaxed? I have Hashimoto's so I'm wondering if maybe it helped my thyroid too much...
I"m so glad that this video has been helpful. Did you check out my COMT video too? Regarding magnesium I don't really have a reason for you. A few people do respond that way. I would suggest that you trial a different type of magnesium. I usually recommend magnesium glycinate for depression and anxiety, but others like magnesium threonate if you can find it.
Dana Does thats my next step. Going carnivore. Seeking health has some really good products to choose from. I am very intolerant to methylfolate and methylb12. I picked up this multi from seeking health that has all of the active b vitamins including R5P, and folinic acid along with a small dose of hydroxo b12 and adenosyl b12. I’m really hoping this can help out! I have TMG if I need to add methyl groups. Good luck!
Hi Dr Sinclair, Thank you for providing such clear and helpful information! I'm heterozygous for C677T only, I was wondering about my risk for restarting hormonal birth control. Previously I've used the combined pill, implant and Depo Provera. I noticed any serious negative side effects from the implant. I'm currently not on any birth control. I was wondering if it's safe for me to restart the pill, or have another Depo Provera shot? Would supplements counteract any negative reactions or is it safer to avoid completely? And is Depo safer than the pill? Thanks!
@DrJanelleSinclair Hello Doctor, I ran my DNA data through Genetic Genie (free) and 7 of 21 methylation genes have 1 variant, 6 more have double variants (MTHFR, 2x COMT, VDR, MAO-A, SHMY1). And 1/3 of my detox genes have variants. I'm disabled, l from bipolar (lucky 1%) and it's hard to spend a lot on my budget but I see you're not taking clients too. I'm wondering what supplements you'd recommend? I can send those results if you'd like too. I'd be so grateful if you have a moment to answer!
I suggest you check out the mthfr treatment report. Take note of the best B vitamins for COMT i.e. folinic acid and hydroxyB12. www.drjanellesinclair.com/mthfr Also get your vitamin D levels tested and supplement if necessary (see video on vitamin D).
Dr Ben Lunch recommends that people with the mthfr genetic weakness eat gluten free. Eating gluten free is definitely preferable especially for anyone with poor mental health to help lower inflammation in the body. But as far as I know there's no interaction between wheat and the mthfr gene or folate.
For most people there's no need. But if you have anxiety, have comt++ or are sensitive to supplements or vitamins, then yes it's a good idea. But most people including practitioners don't know this
@@DrJanelleSinclair thank you! Well, I don't know yet if I have it. But, if so, I am very prone to ( is that the word ?) Anxiety en sensitive for food en supplements and herbs etc. A lit of them don't work for me, or do the opposite of what thet d o for most people. So I can imagine that I would have to use this form.
If you don't methylate correctly, folic acid will be toxic. Folate is more bioavailable, methylfolate is even more bioavailable where as Folic Acid is a synthetic vitamin you cannot breakdown.
Folic acid is the synthetic form of folate that is found in some supplements and fortified foods. Natural folate in foods is not in the form of folic acid. So you don't avoid natural folate.
@@DrJanelleSinclair Thanks for answering that. I was confused after googling foods that contain folate and then googling foods that contain folic acid and got lists of the same foods in both categories.
That's the medical model treatment for MTHFR. But if you have the slow COMT enzyme it's likely that this dose may increase anxiety and anger. If you're homozygous for COMT rather than homozygous "normal" for COMT you may do better with folinate and hydroxyB12
@@DrJanelleSinclair I am slow COMT as well as MTHFR Homyzygus for c677. I recently lowered the dose to 7.5mg methylfolate after learning this. I’ve been taking 15mg for years. I do have some anxiety but, never noticed Initial changes when starting the 15mg. I wonder if I should stop it and try the hydroxy b12 / folincic acid your recommend in your COMT video. I just want to make sure I can still support my methylation issue. After taking 15mg for 4 years should I taper down?
The supplement I take contains the following: 400 mcg of folate - 6(S)-5-methyltetrahydrofolate, 5 mcg of vitamin B12 cyanocobalamine Should I get one with methylcobalamine or another kind? They created it specifically for this but I still have depression regardless...and feel like I am not at my best health-wise. Thank you, I am homozygote.
