Standard Curcumin even with Bioperine has a half life of around 18 minutes, Liposomal Curcumin has a half life of nearly 8 hours in the plasma, (Liposomes can pass the BBB btw) so the fact that Liposomal Melatonin and or time released Melatonin exist may weigh into your dosing strategies. Liposomal encapsulation magnifes absorption rates by quite a bit.
Hi Doris, excellent presentation, but is the melatonin you are taking synthetic? You did not explain the impact of using synthetic melatonin in high doses and for a long time.
I think she needs to address prolactin increase due to melatonin supplements. Not addressing it is a grand oversight if your specialty is melatonin imo. Ill be sticking to 3 to 5 mg at night only.
Totally agree - I've been a virus skeptic since 2008. A germ (causing disease skeptic, even before that). and I have critically examined the science.....closer to $cience. Point being, Electron micographs do not prove conjectured particles causing disease. Growing a "viral' soup via cell culture is not true isolation. If we examine how any functional medicine or drug works on an alleged viral cell culture, the beneficial effect we are seeing is its effect on the antibiotic and anti-fungals added to the cell culture, alleged to contain viruses. So is how part of the self-fooling occurs. Indoctrinated, trained scientist assumes these standard lab protocols have been well vetted, however....only as far as the grant money flows. That being said, in terms of mitigating disease, either pro-oxidative therapies or upregulation of NRF2, or diet that does not perturb the glycerol-fatty acid cycle (mixing carbs and fats for example) will allow not to aggregate as much toxin beyond our bodies ability to deal with it.
Hi Doris, I am a male 74 years old. Last year I had 3 stents inserted into my right artery and the left main artery. My cardiologist also diagnosed me to have stage 1 dystolic dysfunction with mild left ventricular hypertrophy. Would taking melatonin help and what should be the daily dosage to prevent it from progressing?
I think she needs to address prolactin increase due to melatonin supplements. Not addressing it is a grand oversight if your specialty is melatonin imo. Ill be sticking to 3 to 5 mg at night only.
@@baloog8 She has been asked about prolactin increase and its relation to prostate cancer. This was her response: “The prolactin signaling cascade associated with prostate cancer is not an item in isolation. For it to promote cancer proliferation, synergistic effects with other molecules and pathways need to happen. Therefore, the assumption that an increase in prolactin completely negates an entire literature of studies and reviews on the benefits of melatonin in prostate cancer is flawed, IMHO. In addition, it is unknown what amount of melatonin was given even though the term high dose was used. Understand that there is a huge difference in effects that can be associated with the use of 30, 300, and 3000 mg melatonin.”
There is SCC metastasis in the right side neck lymph’s from previous HPV P16 tonsil cancer! Which has been removed. I have tried high dose Melatonin of 100-200mg over the course of 5 days and I experienced rapid weight gain, but particularly male gynaecomastia in both sides of my chest, but more particularly on the right side which ironically is the same side as the neck tumours! I tried to offset the estrogenic effects using Indole 3 Carbinole along with. Calcium D Glucarate, but I still put weight on!!! How do I offset and rectify to get the best benefits of high dose Melatonin for tumour aptosis without putting on weight?
It may interest you to know that Liposomal Curcumin has a half life of nearly 8 hours in the plasma, (Curcumin is also beneficial for preventing dementia) Liposomes can pass the BBB, Liposomal Melatonin exists, just some things for you to consider when it comes to dosing and half lifes.
8:43 she lost me when she indicated that mankind originated from some type of "primordial soup". Talk about religious dogma. It takes much more faith to believe that mankind crawled up out of a cesspool than to believe that mankind was created by a creator. These brilliant people must know that human life could not have evolved from chaos into this extremely complex system. I can assure you that if you put a hunk of metal in a pile and leave it for 1 million years you would not find a Swiss watch when you returned. No, we were created.
I agree with you wholeheartedly but you just have to overlook these comments because you’ll miss important information if you focus on that small part. They know how the body works and what can help people. Just have faith in your beliefs and respect theirs by ignoring those statements. We know we were created.
Doris should be Nobel nominated
similar like Obama ? , nobel... scam prize for mostly fake or lie discovers
Standard Curcumin even with Bioperine has a half life of around 18 minutes, Liposomal Curcumin has a half life of nearly 8 hours in the plasma, (Liposomes can pass the BBB btw) so the fact that Liposomal Melatonin and or time released Melatonin exist may weigh into your dosing strategies. Liposomal encapsulation magnifes absorption rates by quite a bit.
Not gonna lie most of this went over my head but I appreciate its in depth presentation.
Doris Loh rocks! 👋 Yours truly is 79, never gets sick, and takes *_3 grams of melatonin powder Monday to Friday._* 🤣💕☮🌎🌌
Thank you thank you ….post long haul covid has had devastating effect on daily life-your dosing schedule finally set me on path to regained health
Look into Dr Ardis and nicotine, amazing results for long covid
Thank you Doris Loh and Jay C. for such an educational experience ❤
thank you for an incisive, informative talk! I have learned so much from your papers and interviews
One of the best presentation I have seen on you tube in a long time .. Thank you Doris Loh 🤩
Hi Doris, excellent presentation, but is the melatonin you are taking synthetic? You did not explain the impact of using synthetic melatonin in high doses and for a long time.
Does it matter how it was synthesized if its still the same molecule?
