I just finished my metabolism exam, and after learning that at school feels so good to know what's happening here. Also, you make everything so easy to understand and make it interesting to learn.
I got stoned for the first time in university, and expecting "munchies" was surprised that I felt only mildly hungry. I had a 5 lb bag of raw almonds which I would grab a small handful of every day for a quick snack before my earliest class...and by the time I tried the pot, I was down to about 3 lbs. Before I realized it, I had eaten three full pounds of raw almonds in one sitting...then proceeded to have 2 full days of flu-like symptoms and increased propensity for asthma attacks. I thought I was just sensitive to pot, and decided against using again...until I described what I experienced to a med student on the campus, who basically immediately told me that I had suffered mild cyanide poisoning from the raw almonds...which contain small amounts of a chemical called amygdalin, which our body processes into HCN. Most people don't eat 3 lbs of raw sweet almonds in one sitting, so the trace amounts of amygdalin isn't deemed to be too much of an issue and isn't mentioned on the bag or anything. TL;DR: Don't eat multiple pounds of raw almonds in one sitting.
Since we are on the topic... Don't eat an entire 2lb bag of Costco dried Apricots all at once... I did a big hike on a cold rainy day, on the way home, I realized I had the bag of dried Apricots flopping around in my rear floorboard (apparently they slid off the top of my Costco load the day before). Anyways, I had a few and they were delicious, then I really laid into them and finished the bag in less than 10 minutes... I woke up the next day with a pressure in all of my bowels that was beyond anything I've ever experienced, and I was cramping from my chest to my butthole... I ran to the bathroom and threw my buttcheeks on the pot as the explosion happened... At this point force and pressure of the evacuation caused the chunks to shoot back up my butt crack, up the wall, and across the ceiling, as I stood up to relieve the pressure, there was a secondary explosion... From working out of the bathtub and using all of the towels, it took me 3 hours to clean and sanitize all the shit that had exploded all over the bathroom... If an MD can explain what happened, I would love to know...
when I was trucking I kept smoked almonds with me at all times, I loved to snack on it and trail mix for a easy meal n energy, I started getting severe cramps after I left home n was on the road a few days, then I remembered somehow that almonds either has trace cyanide or resembles it, I stopped eating all together n my health issues got better, but i really loved almonds, but its crazy how something promoted as a healthy snack can hurt or kill you over time
I'm a jeweler and I've worked with cyanide based plating solutions for years. I just don't drink it or mix it with acid. I remember my old boss telling me that the amount of cyanide you could pile on your little finger nail could kill you easily. I have a healthy respect for the stuff.
There's sodium cyanide and potassium cyanide. Potassium cyanide is more poisonous whereas sodium cyanide is used to work with metals and the like,,,but still toxic.
More info about cyanide: As mentioned, amyl Nitrate (the cure mentioned in the video) converts hemoglobin into methemoglobin. Hemoglobin is made up of Ferrous (iron with a +2 positive charge), but methemoglobin is made up of Ferric (iron with a +3 positive charge). Cyanide does not bind to ferrous, but it does bind to ferric. Therefore, amyl nitrate will cause much of the cyanide to bind to your blood cells, which has a lot of iron. Each blood cell contains 300 million hemoglobin and each hemoglobin has 4 iron atoms. Therefore, a blood cel can bind to 1.2 billion molecules of cyanide. Interestingly, there is also a medical condition known as methemoglobinemia, in which people have an abnormally high amount of methemoglobin (this causes them to be more resistant to cyanide poisoning). Also, as mentioned above, ferric has a 3+ charge which makes it capable of binding to cyanide. Another treatment for cyanide poisoning is hydroxycobalamin-this molecule is basically a form of vitamin B12. What makes this molecule interesting is that it has a cobalt atom with a 3+ charge (just like ferric). So, this molecule is also given as a treatment for cyanide poisoning because cyanide can bind to this molecule just like it can bind to ferric in the methemoglobin of blood cell. When hydroxycobalamin binds to cyanide, it turns into cyanocobalamin. This is another form of Vitamin B12-completely harmless. It’ll get used by your body or it will be excreted through urination.
I am a current paramedic student, I have just recently discovered this page and several of these videos they cover very important topics and essential information that first responders need to know down to the cellular level and chemistry. Very informative! Thank you for posting!
This video singlehandedly explained a puzzle I was wondering about, how can such a tiny quantity of something kill you. It's because I didn't realise how many cells in the body there are and how many molecules go into a mole of something. Thanks for explaining! Now I understand why, it's such a staggeringly large number that even at such a low quantity, there is an overwhelmingly large quantity of the something that kills you.
i ve had various college chemistry courses including organic chemistry and yet i didn't knew how simple cyanide poisoning worked. this felt like it being spoon fed directly to my brain. Great content!
@@darkscienceyt hey pals, your videos are good with nifty explication and coherent with graphics you offer But if you put any hecking music, i'll forsaken you, discern this, that'll perturb the Knowledge you want to convey
Because it's kind of a sensitive subject and most people don't want to touch it, or show interest, I figured it might be a good idea to know more about possible health hazards.
This is so enlightening. I was given an entirely, non- biochemistry, different explanation in undergraduate inorganic chemistry decades ago. I was told that the CN was a powerful ligand that bonded to the hemoglobin and caused suffocation.
I was actually surprised that there was another explanation. Always thought cyanide would bind to to hemoglobin kinda like carbon monoxide. Like both can form pi back bonding to iron(II)
Another antidote is the reducing agent sodium thiosulfate (known to film photographers as “hypo”), and also used in hair salons to break the disulfide bonds between amino acid chains in hair so that the hair can be curled or straightened, then another compound rebuilds the bonds. Also, there are certain species of mammals that are immune to cyanide. How do they accomplish this?
