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Sir u had choosed a right profession and you're made for it videos was soo helpful...... Please make one video on ventilatory response to co2, o2 deficiency, effects on hypoxia on co2 response curve, effects of h+on the co2 response ganong page 650,651they are so confusing
Please answer me, is there any difference between two theory question,. Cardiorespiratory change during moderate exercise or Cardiorespiratory change during muscular exercise
I am not sure if that is the case. In fact, voluntary stoppage of breathing is abrupt, so CO2 should rise instantaneously. Hypoventilation happens over a period, so build up of CO2 should be gradual.
Kavita Thakur Peripheral chemoreceptor or the chemosensitive cells have O2-sensitive K+ channels. Actually, those channels are hypoxia-sensitive K+ channels. They sense hypoxia and trigger impulses in IX & X nerves. However, one important fact should be noted. The peripheral chemoreceptors (carotid & aortic bodies) have massive blood flow. Measured in mL/100 gm of tissue/min, it is the highest blood flow. The DISSOLVED oxygen reaching the chemoreceptors is therefore good enough or more than adequate. Hence, initial fall in PO2 is not sensed as hypoxia by those O2-sensitive K+ channels. Only when PO2 goes below 60 mm Hg, even the massive blood flow to them is unable to compensate for the severe hypoxia. The other point is - even if the carotid bodies respond to initial hypoxia (PO2 between 100 - 60 mm Hg), and ventilation is stimulated -> CO2 gets washed out of the body. And CO2 wash out will depress ventilation via action on central chemoreceptor (medulla). So, anyways the effect of initial hypoxia (causing stimulation of ventilation) will not be seen. Only when PO2 falls below 60 mm Hg, now the stimulation of carotid chemoreceptor is so strong, that it overrides the ‘CO2 washout effect’, and then it will be the sole driver of ventilation.
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So helpful video 😀 thanks 👍😊
That was very helpful! One of the few videos on youtube that seems to explain this mechanism so simply.
Tqsm sir
U made me to understand both CVS change ND respiratory change within an hour 🥰
Sir u had choosed a right profession and you're made for it videos was soo helpful...... Please make one video on ventilatory response to co2, o2 deficiency, effects on hypoxia on co2 response curve, effects of h+on the co2 response ganong page 650,651they are so confusing
Awesome 👏✊👍 sir
Thank you so much
Superb explaination sir 🙏
Thanks.
Please add up more lectures of CNS
Tysm ❤
Please answer me, is there any difference between two theory question,. Cardiorespiratory change during moderate exercise or Cardiorespiratory change during muscular exercise
No difference. Answer will be the same.
@@VivekSirsPhysiology Thanks a lot sir!!! ❤️
🙏🙏🙏🙏🙏🙏pls keep this up
awesome sir, but unfortunatly i cant meet you due to rain and election.
Hello sir
Sir in case of voluntary. stopp breathing co2 rise grdualy but................ hypoventilation co2 rise immediately why???
I am not sure if that is the case. In fact, voluntary stoppage of breathing is abrupt, so CO2 should rise instantaneously. Hypoventilation happens over a period, so build up of CO2 should be gradual.
👏👏👏👏
Sir, I love your teaching
Thanks.
I have one issue with lighting I have same trchinwq of senses
Oxygen debt unit is only Lit or is it lit/min??
Oxygen consumption by the body is expressed in L/min; O2 debt also is generally expressed as L/min.
Sir i have one query why peripheral chemoreceptor responde strongly only when po2 is less than 60mm of hg and not strongly to 100-60mm of hg
Kavita Thakur Peripheral chemoreceptor or the chemosensitive cells have O2-sensitive K+ channels. Actually, those channels are hypoxia-sensitive K+ channels. They sense hypoxia and trigger impulses in IX & X nerves. However, one important fact should be noted. The peripheral chemoreceptors (carotid & aortic bodies) have massive blood flow. Measured in mL/100 gm of tissue/min, it is the highest blood flow. The DISSOLVED oxygen reaching the chemoreceptors is therefore good enough or more than adequate. Hence, initial fall in PO2 is not sensed as hypoxia by those O2-sensitive K+ channels. Only when PO2 goes below 60 mm Hg, even the massive blood flow to them is unable to compensate for the severe hypoxia.
The other point is - even if the carotid bodies respond to initial hypoxia (PO2 between 100 - 60 mm Hg), and ventilation is stimulated -> CO2 gets washed out of the body. And CO2 wash out will depress ventilation via action on central chemoreceptor (medulla). So, anyways the effect of initial hypoxia (causing stimulation of ventilation) will not be seen. Only when PO2 falls below 60 mm Hg, now the stimulation of carotid chemoreceptor is so strong, that it overrides the ‘CO2 washout effect’, and then it will be the sole driver of ventilation.
@@VivekSirsPhysiology thank you sir😇
Sir thank you this was also my doubt
Sir please make the notes
Notes of ? This topic? Already those notes have been posted in my telegram channel .