Long time NR user here. I am 50. I feel 40. I can do very hard workouts that I could not do in my 30s. Maybe it is just placebo, but it sure seems to really help me feel more robust.
Taking 2 grams Rugby Niacin - I notice a flush every few days at relatively random times. Usually lasts about a minute. I know it's working, so I don't mind.
$30 is a no-brainer based on the quality of information in your videos. My doctor had no idea there was the Cardio Risk Test package from Cleveland Heart Labs. Thanks to you I had my test and waiting for results to analyze and monitor. IMO everybody should invest in this!
Looking forward to more on this. I tried Niacin many years ago as it was being talked about amongst body builders and other gym rats (like me) in the 1980s. The flush drove me crazy and interfered with my life too much, so stopped. My younger brother did it as well and tolerated the effects much better (or he was just tough enough). Interestingly he has had a much healthier life overall than all of his family including our parents, and siblings! His lifestyle was not really any different than the rest of us. We are all fitness and health oriented. Makes you wonder...
it seems that you can tolerate a certain amount before flushing. I try to keep under that amount because otherwise the flushing is terrible. one day I had to take a cold shower to help reduce the redness and skin pain. it usually takes about an hour or two to go away.
PS: don’t be embarrassed about making money-$30 is a fair price and it isn’t like I need college credit. It would be nice if it was hooked up with some kind of continuing Ed thing for the PA and MDs, but for an average researcher- that might not be needed.
Hi Dr. Brewer I've seen a report that NMN needs be taken sub-lingual - that NMN in capsules are inactivated by stomach acid. Do you have any opinion or information on that? Thank you for these videos. You are right - there should be several million views!
Dr. Brewer, _any_ form of B3 that doesn't cause flushing will _not_ impact lipids. Niacinamide/nicotinamide prevent and treat pallegra, but have zero impact on lipids.
I have been taking 2 gms of Doctor's Best sustained release Niacin which I thing is waxed base matrix. I might get a tiny tingling of flush. Thanks Dr Brewer Am Zn
@@amazon8835 Sustained release may be hard on your liver. Maybe like he said, if you're using the waxed version it won't, but I haven't heard about that until now. I'd keep an eye on it though.
Niacinamide does not cause flushing for me and didn't help with my low HDL after taking it for 18 months. When I switched to Nicotinic Acid at 500mgs along with TMG I got the hard flush and within 3 months my HDL went up 40 points. I haven't tried the NR yet but am considering ordering it for the NAD+ boost.
Good subject yes please compare this against NMN I have personally seen good results with NMN but on the athletic level. I do not know how that turns out longevity wise. I know as you have said losing weight you add time to your lifespan. My BMI is too low to calculate most likely and taking NMN I just saw a better athletic performance and muscle growth just under 2 years into constant use. Btw I would prescribe Fluticasone Propionate 50 mcg one spray 30 mins before your RUclips videos. Gotta manage that inflammation as you say Dr : )
My NA (Niacinamide), NR, NMN problems... Dosing: can we use more than about 35mg a day? If no, then the excess may burn up methyl groups that are needed for other methylation chores (Homocysteine)? Does NA shut down NAD+ production at high levels? NMN has a phosphor group on it, I understand that that gets taken off in the liver, so why bother? Does NR get across the blood brain barrier better than the others?
Thank you for your reply Dr Brewer! I use methylated folate & B12 + TMGlycine to manage a homocysteine problem. Dosing of NR is still a problem. Why take 150mg of NR when we can only use 35 mg/day? I'm missing something. Dr David Sinclair is taking 1gr of NMN/day. That makes no sense to me. And he's doing the research.
I had a terrible experience with Niacin. It wasn’t the flush that bothered me but I felt like I was having a heart attack. My chest tightened and I thought for sure I was going to throw up or pass out. I don’t know if that means I have heart problems but I shouldn’t.
Niacin was the thing, then Resveratrol was in vogue, followed by nr, then NAD+, NADH, and now NMN. Is it all just marketing? Is it beneficial to take them all, a few, or only one ... ? Can there be overdose, potentiation, or interdiction when combined ...? There's lots of interest, but little comprehensive information in one video.
