Hormones for Menopause | Progesterone Cream and Endometrial Hyperplasia
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- Опубликовано: 26 окт 2024
- Dr. John R. Lee popularized the use of progesterone transdermal cream in menopause. But does progesterone in a topical cream work to prevent endometrial hyperplasia?
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You are one of my favorite people in regards to hormones. You really explain things well. Thank you!!
C V - thank you for that comment!
@@SimpleHormones Hi, I am a lost cause , i have health and medication phobia and extreme anxiety and panic attacks . I am 58 postmenopausal of 10 years did not take HRT do smoke or drink , I was diagnosed with type 2 diabetes in 2017, the latest A1c says stable . Last Monday i stupidly did a douche and the next day I bled it wasn't a lot and not enough to put a pad on , I got scared and went to see the doctor I had an ultrasound and internal scan which showed some thickening of the lining of the uterus, now my doctor wants me to have a biopsy i won't have one done i do not trust them . I don't know how thick the lining is . The bleeding has stopped there is nothing , I am just a bit in pain from that barbaric procedure . I know what it feels like having the cervix cut while awake as I had abnormal cells on my cervix when I was 25 , i was awake through laser treatment and cervical biopsy and passed out during the procedure . I'm not going through that again . I am a lost cause i guess .
Im a 47 perimenopausica .
Im already taking birth control so my.period lasts 1 week. But that week is still heavy. So I just odered online Progesterone cream 3000 mg (a dose 20mg daily) and DIM hormonal.balance suplement.
So hopefully help me wth my heavy period and my melasma on my cheeks.
We'll see.
This has been very helpful!! I am having an endometrial biopsy tomorrow. Mines was thickened 1.1cm and I also have a polyp 0.5×0.6, a fibroid and a cyst that is coming and going. Im 46 & entered perimenopause about 2yrs ago. I am praying that my biopsy results are negative
That endometrial thickness doesn't sound too bad. Good luck on the biopsy though.
What was ur biopsy result.
@@sanakhalilurrehman2309 it was fine Thank God!!
@@sanakhalilurrehman2309 it was negative thank God!!
This is the best channel. It’s so helpful. Thanks 🙏
The days before I ovulate, about days 11-18, I feel an incredible amount of anxiety and insomnia.
I have been told this is because my estrogen is rising too high at that time, causing a histamine release (insomnia) and anxiety. I also get heart palpitations at this time. This theory makes sense to me but I’m not sure that there is a solution (outside of birth control, which I have had issues with). I am now experimenting with various treatments, such as estradiol patches combined with micronized progesterone, but I just can’t seem to “fix” my symptoms during those 5-7 days. I usually just take antihistamines and that’s the only thing that helps.
I am 42.
Same here, I m not taking any medicines yet
I am so happy that I found you 🙂
Please do a video on natural supplements you recommend for hormone balance during perimenopause...thank you....blessings....💐🌸💮🏵🌹🥀🌺🌻
@crytogod Great suggestion. I have a handout I give to providers that lists maybe a dozen of those. I’ll have to look at summarizing them in a video.
I’ve been working on building a digital course for perimenopause but it’s a lot more complicated than menopause. I have an outline and some pieces, like handouts. I’m also talking with a nurse friend who may help me flesh it out.
You're a saint 🙏
Thank so much for this information. It helped me a lot to decide what is the best for me.
Interesting you've said it that way . . . "helped me a lot to decide." That's the emphasis of a brand new course I'm building "The Menopause Solution." If you'd like to join the waiting list and learn more about the course, check it out here: www.simplehormones.com/the-menopause-solution/
Hello.. wow love how you explain everything so well. Thank you! Just found your channel and so glad to have found it. I noticed you did not specify if the estradiol replacement is vaginal route as well. You mention oral and cream, does that include the estradiol vaginal low doses (4 mcg or 10 mcg). I am curious if progesterone should also be prescribed with that?? Thank you again!!
In general, vaginal estradiol is somewhat less effective for overall body symptoms like weight gain and hot flashes, with some exceptions. It's most effective for vaginal dryness and painful intimacy.
thank you, yes that is the only reason it was prescribed. Hoping it has less systemic effect, hence no need for progesterone? thank you again! @@SimpleHormones
What do you recommend for menopausal women who are sensitive to oral micronized progesterone?
