Cancer Immunotherapy - PD-1 and PD-L1

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  • Опубликовано: 2 окт 2024

Комментарии • 95

  • @foodanddrink333
    @foodanddrink333 2 года назад +7

    I started immunotherapy last week in part because the radiation and chemo, although effective against my mouth, neck and lymph tumors, were not effective against the cancer in my lungs. I am a reasonable candidate for this treatment, and I am cautiously optimistic. Attacking cancer on the cellular level seems like quite an advance, verse the poisoning through chemo, the burning by radiation, and the cutting by surgery. Medical science progress, an answer to the prayers of many people.

    • @SA-ux7xb
      @SA-ux7xb 2 года назад +1

      How are you now?

    • @godschild3640
      @godschild3640 Год назад +1

      @@SA-ux7xbI STARTED KEYTRUDA. I’ve been very sleepy for four months, but now I’m starting to get stronger but I’m still sleepy but I think I’m going to live now.

    • @P3ACE_HAS_TO_BE_H3RE
      @P3ACE_HAS_TO_BE_H3RE Год назад +2

      Immunotherapy keytruda Sáved my dad from stage 4lung cancer to stage 0 but he did chemo with immutherapy after clean results they want to still do immunotherapy for as long as possible just in case .
      Doctors are still saying that its a miracle what had happend they didnt expect this results not after 3 months treaťment
      We prayed everyday we did even before that but believe in GOD pray be thankfull and trust me miracles happens

  • @pharmrocks
    @pharmrocks 9 лет назад +58

    If only we had videos like these throughout pharmacy school!! Thanks for the upload! :)

    • @skatergirl222
      @skatergirl222 9 лет назад +1

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    • @PhillysOkayestDad
      @PhillysOkayestDad 6 лет назад

      RxPharmacist you’re right! Man, pharmacy school would’ve been entertaining!

    • @D_kiki999
      @D_kiki999 3 года назад

      Totally!!!

  • @sneakyguy4444
    @sneakyguy4444 5 лет назад +4

    Its not so simple because blocking the pathway also removes the self recognition of most other healthy cells in your body. They all can be attacked.

  • @Audrey_Yo
    @Audrey_Yo 5 лет назад +7

    greatest, simplest and ...most of all, CUTEST explanation ever for PD-L1 !!! Thank you so much for the video.

  •  4 года назад +1

    This was amazing, thanks so much!

  • @OM231
    @OM231 6 лет назад

    Amazing video ,, very illustrative.

  • @jacobdavison93
    @jacobdavison93 2 года назад +1

    Great content and video but that marker hitting the board sound killed me inside a little.

  • @akshittuli1211
    @akshittuli1211 7 лет назад

    OMG !!! Amazing explanation....and the animation....too good !!!

  • @margigannon1748
    @margigannon1748 3 года назад +1

    So does pdl1 bind to pd1 and turn off the t-cell?

  • @kathya1956
    @kathya1956 3 месяца назад

    How long will you all go down this alley?

  • @bartoszbarejko1585
    @bartoszbarejko1585 8 лет назад +2

    In the next 2015-2025 there will be nothing to forecast, the spread of innovating technology will be unstoppable by big companies and governments, Wide access to the technical data and the resources will be beyond the borders and any control, and people will have access to the internet freely or very cheap. And i well be no exception. So the only way to work it is by working together.

  • @user-kt2rk6lf6y
    @user-kt2rk6lf6y 5 лет назад

    This is an awesome video.

  • @creator4836
    @creator4836 4 года назад

    3:00 T cells do not have B7.1 molecules. B7 costimulatory molecules express on APCs, the counter part CD28 express on T cells.

  • @oscarmora4919
    @oscarmora4919 7 месяцев назад +1

    Love the format and simplicity that this was developed! Many thanks
    👏

  • @mannyquintana4761
    @mannyquintana4761 8 лет назад +3

    Excellent explanation of this type of treatment. Helped me understand a lot better

  • @remembranceproduction4395
    @remembranceproduction4395 8 лет назад +3

    blocking the pd l1 and cd 47 can help more and more people.

  • @adnanworks
    @adnanworks 6 лет назад +2

    Complex concept broken down to an easy, understandable demo. Thanks!

  • @remembranceproduction4395
    @remembranceproduction4395 8 лет назад +4

    immunotherapy is so interesting, hope might be near to those who need it!

  • @bharathraj5862
    @bharathraj5862 8 лет назад +4

    Easily understandable Sir!

  • @kathya1956
    @kathya1956 3 месяца назад

    Why do only 20% have some response that’s good while 20% of people die from therapy and in 60% people it does nothing?

  • @av8480
    @av8480 3 года назад

    Is lenvatinib and Nivolumab injection...... Are immunotherapy drug ????

  • @flow4458
    @flow4458 3 года назад +1

    Nawww, this animation was so cute!

  • @ResidualSelfImage
    @ResidualSelfImage 2 года назад

    PD=programmed death receptor, T=thymus glands, As the Thymus glands ages , Thymus gland cells aka T-cells become less effective. In immunotherapy, PD-1 receptors on a tumor cell are blocked/molecularly locked so T-cells can recognize tumor cell that needs to be marked for destruction/autophagy. a very useful option in non-resectable cancer. It could be safer than surgery to remove tumors too.

  • @rohitsaxena22
    @rohitsaxena22 3 года назад

    So what happens to the already deactivated T-cells. Does immunotherapy only prevents new T-cell to attach to tumor cells. If yes, then starting immunotherapy early can give better results (considering the patient has PDL-1 inhibitor )??