Had this guy from high school (we weren’t close but I knew him well) who committed suicide by creating and stealing hydrogen cyanide from his university chemistry laboratory. He was gifted and his death was very tragic. Low key it’s interesting to see how it works, wish it wasn’t a thing though.
@@TonyDanza4Lyfe I vaguely recall him making a joke about it a time or two in high school. May have been psychological. We weren’t friends, but I’ve had a lot of respect for him. He was talented, smart, and funny.
@@TonyDanza4Lyfe To be fair most people could probably acquire arguably one of the better ones fairly easily with a little effort. Opioids are probably one of the gentlest method if one is that way inclined, initial effects of a lethal dose begin with a brief period of intense relaxation and euphoria followed by unconsciousness and death from respiratory suppression. But the patient loses consciousness prior to the effects of the respiratory depression kicking in so they just drift off never to awaken again. There is a reason why they are usually the drugs of choice for euthanasia by both veterinarians and doctors in jurisdictions where human euthanasia is legal. It is pretty much the gentlest way to accomplish the result with a single drug as it in effect happens to function as a relaxant and anaesthetic prior to actually doing the deed.
@@ravenID429no i think what he meant was that you weren't allowed to give the antidote to a gay person, because if they have remains of a drug that is or used to be very popular in gay clubs in their blood, the antidote will kill them. at least someone i work with told me that and i work in electroplating, where we use a lot of cyanide for solutions. but idk it might be wrong
@@ravenID429 nope, not the Cyanide, the antidote is commonly sold in Sex shops or online it's street name it's Poppers as it gives a short lived rush as inhaled. Truly interesting that while injected it could save your life if poisoned as in Agata Cristies book 📙😎💅
More people are getting awed by how big the universe really is, thanks to spectacular new astronomic discoveries. And that's great, but not yet enough realise the universe's scaling goes the other way too, into smaller quantities. And the orders of magnitude involved are even more awe inspiring of you think about it. E.g. there are more molecules in a glass of water than the current estimate of the number of stars in the known universe. Videos like this one are a great way of improving the visibility of this. You have no idea how interesting chemistry is until you really start studying it.
All the interesting science and learning stuff aside, watching Joffrey Baratheon take his last wretched miserable breaths was one of the most satisfying moments to ever grace my television screen.
I’m back here after 2 years, when your videos got sued and I commented, my life has been much much more busier now so yeah, still love the vids, I can understand how much time it takes for one vid but keep it up, this is very understandable and clearer :)
Hey, thanks for sticking around and understanding! That was a very dark time for me, and I was close to giving up. I'm thankful for viewers/subs like you!
Not only lactic acid is created during anaerobic metabolism. Even alcohol and carbon dioxide. But in muscles during heavy exercise, lactic acid is created and accumulates to cause cramping. Even Co2 is generated when we use small amounts of oxygen
My friends grandfather was a trapper that would use Cyanide in traps to kill coyotes going after his livestock. My friend and I watched his dog die after getting in one of the cyanide traps while walking in the woods. That dog died in about 1 minute.
I wanted to make some cyanide-based rat poison. I don't want them to suffer, just expire quickly. (A company employee told me they deliberately make it "slow kill," in the event your child or pet ingests it; this allows time to get to medical help before it's too late).
@@elultimo102 Makes sense..... Imagine if someone got a hold of that chemical and it wasn't slowed down but nearly instant or the minute instant anyways it could be used as a terrorist weapon...... Very good move on that company's part
This is a really good explanation, not only you made the tossic mechanism clear, but you also brought the point of view from a number perspective thet I wouldn't consider, you've really done a good job with this video 👍
Wow, you explained everything in such a simple and easy way, i usually hate chemistry because i always had trouble to understand it, but this video was so clear. Good job
As a professional opossum hunter for many years in New Zealand, I was licensed to use potassium cyanide paste as a rodent-control poison. Virtually all opossum hunters in New Zealand still use this paste, and as part of the legal requirements for an operator using cyanide, you must always carry a few amyl nitrite-filled glass capsules in your pocket in case you accidentally ingest or inhale some cyanide. You were to break open the glass capsule and deeply inhale the amyl nitrite fumes from the liquid. Fortunately I never had to do that during my years of wandering through remote alpine forest while laying out lines of cyanide baits for opossums. One bait the size of an pea, can kill several opossums, and finding four dead opossums around one bait is common. The poison kills virtually instantly and the opossum does not get much chance to wander away from the bait. Cyanide is a very efficient and inexpensive way to control the millions of non-native opossums (these are actually Australian brush-tailed opossums from Australia) which were liberated in New Zealand in the 1800s in the days when conservation was not heard of. These opossums now live in New Zealand in large numbers and do much damage to native species and forests there. There is, from time to time, also a lucrative market for opossum furs from New Zealand. I appreciate this video, thank you, as it has refreshed my knowledge of cyanide, which I have not used since 1981.
Be careful here in the USA I had a very large opossum that had rabies most likely charge at me full speed as it came up over a small rise I was deep in the woods of west virginia n hunting a old hollowed out Beech tree for squirrel one evening, that creature saw me sitting there and came running at me full speed snapping his teeth and was a running full speed fast towards me I had a spilt second to realise it was coming for me, and had to shoot it right as itt got almost to me feet, the dang thing weighed close to 4o lbs, I was just 13 i took it home to show my dad what happened, n he was so pissed i shot something i wasn't going to eat, he told me if i ever shot another n brought it home I would have to eat it, man dad was old school, n thats the way to be, but not when one charges u like that! I doubt dad believed me, i shot everyone of them in the woods i ran across after that, it was fun to hunt in front of the house n fish the river behind us, those 3 yrs were the funnest times with some of the best salt of the earth people you would ever hope to meet, it took me a couple yrs to be fully accepted there, but once they know u n can trust you, its the best place to grow up
Nowadays the preferred antidote is hydroxocobalamin, which is entirely non-toxic but unfortunately has to be given by injection. It reacts with cyanide to form water and vitamin B12, which you pee out. The cobalt atom in vitamin B12 holds on to cyanide more strongly than the enzymes in your mitochondria.