It's usually recommended that if you have mthfr genetic weaknesses that you take much higher doses of methylfolate. I.e. more than one capsule. I'd also suggest that you do take another supplement with higher methylcobalamine.
I just got my genetics results. I have c/c (C677T) and c/c (A1298C) and also COMT genotype A/A. Should I try supplementation? I have pcos and have always struggled with obesity and anxiety. I had preeclampsia in my first pregnancy as well and I am afraid to have another.
When I take folate (~400 mcg daily) I start to feel puffy (like an allergy): It feels like I'm taking too much. On the other hand taking 5 mg of extra folic acid (as required ~ 1/wk) agrees with me. Taking too too much folic acid e.g. 5 mg daily... makes me feel like I've had too much (I feel puffy): My methylation profile was tested, but folate levels are normal so the folic -> folate conversion is working. Maybe higher than normal folic acid is all that is required to push the reaction to the right? My doc has suggested I try hydroxy-B12 (currently on methyl-B12)... which I like, but it makes me feel puffy (like an allergy) if I have too much i.e. 2000 mcg daily. Is hydroxylation preferable to methylation? I'm homozygous for the MTHFR (C677T) mutation and heterozygous for COMT (only one allele inherited). 🙂
I would usually only recommend 600-1200mcg (0.6-1.2mg) of folate. 5mg is a lot. When you say you are homozygous for mthfr, do you mean homozygous normal/wild type or homozygous for the mutation?
@@DrJanelleSinclair I only took 400 mcg of folate. It is folic acid that agrees with me in higher amounts i.e. 5 mg (prn). My homocysteine has been normal for many years... suggesting that the folic -> folate conversion is occurring just fine. My doctor found this surprising... which is why we followed up with a methylation profile to check. My daily B-complex contains folic acid but if I flush (very mildly) when taking slow release niacin I take extra folic acid (5 mg) i.e.Normally you don't get any flush with slow release niacin (inositol hexanicotinate 500 mg). Folic acid is the rate limiting step in niacin metabolism. If you get a flush it means you are a bit short of folic acid: The flush disappears as soon as you take extra folic acid. MTHFR is homozygous for the mutation. 🙂
Everyone in my family that has tested positive for the mthfr mutation is A- including myself and my daughter. Our family is huge too. Granny was a bit old fashioned lol.
@@Truerealism747 i actually have Asperger’s! So do many of the “younger “ relatives. I say younger because of misdiagnosis decades ago. My youngest and oldest are O- and O+ and are completely different from myself and my middle kiddo. I never thought blood type had anything to do with personality, but wow. I do now lol.
Only read if you or someone you know has overmethylation. If you have overmethylation then avoid all the fish, meat, liver and eggs, they are incredibly high in methionine and will worsen your symptoms very quickly. Methionine is a methyl donor and you don't need more methyl groups with overmethylation. Pretty self explanatory. You can try for yourself but I guarantee you will feel much worse until you stop and go on a mainly vegan diet. Also incorporate glycine, overmethylation has a lot to do with glycine deficiency as that's the only natural way to lower methionine from the food we eat. 3 grams before bed on an empty stomach. And possibly supplement b3 as niacinamide as that lowers serotonergic and dopaminergic activity and in order to metabolise niacinamide you need to methylate the metabolites to pee them out thus reducing methylation. The only thing you have to watch out for while supplementing with niacinamide is an increase in homocysteine levels. Methionine is the main methyl donor used to methylated and excrete niacinamide. And when you strip away the methyl group from methionine you are left with homocysteine. I was taking a lot of niacinamide and after a few weeks started getting sores in my mouth and my skin started flushing and that would subside about 2 days after stopping the b3. My current stack: 1,200mcg Folinic acid (unmethylated activated natural folate) 2,000mcg B12 as hydrox/adenosylcobalamin Glycine (safe up to 50g+ daily) Niacinamide 1,000mg 5x a week The folate and b12 works to lower homocysteine so whenever your homocysteine levels go up too much just stop the niacinamide and any symptoms should go away pretty fast especially with higher doses of both b9+b12. B6 also helps convert homocysteine to glutathione, our main antioxidant. All of what I just stated is for people who overmethylate only. It is hard to find information on overmethylation that's why I took the time to help you now. You can verify everything I said, it's 100% correct. To sum everything up, avoid high methionine food. It will worsen your symptoms pretty fast. Supplement with natural folate, if you can't handle methylfolate then try folinic acid. Supplement with b12 as hydroxocobalamin, or hydrox/adenosylcobalamin mix. Take glycine, 3grams before bed on empty stomach. Eat plenty carrots/vitamin A foods as they're required to make the enzyme that glycine uses to lower methionine. Supplement with niacinamide also if you have severe overmethylation like me, but watch out for high homocysteine. You can get it chacked but you should know when it goes too high as your skin will start randomly flushing hours after taking it, and you'll start getting worsening mouth sores until you stop. Also consider taking b6 either alone or in a multivitamin (I take multivitamin). It is required to convert homocysteine to glutathione the master antioxidant. I am not sponsored or anything but I get all my supplements from seekinghealth.com they are dedicated to people who have these kinds of problems. They have an unmethylated multivitamin called Multivitamin Minus One for all those out there that can't handle methylated forms. That should be everything :)
Why would you want to reduce the body’s natural ability to properly methylate. There’s not a genetic defect that causes “over methylation” is there…???
