I hope you're ok with me using this for some of my sessions in addiction counseling, it usually helps the parents and loved ones more to see a physiological and biological basis for the aberrant behavior they blame themselves for. So well done!
It's sad that school forces students to memorise things to pass a test and forget everything after when you could actually learn and enjoy instead of being a stressful thing. What a joke, they talk about rewarding system but don't know how to use it effectively.
Random Question but; have they taught you about natural remedies? Or is it all about pharmaceuticals? I think the psychological part is the foundation to good health! ❤️
"Here's your brain stem, PFC... and... the rest of it." I knew this would be a good video from that point on. Nice summary though, saved me rereading about 6 lecture slides - result.
Great job with one minor modification which is that VTA is not sending dopamine to these other brain regions. VTA sends projections, axons, to these brain areas. Dopamine is synthesized, stored at these axon terminals, which are located in the nucleus accumbens, pfCTX, etc. When VTA is stimulated an action potential is generated which travels along the axon. Once reaches the axon terminal, it causes opening of voltage gated calcium channels. Entry of calcium inside the presynaptic terminal facilitates exocytosis and release of dopamine.
Thank you for sharing this well explained information. I particularly enjoy they way the video is presented. The voice, pace and creative images are very well done :) Useful information for anyone seeking to learn more about the brain.
Thank you very much for all your efforts. This is very useful even at an MSc level. I'm interested in the references you used. If you could provide it, that would be great
thanks for the class, very helpful, nice drawing and sweet voice. I really didnt know serotonin levels go down when dopamine rises, i used to take prescription medicine to rise serotonin levels when i was a teen due to genetic reasons (guess i was born like that), and now im watching this cuz i think i damaged it all again due to cannabis addiction. like you said nothing's set in stone. thumbs up.
Cannabis hits the anandamide receptors which do tie into the reward pathway but to a different degree. Its possible to be mentally addicted to it which can cause mental health issues to be exacerbated. Eat a lot of protein to increase tryptophan levels which directly increases serotonin. Take supplemental tryptophan as well. Other methods include exercise and microdosing with psychedelics. Both work to rebalance serotonin in different ways. Psychedelics help tremendously with depression, anxiety, and PTSD if done properly and with a good set and setting. Taking antidepressants and then getting off them creates an even worse depression for some and personally I stick to weed over that hell hole of drugs. I hope you got what you needed even though I am 9 months late I would like to offer advice in how I work through bouts of depression.
Oh my gooooooodness; soooooo very helpful in helping me understand my own addictive behavior - one of those things being CAKE!!!!!! You did an amazing job creating this video!!!!!
7:30 Addiction kills your rational mind , so leave any Addiction as soon as possible if have , that means even if suppose anyone have food addiction like very well explained by mam
Thanks for excellent videos! Easy to digest information for a jabroni like me to comprehend/retain. These videos have been both helpful and applicable in my life.
Beautiful video that covers my entire computer science application am developing on intelligence rewards system. My intention the application will assist humanity in solving psychiatric and other related problems. Please permit me to use this presentation.
No, Nucleo Accumbens does not control the motor functions it controls how pleasurable that experience was, so whether or not it's good, or all the euphoria you feel or happiness comes from there.
Great video. Really useful for review after a few years. Just to check my understanding, isn't dopamine more associated with attribution of salience to stimuli, whilst happiness, euphoria, a pleasurable response etc. attributed to co-occuring release of endogenous opioids?
Hahah, this was funny to watch. It's kinda late at night here and it helped me to wake up while I continued reading for my Step 1/medschool exams. Love your voice as well.
What the rodent study also found was that these rats would prefer the heroin over water and be "addicted" only when they were in cold, lonely environments. When the study was reproduced with the rats in a comfortable, nurturing community of other rats, they no longer chose the heroin.
