Shiv Pillai (Harvard) 3: IgG4-Related Disease: Collaboration Between B and T Cells

www.ibiology.org/immunology/b...
Shiv Pillai provides a historical perspective on the steps that led to formulate today’s model on how the immune system works and outlines the underpinnings of B cell development.
Talk Overview:
Dr. Shiv Pillai provides a historical perspective on the steps that led to formulate today’s model on how the immune system works. Scientists observed that the body produces molecules (antibodies) that recognize the entry of foreign particles (antigens). He outlines the different models of the structure and functions of antibodies and explains the process by which antibody diversity is generated during B cell development (VDJ recombination). B cell development also involves two checkpoints to ensure the generation of functional antibodies and prevent the recognition of self-structures.
In his second lecture, Pillai explains how earlier in his career he discovered that two surrogate light chains bind to the heavy chain in pre-B cells to create the pre-B cell receptor (pre-BCR). He showed that binding of the surrogate chains facilitates the formation of the pre-BCR that is needed for B cell development. Pillai demonstrated that the pre-BCR signals through Bruton Tyrosine Kinase (Btk). Patients with non-functional Btk manifest signs of immunodeficiency and deficiency of B-cells in the blood, which shows the importance pre-BCR signaling for proper B-cell development.
In his third lecture, Pillai explains IgG4-Related Disease (IgG4-RD), a chronic inflammatory condition characterized by elevated numbers of T cells and IgG4 secreting plasma cells in the affected tissue. Using tissue samples from patients with the disease, his laboratory isolated and characterized the CD4+ T cells associated with IgG4-RD. Furthermore, he explains how the crosstalk between these CD4+ T cells and B cells is important for IgG4-RD development, and showed that depletion of B cells improves the outcome of the disease.
Speaker Biography:
Dr. Shiv Pillai is a professor of medicine and health sciences and technology at Harvard Medical School, and a Ragon Institute investigator. Pillai completed his medical studies at Christian Medical College Vellore, India (1976), and subsequently obtained his doctorate in biochemistry at Calcutta University, India. He continued his postdoctoral training at David Baltimore’s lab at MIT (1984-1988). It was at Baltimore’s lab where Pillai discovered the existence and importance of surrogate light chains for B cell development. The surrogate light chains bind the antibody heavy chain in pre-B cells (immature B cells), and form the pre-B cell receptor (pre-BCR). The signaling of pre-BCR is crucial for proper B-cell development. In 1988, he joined the faculty of Massachusetts General Hospital and Harvard Medical School. Today, his lab continues to study the basis of the immune system in order to provide further understanding to human disease.
Learn more about Pillai’s research at his lab website:
www.ragoninstitute.org/portfol...

[@hangzhou8008]

Wow! Fantastic speech! I am reading your most recent published papers right now. haha

[@ivo3185]

Fascinating. Thank you!

[@debbieblanton9569]

Thank you. Well spoken. Explains my sister's diagnosis after baffling the doctors for quite sometime. She has had asthma most all her life.
Keep up the research!

[@FoodForestPermaculture]

Must say thank you to every one involved . Having IgG4 related Disease is very hard to have a normal life so my Best To You All . Howard R Jones

[@czechmeoutbabe1997]

this is so unbelievably understandable, thank you so much

[@danchokonstantinov6735]

Great, wonder why many lecturers even now do not elaborate on CD4+CTL / Tfh interface and role of interleucins constellation .

[@khalidsaifullah4510]

Nicely explained

[@AnitaCorbett]

Great information

[@dcr8888]

It is believed that we are now seeing increased IgG4 levels and activity in a number of patients after their Covid booster(s).

[@devochile]

Yes, I know it's sad but true...I know a person who's life changed overnight from the booster....Do you have any links that you know of where I can get more info please ?? Thanks so much.

[@Smcquoid12345]

ruclips.net/video/L7mxQ_FtXp0/видео.htmlsi=2cJaW5mLGtN5cYtE

[@Smcquoid12345]

Canadian researcher. He does an entire series on this subject. Everything is resourced. Just follow the link. He does a pretty good job

[@ctdali]

That is what peer reviewed research is showing

[@EGlobalTrading]

This guy is a walking biological encyclopedia jeez.

[@evette45evette21]

Which igg is worst? Example 123 or 4.

[@sugabay]

@5:00 exactly right

[@ezracheney5435]

very descriptive/phenomenology, no insight on etiology nor recongition of TCR (what B cells are presenting?), is this autoimmne against IgG4 determinant, should mention the antiinflammatory IgG4 FcgR and its large picture on the potential benefit---this lecture is missing a large picure and deeper stories or direction of research

[@driekiedutoit3327]

Thank you we all knimow but how does it make you different. Additional i would like to add that we r all making our own decisions. If you want to agree geat but about the fact that each r in case control.. sleep well

[@sugabay]

@4:48 yep

[@madanthakur9534]

Hindi

[@Tassilago]

And now we see millions and millions of people with a 4000% rise in igG4 after boosting... and pharma is still going to just treat the symptoms. 💰