I have progesterone intolerance as well, 45yo perimenopause and still regular cycles. Micronized oral progesterone has a horrid effect on me. Puts me in a very dark place mentally, emotionally, physically ill. Estradiol transdermal Evamist is however miraculous! I cannot and will never be without it again. It’s been life changing. Total opposite of progesterone as it makes me happy, motivated, I can think clearly and easily stay fit. I know it doesn’t absorb as well, but I have switched to compounded progesterone cream only the last half of
My cycle and I am doing well!
The cream does not have the negative effects and I can take my estrodil and live happily. I might switch to vaginally compound cream progesterone once I truly hit menopause. Be careful! Prometrium is made with peanut oil! And I’m allergic
i asked my Dr to check my hormones, she referred me to a guynacologist who turned me down because i am 81 . Where can i buy the cream, i used it years ago but the company no
longer exist.
What about chasteberry?
I have atypical endometrial hyperplasia and pcos.
Will progesterone cure this issue or do I need total hysterectomy?
I don’t want to do hysterectomy if I can prevent it?
Hi, it was very interesting to listen to you. but now, I am even more confused and at a total loss. I am in Canada and where I live there are no hormone specialists available. My MD is a totally clueless regarding hormones and even if I go the telemedicine route and find a hormone specialist, I won't be able to fill any prescription because they are not practicing in the same province as I live in . I am 10 years menopausal. took synthetic Estrogen and Progestens for 8 years, doing well on them but then stopped, due to the scary cancer scare that came out. I suffered for 2 years awfully without hormones and started 3 months ago on estradiol gel and got a prescription for prometrium 100mg capsules. The issue I have is, I tried the Progesterone capsule for a month, but one hour after taking it, I get almost comatose, dizzy and so sleepy that I can't talk, or walk. Vaginal have a similar effect and rectal is not absorbed at all. I tried a 200mg per pump progesterone cream but now you say that this is not helping my uterine lining? What else to do now? should I just go back to the synthetic norethindrone (progestin)?
The best way to find a hormone specialist, somebody who really knows how to manage all your hormone issues and get you to optimal levels, is to visit this page on my website and fill out my Patient Referral Request Form here simplehormones.com/referral If you leave a referral request on RUclips or email it to me, it's extremely likely I'll drop the ball or it will fall through the cracks. Once you fill out the form, be sure to check your email for a message that says "Confirm your email address." Thanks!
Awesome info. I am on compounded estro/prog/test, age 48. I am planning to discuss changing the prog to pills. 🤔
This was really informative. What about the mire a iud as a source of progesterone for hyperplasia?
Thanks for watching. There are a lot of "progestins" that are used for birth control or for menopause issues. Mirena is a progestin called levonorgestrel. It's NOT actually progesterone, but a synthetic version that's been chemically altered to be maybe 45 times as potent as progesterone. It certainly has its usefulness, especially in perimenopause. But after you go into menopause, it won't do the same things as progesterone does. It won't have the same effects on anxiety, depression, and insomnia as progesterone has. I’m not sure how well it prevents endometrial hyperplasia but I would expect it probably does that.
Of all the studies in your research, which study carried more weight to discredit the Leonetti study of 2005 that showed transdermal cream did protect the uterus?
Steve,
I heard another hormone doctor say that only the synthetic, oral, progesterone reduces the uterine lining. Is there any truth to that? Also, does oral progesterone harm the liver? Thanks 🙏
Wow amazing what a woman’s body can create! We should be empress’s lol 😂
Can I have a look at the resources or references?
@PMSURFERYAHOO It looks like I switched out that link and it's no longer available. Send me an email contact@simplehormones.com and I'll forward the references.
Can natural progesterone cream cause blood clots and see what side effects
What about those who have adverse effects from PO progesterone? I ended up in the ER with a rapid heart rate. I can use low-dose cream somewhat. On estradiol 0.025 mg patch. I’m in late peri. What other options do I have? Thank you.
If you are using progesterone to prevent endometriosis regrowth after removal surgery is a cream effective enough? Or would you recommend using an oral progesterone capsule instead? I have an endometrial growth on my c-section scar. And I know I could be at risk of regrowth after removal surgery since I’m only 37. Any advice is much appreciated. I live in North Dakota and hormone experts are non existent. I do have very low progesterone levels showing up currently on my blood work as well. Thanks!
I can’t take oral progesterone, it affects my gallbladder function somehow, I get bad gallbladder pain every time I try the progesterone. To protect the endometrium, Is vaginal progesterone better than the patch ?