Dissapointing to see your telling people to avoid vegan/ vegetarian diet. People who are vegan won't add meat as it is an ethical stance. Beans and legumes are a large part of the diet. B12 is routinely given to the animals feed so may as well take b12 supplement rather than have it filtered through the animal. Other than this criticism, I really appreciate your videos. Very educational. Thankyou
Thanks for the feedback. I understand that for some people a vegan diet is about the ethical stand but for others it's for their health. We can all have different opinions but I feel that it allows others to go and do some research. It's good for people to know that risks and compensate for them.
Download my free MTHFR symptoms and treatment guide. www.drjanellesinclair.com/mthfr Have you tested your MTHFR genetic SNPs? What did you find? Did it help your health?
Hi Janelle, the link does not seem to work.
@@donnabryce9981 sorry about that Donna. It should be working now. Apologies for the inconvenience.
Dr Janelle Sinclair how can I contact you? I have major anxiety can’t breath and I have many labs test and genesight test for MTHFR. Can you help me please
Dr. Sinclair, is there any way to get access to this guide? The link doesn't work... I know this post is old but I am desperate for help!
Hello Dr! The link goes to the 7 hidden causes of anxiety and depression page. Is this guide still available somewhere? Thanks!
Thank you Doctor Sinclair, a great presentation.
The guide is extremely useful. Thank you.
One of the most informative videos I've seen on how to compensate for MTHFR mutations in a LONG time. Great information, particularly about how to start taking supplements, the order in which you should begin your regimen, what type of negative side effects you can expect to see, and what you should do if you experience them. Bookmarking and sharing!
Very helpful video. Thank you.
U are very clear and informative thanks so much
Thank you so much for this video!!!!
Thank you 🙏 I wish doctors here understood MTHFR and even know a small tid about it. I was polydrugged because of this mutation and injured by the medications I was put on never addressing the root cause. I’m trying my hardest to learn this but it’s so hard by myself. I’m also histamine intolerant so it makes it hard to eat the right foods. Please do a video on low histamine foods that are high folate. I really wish there was a cookbook for MTHFR with histamine intolerance. Thank you
Dr that hydroxo b12 with folinic acid you recommended is seriously sold out and the comments from previous purchasers says it’s frequently sold out. How can you maintain stability with a protocol this way? Hoping other brands are equally as efficacious. Btw I feel so inspired by your videos. Our lives have taken an abrupt dive because my daughter hit an all time anxiety-related high resulting in Tourette’s and the roller coaster of emotional crashes has been robbing her of her happiness. Thank you for your generosity in sharing this info on RUclips.
Thank you very much for this video, one of the useful on the internet. The only thing I did not understand is whay or how the hidroxicobalamin can help improve Methylation?
How long does it take for the detox symptoms to pass?
It’s the first video where someone mentioned b12 methycobalamin could be an issue. I have been taking it on suggestions of multiple ND. I stopped taking it for a few days bc I ran out and felt so much better. Thank you for these suggestions and info!!!
Hi I’ve been loving your videos. Can you please do a video on B12 supplements for helping depression. I’ve tried to look online but dosing information is very hard to find. Thank you for the videos!
