Your knowledge is beyond an instructor. You sounds like a Phd professor. You are doing a great job. I'm a MD student, and we do have medical cell biology. Your lecture helped me a lot with neuroscience and also biochemistry. You are the best! Keep up with the great job! Thanks again!
there really should have been extra visualization for the small/large hydrophobic amino acids you mention that exist within the acetylcholine receptor channel.
7:20 Ok, so with the binding of a ligand to the binding site, some of the helices are caused to rotate and thus 'hide' big hydrophobic portions of the channel which are preventing ions from passing through. Good, and thanks, details matter. But *what causes the rotation* , mechanically? And what then causes the ligand to be *expelled* , sometime later, so the pore closes? 1. My thought is that the binding of the ligand brings the ligand so close to parts of the binding site that intermolecular forces (Van der Waals forces?) come into play, and *attract* some parts of the binding site, which are attached to the helices & thus *move* parts of the helices, causing them to rotate etc. 2. And I think that maybe the moving of the helices *then* in turn moves parts of the *binding* site, changing the shape of that binding site, so as to reduce the intermolecular attraction forces between it and the ligand, allowing the ligand to diffuse out, which allows the pore to return to its original closed conformation. Does that make sense, and/or is it in any way validated to be known & true?
@@salifusadat3002 Hi, and thanks for replying, and that's a good question, but wasn't my first point actually about that? My first point tried to guess how the helices are caused to move. Didn't it make any sense? Can you explain what is confusing to you? My whole post is definitely conjectural, in that I'm just making the best guesses I can to try to understand some of this stuff.
Petition for people on the internet who make educational videos like these to write the textbooks, instead of the people that wrote the ones that I’m trying to escape from because they are so unclear...
Just be careful when describing the structure of the nAChR as being composed of 2alpha, 1beta, 1gamma, 1delta subunits etc, as this combination varies between different tissues! Great Video though!
Hi, I agree that he's really good at explaining difficult stuff, and it's 5 years later, but you have 4 duplicated posts here. I wonder if you could delete 3 of them? I know you may not have done that duplicate posting on purpose, as I've seen it happen to me too, which is why I often re-check a site I post at to see how it looks.
Your knowledge is beyond an instructor. You sounds like a Phd professor. You are doing a great job. I'm a MD student, and we do have medical cell biology. Your lecture helped me a lot with neuroscience and also biochemistry. You are the best! Keep up with the great job! Thanks again!
this.... is honestly the best lecture video out there that explains this concept in most clear way. ty so much.
now I can get at least C in biochem.
Excellent video- Clear, enthusiastic delivery, excellent diagrams and Accurate information! Thank you!
You are amazing I love the way you explain keep it up we need teachers like you ♥️
Extremely helpful in my studies of psychopathopharmacology. Thanks much!
Something major clicked for me watching this. Thank you!
omg thank you so much for your instruction. your teaching is much better than my lecturer ughhhh
WOW! Thank you so much, super grateful for this free education online
So thankful I have a test tomorrow
Great explanation ❤️ .... Thanks a lot❤
best biology channel
Excellent teaching.... thnk u sir
You videos are saving my ass!!! Thank you so much ❤
thank u soo much for explaning it elaborately....
Your videos have improved. You used to talk a little fast. Thanks for the in-depth explanation!
Excellent video, despite the thick accent. Do both locations need to be bound, to actuate the gate, or just one?
Awesome lecture!
Good!!!! this is an enjoyable lecture
Love your lecture style man
there really should have been extra visualization for the small/large hydrophobic amino acids you mention that exist within the acetylcholine receptor channel.
7:20 Ok, so with the binding of a ligand to the binding site, some of the helices are caused to rotate and thus 'hide' big hydrophobic portions of the channel which are preventing ions from passing through. Good, and thanks, details matter. But *what causes the rotation* , mechanically? And what then causes the ligand to be *expelled* , sometime later, so the pore closes?
1. My thought is that the binding of the ligand brings the ligand so close to parts of the binding site that intermolecular forces (Van der Waals forces?) come into play, and *attract* some parts of the binding site, which are attached to the helices & thus *move* parts of the helices, causing them to rotate etc.
2. And I think that maybe the moving of the helices *then* in turn moves parts of the *binding* site, changing the shape of that binding site, so as to reduce the intermolecular attraction forces between it and the ligand, allowing the ligand to diffuse out, which allows the pore to return to its original closed conformation.
Does that make sense, and/or is it in any way validated to be known & true?
What causes the helices to move in your second point?
@@salifusadat3002 Hi, and thanks for replying, and that's a good question, but wasn't my first point actually about that? My first point tried to guess how the helices are caused to move. Didn't it make any sense? Can you explain what is confusing to you? My whole post is definitely conjectural, in that I'm just making the best guesses I can to try to understand some of this stuff.
@@dannichols6261 I commented before watching the video to the end. I now get your point tho.
Love you so much :) thnx for ur efforts
thank you!!! I wish u r my lecturer
Not all heroes wear capes, some wear AK Lectures T-shirts
Thank you so much man💥💥
Petition for people on the internet who make educational videos like these to write the textbooks, instead of the people that wrote the ones that I’m trying to escape from because they are so unclear...
Thank you so much! Well explained
Wonderful lecture
One change you might want to make: you say " let's focus on the structure of Acetylcholine" and you mean the structure of the ACh receptor.
You are superb
thank you so much for the video! best lecture
Just be careful when describing the structure of the nAChR as being composed of 2alpha, 1beta, 1gamma, 1delta subunits etc, as this combination varies between different tissues! Great Video though!
i love you dude
THANK YOU ♥️♥️
you are great
So is it chemical or electrical channel
Are you from New York?
thanks brothe
Tnku Sir😊
7:29 acetylcholine channels opening
this.... is honestly the best lecture video out there that explains this concept in most clear way. ty so much.
now I can get at least C in biochem.
this.... is honestly the best lecture video out there that explains this concept in most clear way. ty so much.
now I can get at least C in biochem.
this.... is honestly the best lecture video out there that explains this concept in most clear way. ty so much.
now I can get at least C in biochem.
Hi, I agree that he's really good at explaining difficult stuff, and it's 5 years later, but you have 4 duplicated posts here. I wonder if you could delete 3 of them? I know you may not have done that duplicate posting on purpose, as I've seen it happen to me too, which is why I often re-check a site I post at to see how it looks.