@@marc-andreservant201 Interesting. I wonder if New Zealand's large number of cyanide-using rodent-controllers have been upgraded to this new antidote, and now carry the antidote and a syringe with them, instead of the glass amyl nitrate capsules. You would have to act VERY quickly to get the injection into you if you ingested cyanide, as it acts so quickly. I passed my poisons exams in New Zealand in 1970, and then was entitled to buy and use cyanide. I have not used it since 1981, my final season of poisoning rodents with cyanide. My cyanide license has probably long-ago become invalid, but, when I passed the exams in 1970 it was supposedly good for life. In 1983/84 I worked for the New Zealand Forest Service poisoning possums in Westland, but that was all done with 1080 poison and is still the case today.
I always find it nuts how life is just chemical machinery. I mean, I know it's obvious but at the same time the chain of events is mindblowingly simple.
@1:57 - Minor point - The acrylo in acryloitrile is pronounced uh - krillo (short i) - nitrile (long i) Et cetera - Cytochrome P450, sodium thiosulfate, vitamin B12
I am a former autobody painter. There is a chemical in the paints that is called isocyanates which will have the same effect on the human body as cyanide does. The chemical is a very close relative to cyanide. The molecule promotes adhesion and is found also in things like Super glue, and high quality chip resistant nail polish. Few people are sensitive to this chemical, actually we are exposed to it all the time but most will never feel it. I on the other hand, and people who are sensitive to it will get tremors, difficulty breathing and a few other issues that depend on the person.
At 2:57 he said that cytochrome c oxidase is also called the cox enzyme, however the cox enzyme is actually cyclooxygenase, which makes prostaglandins and has nothing to do with electron transport. Still a fantastic video in any case!
Now you made me remember one of my favorite drinks, bitter almond liquor with a bit of a lemon squeeze. Bitter almonds contain Cyanide, I believe less than 20 really bitter ones can poison you with a letal dose. But that's safe on that liquor. How didn't I remember this during lockdowns? Well, I guess I now have a drink for the winter. Thanks!!
I stopped studying chemistry at 16 and moved onto engineering in polytechnic and I must say, the guy that figured out the antidote to cyanide must be smart as hell
The fire at The Station club in Rhode Island..there was soundproofing foam where the drummer sits on the stage. When it burned it produced hydrogen cyanide gas in the smoke, many patrons that night lost their lives to the inhalation of that toxic gas.
Correction. The affinity of the cyanide anion for iron in hemoglobin is orders of magnitude higher than that of oxygen, effectively blocking the uptake of oxygen and the removal of CO2. Certainly some cyanide will make it inside cells and wreak havoc there, but the most important mechanism of asfixia is the blocking of hemoglobin. Iron-cyanide complexes are so stable that they once were used as pigments. The most popular is Prussian blue.
Now hydroxocobalamin is more commonly used as an antidote since it directly reacts with cyanide to form cyanocobalamin and it's far less toxic than amyl nitrite.
I was working on a paper while eating cherrys. I tend to chew on things when I am stressed. I ended chewing on the pits. I completely blacked out soon and I could not move any part of my body. I woke up two days later and my lungs felt like sandbags. I immediately opened a window thinking it was co2. The sense of doom scared me in ways I don’t think even think I can completely understand. Thankfully I got help. I definitely don’t like cherries now.
In the 70s I worked in an automobile component plant. Chemicals used in metal hardening produced Hydrogen Cyanide myself and a work colleague were exposed. I spent a day in hospital.
The COX enzyme in the electron transport chain is also commonly called complex IV (4). Just thought I should add this given that I’ve studied it today lol.
I was in the shower and was like “huh I wonder how poison works” this is the first video that pops up and I was like “yeah how does cynide do that” thank you
To any 3D printing and/or laser cutting people watching this, Acrylonitrile is most often seen in DIY as the plastic ABS, which stands for Acrylonitrile Butadiene Styrene. 3D printing folks often use Acetone vapors to melt the ABS so the surface can be smoothed out. It's way safer than melting it with fire, but please be careful, as Acetone vapors are neither harmless. Anyone interested in laser cutting ABS, should only do so with a specialized filter attached. Don't ever cut it without your laser being in an airtight container with an exhaust through a filter. The consequence is presented in this video. You'll wind up producing Cyanide gas, which will kill you pretty damn quickly. Same reason why you don't cut PVC in a laser, as that produces Chlorine gas (PVC is short for Poly Vinyl Chloride).
Here's a question: When you print ABS on a FDM 3D printer - you heat up the ABS filament. I know the burning ABS releases hydrogen cyanide gas. But will it happen as well, when you heat it up to 200 degrees Celsius? (392 Fahrenheit) Also, RIP Geoffrey, he didn't activated Windows.
I need to know exactly to the letter why it is that every person remembers Mitochondria as the powerhouse of the cell but basically none of the other organelles.
Ingested in the right amount it can render a person permanently blind almost instantly. I know of a case where the victim inadvertently drank a glass of cyanide solution in the belief that it was drinking water at a jewelry manufacturing workshop and went completely blind in no time.
You can also dilute cyanide with Cobalamin aka Vitamin B12. So, if in the situation many walmarts sell liquid B12 in the Vitamin aisle. Liquids would be your best bet in a strenuous situation, well actually gaseous is might be the quickest but inhaling acid is also probably a bad idea, just like cyanide.
