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this is incorrect... ALL noncompliant patients are excluded in per protocol, not just the ones from the experimental group

This is great information. Thank you

Isn't it sad that evidence-based medicine is ignored in favor of political will?

Perfect !!!!

Best ever !! Thank you

This helps with learn how to read some photos of Ariana grande

Thank you, i finally understood those terms for the first time.

Bro I am searching for "Electronic beam machining" and I got this video 😑

how can a lowst to follow up be bigger than the effect size? They are different kind of numbers.

Does lost to follow up harm the internal validity of a study? Does an intention to treat analysis correct this internal validity flaw?

Bro i clicked on this for electric Body Music /:

Is this the same as 'N = 1 Studies' and the commonly seen 'N-of-1 trials' in current journals? In the Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence, N=1 is classified as Level One (N-of-1 trial with the patient you are raising the question about, or observational study with dramatic effect). Does this mean there is currently a higher chance of publication in journals? What are the prerequisites for its publication? For instance, does it require not only visual analysis but also statistical analysis? thanks

How do you do that?

Is Intention to Treat becoming a "buzz word" in data science? A team in my analytics department at a large insurance company claimed they'd conducted an "ITT" study. After reading their paper, it was clear they had run a case-control analysis on observed data, not an ITT RCT. Maybe "Intent to Treat" sounds fancier?

nbme 20 hahaha

Epic Bacon man

You can't skip the Intro because the last paragraph includes the hypothesis, the outcomes, etc.!

EBM is well explained with illustration..lots of regards from chennai india

Great video! But why an intention-to-treat group is better than a per-protocol group in minimizing biases of protocol-violating subjects is asserted but not explained. On its face, the opposite would seem more likely. If half of the controls used the treatment and half of the treatment group didn't use the treatment, any efficacy of the treatment should be undetectable in the intention-to-treat groups but could be uncovered in the per-protocol group. No?

👉Y was it in per protocol, just 75% instead 100%, and the experimental group get 100%, wen it was the experimental group affected and 1 fall out from experimental group happened? Pls explain

This is a great channel! 5 videos in so far, huge help! Great work!

I am still confused how if we don't know the "satisfaction" (the outcome in this video) of the dropped out subjects? In this video, you explain like the researchers know about the dropped out subjects outcome. For example, 100 subjects in control group vs 100 subjects in experimental group are followed for survival after 5 years. If there are 10 dropped out subjects in experimental group and (for the sake of simplicity) the rest of them is alive, how should we calculate the survival rate of experimental group? PP analysis: 90/90 = 100% ITT analysis: 90/100? And how about if I study their mortality rate? PP analysis: 0/90 = 0% ITT analysis: 10/100 = 10% (we count the dropped out subjects as "failure") or 0/100 (because we only include the dropped out as they were randomized, without any outcome)? Thank you

Excellent explanation. Thanks!

Great sketch and info! I am here from The University of Maryland School of Pharmacy with the MS in Medical Cannabis Science and Therapeutics program. So intrigued to be learning about this. I liked that you mentioned the risks as well. Thank you.

genius

I came here cuz I thought he was gonna talk about Electronic Body Music.

Is there a difference between evidence-based medicine and evidence-based practice?

Very good and clear explanation

Can you please make more videos on clinical trials concepts? Your explanation is super simple and comprehensive.

Extremely helpful. thankyou so much!

Thank you

What does this have to do with Electronic Body Music?!

Still not a straight answer

THANK YOU FOR THE VALUABLE INFORMATION. I HAVE A QUESTION REGARDING THE FIRST AND SECOND EXAMPLE. IN THE FIRST ONE 50% CHANCE OF GETTING A FATAL MI : IS THIS A 2 NNH NUMBER NEEDED TO HARM FOR THAT DRUG. OR IS THERE IS ANOTHER TERM ? IN EXAMPLE 2 IS THERE A TERM THAT DESCRIBES THE HIGH COST FOR A TREATMENT? . THANK YOU SO MUCH

BASED BASED BASED REEEEEEE

This helped ALOT for my assignment this wk thank u dr!!!!

Omg thank u so much dr

So helpful! Sketchy EBM you may get me through my doctoral program

wow! thanks for the great video!!!!!!!! :) I have to subscribe!!!!!!!!!!!!!!!!\(￣︶￣*\) （づ￣3￣）づ╭❤～ (○｀ 3′○ ) ༼ つ ◕_◕ ༽つ

are there specific names for the bias you mentioned in each example?