I was going to post this. the rats only preferred drugs in a miserable environment. if you put the rats in a fulfilling social environment they quit wanting the drugs
John Kempf Try L-Tyrosine first. It is precursor to L-Dopa which is precursor to dopamine. It much more safer than stimulant because it has "rate limiting step" which is how brain automatically limit how much dopamine is being produced. Trust me, you dont want excessive dopamine because excessive dopsmine is underlying cause of psychosis in schizophrenia. Stimulant on the other hand, force the production of dopamine of prevent the reuptake of dopamine in synaptic cleft. Drug like meth and amphetamine stimulate production of dopamine and at the same time, prevent reuptake of dopamine.
Replication of the cocaine experiments in rats when the animals were in a stimulating, enriching environment did not duplicate the results of the studies that were famously done in the 80's. Current thought is leaning more and more towards environmental factors playing a huge role in addiction and not just the brains pleasure pathways.
Thank you for this wonderful video. I also sincerely hope the scientific community can find an alternative way to conduct research on instead of innocent animals. Onc can argue it is for the greater good, but it still breaks my heart.
accumbens has two parts, core and shell. core encodes appetitive function (doing things to get reward) and shell is consummatory in function (signals getting reward). in my hands, these two regions are involved in value judgment and this applies to both rewarding and punishing stimuli.
I appreciate what Khan Academy strives to accomplish, but it's unfortunate that there are so many errors or intentional oversimplification your videos. In this video, for example, the mesolimbic and mesocortical pathways are in combination being referred to as the mesolimbic pathway. Discrepancies in the information that learners come across can be a bit confusing 🙃.
nucleus accumbens does not control bodys motor functions it's involved in the reward pathway. What it does do is integrate motivation with some sort of action.
I hope you're ok with me using this for some of my sessions in addiction counseling, it usually helps the parents and loved ones more to see a physiological and biological basis for the aberrant behavior they blame themselves for. So well done!
the voice was really pleasant to listen to as i am studying for a test and slightly stressed this was a relief..
I would date her
Sounds like you could use music while you study
same here. i feel calm when i heard her voice
So many dopamine release can be felt in these comments... xD
It's sad that school forces students to memorise things to pass a test and forget everything after when you could actually learn and enjoy instead of being a stressful thing. What a joke, they talk about rewarding system but don't know how to use it effectively.
I love you guys for putting up so much high quality content on Khan Academy Medicine. You rock!
Random Question but; have they taught you about natural remedies? Or is it all about pharmaceuticals?
I think the psychological part is the foundation to good health! ❤️
your voice increases secretion of dopamine from my VTA
This is sooo informative in a very simplified way. Thank you
"Here's your brain stem, PFC... and... the rest of it."
I knew this would be a good video from that point on.
Nice summary though, saved me rereading about 6 lecture slides - result.
( 02:05) How is Nucleus accumbens related to motor function? isn't part of the addiction and reward center? Thanks!
She lost my attention right there. Disturbing that this passes as fact for training medical professionals.
😂😂
Excellent explanation by portraying conversations among “hippocampus,” “amygdala,” “nucleus accumbens” and “prefrontal cortex” !!!!!!
Great job with one minor modification which is that VTA is not sending dopamine to these other brain regions. VTA sends projections, axons, to these brain areas. Dopamine is synthesized, stored at these axon terminals, which are located in the nucleus accumbens, pfCTX, etc. When VTA is stimulated an action potential is generated which travels along the axon. Once reaches the axon terminal, it causes opening of voltage gated calcium channels. Entry of calcium inside the presynaptic terminal facilitates exocytosis and release of dopamine.
Thanks a lot for the clarifications🙏I was getting tired of these explanations about sending dopamine somewhere.
Thank you for sharing this well explained information. I particularly enjoy they way the video is presented. The voice, pace and creative images are very well done :) Useful information for anyone seeking to learn more about the brain.
Thank you, and your voice is so pleasant :)
THIS IS A FREAKING AMAZING EXPLANATION EVERY HUMAN SHOULD WATCH
"Every Human" LOl, could not stop laughing
Great video - so helpful to see it displayed and explained in this way!
Thank you!
oh and i love your art :)
Thank you very much for all your efforts. This is very useful even at an MSc level.
I'm interested in the references you used. If you could provide it, that would be great
Feeding good and rewarded!
thanks for the class, very helpful, nice drawing and sweet voice.