My pleasure. Great topic idea. Thanks.
Dr Janelle Sinclair thank you dr Sinclair :)
What about Sam-e? Is that effective in the process?
How does one get tested for that? I am an expat in Korea, and I never heard of the mutation until a few days ago. And no doctor has brought up the idea. I have bad IBS, histamine problems, symptoms of pyloruria (spelling, though no one ever tested me).
Hi I respect you so much. Do you know how to increase dopamine safety for AKATHISIA and dystonia? I tried lithium orotate 5mg and it made akathisia worse. Myself and others have been injured by pharmaceuticals. Please if you could help this will save a lot of lives there’s really no treatment for it except smoking pot and I’m tired of smoking pot depressed and fighting bad intrusive thoughts because of torture.
I'm not finding the guide that is mentioned.
Do you have a recommendation for children? Dosage of supplements? Should they take a full bcomplex with methylfolate Thanks ❤
So do I use when going to dentist? Need root canal
Thank you for reinforcing the benefits of red meat fish and eggs for MTHFR. So many naturopaths and Drs think vegetarian diets are a healthier alternative
I have anxiety, I don t know if i have MTHFR or COMT , but it is ok to take all B complex methil? - AOR Advanced Bcomplex
Do seizure disorders happen following years of neglecting such genetic issues (not knowing)?
Wow what a helpful video. I just found out I am homozygous and feeling a bit anxious as as soon as I started supplementing, I suffer from crippling migraines.
Swap to folinic acid and hydroxyb12 rather than the methylated Bs. Glad you found the video helpful ☺️
@@DrJanelleSinclair Hey, thank you so much for the suggestion. Do you have an Instagram page? I’m wondering if there’s any possible way to do a consultation with you? Of course I would pay your fees. Please let me know. I don’t need medical advice. Just more like a paid friend who can walk me through this whole thing lol please let me know
@@kaoruyamazaki5724 I am available for consultations. My website is www.drjanellesinclair.com/consulting you can book in an appointment via the website. When you book in please add the upgrade option for me to analyse your test results. I can therefore give you recommendations on your genetic vulnerabilities, not just mthfr.
The link doesn’t work for the guide 😢
I'm heterozygous for dhfr, mthd1, and MTHFR C677T. Since these are all enzymes that convert folic acid into the active form of folate, doesn't this mean that I have a significantly reduced ability to complete this process? I am helped immensly by the bioactive form of folate, so I'm trying to figure out why, as someone who is only heterozygous for MTHFR C677T would benefit so much. Is there a funnel down process in methylation where if you are heterozygous at the dhfr stage, your ability to convert folic acid is limited at each stage due to enzymes working at half their abilty?
Because you are heterozygous for mthfr c677t it does mean your ability to process folate is decreased by 25%. I'm not surprised that methylfolate can be of benefit for you.
Audio is very low
And ldn?
At 61 I learned I have the TT variant. Never was able to conceive...
How did you learn that. Same here
We just received our order of hydroxyl B12 and folinic acid....Only to read on the package that you cannot take it with gabapentin. Is this because it will reduce the effectiveness of gabapentin? Or is it because there is a negative drug interaction between the two?
No problem read Dr TS book
I kinda like hydroxyB12
What do you mean by not tolerating it? I just started taking both Methyl (b12 and folate) I feel drowsy but still awake which is weird. I heard if I take glycine helps. How do you feel if you overmethylate?
Usually angry, unable to sleep, and wound up normally
How do you fix this in benzo withdrawl? Most supplements rev my withdrawals
By following the troubleshooting guidelines provided in the video. Start with very low doses and increase very slowly
use gluten free sushi or poke bowls also for raw meat
What about if u have comt also? How do u avoid anxiety with increased methyl groups?
I'm sure that is described in the troubleshooting part of the video
Thank you for this video! I have compound heterozygous MTHFR polymorphisms (C677T and A1298C). I bought a supplement called 'B-Healthy' because it has methylated folate and methylated B12 but felt worse on it! Now I know why and what to try! I have weakened COMT, compound heterozygous (V158M and H62H). I'm so excited to try hydroxy B12 as I've felt so lost since trying methylated B12 and folate and feeling worse.
