Staying Sharp: Current and Future Approaches to Brain Health and Alzheimer’s Therapeutics
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- Опубликовано: 28 июн 2024
- Dr. Aimee Kao looks at recent news in Alzheimer's Disease therapeutics including drugs in development and the potential of stem cells and genome editing. Recorded on 10/24/2019. [12/2019] [Show ID: 35238]
More from: Next: UCSF Scientists Outline What’s To Come
(www.uctv.tv/mini-med-next)
#brainhealth #alzheimer #mentalwellness
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0:00 Introduction
3:53 What goes into a cognitive evaluation?
6:09 What contributes to cognitive decline?
10:54 The most common diagnoses at a Memory Clinic
15:42 The Long and Expensive Drug Development Pipeline
17:45 Current drugs in the pipeline for neurodegeneration
19:20 The benevolent cycle of human disease research
22:17 Neuronal protein aggregates are the "pathognomonic" feature of neurodegenerative diseases
30:42 What are characteristics of stem cells?
36:48 CRISPR gene editing came from the basic science study of bacterial immunity!
38:36 How did bacterial immunity turn into genome editing?
39:49 Uses for CRISPR/Cas9 gene editing
45:09 Lysosomes are responsible for breaking down misfolded proteins
46:00 Genetic clues from neurodegenerative diseases from point to the importance of the lysosome
47:09 Like lemons, lysosomes are acidic pH varies in different part of the cell
48:09 How is lysosome function controlled?
48:44 Supercharge the lysosome by sharpening the shredder blades Lysosomal proteases = Shredder blades
50:12 Supercharge the lysosome by sharpening the shredder blades Lysosomal proteases - Shredder blades
53:05 Rejuvenating the lysosome could help to cure diseases of aging like Alzheimer's
Fascinating talk, can't thank you enough for making these available. My neurons approve :)
Haha!
Thank you. It’s informative to the public.
wonderful talk
So shining.
It's nice information
Dr. Kao resebles my daugher SOooo much
Isn't it from mitochondrial problems?
mitochondrial problems do matter
I understand that you are not optimist about the approvement of your drug targetting AMYLOIDE PLAQUES...as they are not the cause of Alzheimer's desease ( see DALE BREDESEN's lectures)
Not very useful to me. Thought this would be a more practical discussion of brain health; things we can really do to offset this horrible brain disease like ways to improve brain health like diet and exercise. Nutrition and exercise to me are the most important things for brain and overall health and she didn't even mention that here. Will keep searching for more useful info
just not true. watch again. you don't have to wait too long till she's talking about it
Not very useful to you....but for others useful for them...its for everybody to know.