Thank you Shomu! You will be the biggest Biological sciences teacher in the world one day! I honor you for sharing and promoting freedom of information and education.
I don't know much about medical terminology but this video helped me understand more about a company I'm considering investing in that uses these same proteins as transport for vaccines! Pretty cool that they are found in most biological entities on earth. Thank you for the well illustrated information!
When I'm unable to understand concept ...then I always take help with yr video ...and just solve my problem ....really ...its help full for me in a great way ....
Thank you so much, Sir :) Though it was just a mention in our veterinary pathology textbooks, Curiosity led me to look it up.. You video really gave me a lot more knowledge about it..!!! Thank you and please keep uploading more..
I knew nothing of heat shock protein only saw videos of people talking about it and this made it make a bit more sence . With how the protein activities as well. So thanks.
Thank you soo much sir... your vedios are saving my time since bsc 1st year ... and now i am doing msc and able to get all the related topics which i need to understand ,all of those topics are available in your page.... 😇
Thanks. I will mention this to my doctor. However, do barriers from criteria, insurance, legal, and personal policy (it's their call...). I doubt I will get very far at all.
Here in Massachusetts they can only generate a report but can't do anything with it. Lots of tests, expensive, to generate reports but because their hands (medical) are tied, therefore limited... Well, we get snacks like candy, prescriptions and non prescription snacks. We love boxes and bags. Would you like a bag? You'll here often in Massachusetts.
Is there any correlation between heat shock protein and human growth hormone? This would be a really interesting subject as it's becoming viral. Please send the link here if you do any an thank you for the greath info even if I see this after 7 years .
I think the term "Intra-cellular" space used, from 8:37 onwards for the space between the outer and inner membranes is incorrect. It should instead be "Intra-membrane" space.
Awesome video! Do you have any idea if the stimulation of HSP affect the organisms offspring? For example if an organism is exposed to extreme heat will their offspring have a higher resistance to the heat because their parents have produced more HSP?
Hey sir please Can talle me séquence ADN in this texte becouse I dont know Heat stress transcription factors (Hsfs) are the major regulators of the plant heat stress (hs) response. Sequencing of the Arabidopsis genome revealed the existence of 21 open-reading frames (ORFs) encoding putative Hsfs assigned to classes A-C. Here we present results of a functional genomics approach to the Arabidopsis Hsf family focused on the analysis of their C-terminal domains (CTDs) harboring conserved modules for their function as transcription factors and their intracellular localization. Using reporter assays in tobacco protoplasts and yeast as well as glutathione-S-transferase (GST) pull-down assays, we demonstrate that short peptide motifs enriched with aromatic and large hydrophobic amino acid (aa) residues embedded in an acidic surrounding (AHA motifs) are essential for transcriptional activity of class A Hsfs. In contrast to this, class B and C Hsfs lack AHA motifs and have no activator function on their own. We also provide evidence for the function of a leucine (Leu)-rich region centered around a conserved QMGΦL motif at the very C-terminus as a nuclear export signal (NES) of class A Hsfs. Sequence comparison indicates that the combination of a C-terminal AHA motif with the consensus sequence FWxxF/L,F/I/L as well as the adjacent NES represents a signature domain for plant class A Hsfs, which allowed to identify more than 60 new Hsfs from the expressed sequence tag (EST) database.
Such are these postmodern times that at first glance I have ask the question: "is he really discussing heat shock proteins or is this an elaborate attempt at trolling Joe Rogan? "
dear fnd...one doubt here??? at (9.51 minute ) you said outer membrane protien is providing signal to inner membrane protien called Deg S. Then it signal is going to trigger the activation of Sigma E factor .But here i want know that what kind of signal mechanism at molecular level is taking place inbetween OMP and IMP protien called Deg S? plz clarify
at Shomu's Biology hello! I was wondering if the stress was heat and lets just say i am running two different temperatures on same cell. One is 37 degree Celsius and the other is 42 degree Celcius, are there any changes on the products? or will it be the same proteins? would one with the higher temp. produce a faster proteins because of the fast rate due to the higher temperature??
Thank you Shomu! You will be the biggest Biological sciences teacher in the world one day! I honor you for sharing and promoting freedom of information and education.
I don't know much about medical terminology but this video helped me understand more about a company I'm considering investing in that uses these same proteins as transport for vaccines! Pretty cool that they are found in most biological entities on earth. Thank you for the well illustrated information!
