Insulin Resistance and Beta Cell Dysfunction | CDE Exam Tips

This presentation provides information on the defects in insulin response in TYPE 2 DIABETES (insulin resistance and beta-cell dysfunction).
-Contributing factors to the defects in insulin secretion in T2DM(eg: obesity, pro-inflammatory mediators, beta cell oxidative stress etc...) are discussed
-Significance of adipokines and proinflammatory cytokines in INSULIN RESISTANCE
-Mechanisms of pro-inflammatory mediators that impact insulin signalling
-Chronic hyperglycemia and oxidative stress leading to beta-cell dysfunction
-----CONTENTS OF THIS VIDEO-----
00:00 - INTRO
00:24 - Insulin Resistance
06:28 - Beta Cell Dysfunction
08:52 - Summary Flow Chart for Defect in Insulin Secretion
Also check out our video on:
Phases of Insulin Secretion (PART 1) CLICK HERE: • Phases of Insulin Secr...
-Phases of Insulin Secretion in Type 2 Diabetes(PART 1 cont.) CLICK here: • Phases of Insulin Secr...
FOR FURTHER READING ON THIS TOPIC, CHECK OUT THE REFERENCES BELOW:
Hardy OT, Czech MP, Corvera S. What causes the insulin resistance underlying obesity?. Curr Opin Endocrinol Diabetes Obes. 2012;19(2):81-87. doi:10.1097/MED.0b013e3283514e13. www.ncbi.nlm.nih.gov/pmc/arti.... [Last accessed Oct 17,2021]
Saisho, Y. (2014). Obesity, Type 2 Diabetes and Beta Cell Failure: An Asian Perspective. Journal of Molecular and Genetic Medicine, s1(01). doi.org/10.4172/1747-0862.s1-008 [Last accessed Oct 14,2021]
Freeman AM, Pennings N. Insulin Resistance. [Updated 2021 Jul 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: www.ncbi.nlm.nih.gov/books/NB... www.ncbi.nlm.nih.gov/books/NB...[Last accessed Nov 5,2021]
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[@grahamedwards6824]

Excellent presentation.
I only wish that I was back in Med school...!!
But I think that we are doing the right things to reverse the process.
Low Carb and intermittent fasting......!!
Enhanced by Autophagy and the metabolic switch from mostly glucose metabolism, to metabolising the stored fat and producing ketones, which provide a complementary energy source for all of those 'compromised' cells....

[@heatherwilliams90]

I am currently working on an advanced pathophysiology assignment of type 2 diabetes, I understood the beta cell dysfunction, but I kept getting stuck on the cellular mechanisms around insulin resistance despite reading multiple books, articles, and various you-tube clips I just couldn't get exactly where the problem arose, after watching this it is finally very clear and I think I might actually get my assignment done. Thank you so much.

[@cdeexamtips]

Thanks. Glad this video helped.

[@elianamarji8142]

AMAZING

[@SamanPiroti]

this was great! I had to read an entire article about this but I still struggled to understand exactly what happens. thank you for making it simple for us!

[@cdeexamtips]

Thanks, glad you found it helpful. Please share

[@wellnesssecrets2014]

Excellent

[@cdeexamtips]

Thank you!

[@surajsonkar2052]

How comes any medicine daibities reversal

[@HaifaHS]

Thank u!!

[@cdeexamtips]

You're welcome! Thanks for watching