I have one question, is there a reason why someone could take magnesium and feel manic instead of relaxed? I have Hashimoto's so I'm wondering if maybe it helped my thyroid too much...
I"m so glad that this video has been helpful. Did you check out my COMT video too? Regarding magnesium I don't really have a reason for you. A few people do respond that way. I would suggest that you trial a different type of magnesium. I usually recommend magnesium glycinate for depression and anxiety, but others like magnesium threonate if you can find it.
@@DrJanelleSinclair Thank you! Going to watch your COMT video now. I'll look into those other forms of magnesium!
How did the hyrdoxocobalamin work?
Dana Does thats my next step. Going carnivore. Seeking health has some really good products to choose from. I am very intolerant to methylfolate and methylb12. I picked up this multi from seeking health that has all of the active b vitamins including R5P, and folinic acid along with a small dose of hydroxo b12 and adenosyl b12. I’m really hoping this can help out! I have TMG if I need to add methyl groups. Good luck!
Thank you 🙏🏻
How long and how much methyl folate do I take in pregnacy?
Pink stork has some great prenatal vitamins for people with mthfr
Hi Dr Sinclair,
Thank you for providing such clear and helpful information!
I'm heterozygous for C677T only, I was wondering about my risk for restarting hormonal birth control. Previously I've used the combined pill, implant and Depo Provera. I noticed any serious negative side effects from the implant. I'm currently not on any birth control.
I was wondering if it's safe for me to restart the pill, or have another Depo Provera shot? Would supplements counteract any negative reactions or is it safer to avoid completely? And is Depo safer than the pill?
Thanks!
Depo cause my other half to get breast cancer no way now
Depo cause my other half to get breast cancer no way now
@DrJanelleSinclair
Hello Doctor, I ran my DNA data through Genetic Genie (free) and 7 of 21 methylation genes have 1 variant, 6 more have double variants (MTHFR, 2x COMT, VDR, MAO-A, SHMY1).
And 1/3 of my detox genes have variants. I'm disabled, l from bipolar (lucky 1%) and it's hard to spend a lot on my budget but I see you're not taking clients too. I'm wondering what supplements you'd recommend? I can send those results if you'd like too. I'd be so grateful if you have a moment to answer!
I suggest you check out the mthfr treatment report. Take note of the best B vitamins for COMT i.e. folinic acid and hydroxyB12. www.drjanellesinclair.com/mthfr Also get your vitamin D levels tested and supplement if necessary (see video on vitamin D).
@@DrJanelleSinclair Thank you so much! I'm going over those reports now.
I have the mutation and had a question about whole wheat. Can I consume whole wheat if the label doesn’t say folic acid?
Dr Ben Lunch recommends that people with the mthfr genetic weakness eat gluten free. Eating gluten free is definitely preferable especially for anyone with poor mental health to help lower inflammation in the body. But as far as I know there's no interaction between wheat and the mthfr gene or folate.
I've heard all grain products are sprayed with folic acid and that it can cause people methylation problems.
Thank you! 8sn't it better to just start straight with the folinic and oxy ... ( what was it ..) b12?
For most people there's no need. But if you have anxiety, have comt++ or are sensitive to supplements or vitamins, then yes it's a good idea. But most people including practitioners don't know this
@@DrJanelleSinclair thank you!
Well, I don't know yet if I have it. But, if so, I am very prone to ( is that the word ?) Anxiety en sensitive for food en supplements and herbs etc.
A lit of them don't work for me, or do the opposite of what thet d o for most people.
So I can imagine that I would have to use this form.
@@DrJanelleSinclair and do all people with mthfr defect suffer from headaches?
@@maaikewilhelmina1457 no not all.
@@maaikewilhelmina1457 no harm in being on the cautious side
why would you want to eat foods that are high in folate but avoid foods with folic acid?
If you don't methylate correctly, folic acid will be toxic. Folate is more bioavailable, methylfolate is even more bioavailable where as Folic Acid is a synthetic vitamin you cannot breakdown.
Foods with folate have folic acid. How do you eat and avoid those foods at the same time?
Folic acid is the synthetic form of folate that is found in some supplements and fortified foods. Natural folate in foods is not in the form of folic acid. So you don't avoid natural folate.