You're welcome. Glad to hear that you're getting benefit from my lectures. Please subscribe and share
Finals in 12 hours. This has been a saviour..even after 7years of being uploded🥺🤞🙏
Glad to help
You are saving me for my biochem final!
ousaxx same here I have biochemistry exam and he save my lots of time
When I'm unable to understand concept ...then I always take help with yr video ...and just solve my problem ....really ...its help full for me in a great way ....
This channel will be popular sooner or later, keep up the amazing work randomly found this channel looking up info on HSPs will subscribe
Thank you so much, Sir :)
Though it was just a mention in our veterinary pathology textbooks, Curiosity led me to look it up.. You video really gave me a lot more knowledge about it..!!!
Thank you and please keep uploading more..
Thank you soooooo much! Whenever I have questions, I will search your video first.
You're welcome
Wonderfully articulate and concise. I don't think I heard you use a filler word ("uhm") a single a time. Thanks for taking the time to make this!
Glad you liked my lectures. Please subscribe and share
What a teacher!! Incredible
Thank you
I knew nothing of heat shock protein only saw videos of people talking about it and this made it make a bit more sence . With how the protein activities as well. So thanks.
Thank you so much for the easy to understand HSP.
You're welcome
Thank you soo much sir... your vedios are saving my time since bsc 1st year ... and now i am doing msc and able to get all the related topics which i need to understand ,all of those topics are available in your page.... 😇
Thank you so much for appreciating my efforts
@@shomusbiologyofficial can i get a lec on heavy metal stress in plants? its urgent
very simple and best illustration so far, thank you.
great video, saved me before my pathology exam in 2 days
You're welcome. Glad to hear that you're getting benefit from my lectures
Mr. Shomu you are a life saver.
All the best
Not all heroes wear cape. Thank you, sir.
Thank you for appreciating my efforts
ur doing a great job keep it up. ur really making our work very simplyfied
Very well explained. It helps a lot
You're welcome
Great easy to follow diagrams
Thank you Soo much sir...... You make this concept of HSP very simple and easy for us.... 👍👍👍👍😍💓
May Allah bless you...
great information
You're welcome
Thank you... Now I got a some idea about it
You're welcome. Glad to hear that you're getting benefit from my lectures
75% biochem students
20% joe rogan fans
5% of people are far down a RUclips rabbit hole
Nice teaching
really easy and effective
thanks
You're welcome
very informative
nice teaching, with simple words easily understand by all. thank you
Thank u soooooo much...it really helps me to understand what's the HSP actually....thanks a lot
Glad to hear that
Thanks for making this simple!!!
Thank you.
Thanks. I will mention this to my doctor. However, do barriers from criteria, insurance, legal, and personal policy (it's their call...). I doubt I will get very far at all.
Here in Massachusetts they can only generate a report but can't do anything with it. Lots of tests, expensive, to generate reports but because their hands (medical) are tied, therefore limited...
Well, we get snacks like candy, prescriptions and non prescription snacks. We love boxes and bags. Would you like a bag? You'll here often in Massachusetts.
Thank you so much for the wonderful explanation 😊
You're welcome
Thanks dear friend, for all of your helpful videos
Thank you for these video..it helos me lot in my examination i really appreciate you work
Glad to hear that you're getting benefit from my lectures
Thank you
You're welcome
Thank you so much 😊 Sir 🙏
You're welcome
Shomu is the GOAT, he's singlehandedly getting me through biochem
you are brillent sir you saving my life me bht acha smj rahi hu thanks a lot sir
Glad to hear that you're getting benefit from my lectures
Thanks for posting, this was really helpful!
Hatts off to ur great efforts sir
Very useful
Thank you 😊
Glad to hear that you're getting benefit from my lectures
Great👍
Thank you
Is there any correlation between heat shock protein and human growth hormone? This would be a really interesting subject as it's becoming viral. Please send the link here if you do any an thank you for the greath info even if I see this after 7 years .
it really helped in my exam.thanks for teaching.
Thank you sir 🙏
You're welcome
It was helpful thank u sir
You're welcome
What is your opinion of Ashwagandha and does it have benefits regulating HSP's?
THANK YOU SO MUCH!
You're welcome
They do also have a role in activating the transcription , why haven’t you mentioned that? Thank you
thank u so much
You're welcome
Bless you
Thank you
Thank u so much sir. Very well explained.
You're welcome
I think the term "Intra-cellular" space used, from 8:37 onwards for the space between the outer and inner membranes is incorrect. It should instead be "Intra-membrane" space.