I had endometrial thickening, 9 mm taking 05 estradiol and 100 mg of progesterone it did finally shed decidual cast,but it’s frustrating that my body is not absorbing progesterone. What are your suggestions? They both are bio identical FDA approved.
Do you think it would help if I took that progesterone orally and the cream?
I was thinking about combining the treatments as well - orally and progesterone suppositories.
The line of my uterus is 3cm
I am in perimenopause. I'm experiencing hot flashes depression and anxiety. Also dry skin heart palpitations headaches the list goes on. I'm using a bioidentical progesterone cream. I am confused as to whether I should use it two or three weeks out of the month?
If that was prescribed by a physician, you may want to ask them. Often women in perimenopause will use progesterone for the last 2 weeks of their cycle, which mimicks the way progesterone works if your body makes enough on its own.
Hello! Thank you so much for this video! Extremely helpful.
Question: If a pre menopausal woman is taking oral progestin to help with endometrial hyperplasia... will the thickened lining execrate from the body similar to a period (clots & bloods)? What exactly happens to the thickened lining? Should one expect to experience bleeding as the thickened endometrium disintegrates and leaves the body (if that's what happens)?
Essentially . . . yes. When the endometrium sloughs off every month, that's exactly WHY you get a menstrual period. The reduction of the endometrium causes vaginal bleeding.
Is it true that progesterone cream can build up in the fat and release at one time and cause issues? Is it necessary to have a Dutch test to be sure pathways are clear? Thanks
That's possible . . . but not all that common. DUTCH Testing is a useful tool in some situations for certain patients, especially those who respond outside the normal side effects of hormones.
What about high estrone? Can that lead to endometrial hyperplasia? Would prometrium be effective?
Yes. Estrone can led to endometrial hyperplasia. It's converted into estradiol and that may be the biggest factor. Prometrium® (oral progesterone capsules) can help with that either way.
What about using the capsule vaginally if it makes you too groggy?
That’s been recommended to me but I’m worried that I am now cramping -no bleeding though
Sir, can I break open the Micronized Progesterone USP capsule & rub on skin? Instead of swallowing?
You can break open progesterone capsules . . . but they're going to be incredibly messy. The commercially available ones, like Prometrium, are filled with peanut oil. You'll need to cut one carefully with a sharp knife and avoid cutting yourself at the same time. Once you do manage to cut the thick capsule open, what you'll get is the VERY liquid, oozy, oily contents leaking all over the place. It's possible to place that on the skin . . . but I don't think you're gong to be able to absorb an adequate dose from that.
Is it true that synthetic pharmaceutical progesterone is more effective than bio identical pharmaceutical progesterone at preventing endometrial cancer? I am weighing options after a hysteroscopy/d&c for endometrial hyperplasia and polyps.
@Sara87521 Thanks for watching.
That's an interesting question. I made a video a while back that explains the terms "bioidentical" and "synthetic" in relation to hormones like progesterone. In my somewhat informed opinion, almost everyone, including the vast majority of doctors, uses those terms incorrectly.
Here's a link to that video:
ruclips.net/video/iN-gkBSc5S4/видео.htmlsi=zDkgGReaxOfCueUu
I would not say that progesterone made by a drug manufacturer ("pharmaceutical progesterone") is more effective against endometrial hyperplasia than progesterone compounded by a compounding pharmacy. The key is that BOTH use the exact same type of progesterone, called "Progesterone Micronized USP." I would also point out, as I have in the video you watched, that progesterone in an oral capsule has been shown in several studies to be more effective at slowing the overgrowth of the uterine lining (endometrium) than progesterone in a transdermal cream form.
@@SimpleHormones What about the vaginal progesterone suppositories? Are they effective at slowing overgrowth as well?
Can you help with umbilical endometriosis?
Yanique - not familiar with that. But some of my hormone specialist colleagues may be able to help. Request a referral here and I’ll see if I can find someone who can help. No guarantees but I can check. www.simplehormones.com/find-hormone-optimization-specialist/
I would like to ask you about the dose of Micronised Progesterone (Utrogestan).
Why the dose of the Utrogestan in continuous form always 100mg regardless what the dose of Esradiol?
Some women take only 50 mg of Estradiol , advised to take 100mg Utrogestan as well as women take 100 mg or more of Estradiol?