@@DrJanelleSinclair Thanks for answering that. I was confused after googling foods that contain folate and then googling foods that contain folic acid and got lists of the same foods in both categories.
I’ve been taking 15mg methyfolate for 4 years is this too much? I have homozygous for both MTHFR and COMT
That's the medical model treatment for MTHFR. But if you have the slow COMT enzyme it's likely that this dose may increase anxiety and anger. If you're homozygous for COMT rather than homozygous "normal" for COMT you may do better with folinate and hydroxyB12
@@DrJanelleSinclair I am slow COMT as well as MTHFR Homyzygus for c677. I recently lowered the dose to 7.5mg methylfolate after learning this. I’ve been taking 15mg for years. I do have some anxiety but, never noticed Initial changes when starting the 15mg. I wonder if I should stop it and try the hydroxy b12 / folincic acid your recommend in your COMT video. I just want to make sure I can still support my methylation issue. After taking 15mg for 4 years should I taper down?
I have this . I don’t understand what to do .
The most important thing is to take a high amount of B12 and folate supplements.
The supplement I take contains the following: 400 mcg of folate - 6(S)-5-methyltetrahydrofolate, 5 mcg of vitamin B12 cyanocobalamine
Should I get one with methylcobalamine or another kind? They created it specifically for this but I still have depression regardless...and feel like I am not at my best health-wise. Thank you, I am homozygote.
It's usually recommended that if you have mthfr genetic weaknesses that you take much higher doses of methylfolate. I.e. more than one capsule. I'd also suggest that you do take another supplement with higher methylcobalamine.
@@DrJanelleSinclair Thank you very much!!
I just got my genetics results. I have c/c (C677T) and c/c (A1298C) and also COMT genotype A/A. Should I try supplementation? I have pcos and have always struggled with obesity and anxiety. I had preeclampsia in my first pregnancy as well and I am afraid to have another.
Which tests did you take? Did your doctor prescribe them, or did you buy an online gene test?
When I take folate (~400 mcg daily) I start to feel puffy (like an allergy): It feels like I'm taking too much.
On the other hand taking 5 mg of extra folic acid (as required ~ 1/wk) agrees with me.
Taking too too much folic acid e.g. 5 mg daily... makes me feel like I've had too much (I feel puffy):
My methylation profile was tested, but folate levels are normal so the folic -> folate conversion is working.
Maybe higher than normal folic acid is all that is required to push the reaction to the right?
My doc has suggested I try hydroxy-B12 (currently on methyl-B12)... which I like, but it makes me feel puffy (like an allergy) if I have too much i.e. 2000 mcg daily.
Is hydroxylation preferable to methylation?
I'm homozygous for the MTHFR (C677T) mutation and heterozygous for COMT (only one allele inherited).
🙂
I would usually only recommend 600-1200mcg (0.6-1.2mg) of folate. 5mg is a lot. When you say you are homozygous for mthfr, do you mean homozygous normal/wild type or homozygous for the mutation?
@@DrJanelleSinclair I only took 400 mcg of folate. It is folic acid that agrees with me in higher amounts i.e. 5 mg (prn).
My homocysteine has been normal for many years... suggesting that the folic -> folate conversion is occurring just fine. My doctor found this surprising... which is why we followed up with a methylation profile to check.
My daily B-complex contains folic acid but if I flush (very mildly) when taking slow release niacin I take extra folic acid (5 mg) i.e.Normally you don't get any flush with slow release niacin (inositol hexanicotinate 500 mg). Folic acid is the rate limiting step in niacin metabolism. If you get a flush it means you are a bit short of folic acid: The flush disappears as soon as you take extra folic acid.
MTHFR is homozygous for the mutation.
🙂
Is itpossible that at first symptoms becone worse, like fatigue?
Yes that's a detox effect. Perhaps reduce dose for a while and try some electrolytes including potassium
@@DrJanelleSinclair thank you! I will start the electrolytes again!
@@maaikewilhelmina1457 did you also try the hydroxob12 and folinic acid instead of the methyl b12 and methyl folate?
@@DrJanelleSinclair yes, but I can't say I feel diffrent or better. I am now taking
essentialorganics.nl/producten/vitaal-45/
Linked to ADHD Asperger's
Have you noticed it's linked to type o blood type
I’m O+
@@Snowfox23 same as me
Everyone in my family that has tested positive for the mthfr mutation is A- including myself and my daughter. Our family is huge too. Granny was a bit old fashioned lol.