While we're on this topic, how about a video on chloroform? Recently watched a video that showed misconceptions and one of them is that chloroform use in movies are very inaccurate and actually should take way longer.
This is well done with the exception of the treatment section which is not correct by today’s standard. Today the ambulance paramedics and emergency room physicians use intravenous hydroxycobalamin or cobinamide. Amyl nitrite, sodium thiosulfate and sodium nitrite are only used in very rare scenarios.
I don't know if I can trust you if you don't say "Mitochondria, which is the powerhouse of the cell." I mean, come on! This is important information people NEED to know
exactly- because there are these (mis) conceptions that you just crack open the cyanide pill and 2 seconds later you are dead… (used in many movies) … yes we know movies are not the real thing but there isnt just any counter information available as readily as it should be. (for example if there is a cure and can be administered into the bloodstream then surely the ‘you have two seconds to live’ is not the case) but still would be good to know what are the timescales to get help) :) good video otherwise:)
Might be good to precise amyl nitrite also act as a vasodilatator, this conter the vein contraction effect that cyanide produce when ingested. I personally have been pretty badly cyanide poisoned once while doing chemistry. I can relate to the asphyxiation effect, and more especially to the muscles spasms. I suffered of uncontrolled spasms in arms and neck for the next 4 to 5 month, but it seem like it ended up wearing off
As I recall from the book, poison that killed Joffrey was causing larynx swolling so severe that made breathing impossible, but video very interesting still.
And here I thought that cyanide made you foam at the mouth and barely have time to grunt "Hail... Hydra!". Can you do episodes on other "famous" poisons? Strychnine, sarin, ricin, etc.
watched a guy on courtTV secretly ingest a cyanide capsule. Started out with a cough, tremors, then he began snorting, shaking, and then collapsed. Seemed like a horrible way to go.
It's probably not the worst and it is one of the simplest. My method of choice would be an inert atmosphere. You just fall unconscious. It's not something that can be accomplished on the spur of the moment, though. The absolute worst way to go has to be strychnine.
Just a thought. Seeing how Cyanide stops the production of ATP, is it not possible to synthesize ATP artificially or a substitute that could be administered along with Amyl Nitrite?
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So how do I reverse the damage
How Cyanide poisoning works for idiots:
1. Ingest cyanide.
2. You're poisoned.
3. You die.
Did I miss anything?
They are signed into my account.
The victim slows down to a coma... Blah blah blah.
8th century.llk
nah
No.
From biology I do remember that the mitochondria is the powerhouse of the cell.
Get out
This is what will happen to your kidneys!
midichlorians*
So it will turn em off ?
Presenting ☝🏻 to the emergency room
I just finished my metabolism exam, and after learning that at school feels so good to know what's happening here. Also, you make everything so easy to understand and make it interesting to learn.
Same bro
Easy way to tell that someone understand what they’re talking about. When they can do it in a way that others can understand
Are you more indoctrinated or educated?
I got stoned for the first time in university, and expecting "munchies" was surprised that I felt only mildly hungry. I had a 5 lb bag of raw almonds which I would grab a small handful of every day for a quick snack before my earliest class...and by the time I tried the pot, I was down to about 3 lbs. Before I realized it, I had eaten three full pounds of raw almonds in one sitting...then proceeded to have 2 full days of flu-like symptoms and increased propensity for asthma attacks. I thought I was just sensitive to pot, and decided against using again...until I described what I experienced to a med student on the campus, who basically immediately told me that I had suffered mild cyanide poisoning from the raw almonds...which contain small amounts of a chemical called amygdalin, which our body processes into HCN. Most people don't eat 3 lbs of raw sweet almonds in one sitting, so the trace amounts of amygdalin isn't deemed to be too much of an issue and isn't mentioned on the bag or anything. TL;DR: Don't eat multiple pounds of raw almonds in one sitting.
Since we are on the topic... Don't eat an entire 2lb bag of Costco dried Apricots all at once... I did a big hike on a cold rainy day, on the way home, I realized I had the bag of dried Apricots flopping around in my rear floorboard (apparently they slid off the top of my Costco load the day before). Anyways, I had a few and they were delicious, then I really laid into them and finished the bag in less than 10 minutes... I woke up the next day with a pressure in all of my bowels that was beyond anything I've ever experienced, and I was cramping from my chest to my butthole... I ran to the bathroom and threw my buttcheeks on the pot as the explosion happened...
At this point force and pressure of the evacuation caused the chunks to shoot back up my butt crack, up the wall, and across the ceiling, as I stood up to relieve the pressure, there was a secondary explosion... From working out of the bathtub and using all of the towels, it took me 3 hours to clean and sanitize all the shit that had exploded all over the bathroom... If an MD can explain what happened, I would love to know...
@@jimvick8397 holy shit.
@@exan8825 Literally! lol
Also also don’t eat a bunch of donut holes in one sitting either you will get food poisoning and that is an experience all by itself
when I was trucking I kept smoked almonds with me at all times, I loved to snack on it and trail mix for a easy meal n energy, I started getting severe cramps after I left home n was on the road a few days, then I remembered somehow that almonds either has trace cyanide or resembles it, I stopped eating all together n my health issues got better, but i really loved almonds, but its crazy how something promoted as a healthy snack can hurt or kill you over time
I'm a jeweler and I've worked with cyanide based plating solutions for years. I just don't drink it or mix it with acid. I remember my old boss telling me that the amount of cyanide you could pile on your little finger nail could kill you easily. I have a healthy respect for the stuff.
glad you don’t drink it! lmao?
There's sodium cyanide and potassium cyanide. Potassium cyanide is more poisonous whereas sodium cyanide is used to work with metals and the like,,,but still toxic.