That's a good question. The dose of progesterone is not really related to the dose of estradiol. It's more that progesterone has to be at an optimal level to protect the uterine lining (called the endometrium) whenever there's estradiol in your system and at whatever dose. I and the providers I work with like to see Progesterone levels at 10 ng/ml or higher, which isn't always easy to get to. It's basically impossible with a transdermal progesterone cream. 100MG of progesterone is often not enough to get optimal levels OR to relieve symptoms like insomnia and depression/anxiety. I see LOTS of providers starting women at 100MG, then increasing to 2 or even 4 times that much.
@@SimpleHormones Thank you for the reply.
Will progesterone cause stomach issues? I started 200 mg in April. Now taking 100 mg sublingual.
Progesterone can cause nausea. especially when it's taken in an oral capsule.
Thanks
Yes! Progesterone pills and cream made me very nauseous and sick I stopped and feel much better
Is DHEA better then estradiol?
DHEA is different than estradiol, although they may both be used for vaginal dryness and painful intimacy. There's not really a way to say one is better than the other. For most women in menopause, estradiol is a bigger concern because not having enough causes hot flashes, irritability, weight gain, and a long list of health risks.
Is megestrol bio-identical progesterone?
No it's a non-bioidentical progestin.
Great video, thx! I am 48 and perimenopausal (cycles have become longer, many common symptoms). I found a company called RenewYouth and after labwork and speaking to a collaborating functional doctor, I was prescribed daily (not cyclical) oral progesterone 150mg as well as testosterone. I was surprised that the progesterone was not prescribed cyclically but the Dr said that as cycles become irregular it becomes difficult to identify when that time of the cycle would be. So he feels daily progesterone is better during this time. My estradiol was 81 when measured (this varies daily of course so not reliable). Do you think continuous progesterone is appropriate for me? And what do you think regarding not supplementing estradiol at all? Thank you!
Sounds like what that doctor is recommending is pretty reasonable. In perimenopause, most of the providers I work with try to stay away from prescribing estradiol because it's extremely volatile, sky high one day and close to zero the next. There's as good a chance that you'll get too much estradiol as any if it's prescribed to you. As for the progesterone, that doctor is probably right about continuous dosing. If your cycles were still normal, you probably wouldn't really need progesterone and you might not have many symptoms.
@@SimpleHormones Thank you! Your feedback is much appreciated!
Can you get skin rash with HRT?
Yes . . . but it's almost always not the actual hormones. They're very small molecules and extremely unlikely to cause an allergic reaction. Most commonly, it's the adhesive in a hormone patch or the cream base in a transdermal cream or the vehicle in a gel that causes an allergic reaction.
@@SimpleHormones thank you, I did a week of HRT progesterone pill, and 2 injections one estrogen and the other one testosterone. I got a rash all over and I had to stop taking it 😭
👍👍👍
Thank you for such valuable information. My question is: can someone with endometriosis and already on hormonal iud can use transdermal progesterone cream to help discomfort before periods?? Is that ok to combine the two?? Kyleena IUd and natural progression cream?
Hi l like espik with you
What would you suggest if prometrium causes the opposite and created insomnia in me. I noticed taken orally then tried vaginally but created immense sleeplessness. Is it possible to take one tablet every 2nd day to prevent this side effect? I take estrogel as well.
Thanks for watching. Those kinds of side effects can make things more difficult. There are several things that might help. A different dosage form (vaginal, sublingual troche, etc.), a lower dose, a compounded progesterone capsule that’s “sustained release” so it comes on more gradually, taking progesterone early in the day.
It’s also important to give progesterone some time to work. I usually recommend women take a hormone for at least a month or 6 weeks to see how things settle out. Progesterone especially may behave one way for the first week or two, then differently after it’s built up to what’s called a “steady state.”
@@SimpleHormones thank you for the reply but there is no way I could continue prometrium, absolutely zero sleep, felt like I was back on prednisone. Progesterone is a steroid hormone, so makes sense. I couldn't go that long without sleep.
I have the very same problem with prometrium. It gives me 1-2 hours of sleep then covered insomnia. I switched to a sustained release oral progesterone and I slept great night 1 then the next night severe insomnia. Not even 30 min of sleep. I know I need it. Please help
@@loriscott3290 I am going to talk with my gynecologist about an iud, I hear that has no side effects and progesterone stays only on the uterus
What do you think about a femmring and a progesterone only i u d? For post menopausal women. Thank you!
Denae - Hey thanks for watching. Femring and progestin (not progesterone) IUDs have their place. Because the progestin is not exactly the same as your body's progesterone, it's probably not going to help as much with insomnia, depression, or anxiety. I'm not saying that combination should never be used, but each hormone approach has its advantages and disadvantages.