I think she needs to address prolactin increase due to melatonin supplements. Not addressing it is a grand oversight if your specialty is melatonin imo.
Ill be sticking to 3 to 5 mg at night only.
@@baloog8 I feel awesome at 79 and take *_3 grams_* Monday to Friday. 😝
Where do I get quality melatonin in powder form?
Doris is amazing.
Thanks for sharing this outstanding presentation and information
Martin Kimberly Hernandez Brian Davis Larry
Where can we purchase the bulk powder in Canada? small doses are very expensive
What dose would you recommend for a healthy 72 year old. I take no drugs of any kind. Thanks for video.
Can the Epstein-Barr virus also hijack the mitochondria of healthy cells the same way as COVID, and will high doses of melatonin help with this?
Any thoughts and/or research RE: taking Phytomelatonin rather than synthetic Melatonin?
I'll have what you're having. Thank you.
The longest lived people don't take anything!
And they certainly don't live in the US.
Thank you for a very informative discussion!
52:10 if the solvent enhanced bioavailablity, why would you increase dose instead of decreasing it?
For the rodents it was… so have to take that into account for human dose
Doris needs to provide written proof of the “virus” including proof of isolation, purification and characterization.
Totally agree - I've been a virus skeptic since 2008. A germ (causing disease skeptic, even before that). and I have critically examined the science.....closer to $cience. Point being, Electron micographs do not prove conjectured particles causing disease. Growing a "viral' soup via cell culture is not true isolation. If we examine how any functional medicine or drug works on an alleged viral cell culture, the beneficial effect we are seeing is its effect on the antibiotic and anti-fungals added to the cell culture, alleged to contain viruses. So is how part of the self-fooling occurs. Indoctrinated, trained scientist assumes these standard lab protocols have been well vetted, however....only as far as the grant money flows. That being said, in terms of mitigating disease, either pro-oxidative therapies or upregulation of NRF2, or diet that does not perturb the glycerol-fatty acid cycle (mixing carbs and fats for example) will allow not to aggregate as much toxin beyond our bodies ability to deal with it.
Mice are not men and women?!
I think she’s just broken down/potentially found a cure for ME/CFS?
What's the proper dosage more or less for aggressive cancers?
Whose melatonin does she use
Hi Doris, I am a male 74 years old. Last year I had 3 stents inserted into my right artery and the left main artery. My cardiologist also diagnosed me to have stage 1 dystolic dysfunction with mild left ventricular hypertrophy. Would taking melatonin help and what should be the daily dosage to prevent it from progressing?
If it is due to calcification, you may want to study K2 in the form of MK-7.
A brilliant presentation!
What brand of powder does she use? Please!
I believe it’s Pure Bulk.
@@mrcove1 Did you ever try the higher dose? How'd you respond?
I think she needs to address prolactin increase due to melatonin supplements. Not addressing it is a grand oversight if your specialty is melatonin imo.
Ill be sticking to 3 to 5 mg at night only.
@@baloog8 She has been asked about prolactin increase and its relation to prostate cancer. This was her response: “The prolactin signaling cascade associated with prostate cancer is not an item in isolation. For it to promote cancer proliferation, synergistic effects with other molecules and pathways need to happen.
Therefore, the assumption that an increase in prolactin completely negates an entire literature of studies and reviews on the benefits of melatonin in prostate cancer is flawed, IMHO.
In addition, it is unknown what amount of melatonin was given even though the term high dose was used.
Understand that there is a huge difference in effects that can be associated with the use of 30, 300, and 3000 mg melatonin.”
There is SCC metastasis in the right side neck lymph’s from previous HPV P16 tonsil cancer! Which has been removed. I have tried high dose Melatonin of 100-200mg over the course of 5 days and I experienced rapid weight gain, but particularly male gynaecomastia in both sides of my chest, but more particularly on the right side which ironically is the same side as the neck tumours! I tried to offset the estrogenic effects using Indole 3 Carbinole along with. Calcium D Glucarate, but I still put weight on!!! How do I offset and rectify to get the best benefits of high dose Melatonin for tumour aptosis without putting on weight?
Can you explain how it created weight gain? Do you know the mechanism? Hope all is good for you though.
Human Fenbendazole is on Amazon, 222mg and 444mg.
It may interest you to know that Liposomal Curcumin has a half life of nearly 8 hours in the plasma, (Curcumin is also beneficial for preventing dementia) Liposomes can pass the BBB, Liposomal Melatonin exists, just some things for you to consider when it comes to dosing and half lifes.
probably prolactin production@@alexanderohanlon8825
8:43 she lost me when she indicated that mankind originated from some type of "primordial soup". Talk about religious dogma. It takes much more faith to believe that mankind crawled up out of a cesspool than to believe that mankind was created by a creator. These brilliant people must know that human life could not have evolved from chaos into this extremely complex system. I can assure you that if you put a hunk of metal in a pile and leave it for 1 million years you would not find a Swiss watch when you returned. No, we were created.
I agree with you wholeheartedly but you just have to overlook these comments because you’ll miss important information if you focus on that small part. They know how the body works and what can help people. Just have faith in your beliefs and respect theirs by ignoring those statements. We know we were created.
In your mind a magical super entity that you call god is more likely than complex but natural evolutionary forces?
SmFh…🙄 living from the neck up in fairy tales is the antithesis of understanding.
We were not created. There's no God. Evolution rocks! Religion and pseudoscience suck!