Hey, first of all thank you for all the videos, I learned a lot You say that the ball covers the channel, but the ball has a positive charge, why would it go towards the channel if it also has a positive charge? the paddle domain has a positive charge, so I do not understand why the ball goes there
Can you explain how the new drug pregablin works that is prescribed to people with epilepsy and who may suffer from anxiety. Those who supply this drug cannot explain the mechanism of this drug - but they suspect that it binds calcium to the alpha 1 gated receptor. Pregabalin is an anticonvulsant drug used for neuropathic pain, epilepsy and generalized anxiety disorder.[4] It presents antihyperalgesic actions by binding to the α2δ subunit of the voltage-dependent calcium channels without presenting antinociceptive actions.[5] Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release).[13] It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S.[4]
Why would the positively charged ball and chain follow the conductance of positively charged potassium ions? Electrostatically it should be repelled by those charges, what brings it into position?
From what I can tell, the negative space is attracting both the ball and potassium ions much stronger than they repel one another, so they both try to move in the same direction,
proteins generally have a negative net charge, and you could imagine inside a cell there will be many many proteins. Among other negatively charged ions/molecules.
+hyhyhyhy1521 that is only taking into account the K+ that is inside. There are many other negatively charged molecules (many organic) on the inside that are responsible for the negative net charge. Also could have to do with the resting potential (if you're talking about the negative membrane potential) given the permeability and outside/inside concentrations of ions across the membrane. Watch his video on resting membrane potential.
The main ions which make negative potential inside at resting state are bulky phosphate ions PO4- and negatively charged proteins. Outside the cell membrane only chloride ion adds negative charge. When the gates open Na+ and K+ makes positive potential inside and chloride ion which is Outside accounts for negative potential outside.
I was thinking the same thing but I think depolarization starts with other types of channels and gated channels only opens up when depolarization reaches the gated channel vicinity and once gated channel is open the depolarization occurs faster. Not sure though.
this was just horrible , this could have been explained in 4 minutes , I have never heard same thing repeated 7 times , he is reallz horrible and he has no idea what hes talking about
I have learnt so much from your lectures, thank you!!!
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Thank you for the great explanations!
This is amazing! Thank you so much! You are such a good tutor
Hey, first of all thank you for all the videos, I learned a lot
You say that the ball covers the channel, but the ball has a positive charge, why would it go towards the channel if it also has a positive charge? the paddle domain has a positive charge, so I do not understand why the ball goes there
Can you explain how the new drug pregablin works that is prescribed to people with epilepsy and who may suffer from anxiety. Those who supply this drug cannot explain the mechanism of this drug - but they suspect that it binds calcium to the alpha 1 gated receptor.
Pregabalin is an anticonvulsant drug used for neuropathic pain, epilepsy and generalized anxiety disorder.[4] It presents antihyperalgesic actions by binding to the α2δ subunit of the voltage-dependent calcium channels without presenting antinociceptive actions.[5] Pregabalin is marketed by Pfizer under the trade name Lyrica and Lyrica Cr (extended release).[13] It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S.[4]
For voltage gated calcium channels, what is the difference in voltage that is needed to open the channel?
Thanks. Nicely explained
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🙏Thank you so much! Very helpful!
my favorite teacher
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What happened when the inactivated sodium channel is stabilized?
Is The sodium voltage gate have negative charge??? Please answer 😊
just awesome
When the channel open at hyperpolarization. How does it works?
Why would the positively charged ball and chain follow the conductance of positively charged potassium ions? Electrostatically it should be repelled by those charges, what brings it into position?
From what I can tell, the negative space is attracting both the ball and potassium ions much stronger than they repel one another, so they both try to move in the same direction,
Emam Diop That makes sense, thank you
proteins generally have a negative net charge, and you could imagine inside a cell there will be many many proteins. Among other negatively charged ions/molecules.
How get paddle charge
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if there is a high concentration of potassium inside doesnt it make the inside positive
hmmm i wanna know this answer :(
+hyhyhyhy1521 that is only taking into account the K+ that is inside. There are many other negatively charged molecules (many organic) on the inside that are responsible for the negative net charge. Also could have to do with the resting potential (if you're talking about the negative membrane potential) given the permeability and outside/inside concentrations of ions across the membrane. Watch his video on resting membrane potential.
The main ions which make negative potential inside at resting state are bulky phosphate ions PO4- and negatively charged proteins. Outside the cell membrane only chloride ion adds negative charge. When the gates open Na+ and K+ makes positive potential inside and chloride ion which is Outside accounts for negative potential outside.
you mention that the ion gate will re-orientate itself once depolarization has occurred. How can depolarization occur if the gate is closed?
I was thinking the same thing but I think depolarization starts with other types of channels and gated channels only opens up when depolarization reaches the gated channel vicinity and once gated channel is open the depolarization occurs faster. Not sure though.
^ That's it
not actually..depolarization occurs with voltage gated sodium channels which opens when the membrane reaches a threshold potential
i think the K+ leaking channel also has something to do with it returning to the resting membrane potential state
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You teach like everything
now I see.. thanks a ton
this was just horrible , this could have been explained in 4 minutes , I have never heard same thing repeated 7 times , he is reallz horrible and he has no idea what hes talking about