I really didnt know serotonin levels go down when dopamine rises, i used to take prescription medicine to rise serotonin levels when i was a teen due to genetic reasons (guess i was born like that), and now im watching this cuz i think i damaged it all again due to cannabis addiction.
like you said nothing's set in stone. thumbs up.
Cannabis hits the anandamide receptors which do tie into the reward pathway but to a different degree. Its possible to be mentally addicted to it which can cause mental health issues to be exacerbated. Eat a lot of protein to increase tryptophan levels which directly increases serotonin. Take supplemental tryptophan as well. Other methods include exercise and microdosing with psychedelics. Both work to rebalance serotonin in different ways. Psychedelics help tremendously with depression, anxiety, and PTSD if done properly and with a good set and setting. Taking antidepressants and then getting off them creates an even worse depression for some and personally I stick to weed over that hell hole of drugs. I hope you got what you needed even though I am 9 months late I would like to offer advice in how I work through bouts of depression.
I think I'm addicted to your voice.
Give me more!
lol
I was thinking the same shit
Great video, you have blessed me with understanding.
You made things extremely clear and you had my attention the whole time!
love it thank you 😊😊😊
I like the drawings😊, but at 2:55 just replace Dopamine with VTA.
Oh my gooooooodness; soooooo very helpful in helping me understand my own addictive behavior - one of those things being CAKE!!!!!! You did an amazing job creating this video!!!!!
What a soothing voice x
7:30 Addiction kills your rational mind , so leave any Addiction as soon as possible if have , that means even if suppose anyone have food addiction like very well explained by mam
Serotonin levels high after watchin this video.
Prefrontal cortex... and the rest of it. Very high quality
nice handwriting and voice, happy i have a brain to receive them
Thank u sir .. great class
I love you , a thousand thanks of this content ❤
Thanks. Your presentation was enjoyable, especially your voice and the visual illustrations.
Thanks for excellent videos! Easy to digest information for a jabroni like me to comprehend/retain. These videos have been both helpful and applicable in my life.
love the voice!
An actually good explanation of the reward system
Beautiful video that covers my entire computer science application am developing on intelligence rewards system. My intention the application will assist humanity in solving psychiatric and other related problems. Please permit me to use this presentation.
No, Nucleo Accumbens does not control the motor functions it controls how pleasurable that experience was, so whether or not it's good, or all the euphoria you feel or happiness comes from there.
thank you!
great video!!! thnx
Thank you so much, the video was very clear and not bombarded by overly confusing jargon. The person teaching was also very clear. :)
Very well explained! Thanks.
wow, I am speechless! thank u!
Great video. Really useful for review after a few years. Just to check my understanding, isn't dopamine more associated with attribution of salience to stimuli, whilst happiness, euphoria, a pleasurable response etc. attributed to co-occuring release of endogenous opioids?
Yes you are right. Some of the information she presented is false. It's simply a previous misconception about DA.
I am so happy to find this!
Hahah, this was funny to watch. It's kinda late at night here and it helped me to wake up while I continued reading for my Step 1/medschool exams. Love your voice as well.
Thank you very very much
I love the voice！
This was a great explanation. thank you
wow. Very helpful. Easy and simple. Thanks a million :)
This was so helpful. Thanks
Like always, thanks heaps for the help.
What the rodent study also found was that these rats would prefer the heroin over water and be "addicted" only when they were in cold, lonely environments. When the study was reproduced with the rats in a comfortable, nurturing community of other rats, they no longer chose the heroin.
I was going to post this. the rats only preferred drugs in a miserable environment. if you put the rats in a fulfilling social environment they quit wanting the drugs
I love this video. 😍
After hearing your voice I’ve released dopamine!
Behave my brother, Hope it dose not progress to tolerance and dependence
Excellent
very very simple and useful!!
0:25
So that's what Ronaldo Da Lima had on his fronthead.
His brain.
its great. ı appericiate for your sharing.
this video took away all my dopamine
I LOVE REWARDS
great vid,
Great video. Thanks :-)
Great video
perfect!
