DNA Methylation and Cancer - Garvan Institute
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- Опубликовано: 6 сен 2024
- This epigenetics sketch was created by Armando Hasudungan, in collaboration with Professor Susan Clark and Dr Kate Patterson at the Garvan Institute of Medical Research. It has been created for a broad, non-expert audience to highlight key messages about the role epigenetics plays in biological processes like development and diseases such as cancer. Find out more: www.garvan.org...
In normal, healthy cells, two epigenetic processes - DNA methylation and DNA de-methylation - are maintained in a delicate balance. This balance is disrupted in cancer. Gene promoter regions that are typically unmethylated in healthy cells commonly become highly methylated in cancer and the associated gene is silenced. In comparison, the non-genic regions of DNA become de-methylated in cancer often leading to DNA instability. This disorganized DNA methylation pattern means that the cancer DNA becomes de-arranged and genes responsible for stopping cancer growth, also called tumour suppressor genes, are switched off, allowing cancers to grow unchecked.
Excellent explanation: concise, jargon-limited, and straight to the point. We need more 3-5 minute videos explaining complicated processes to the public at large.
Thanks again!
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So presumably hyper-methylation can deactivate a lot of DNA repair genes too.
This information is not getting out early enough to the masses. So sad!!!!
Highly impressed with this vedioclip and for the first time through your deliberation a professor has understood this complex process. Thank you very much indeed. Would love to learn from you more and more Sir! Regards
Thank you, Subhash!
please correct me any part of the statements if they are wrong.
I understood that:
1) promoter DNA methylation is a NORMAL action in response to the environment/epigenetics and ultimately results in gene silencing.
2) CpG site(s) methylation (another NORMAL nature of genome) ultimately creates different cell types and furthers their division (via unique methylation patterns per cell type, across the genome of cell types).
3) It is UNCOMMON for PROMOTER CpG islands to be methylated, because they (promoter regions) have important regulatory elements that control gene transcription (and shouldn't be 'messed' with).... and offset balance of promoter dna methylation and CpG island methylation.....
4) So, in cancer cells we not only have the UNCOMMONality of the methylation of DNA PROMOTER CpG islands, but they are HYPERMETHYLATED. This means
the normal inactivation for silencing of the gene for suppressing tumors is otherwise, due to hypermethylation, now allowed to be activated (so NO silencing of gene for suppressing tumors) and thus, allowed to differentiate/divide/aka behave like a tumor and go crazy!.......
Let me know.
Thanks!
This is so straight to the point and easy to understand, thanks!
Glad you found it useful!
Naive question: Could manipulation of the methylation on DNA cause a generation of a stem cell. Is a stem cell just one that has yet to undergo any methylation (expressing all genes)?
Thank you for this explanation
Thanks so much for clear explanation : )
Glad you enjoyed it :)
Where does *RNA* fit in?? Do the methylated spots on the DNA affect the transcription process into RNA?
great explanation and drawing skills
Balance is important. Great short presentation.
There is an "H" miising on each cytosine at the 1-N position. Or you could just write "Rest".
Alteration in methylated patterns, what if its hyper or hypomethylated ?
I love you Armando.
If you ever need a kidney transplant, you can have one of mine xx.
OMG Lol
best regards message ever
haha such devotion
That's beautiful, TYSM for the explication.
Saludos desde México.
nice explaination...but how promoters of housekeeping genes remains unmethylated
Thank you very much for uploading this excellent video
Glad you enjoyed it :)
So clear!! So useful!! Thanksss
excellent as always thank you, just need to slow delivery speed down a touch. thanks love all your amazing work.
Awesome video, thanks for posting it
Very cool, but where does these DNMT comes from? What is regulating DNMT for us to take human shape?
DNMT1o is synthesized and stored in the cytoplasm of the oocyte and translocated to the cell nucleus during early embryonic development, while the somatic DNMT1 is always found in the nucleus of somatic tissue.
@@tievoli83 Thanks a lot for the info🙏
I have experienced very severe neurological disorders with the use of PPIs.
I have the characteristics under methylation _ I learned this with my own research after the disorder_
I can't get rid of paresthesias, especially pins and needles.
What can you suggest me about this?
Question..... can anyone explain or give clarity on the following ... does any change to typical Purine & Pyrimidine, folate, B6 or B12 pathways during pre or early post natal periods result in heritable genetics that could be passed from that baby should they procreate in later life?
what does DNMT 1 do? produce more of a specific cell?
👍🏼💪🏾👑 Top thanks. A question please, the methylation and ipermethylation of the DNA can stopped celular neoplastic? SAM ( S- Adenosil Metionina) is it useful, is it good to take 400 mg every day to silence the transcription of cancer? thank you very much.
Andrea Lacerenza
Very nice for someone without a bio background.
Thanks for the your perfect explanation.
Amazing video , theank you
Super useful and easy to understand. Helped the big time! Thanks!
Thank you so much, sir..
Cant thank enough for this video
Do you sell a poster of this? Would love to buy 10 for my big family. They need to learn this.
This is great, thank you!
Methylation might affect the enlargement or maintenance of telomeres
Read this pls..i just took a tetanus vaccine and it has differential extraction-methylation CAN THIS CHANGE MY DNA ?
Very good, most of it I got it, but I didn't understand the flip part of CpG. If DNMT3a and DNMT3b already methylated, is that cause the flip and later when it obtains methyl from SAM it comes back?
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Great video! Is there a place I can buy or print that final graphic in high-res format? I searched your site but could not find anything. Thx!
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Very clear!
Amazing video. Thank you
i didn't understand anything,, so methylation activates or deactivates gene transcription ??!!
Deactivates
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excellent video! thanks :)
macam mana nak buat?
amzing video thanks.
No problem
exlnt video sir
Thank you ❤️❤️
No problem :)
awesome
ottimo video grazie
nearly 10k subs xd
subbed
Good
2:58
Wrong !!
SAM will become SAH after the reaction
4:40
dnmt2:
am I a joke to you?