"Reverse Vaccinology" Dr. Rino Rappuoli
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- Опубликовано: 19 окт 2024
- Dr. Rino Rappuoli
Chief Scientist and Head External R&D, GSK Vaccines, Siena, Italy
2017 Canada Gairdner International Award Laureate lecture on October 26, 2017.
Dr. Rappuoli received his Award for pioneering the genomic approach, known as reverse vaccinology, used to develop a vaccine against meningococcus B which has saved many lives worldwide.
The work:
Dr. Rappuoli is a pioneer in the world of vaccines and has introduced several novel scientific concepts. First, he introduced the concept that bacterial toxins can be detoxified by manipulation of their genes (genetic detoxification, 1987). Next, the concept that microbes are better studied in the context of the cells they interact with (cellular microbiology, 1996), and then the use of genomes to develop new vaccines (reverse vaccinology, 2000). In the process of reverse vaccinology the entire genomic sequence of a pathogen is screened using bioinformatics tools to help determine which genes code for which proteins, against which vaccines can be developed.
The impact:
Dr. Rappuoli also worked on several molecules which became part of licensed vaccines. He characterized a molecule, CRM197, that today is the most widely used carrier for vaccines against Haemophilus influenzae, meningococcus and pneumococcus. Later he developed a vaccine against pertussis containing genetically detoxified pertussis toxin and the first conjugate vaccine against meningococcus C that eliminated the disease in the United Kingdom in 2000. His work on reverse vaccinology led to the licensure of the first meningococcus B vaccine approved in Europe and Canada in 2013 and USA in 2015.
Great science....
Pleasure listening to the great scientist.
muy interesante el video
Very Insightful, Thanks for the service
Repent of your sins and believe on the Lord Jesus Christ, believe in your heart that He has died for sins and rose from the tomb on the third day and let the Holy Spirit within you, and you shall be saved. Amen
Great lecture, great science!
Repent of your sins and believe on the Lord Jesus Christ, believe in your heart that He has died for sins and rose from the tomb on the third day and let the Holy Spirit within you, and you shall be saved. Amen
Thank you for sharing these videos.
Repent of your sins and believe on the Lord Jesus Christ, believe in your heart that He has died for sins and rose from the tomb on the third day and let the Holy Spirit within you, and you shall be saved. Amen
Great lecture about reverse vaccinology
Repent of your sins and believe on the Lord Jesus Christ, believe in your heart that He has died for sins and rose from the tomb on the third day and let the Holy Spirit within you, and you shall be saved. Amen
May I say this is Rational approach?
Excellent ideology for corona
Repent of your sins and believe on the Lord Jesus Christ, believe in your heart that He has died for sins and rose from the tomb on the third day and let the Holy Spirit within you, and you shall be saved. Amen