Thank you for the explanation! Quick question - why are n=1 studies not typically published? Is it because it is so unique to the given patient at hand? ie. low generalizability?
Awesome video, thank you so much! A quick question, what is the difference between N =1 and alternating treatment design (ATD) as in the family of single case experimental designs? Thank you again!
Is this the same as 'N = 1 Studies' and the commonly seen 'N-of-1 trials' in current journals? In the Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence, N=1 is classified as Level One (N-of-1 trial with the patient you are raising the question about, or observational study with dramatic effect). Does this mean there is currently a higher chance of publication in journals? What are the prerequisites for its publication? For instance, does it require not only visual analysis but also statistical analysis? thanks
Great question - I have not seen an N=1 trial published, but have only heard of them used in the clinical environment to help with individual case decision-making... It uniqueness to the individual is it's greatest strength but would likely preclude any meaningful generalizability to a broader group.
Um, this isn't what I was told N=1 is. In the cases that I'm thinking of, this would be unethical because it would be potentially "withholding treatment" from someone who needs it. Please update this.
The N=1 study is not that common due to the challenges of setting it up but still requires the same ethical consideration of other studies - specifically equipoise. So for an N=1 study we would still need to consider if it is ethical to have a placebo arm vs. a different therapeutic.
The most concise and easy to understand explanation out there!
This is a great channel! 5 videos in so far, huge help! Great work!
Thank you for the explanation!
Quick question - why are n=1 studies not typically published? Is it because it is so unique to the given patient at hand? ie. low generalizability?
Exactly!
Awesome video, thank you so much! A quick question, what is the difference between N =1 and alternating treatment design (ATD) as in the family of single case experimental designs? Thank you again!
Is this the same as 'N = 1 Studies' and the commonly seen 'N-of-1 trials' in current journals?
In the Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence, N=1 is classified as Level One (N-of-1 trial with the patient you are raising the question about, or observational study with dramatic effect).
Does this mean there is currently a higher chance of publication in journals?
What are the prerequisites for its publication? For instance, does it require not only visual analysis but also statistical analysis?
thanks
Great question - I have not seen an N=1 trial published, but have only heard of them used in the clinical environment to help with individual case decision-making... It uniqueness to the individual is it's greatest strength but would likely preclude any meaningful generalizability to a broader group.
I’m doing an N=1 study on myself
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Um, this isn't what I was told N=1 is.
In the cases that I'm thinking of, this would be unethical because it would be potentially "withholding treatment" from someone who needs it.
Please update this.
The N=1 study is not that common due to the challenges of setting it up but still requires the same ethical consideration of other studies - specifically equipoise. So for an N=1 study we would still need to consider if it is ethical to have a placebo arm vs. a different therapeutic.