  • @SubornaKhatun-b5k
    @SubornaKhatun-b5k 27 дней назад

    Rodriguez Eric Anderson Lisa Martin Lisa

  • @user-rl9qd7db5m
    @user-rl9qd7db5m 8 лет назад

    Confused... I thought B71 (CD80) was only present on APCs for the purpose of costimulatory activity by interacting with T cell's CD28....?

  • @dr.mohammadashrafpal6066
    @dr.mohammadashrafpal6066 6 лет назад

    Is this mechanism workable with NHL

  • @joyniuniu2294
    @joyniuniu2294 6 лет назад

    I am engaged in public scientific popularization , and I think the video is very vivid for people to understand immunotherapy, I want to ask for the permission of reprint it on our Wechat platform but reserve all marks of yours, may I?

  • @cathina22
    @cathina22 3 года назад

    When did my childhood crush Lee Shang from Mulan get a PhD in immunology?

  • @HelloHello-be2li
    @HelloHello-be2li 3 года назад

    Thank You for the info......thanks to RUclips there is a lot of information available....!!!!!!

  • @gb2477
    @gb2477 3 года назад

    instructions unclear... removed all healthy cells wearing sunglasses.. oops

  • @anonymouse7697
    @anonymouse7697 6 лет назад

    You barely scratched the surface my friends....it's here and somewhere along the lines of my Instagram

  • @DoubleGauss
    @DoubleGauss 6 лет назад

    OX40 stimulation may be able to prevent inactivation by PD-1/L1 interaction. Trials are underway to investigate that.

  • @TinyDolphinMusic
    @TinyDolphinMusic 7 лет назад +4

    I'm really hopeful about this new branch of cancer research

    • @brugueiramed1845
      @brugueiramed1845 7 лет назад

      Because of US estrangement from Cuba most cancer patients may be unaware that Cuban vaccines for stage IIIb-IV cancers are more efficient in terms of life expectancy and quality. Seen costs on www.doctorcuba.com affordable for self-pays and on-benefits.

  • @yanhongzhou634
    @yanhongzhou634 3 года назад

    Everything intuitive illustration. Thank you very much!

  • @-cuisinecrafts
    @-cuisinecrafts 5 лет назад

    شكرا لكم

  • @remembranceproduction4395
    @remembranceproduction4395 8 лет назад

    maybe chemotherapy should only be administered when nesecary.

  • @clinicalpaperspodcast1837
    @clinicalpaperspodcast1837 4 года назад

    Thank you so much. Really amazing! I 'll pass this forward for sure!

  • @-cuisinecrafts
    @-cuisinecrafts 5 лет назад

    Thank you

  • @goobydntfear
    @goobydntfear 5 лет назад

    heyhey people, sseth here

  • @shubhimaheshwari8615
    @shubhimaheshwari8615 4 года назад

    SO helpful! thank you

  • @philwong214
    @philwong214 5 лет назад

    this was terrific. Thank you Dr. Chen.

  • @lim4163
    @lim4163 4 года назад

    Thank you for the great lecture :)

  • @brant25
    @brant25 4 года назад

    Very cool animation!

  • @Psych0p4th3
    @Psych0p4th3 2 года назад +1

    Thank you very much for these useful explanations, the lecture is easily understandable for everyone. It helped me a lot !

  • @daffodiles4432
    @daffodiles4432 3 года назад

    Thank u so much

  • @bankseuros6884
    @bankseuros6884 4 года назад

    Hello Dr I'm Vivian from Nigeria, how can I access immunotherapy

    • @alamindewan8875
      @alamindewan8875 4 года назад

      Pls say bengali verson

    • @alamindewan8875
      @alamindewan8875 4 года назад

      Plz say which is the best for cancer treatment immunotherapy ya chemotherapy??

  • @amadeuslow9898
    @amadeuslow9898 6 лет назад

    just wondering if this discovery has been helping cancer patients to recover?

    • @jamesjackson9374
      @jamesjackson9374 3 года назад

      Yes it has. Pembrolizumab is a drug that was FDA approved in 2017

    • @godschild3640
      @godschild3640 Год назад +1

      @@jamesjackson9374. AND NO ONE WROTE BACK. So we don’t know if they are alive or dead.

  • @africacarrilmartin5036
    @africacarrilmartin5036 4 года назад

    Amazing

  • @remembranceproduction4395
    @remembranceproduction4395 8 лет назад +1

    everybody's different, a patient has to try and find the right combination or right medicine for the body.

  • @ayudiahmayasari1182
    @ayudiahmayasari1182 5 лет назад

    Thanks

  • @SiSi-ju1xk
    @SiSi-ju1xk 6 лет назад

    Nice

  • @harissabir8180
    @harissabir8180 6 лет назад

    Nice animation

  • @myfuntime100
    @myfuntime100 6 лет назад

    Awesome presentation !

  • @yumetiger4083
    @yumetiger4083 5 лет назад

    Thank youu so much!

  • @dr.mohammadashrafpal6066
    @dr.mohammadashrafpal6066 6 лет назад

    Brilliantly explained!

  • @shatha9204
    @shatha9204 7 лет назад

    Wonderful !!!!!

  • @blancadominguez1701
    @blancadominguez1701 4 года назад

    Love this!!

  • @cassiacorrea9112
    @cassiacorrea9112 7 лет назад

    Mt didático!

  • @Zilvergun144
    @Zilvergun144 9 лет назад

    2:40

    • @mastanshaikh4234
      @mastanshaikh4234 7 лет назад

      whether this therapy can b apply at advanced stages

  • @danh5183
    @danh5183 3 года назад

    CovidImages need to be invested more than half19

  • @bhushanparab8700
    @bhushanparab8700 2 года назад

    Proud to worked with Roche