Leuprolide Mnemonic for USMLE

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Leuprolide is a synthetic analog of gonadotropin-releasing hormone, or GnRH. It has notably different functions depending on how it is administered to patients. When administered in a short pulsatile fashion, leuprolide acts as an agonist or activator of GnRH receptors and increases the production of FSH and LH. This increase in FSH and LH increases downstream sex hormone synthesis and can be used in the treatment of infertility and hypogonadism. In contrast, when leuprolide is administered in a long continuous fashion, it acts as its antagonist or blocker at GnRH receptors and decreases the production of FSH and LH. This ultimately reduces sex hormone synthesis.
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[@dailydoseofmedicinee]

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[@docdiaries8866]

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