I am interested in finding out info on dopamine deficiencies causes, effects and remedies ! Any suggestions are helpful ! Thank you!
Boom. This matches my interest completely, especially why dopamine is metabolized so much more quickly in some brains than in others.
Thank you John!
John Kempf Try L-Tyrosine first. It is precursor to L-Dopa which is precursor to dopamine. It much more safer than stimulant because it has "rate limiting step" which is how brain automatically limit how much dopamine is being produced. Trust me, you dont want excessive dopamine because excessive dopsmine is underlying cause of psychosis in schizophrenia.
Stimulant on the other hand, force the production of dopamine of prevent the reuptake of dopamine in synaptic cleft. Drug like meth and amphetamine stimulate production of dopamine and at the same time, prevent reuptake of dopamine.
Good vid
Mice to man is a large jump. A jump over intellect and reasoning skills.
This video explained some life changing information. I highly appreciate it
Replication of the cocaine experiments in rats when the animals were in a stimulating, enriching environment did not duplicate the results of the studies that were famously done in the 80's. Current thought is leaning more and more towards environmental factors playing a huge role in addiction and not just the brains pleasure pathways.
Thank you for this wonderful video. I also sincerely hope the scientific community can find an alternative way to conduct research on instead of innocent animals. Onc can argue it is for the greater good, but it still breaks my heart.
grow up
So helpful!!! Thank you!
it is said that we can get more dopamine by doing pleasing activity like sex or sport. But why are we easy to be addicted to sex rather than sport?
Does anyone know why they serotonin levels drop? Does dopamine play a direct role in the decrease in serotonin?
David Balles I had the same question. I've never heard that before
What does the MCAT mean in the title I am assuming it is some test that only occurs in the states?
La grâce au sang Fabricou Setz
Where can i find the study conducted on the mice,0? Its urgent
which part in the brain activated the ventral tegmental ? amygdala or hypothalamus
Is it possible to pharmacologically increase dopamine in the Nucleus Accumbens without also increasing it in the Ventral Tegmental Area?
Why? Becareful though. Excessive dopamine can cause psychosis
accumbens has two parts, core and shell. core encodes appetitive function (doing things to get reward) and shell is consummatory in function (signals getting reward). in my hands, these two regions are involved in value judgment and this applies to both rewarding and punishing stimuli.
should do an asmr video
That cake with a candle looks like a fancy hat haaha.
haha nice
i get hugs from trees
Here's your Pre-Frontal Cortex.....and.....eh...the rest of it.
I appreciate what Khan Academy strives to accomplish, but it's unfortunate that there are so many errors or intentional oversimplification your videos. In this video, for example, the mesolimbic and mesocortical pathways are in combination being referred to as the mesolimbic pathway. Discrepancies in the information that learners come across can be a bit confusing 🙃.
Um.... dopamine is a signal of reward prediction (error), not reward itself.
please, double-check hippocampus location
Inigo Ruiz de Azua Please listen to the video in which she says why she placed it in a different location you piece of shit.
Dang, man. Angry much?
@@justindenson7560 😂init man
so how come it takes me 3 seconds to process information? the dopamine wouldn't help that?
What if it's not delicious?
the rat had a rat...ional mind
nucleus accumbens does not control bodys motor functions it's involved in the reward pathway. What it does do is integrate motivation with some sort of action.
Tickle Your Amygdala- Since 1997- 15 million visitors
www.BrainRadar.com no bull, just science. Also on RUclips:
ruclips.net/user/neilslade
Too. Fast is. Difficult for. Foreign studentd
How does the Striatum fit in to this picture. Why do Dopamine Agonists Increase Sex Drive, compulsive shopping, Binge eating etc.
من فضلكم هل من أحد هنا يفهمني أو يعلمني كيف أترجم هذا الفيديو الى العربية . وشكرااااااا
You don't speak highly of a self-involvement and activating some neurotransmitters!
not a brain at the start
Watch al
Great video
Tickle Your Amygdala- Since 1997- 15 million visitors
www.BrainRadar.com no bull, just science. Also on RUclips:
ruclips.net/user/neilslade