Re. CA19-9 & heterophile antibodies. In a 2022 case study (Zhao et al), a patient with elevated CA19-9 was analysed as a possible false positive case. Three analysis methods used: gradient dilution, PEG precipitation & heterophilic antibody blocking assay. Conclusion was CA19-9 increase was incorrectly identified due to the presence of heterophilic antibodies. My questions: - Are the lab methods used above available in typical commercial labs (ie not just research labs), or are there other heterophile antibodies tests. - could tick bites be a source of heterophile antibodies - would an alpha-gal antibody (mammalian meat allergy) test be of any use, & could heparin impact on heterophile antibodies, & the CA19-9 levels? Ref: Wei Zhao et al. 2022. "Persistent increase of carbohydrate antigen 19-9 with an unknown reason: A seven - year follow-up case" Journal of Clinical Laboratory Analysis/ Vol 36, Issue 12 / e24792
Re. CA19-9 & heterophile antibodies. In a 2022 case study (Zhao et al), a patient with elevated CA19-9 was analysed as a possible false positive case. Three analysis methods used: gradient dilution, PEG precipitation & heterophilic antibody blocking assay. Conclusion was CA19-9 increase was incorrectly identified due to the presence of heterophilic antibodies.
My questions:
- Are the lab methods used above available in typical commercial labs (ie not just research labs), or are there other heterophile antibodies tests.
- could tick bites be a source of heterophile antibodies
- would an alpha-gal antibody (mammalian meat allergy) test be of any use, & could heparin impact on heterophile antibodies, & the CA19-9 levels?
Ref: Wei Zhao et al. 2022. "Persistent increase of carbohydrate antigen 19-9 with an unknown reason: A seven - year follow-up case"
Journal of Clinical Laboratory Analysis/ Vol 36, Issue 12 / e24792