@@whatupquake6790 Asperger's? Same here maternal side but o type plus
@@Truerealism747 i actually have Asperger’s! So do many of the “younger “ relatives. I say younger because of misdiagnosis decades ago.
My youngest and oldest are O- and O+ and are completely different from myself and my middle kiddo. I never thought blood type had anything to do with personality, but wow. I do now lol.
Only read if you or someone you know has overmethylation.
If you have overmethylation then avoid all the fish, meat, liver and eggs, they are incredibly high in methionine and will worsen your symptoms very quickly. Methionine is a methyl donor and you don't need more methyl groups with overmethylation. Pretty self explanatory. You can try for yourself but I guarantee you will feel much worse until you stop and go on a mainly vegan diet.
Also incorporate glycine, overmethylation has a lot to do with glycine deficiency as that's the only natural way to lower methionine from the food we eat. 3 grams before bed on an empty stomach. And possibly supplement b3 as niacinamide as that lowers serotonergic and dopaminergic activity and in order to metabolise niacinamide you need to methylate the metabolites to pee them out thus reducing methylation. The only thing you have to watch out for while supplementing with niacinamide is an increase in homocysteine levels. Methionine is the main methyl donor used to methylated and excrete niacinamide. And when you strip away the methyl group from methionine you are left with homocysteine. I was taking a lot of niacinamide and after a few weeks started getting sores in my mouth and my skin started flushing and that would subside about 2 days after stopping the b3.
My current stack:
1,200mcg Folinic acid (unmethylated activated natural folate)
2,000mcg B12 as hydrox/adenosylcobalamin
Glycine (safe up to 50g+ daily)
Niacinamide 1,000mg 5x a week
The folate and b12 works to lower homocysteine so whenever your homocysteine levels go up too much just stop the niacinamide and any symptoms should go away pretty fast especially with higher doses of both b9+b12. B6 also helps convert homocysteine to glutathione, our main antioxidant. All of what I just stated is for people who overmethylate only. It is hard to find information on overmethylation that's why I took the time to help you now. You can verify everything I said, it's 100% correct.
To sum everything up, avoid high methionine food. It will worsen your symptoms pretty fast. Supplement with natural folate, if you can't handle methylfolate then try folinic acid. Supplement with b12 as hydroxocobalamin, or hydrox/adenosylcobalamin mix. Take glycine, 3grams before bed on empty stomach. Eat plenty carrots/vitamin A foods as they're required to make the enzyme that glycine uses to lower methionine. Supplement with niacinamide also if you have severe overmethylation like me, but watch out for high homocysteine. You can get it chacked but you should know when it goes too high as your skin will start randomly flushing hours after taking it, and you'll start getting worsening mouth sores until you stop. Also consider taking b6 either alone or in a multivitamin (I take multivitamin). It is required to convert homocysteine to glutathione the master antioxidant. I am not sponsored or anything but I get all my supplements from seekinghealth.com they are dedicated to people who have these kinds of problems. They have an unmethylated multivitamin called Multivitamin Minus One for all those out there that can't handle methylated forms.
That should be everything :)
Why would you want to reduce the body’s natural ability to properly methylate. There’s not a genetic defect that causes “over methylation” is there…???
I have it the best treatment for it is Metagenics - ceralin forte. Dont use her sponserd brand
Cocaine destroys folate? But I don't d....oh. Never mind.
Cooking😂
Dissapointing to see your telling people to avoid vegan/ vegetarian diet. People who are vegan won't add meat as it is an ethical stance. Beans and legumes are a large part of the diet. B12 is routinely given to the animals feed so may as well take b12 supplement rather than have it filtered through the animal.
Other than this criticism, I really appreciate your videos. Very educational. Thankyou
Thanks for the feedback. I understand that for some people a vegan diet is about the ethical stand but for others it's for their health. We can all have different opinions but I feel that it allows others to go and do some research. It's good for people to know that risks and compensate for them.
@@DrJanelleSinclair there is also research that supports plant based diets-as long as it includes all nutrients needed.
This is all too much.
Then see a trained practitioner to help you through it.