@@PrevMedHealth 😁 What's funny is I've been looking into this, buying the supplements, and then I see a video of overdoing it by Chris Masterjohn, who cautions about combinations of niacin with the NR compound burning through the methyls, sans mention of NADH or NMN (if I recall correctly) ... and what again happened with resveratrol??? We really need someone to tie a nice bow around these lovely gifts of health and longevity. You got this! 😁👍
Steve H I looked and don’t see your post. I will have to look into the research of Dr Whitcomb. I’m interested in the role these play in mitochondrial function but am getting increasingly confused as how to incorporate B3 into my regimen. Thank w
Question: Common B3 supplements are - Niacin - Niacinamide and Nicotinic Acid. How do these work or fit into your work? Also there was a pioneer Psychiatrist in Schizophrenia, his name is Dr. Abram Hoffer. Have you seen his work, of course he was poo pooed? He rightly so claimed a cure rate of 70% - yes cured. Let me know about these items if you have the time - Thanks
I have heard of him and the use of niacin for schizophrenia reversal... it seems like it works best at the early onset of schizophrenia... but it is a disservice to humanity to not give it a try before starting them off on life long dependence on psychotropics. I know someone whose been on those drugs since the eighties... it’s not good. Maybe naicin would not have worked for her, but what if it had? it is sick, negligent and criminal that the conventional pharma goons who pose as doctors, refuse to offer these options first.
What is the recommended daily dosage? Would it be different between the three types of Niacin?
Niacin flush is awesome in January in Northern Alaska!! However, it doesn’t last very long at -40 and lower, but can be pretty nice on a -30 day.
I never thought of that.
Long time NR user here. I am 50. I feel 40. I can do very hard workouts that I could not do in my 30s. Maybe it is just placebo, but it sure seems to really help me feel more robust.
Thanks for sharing that! We're not getting many NR fans out there.
I have definite increase in endurance with Resveratrol but have noticed nothing with NR and possibly Lower energy with NR.
What is the mechanism of action of Niacin? Does Niacin reduce inflammation which in turn reduce LDL or does it reduce LDL to reduce inflamation?
Taking 2 grams Rugby Niacin - I notice a flush every few days at relatively random times. Usually lasts about a minute. I know it's working, so I don't mind.
Thanks for sharing that.
$30 is a no-brainer based on the quality of information in your videos. My doctor had no idea there was the Cardio Risk Test package from Cleveland Heart Labs. Thanks to you I had my test and waiting for results to analyze and monitor. IMO everybody should invest in this!
Thanks!
Does NMN have the same effect on lowering cholesterol as niacin does?
Dr. Brewer, have you heard of nicotinamide (NAM) intake and the increase in the incidence of diabetes type 2? Any dosage that might trigger it?
Looking forward to more on this. I tried Niacin many years ago as it was being talked about amongst body builders and other gym rats (like me) in the 1980s. The flush drove me crazy and interfered with my life too much, so stopped. My younger brother did it as well and tolerated the effects much better (or he was just tough enough). Interestingly he has had a much healthier life overall than all of his family including our parents, and siblings! His lifestyle was not really any different than the rest of us. We are all fitness and health oriented. Makes you wonder...
Interesting!
it seems that you can tolerate a certain amount before flushing. I try to keep under that amount because otherwise the flushing is terrible. one day I had to take a cold shower to help reduce the redness and skin pain. it usually takes about an hour or two to go away.
Hi, does nicotinamide(no flush niacin) 500mg is good for improving NAD level?
PS: don’t be embarrassed about making money-$30 is a fair price and it isn’t like I need college credit. It would be nice if it was hooked up with some kind of continuing Ed thing for the PA and MDs, but for an average researcher- that might not be needed.
Thanks!
Hi Dr. Brewer
I've seen a report that NMN needs be taken sub-lingual - that NMN in capsules are inactivated by stomach acid. Do you have any opinion or information on that?
Thank you for these videos. You are right - there should be several million views!
Thanks! I haven’t heard - or seen - that.
What would your assessment be regarding this vitamin in megadoses side effects in the realm of psychosis?
More on this. Thanks for all you do doc.
Thanks.
I like the flush because I then know I got the real product.
Dr. Brewer, _any_ form of B3 that doesn't cause flushing will _not_ impact lipids. Niacinamide/nicotinamide prevent and treat pallegra, but have zero impact on lipids.
I have been taking 2 gms of Doctor's Best sustained release Niacin which I thing is waxed base matrix. I might get a tiny tingling of flush. Thanks Dr Brewer Am Zn
Thanks.
Yea, Masterjohn did a huge lift on NR, and the need for TMG with its use or higher dose of any B3s.
@@amazon8835 Sustained release may be hard on your liver. Maybe like he said, if you're using the waxed version it won't, but I haven't heard about that until now. I'd keep an eye on it though.
Niacinamide does not cause flushing for me and didn't help with my low HDL after taking it for 18 months. When I switched to Nicotinic Acid at 500mgs along with TMG I got the hard flush and within 3 months my HDL went up 40 points. I haven't tried the NR yet but am considering ordering it for the NAD+ boost.