@@brandonbrinegar5316i work in electroplating and we use a lot more potassium cyaniye than sodium cyanide. especially for silver plating solutions
More info about cyanide:
As mentioned, amyl Nitrate (the cure mentioned in the video) converts hemoglobin into methemoglobin. Hemoglobin is made up of Ferrous (iron with a +2 positive charge), but methemoglobin is made up of Ferric (iron with a +3 positive charge). Cyanide does not bind to ferrous, but it does bind to ferric. Therefore, amyl nitrate will cause much of the cyanide to bind to your blood cells, which has a lot of iron. Each blood cell contains 300 million hemoglobin and each hemoglobin has 4 iron atoms. Therefore, a blood cel can bind to 1.2 billion molecules of cyanide. Interestingly, there is also a medical condition known as methemoglobinemia, in which people have an abnormally high amount of methemoglobin (this causes them to be more resistant to cyanide poisoning).
Also, as mentioned above, ferric has a 3+ charge which makes it capable of binding to cyanide. Another treatment for cyanide poisoning is hydroxycobalamin-this molecule is basically a form of vitamin B12. What makes this molecule interesting is that it has a cobalt atom with a 3+ charge (just like ferric). So, this molecule is also given as a treatment for cyanide poisoning because cyanide can bind to this molecule just like it can bind to ferric in the methemoglobin of blood cell. When hydroxycobalamin binds to cyanide, it turns into cyanocobalamin. This is another form of Vitamin B12-completely harmless. It’ll get used by your body or it will be excreted through urination.
Very cool, so if the cyanide dose is too high the antidote is ineffective?
How did you learn all this?? is it part of your career?
@@Dantick09 when u have way too much poisons it’s basically lethal
@@HuyNgouc-nl5tb too much of anything is lethal
Has she stopped talking yet? 😴😴😴😴😴😴😴😴😴😴😴😴😴😴😴😴😴😴😴😴😴😴
I am a current paramedic student, I have just recently discovered this page and several of these videos they cover very important topics and essential information that first responders need to know down to the cellular level and chemistry. Very informative! Thank you for posting!
This video singlehandedly explained a puzzle I was wondering about, how can such a tiny quantity of something kill you. It's because I didn't realise how many cells in the body there are and how many molecules go into a mole of something. Thanks for explaining! Now I understand why, it's such a staggeringly large number that even at such a low quantity, there is an overwhelmingly large quantity of the something that kills you.
i ve had various college chemistry courses including organic chemistry and yet i didn't knew how simple cyanide poisoning worked. this felt like it being spoon fed directly to my brain. Great content!
you broke it down way more than I expected and I appreciate that. good content
no problem, thanks!
@@darkscienceyt hey pals, your videos are good with nifty explication and coherent with graphics you offer
But if you put any hecking music, i'll forsaken you, discern this, that'll perturb the Knowledge you want to convey
had to do a case study over the Tylenol poisoning for my anatomy class, this helped a lot thank you!
Hi ! I want to contact you how can i?
It’s just mind blowing to me that such a cool and informative video gets views so slowly, seriously this stuff is too interesting to me
Because it's kind of a sensitive subject and most people don't want to touch it, or show interest, I figured it might be a good idea to know more about possible health hazards.
@@peterzimmerman1114 im obsessesd with it.
This is so enlightening. I was given an entirely, non- biochemistry, different explanation in undergraduate inorganic chemistry decades ago. I was told that the CN was a powerful ligand that bonded to the hemoglobin and caused suffocation.
I was actually surprised that there was another explanation. Always thought cyanide would bind to to hemoglobin kinda like carbon monoxide. Like both can form pi back bonding to iron(II)
Never been to this channel before. I’m really impressed with how in-depth he’s explanation went. Really interesting stuff.
Another antidote is the reducing agent sodium thiosulfate (known to film photographers as “hypo”), and also used in hair salons to break the disulfide bonds between amino acid chains in hair so that the hair can be curled or straightened, then another compound rebuilds the bonds.
Also, there are certain species of mammals that are immune to cyanide. How do they accomplish this?
Had this guy from high school (we weren’t close but I knew him well) who committed suicide by creating and stealing hydrogen cyanide from his university chemistry laboratory. He was gifted and his death was very tragic. Low key it’s interesting to see how it works, wish it wasn’t a thing though.
I don't understand why someone with options would choose cyanide. It just seems like one of the worst ways to go
@@TonyDanza4Lyfe I vaguely recall him making a joke about it a time or two in high school. May have been psychological. We weren’t friends, but I’ve had a lot of respect for him. He was talented, smart, and funny.
Even in death he had to show-off by creating his own poison.
Simpler and cheaper to just buy a few sleeping pills at the corner drugstore.
@@TonyDanza4Lyfe To be fair most people could probably acquire arguably one of the better ones fairly easily with a little effort. Opioids are probably one of the gentlest method if one is that way inclined, initial effects of a lethal dose begin with a brief period of intense relaxation and euphoria followed by unconsciousness and death from respiratory suppression. But the patient loses consciousness prior to the effects of the respiratory depression kicking in so they just drift off never to awaken again. There is a reason why they are usually the drugs of choice for euthanasia by both veterinarians and doctors in jurisdictions where human euthanasia is legal. It is pretty much the gentlest way to accomplish the result with a single drug as it in effect happens to function as a relaxant and anaesthetic prior to actually doing the deed.
@@seraphina985 Right?! If I had to choose between these two ways of exiting life I know which one I would choose.
I like how the antidote for cyanide is itself a poison
We poison the poison, its the only way 😂
Think it's popular in the gay community
@@MrErichonda30Cyanide???