Yes it should be intramembrane space
thank you very much sir for this superb vidio 😊
You're welcome. Glad to hear that you're getting benefit from my lectures
That's a very nice and easy explanation. Can u plz make a video on various other roles of Hsps. That would b very helpful. Thanku
Plz what is the role of 1 group of stress protein as biomarker
Extremely helpful !
thanks you so much , you saved our life
Dear what happend when protein not fold properly
Awesome video! Do you have any idea if the stimulation of HSP affect the organisms offspring? For example if an organism is exposed to extreme heat will their offspring have a higher resistance to the heat because their parents have produced more HSP?
Thank you so much thalaivaah🙏
You're welcome
it is very awesome sir, please tell us about
microbial stress response on antimicrobial agents
Awesome
You're welcome
thanks you sir !!
You're welcome
Tysm
Hey sir please Can talle me séquence ADN in this texte becouse I dont know Heat stress transcription factors (Hsfs) are the major regulators of the plant heat stress (hs) response. Sequencing of the Arabidopsis genome revealed the existence of 21 open-reading frames (ORFs) encoding putative Hsfs assigned to classes A-C. Here we present results of a functional genomics approach to the Arabidopsis Hsf family focused on the analysis of their C-terminal domains (CTDs) harboring conserved modules for their function as transcription factors and their intracellular localization. Using reporter assays in tobacco protoplasts and yeast as well as glutathione-S-transferase (GST) pull-down assays, we demonstrate that short peptide motifs enriched with aromatic and large hydrophobic amino acid (aa) residues embedded in an acidic surrounding (AHA motifs) are essential for transcriptional activity of class A Hsfs. In contrast to this, class B and C Hsfs lack AHA motifs and have no activator function on their own. We also provide evidence for the function of a leucine (Leu)-rich region centered around a conserved QMGΦL motif at the very C-terminus as a nuclear export signal (NES) of class A Hsfs. Sequence comparison indicates that the combination of a C-terminal AHA motif with the consensus sequence FWxxF/L,F/I/L as well as the adjacent NES represents a signature domain for plant class A Hsfs, which allowed to identify more than 60 new Hsfs from the expressed sequence tag (EST) database.
Such are these postmodern times that at first glance I have ask the question: "is he really discussing heat shock proteins or is this an elaborate attempt at trolling Joe Rogan? "
Sir what do u do to make our interest in the topic?Just amazing!
You're welcome
Ty 😇
btw i subscribe! I am actually experimenting HSP17
worth watching ur videos.
Thankyou sir❤
You're welcome
dear fnd...one doubt here??? at (9.51 minute ) you said outer membrane protien is providing signal to inner membrane protien called Deg S. Then it signal is going to trigger the activation of Sigma E factor .But here i want know that what kind of signal mechanism at molecular level is taking place inbetween OMP and IMP protien called Deg S? plz clarify
keep on helping the needy people
+Arshad Shawl thank you. Glad you liked my lectures
Arshad Shawl
j ue08
Kindly make video on activation of hsp 7 in treatment of osteoarthritis
Ok
Here because of Joe Rogan and not because I'm actually studying for this.
You're welcome
worth watching it videos.
at Shomu's Biology hello! I was wondering if the stress was heat and lets just say i am running two different temperatures on same cell. One is 37 degree Celsius and the other is 42 degree Celcius, are there any changes on the products? or will it be the same proteins? would one with the higher temp. produce a faster proteins because of the fast rate due to the higher temperature??
Please I need séquence DNA( HSF)
You are an amazing lecturer 🤩👌🙏🙏🙏
Thank you. Glad you liked my lectures
Thank you!
Thanks a lot for give a video
it's very awesome ,tell me about ABA signalling, thanks sir
sir ,plz explain biotic and abiotic stress signalling
At 0:40 I almost thought u'd kill us
Good man thankyou
superb sir
Does adding or engaging more hsp help a cell fold?
thank you!
So what is the gene that encodes HSPs??? It is confusing to me...are HSP genes or is there another name for the gene that encodes HSP??
haven't you mentioned the role of eIF 4E ??
Why HSP dont denature due to high temprature.
Very nice
You're welcome
thank you,,sir!!!
thanks.....
shomu can u tell me which exon s important in hspb1
Please upload a video on cold shock proteins
Sure
Sir we want video on heat shock method
Okay
Sir can you provide me a free study materials. Please I'm belongs from very poor background 😭
thank youuuu
You're welcome
This is great it works for vitiligo!
Stress is plz describe