Does Chilli pepper have niacin, whn I eat high pepper food I got same side effect of flushing which I experience with Niacin
What niacin do you use doctor? Would appreciate if you give me link, thank you
Enduracin
Good subject yes please compare this against NMN I have personally seen good results with NMN but on the athletic level. I do not know how that turns out longevity wise. I know as you have said losing weight you add time to your lifespan. My BMI is too low to calculate most likely and taking NMN I just saw a better athletic performance and muscle growth just under 2 years into constant use. Btw I would prescribe Fluticasone Propionate 50 mcg one spray 30 mins before your RUclips videos. Gotta manage that inflammation as you say Dr : )
Any bad effects of having a flash to health?
No.
Does everyone experience the flush? If not, do those who dont get it have same level of benefit from niacin?
Hello Dr ..what about NAD IV infusions...are they dangerous ..or beneficial in your opinion. Thankyou !
IV always has significant risk. Is there concern that the GI tract destroys the efficacy?
Ford Brewer MD MPH look up “ NAD treatment center” here in RUclips. Lots of testimonials for IV NAD+
are there any benefits at ALL from niacinamide as it is?
Many would say yes. But, like many things, there’s debate.
Excellent video. Thank you!
Thanks!
My NA (Niacinamide), NR, NMN problems... Dosing: can we use more than about 35mg a day? If no, then the excess may burn up methyl groups that are needed for other methylation chores (Homocysteine)? Does NA shut down NAD+ production at high levels? NMN has a phosphor group on it, I understand that that gets taken off in the liver, so why bother? Does NR get across the blood brain barrier better than the others?
Have you read about Betaine or methylated B complex vitamins? Do you think those could help?
Thank you for your reply Dr Brewer!
I use methylated folate & B12 + TMGlycine to manage a homocysteine problem. Dosing of NR is still a problem. Why take 150mg of NR when we can only use 35 mg/day? I'm missing something. Dr David Sinclair is taking 1gr of NMN/day. That makes no sense to me. And he's doing the research.
I had a terrible experience with Niacin. It wasn’t the flush that bothered me but I felt like I was having a heart attack. My chest tightened and I thought for sure I was going to throw up or pass out. I don’t know if that means I have heart problems but I shouldn’t.
All niacin flushes eventually.
Cheers doc. Another good video
Thanks.
how about a aspirin a half hour before?
Yes. Some do that & say it works well.
Niacin was the thing, then Resveratrol was in vogue, followed by nr, then NAD+, NADH, and now NMN. Is it all just marketing?
Is it beneficial to take them all, a few, or only one ... ?
Can there be overdose, potentiation, or interdiction when combined ...?
There's lots of interest, but little comprehensive information in one video.
See my post above yours. Dr. John Whitcomb explains it well. It has very real long-term application to the health of your mitochondria.
Thanks for sharing that. It’s interesting- I get fat more feedback for being TOO comprehensive...
@@PrevMedHealth 😁 What's funny is I've been looking into this, buying the supplements, and then I see a video of overdoing it by Chris Masterjohn, who cautions about combinations of niacin with the NR compound burning through the methyls, sans mention of NADH or NMN (if I recall correctly) ... and what again happened with resveratrol???
We really need someone to tie a nice bow around these lovely gifts of health and longevity.
You got this!
😁👍
Steve H I looked and don’t see your post. I will have to look into the research of Dr Whitcomb. I’m interested in the role these play in mitochondrial function but am getting increasingly confused as how to incorporate B3 into my regimen. Thank w
We have anti aging tablet since 1944 but we didn't know it..lol...I can't believe it
Yep.
Is niacinamide related to nicotinamide? I use a skin cream with niacinamide and have been told that using it with vitamin C will turn it into niacin.
Yes thanks
The problem with the flush version with me it gives rapid heart beat. So i just take a regular B complex vitamin
Thanks
I can't take Niacin because it worsens my GERD. But I can take Nutritional Yeast and I believe the Yeast has everything in it. At least I hope.
Question: Common B3 supplements are - Niacin - Niacinamide and Nicotinic Acid. How do these work or fit into your work? Also there was a pioneer Psychiatrist in Schizophrenia, his name is Dr. Abram Hoffer. Have you seen his work, of course he was poo pooed? He rightly so claimed a cure rate of 70% - yes cured. Let me know about these items if you have the time - Thanks
Thanks. But I’m not familiar with him.
I have heard of him and the use of niacin for schizophrenia reversal... it seems like it works best at the early onset of schizophrenia... but it is a disservice to humanity to not give it a try before starting them off on life long dependence on psychotropics. I know someone whose been on those drugs since the eighties... it’s not good. Maybe naicin would not have worked for her, but what if it had? it is sick, negligent and criminal that the conventional pharma goons who pose as doctors, refuse to offer these options first.
So confusing. Stick with dirt cheap Niaicn or pop up the $ for NR or NMN. Difficult to say.
Check out Charles Brenner.