@@ravenID429no i think what he meant was that you weren't allowed to give the antidote to a gay person, because if they have remains of a drug that is or used to be very popular in gay clubs in their blood, the antidote will kill them. at least someone i work with told me that and i work in electroplating, where we use a lot of cyanide for solutions. but idk it might be wrong
@@ravenID429 nope, not the Cyanide, the antidote is commonly sold in Sex shops or online it's street name it's Poppers as it gives a short lived rush as inhaled. Truly interesting that while injected it could save your life if poisoned as in Agata Cristies book
📙😎💅
More people are getting awed by how big the universe really is, thanks to spectacular new astronomic discoveries. And that's great, but not yet enough realise the universe's scaling goes the other way too, into smaller quantities. And the orders of magnitude involved are even more awe inspiring of you think about it.
E.g. there are more molecules in a glass of water than the current estimate of the number of stars in the known universe.
Videos like this one are a great way of improving the visibility of this. You have no idea how interesting chemistry is until you really start studying it.
Bless you for putting Joffrey's death scene in there. I needed something funny today.
All the interesting science and learning stuff aside, watching Joffrey Baratheon take his last wretched miserable breaths was one of the most satisfying moments to ever grace my television screen.
I’m back here after 2 years, when your videos got sued and I commented, my life has been much much more busier now so yeah, still love the vids, I can understand how much time it takes for one vid but keep it up, this is very understandable and clearer :)
Hey, thanks for sticking around and understanding! That was a very dark time for me, and I was close to giving up. I'm thankful for viewers/subs like you!
@@darkscienceyt thanks, keep up the hard work 👍
Not only lactic acid is created during anaerobic metabolism. Even alcohol and carbon dioxide. But in muscles during heavy exercise, lactic acid is created and accumulates to cause cramping. Even Co2 is generated when we use small amounts of oxygen
My friends grandfather was a trapper that would use Cyanide in traps to kill coyotes going after his livestock. My friend and I watched his dog die after getting in one of the cyanide traps while walking in the woods. That dog died in about 1 minute.
I wanted to make some cyanide-based rat poison. I don't want them to suffer, just expire quickly. (A company employee told me they deliberately make it "slow kill," in the event your child or pet ingests it; this allows time to get to medical help before it's too late).
@@elultimo102 Makes sense..... Imagine if someone got a hold of that chemical and it wasn't slowed down but nearly instant or the minute instant anyways it could be used as a terrorist weapon...... Very good move on that company's part
This is a really good explanation, not only you made the tossic mechanism clear, but you also brought the point of view from a number perspective thet I wouldn't consider, you've really done a good job with this video 👍
That is hands-down the coolest science video I've seen in years. Thank you, and keep up the great work.
I really enjoy your videos. Super interesting topics presented in easily comprehensible way. Keep up the great work!
Thank you very much!
Wow, you explained everything in such a simple and easy way, i usually hate chemistry because i always had trouble to understand it, but this video was so clear. Good job
As a professional opossum hunter for many years in New Zealand, I was licensed to use potassium cyanide paste as a rodent-control poison. Virtually all opossum hunters in New Zealand still use this paste, and as part of the legal requirements for an operator using cyanide, you must always carry a few amyl nitrite-filled glass capsules in your pocket in case you accidentally ingest or inhale some cyanide. You were to break open the glass capsule and deeply inhale the amyl nitrite fumes from the liquid. Fortunately I never had to do that during my years of wandering through remote alpine forest while laying out lines of cyanide baits for opossums. One bait the size of an pea, can kill several opossums, and finding four dead opossums around one bait is common. The poison kills virtually instantly and the opossum does not get much chance to wander away from the bait. Cyanide is a very efficient and inexpensive way to control the millions of non-native opossums (these are actually Australian brush-tailed opossums from Australia) which were liberated in New Zealand in the 1800s in the days when conservation was not heard of. These opossums now live in New Zealand in large numbers and do much damage to native species and forests there. There is, from time to time, also a lucrative market for opossum furs from New Zealand. I appreciate this video, thank you, as it has refreshed my knowledge of cyanide, which I have not used since 1981.
what an interesting profession.
Be careful here in the USA I had a very large opossum that had rabies most likely charge at me full speed as it came up over a small rise I was deep in the woods of west virginia n hunting a old hollowed out Beech tree for squirrel one evening, that creature saw me sitting there and came running at me full speed snapping his teeth and was a running full speed fast towards me I had a spilt second to realise it was coming for me, and had to shoot it right as itt got almost to me feet, the dang thing weighed close to 4o lbs, I was just 13 i took it home to show my dad what happened, n he was so pissed i shot something i wasn't going to eat, he told me if i ever shot another n brought it home I would have to eat it, man dad was old school, n thats the way to be, but not when one charges u like that! I doubt dad believed me, i shot everyone of them in the woods i ran across after that, it was fun to hunt in front of the house n fish the river behind us, those 3 yrs were the funnest times with some of the best salt of the earth people you would ever hope to meet, it took me a couple yrs to be fully accepted there, but once they know u n can trust you, its the best place to grow up
Nowadays the preferred antidote is hydroxocobalamin, which is entirely non-toxic but unfortunately has to be given by injection. It reacts with cyanide to form water and vitamin B12, which you pee out. The cobalt atom in vitamin B12 holds on to cyanide more strongly than the enzymes in your mitochondria.
@@marc-andreservant201 Interesting. I wonder if New Zealand's large number of cyanide-using rodent-controllers have been upgraded to this new antidote, and now carry the antidote and a syringe with them, instead of the glass amyl nitrate capsules. You would have to act VERY quickly to get the injection into you if you ingested cyanide, as it acts so quickly. I passed my poisons exams in New Zealand in 1970, and then was entitled to buy and use cyanide. I have not used it since 1981, my final season of poisoning rodents with cyanide. My cyanide license has probably long-ago become invalid, but, when I passed the exams in 1970 it was supposedly good for life. In 1983/84 I worked for the New Zealand Forest Service poisoning possums in Westland, but that was all done with 1080 poison and is still the case today.
