Why isn't this channel getting waaay more views? Perfect combination of sardonic humour and tech reporting with excellent production values. Keep it up my man!
Cell specific (ie Moderna's breakthrough) delivery of proteins that can affect histone post translational modifications (especially H3K27meK36ac... known to increase with age) or transcription factor activity will absolutely be revolutionary.
I'm going to look back 100 years from now on where I learned the key advancements in how I will increase my lifespan, and it will be from this goofy guy! keep up the grate videos I was in a flow state the whole time.
You asked the nerds in the Comments section to explain how this doesn't affect DNA, but can still get passed down to later generations...Challenge accepted ! The part about not changing the DNA is straightforward. There is no breaking of the genetic sequence, no insertions, deletions, or swaps. The epigenome is really chemical markers that sit on the DNA. They don't change the DNA, but control whether or not the genes get "expressed" or not. The epigenome is different for different types cells, because different cells have different jobs, and therefore need to make use of different parts of the genetic code in the DNA (i.e., the epigenetic markers on a pancreas cell are going to be different than those on a blood cell). Sperm and egg will also each have an epigenome. But the epigenome is for these specific types of reproductive cells. When they get together, and an embryo forms, ideally the epigenome is wiped clean so that as more cells form (especially different types of cells with different jobs), the epigenome can be formed "from scratch" for the different types of cells in that organism. That is the idealized version. In the real world, some of the epigenetic markers don't get scrubbed from the embryo. So, a certain amount of epigenome gets passed on. If this modification technique became extensively used, there would be a significant amount of markers passed down within the population, especially if this is done over multiple generations. I've seen some studies indicating epigenetic inheritance is more common with the Y chromosome (male parent to male child). How was that for nerdy?
Wow, this is actually amazing. I personally don’t know how it works but I’ve heard that if people become obese, it affects their epigenome and it can pass that on to their children and make them be more likely to be obese, and that can last for generations, so it makes sense that something like this could work for people’s children too. I definitely want to see where this goes. I’ve got planets to terraform and star systems to colonize.
@@HardKore5250 I mean, in a manner of speaking, yes. Although it’s more that the opposite is true, that if you have children while obese, those children’s epigenome activates in a way that an obese person’s would
I think you are right on the money. Also, AI will skip robots and design it's self a perfect self replicating bio body. No need for "manufacturing" AI parts.
![Megan Thee Stallion - Bigger In Texas [Official Video]](http://i.ytimg.com/vi/QxTkZTLWdo4/mqdefault.jpg)
Why did you wait until 6:17 to get to "More sex appeal. Animal magnetism" ? THAT is what you open with.
😂. I coulda used a clip from Seinfeld where Kramer has the Kavorka
@@emmettshort 🤣😂
Why isn't this channel getting waaay more views? Perfect combination of sardonic humour and tech reporting with excellent production values. Keep it up my man!
Agreed! Commenting here for the algorithm ❤️
Cell specific (ie Moderna's breakthrough) delivery of proteins that can affect histone post translational modifications (especially H3K27meK36ac... known to increase with age) or transcription factor activity will absolutely be revolutionary.
I'm going to look back 100 years from now on where I learned the key advancements in how I will increase my lifespan, and it will be from this goofy guy! keep up the grate videos I was in a flow state the whole time.
You asked the nerds in the Comments section to explain how this doesn't affect DNA, but can still get passed down to later generations...Challenge accepted !
The part about not changing the DNA is straightforward. There is no breaking of the genetic sequence, no insertions, deletions, or swaps. The epigenome is really chemical markers that sit on the DNA. They don't change the DNA, but control whether or not the genes get "expressed" or not. The epigenome is different for different types cells, because different cells have different jobs, and therefore need to make use of different parts of the genetic code in the DNA (i.e., the epigenetic markers on a pancreas cell are going to be different than those on a blood cell).
Sperm and egg will also each have an epigenome. But the epigenome is for these specific types of reproductive cells. When they get together, and an embryo forms, ideally the epigenome is wiped clean so that as more cells form (especially different types of cells with different jobs), the epigenome can be formed "from scratch" for the different types of cells in that organism. That is the idealized version.
In the real world, some of the epigenetic markers don't get scrubbed from the embryo. So, a certain amount of epigenome gets passed on. If this modification technique became extensively used, there would be a significant amount of markers passed down within the population, especially if this is done over multiple generations. I've seen some studies indicating epigenetic inheritance is more common with the Y chromosome (male parent to male child).
How was that for nerdy?
Damn. Cool. But is there any method to the madness of epigenetics getting passed on? Is it understood?
Liking the consistency and quality of the uploads.
Thanks!
I would have never heard about this if you didn't report on it, thanks!
Hopefully we can invest in this soon.
Same
Dude you are on fire.
Wow, this is actually amazing. I personally don’t know how it works but I’ve heard that if people become obese, it affects their epigenome and it can pass that on to their children and make them be more likely to be obese, and that can last for generations, so it makes sense that something like this could work for people’s children too. I definitely want to see where this goes. I’ve got planets to terraform and star systems to colonize.
You can turn off obesity?
@@HardKore5250 I mean, in a manner of speaking, yes. Although it’s more that the opposite is true, that if you have children while obese, those children’s epigenome activates in a way that an obese person’s would
@@ryandoesstuffapparently1540 How you turn it off?
@@HardKore5250 Again, you would have to make sure you get extremely fit before having children to pass on those epigenetic markers
@@ryandoesstuffapparently1540 ok
This is exactly what I look for in these videos. I love these subjects
Great episode.
This is cool. Thanks for sharing. I'm surprised this video wasn't recommended to me with how much I've been looking this kind of stuff up.
How did you finally find it? Hope you like my other stuff
@@emmettshort I literally searched for your latest videos because I do like them!
Great work Emmett
So, instead of reaching for the thermostat when it's chilly, I can just use my iPhone app to crank up my body hair? The future is disgusting.
I think you need to spell check disgusting. The actual spelling is fascinating
@@davidjackson2832 You and I are clearly imagining different amounts of body hair.
I think you are right on the money. Also, AI will skip robots and design it's self a perfect self replicating bio body. No need for "manufacturing" AI parts.
That is way into the future
Yes! So glad you decided to do something in this vein! Can you perhaps do a video on the Russian billionaire looking at the "2045 project?"
¡Gracias!
I'm trying to imagine tomorrow's genetically enhanced athletes, and what this means for the future of competition... Good luck with that WADA.
Very exciting! Humanity is about to enter a new era
the future is now, soooo where are you emmet? WHERE? ^_^°
I'm glad ur goal is to be immortal and be part of the space exploration, bcs mine is exactly that too
Amazing technology. You kind of have to wonder what unforeseen effects it might have on the gene pool, but the potential benefits are clearly huge.
My guess is it will put evolution into overdrive. Sounds good to me!!
@@emmettshort What do you mean?
Digital immortality is my way😜
Welcome back to the scary stuff in the pleasure department. Should I recommend a scary sci fi online book?
LOL 😂 Oh man! Will the term robbing the cradle be nonexistent?!!
I want to be a space pirate too.
Living forever is good and all but.... I wont be able to look forward to dying anymore. :(
wow
cool!
hey is that Basic Income Crypto still a thing? time for a update. thanks!
I’m 18 but death it scared me until I realized humans are hacking 😅 now im scared of evil men living forever
Great... Because we really needed all the uber rich to be functionally immortal. What could possibly go wrong?
Everything is going according to plan. Down to its finest details
I only dm people I don't like
Good ur handsome
RNA, they're altering that, not DNA, 😏👍