@@AmericanPatriot-cw9xe That's interesting since opossums are mostly immune to rabies
New video? YES I need to feed my cravings for new informational videos
I always find it nuts how life is just chemical machinery. I mean, I know it's obvious but at the same time the chain of events is mindblowingly simple.
Yep, biology is just applied chemistry
Chemistry is just applied physics
And physics is just applied math
Everything always boils back to math
@1:57 - Minor point - The acrylo in acryloitrile is pronounced uh - krillo (short i) - nitrile (long i)
Et cetera - Cytochrome P450, sodium thiosulfate, vitamin B12
nothing like starting off an 8 minute video with a minute long ad read
i completely LOVE your videos, please please please don't make them stop
I am a former autobody painter. There is a chemical in the paints that is called isocyanates which will have the same effect on the human body as cyanide does. The chemical is a very close relative to cyanide. The molecule promotes adhesion and is found also in things like Super glue, and high quality chip resistant nail polish. Few people are sensitive to this chemical, actually we are exposed to it all the time but most will never feel it. I on the other hand, and people who are sensitive to it will get tremors, difficulty breathing and a few other issues that depend on the person.
"Mitochondria is the powerhouse of the cell"
Cyanide Poisoning: "Say SIKE !!!"
At 2:57 he said that cytochrome c oxidase is also called the cox enzyme, however the cox enzyme is actually cyclooxygenase, which makes prostaglandins and has nothing to do with electron transport.
Still a fantastic video in any case!
Now you made me remember one of my favorite drinks, bitter almond liquor with a bit of a lemon squeeze.
Bitter almonds contain Cyanide, I believe less than 20 really bitter ones can poison you with a letal dose. But that's safe on that liquor.
How didn't I remember this during lockdowns?
Well, I guess I now have a drink for the winter. Thanks!!
sounds like 160 billion bitter almonds could solve the planets problem in one fell swoop. hmm
I stopped studying chemistry at 16 and moved onto engineering in polytechnic and I must say, the guy that figured out the antidote to cyanide must be smart as hell
That Chevy Corvette part was hillarious!
The fire at The Station club in Rhode Island..there was soundproofing foam where the drummer sits on the stage. When it burned it produced hydrogen cyanide gas in the smoke, many patrons that night lost their lives to the inhalation of that toxic gas.
Correction. The affinity of the cyanide anion for iron in hemoglobin is orders of magnitude higher than that of oxygen, effectively blocking the uptake of oxygen and the removal of CO2. Certainly some cyanide will make it inside cells and wreak havoc there, but the most important mechanism of asfixia is the blocking of hemoglobin.
Iron-cyanide complexes are so stable that they once were used as pigments. The most popular is Prussian blue.
I'm happy to see a video blow up your channel is very underrated
I appreciate that!
Who would have thought "poppers" could be an antidote for Cyanide.
You know something is deadly when its whole composition has a ":C" in it
Now hydroxocobalamin is more commonly used as an antidote since it directly reacts with cyanide to form cyanocobalamin and it's far less toxic than amyl nitrite.
Thank you! Corvette example was amazing!
Glad you liked it!
You are a really good teacher. Thank you for the video!
You're very welcome!
I was working on a paper while eating cherrys. I tend to chew on things when I am stressed. I ended chewing on the pits. I completely blacked out soon and I could not move any part of my body. I woke up two days later and my lungs felt like sandbags. I immediately opened a window thinking it was co2. The sense of doom scared me in ways I don’t think even think I can completely understand. Thankfully I got help. I definitely don’t like cherries now.
In the 70s I worked in an automobile component plant. Chemicals used in metal hardening produced Hydrogen Cyanide myself and a work colleague were exposed. I spent a day in hospital.
It's amazing to know how chemistry and biology together works in body
The COX enzyme in the electron transport chain is also commonly called complex IV (4). Just thought I should add this given that I’ve studied it today lol.
Lastly giving a short revision is really helpful.Thank you for that.
Thanks, just Reminded me to arrange that dinner party. 🍽️💀
I can't believe mole made it to SI unit system. It would fit right into imperial system from what I can see about it.
I was in the shower and was like “huh I wonder how poison works” this is the first video that pops up and I was like “yeah how does cynide do that” thank you
One of the most underrated statements ever on RUclips...
"I'm starting to feel a little bit of the effects of the cyanide."
'
Wow this is the first time I understood something without ever questioning
The best teachers are the ones who can explain complicated systems, simply. You do this very well.
Lessons at school would be much more interesting to enhance if teachers let students dive into facts from this channel.
To any 3D printing and/or laser cutting people watching this, Acrylonitrile is most often seen in DIY as the plastic ABS, which stands for Acrylonitrile Butadiene Styrene. 3D printing folks often use Acetone vapors to melt the ABS so the surface can be smoothed out. It's way safer than melting it with fire, but please be careful, as Acetone vapors are neither harmless. Anyone interested in laser cutting ABS, should only do so with a specialized filter attached. Don't ever cut it without your laser being in an airtight container with an exhaust through a filter. The consequence is presented in this video. You'll wind up producing Cyanide gas, which will kill you pretty damn quickly. Same reason why you don't cut PVC in a laser, as that produces Chlorine gas (PVC is short for Poly Vinyl Chloride).
Do a video on thallium next! Super obscure poison, almost no unusual symptoms.
I never heard it before, so it really must be obscure! Thanks for the idea!
THIS IS THE MOST UNDERRATED RUclips CHANNEL
Here's a question: When you print ABS on a FDM 3D printer - you heat up the ABS filament. I know the burning ABS releases hydrogen cyanide gas.
But will it happen as well, when you heat it up to 200 degrees Celsius? (392 Fahrenheit)
Also, RIP Geoffrey, he didn't activated Windows.
I need to know exactly to the letter why it is that every person remembers Mitochondria as the powerhouse of the cell but basically none of the other organelles.
Ingested in the right amount it can render a person permanently blind almost instantly. I know of a case where the victim inadvertently drank a glass of cyanide solution in the belief that it was drinking water at a jewelry manufacturing workshop and went completely blind in no time.
You can also dilute cyanide with Cobalamin aka Vitamin B12. So, if in the situation many walmarts sell liquid B12 in the Vitamin aisle. Liquids would be your best bet in a strenuous situation, well actually gaseous is might be the quickest but inhaling acid is also probably a bad idea, just like cyanide.
MITOCHONDRIA IS THE POWERHOUSE OF THE CELL YEAAA BABYYYY 💪
Step 1: Get some Kool-Aid
While we're on this topic, how about a video on chloroform? Recently watched a video that showed misconceptions and one of them is that chloroform use in movies are very inaccurate and actually should take way longer.
Hey thanks for the idea! I'll run it by my patrons
Oh dear, you’ve now added several more things I don’t understand to an already rather long list. Thanks for trying.
Great, now if me wife passes away "they" are going to see I watched a cyanide video! lol
As long as you don't Google : How to dispose of a dead body .? "
As some idiots have done . ( Unsurprisingly they are now incarcerated ! )
Ya gotta love a video that doesn’t get to the point straight away
This is well done with the exception of the treatment section which is not correct by today’s standard. Today the ambulance paramedics and emergency room physicians use intravenous hydroxycobalamin or cobinamide. Amyl nitrite, sodium thiosulfate and sodium nitrite are only used in very rare scenarios.
Nice of you to show Joffrey in the thumbnail
I previously thought it just shut down your respiratory system like so many other things do, but oh no, it's FAR worse. That's freaking evil.
I don't know if I can trust you if you don't say "Mitochondria, which is the powerhouse of the cell." I mean, come on! This is important information people NEED to know
It would have been nice to include the timeline of how a lethal dose of cyanide oral route effects the body and when death occurs.
exactly- because there are these (mis) conceptions that you just crack open the cyanide pill and 2 seconds later you are dead… (used in many movies) … yes we know movies are not the real thing but there isnt just any counter information available as readily as it should be.
(for example if there is a cure and can be administered into the bloodstream then surely the ‘you have two seconds to live’ is not the case)
but still would be good to know what are the timescales to get help) :)
good video otherwise:)
@@mityaboy4639 Inhalation - ~ 2 minutes.
@@mityaboy4639
Cyanide pill orally 2-5 minutes.
@@julybailey2326what about two or more pills ? Does it fasten the process or just make the effects worse
100mg ingestion will kill you in an hour.
Me:looks at bottle of isobutyl nitrite
Also me: *poppers intensify*
Then me: dies from cyanide
Wow, didn’t even knew it back then, but I’ve probably had a cyanide poisoning in Thailand bc of cassava…
“Joffrey Lannister” This guy knows his game of thrones trivia
I will take cyanide when i cant deal with my severe depression anymore. Life still really sucks.
Don’t do that
@@LifeFilosophy do you know where to buy it
From personal experience, you can also feel a burning sensation as well, it's a very unpleasant and desperate feeling and you suddenly feel heavier.
imagine dying from getting coxblocked
This is so sad. Just saw news that tourist deaths could be connected to cyanid as it was found in food of restaurant.
This looks familiar but diferent at the same time, like a wierd dejavu.
I too remember that the mitochondria is the powerhouse of the cell.
Im not a sadistic person but Joffrey's death satisfied me like nothing else did .
I would've appreciated a spoiler alert for the Game of Thrones spoiler. That show is still on my watch list.
cyanide also bonds very strong to the iron atoms in the blood hemoglobin to inhibit the transport oxygen.
I do chemistry well in school,always acd my calculations but never knew wtf a mol was till this video,i always just calculate it, shout you bro
If schools got topics as interesting as these, I wouldn't skip a minute of it.
No you will learn that there are 150 different genders and men can give birth… and you will like it.. no need to learn this useless cyanide crap
They do you just don’t pay attention
I've just remembered why I hated chemistry at school 50 years ago!
Might be good to precise amyl nitrite also act as a vasodilatator, this conter the vein contraction effect that cyanide produce when ingested. I personally have been pretty badly cyanide poisoned once while doing chemistry. I can relate to the asphyxiation effect, and more especially to the muscles spasms. I suffered of uncontrolled spasms in arms and neck for the next 4 to 5 month, but it seem like it ended up wearing off
😮
so THIS is why mr patrick joined the chemical industry
As I recall from the book, poison that killed Joffrey was causing larynx swolling so severe that made breathing impossible, but video very interesting still.
"You may remember that you have mitochondria"
Me, nodding: yes, it is the powerhouse of the cell
And here I thought that cyanide made you foam at the mouth and barely have time to grunt "Hail... Hydra!". Can you do episodes on other "famous" poisons? Strychnine, sarin, ricin, etc.
watched a guy on courtTV secretly ingest a cyanide capsule. Started out with a cough, tremors, then he began snorting, shaking, and then collapsed. Seemed like a horrible way to go.
It's probably not the worst and it is one of the simplest. My method of choice would be an inert atmosphere. You just fall unconscious. It's not something that can be accomplished on the spur of the moment, though. The absolute worst way to go has to be strychnine.
Just a thought. Seeing how Cyanide stops the production of ATP, is it not possible to synthesize ATP artificially or a substitute that could be administered along with Amyl Nitrite?
Finally someone explains how dosages work