Your channel is fantastic, informative and well presented. I just self research/study topics such as these in my own time and really am enjoying your channel, keep uploading!
Awesome video- really clear and concise articulation of the process, just self-studying and found this was incredibly helpful! Thanks! do you happen to have a transcript of what you say in the video? I'd like to be able to read your verbal descriptions of the pathway :)
Human CYPs are primarily membrane-associated proteins[20] located either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells. CYPs metabolize thousands of endogenous and exogenous chemicals. Some CYPs metabolize only one (or a very few) substrates, such as CYP19 (aromatase), while others may metabolize multiple substrates. Both of these characteristics account for their central importance in medicine. Cytochrome P450 enzymes are present in most tissues of the body, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. Cytochrome P450 enzymes also function to metabolize potentially toxic compounds, including drugs and products of endogenous metabolism such as bilirubin, principally in the liver. The Human Genome Project has identified 57 human genes coding for the various cytochrome P450 enzymes.[21]
Love the energy and speed. First time i kinda understood this. As a med student i'd maybe like more clinical relevance, like deficiency in 5alfareductas, anti bodies against 21-hydroxylas (addison) and their consequense. This is what makes me remember the steps (like when u involved mice with corticoids, loved that). Just ideas mb for a follow up vid.
Really concise and elucidating video! I especially like the use of this diagram. Juat one note. I believe aldosterone was later discovered to lack an aldehyde group, so its etymological "aldo" naming is incorrect. The name wasn't changed since then, but even in your diagram, it can be seen that carbon 18, double-bonded to an oxygen, is bound to another carbon - not a hydrogen. Love your videos. Thanks for all your good work!
Awesome video. Curious to get your thoughts. What would make someone not be able to convert cholesterol into these hormones? I have lots of cholesterol but can't convert it.
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This is the most clear and straightforward biochemistry explanation I've ever heard.
I appreciate you :)
Your channel is fantastic, informative and well presented. I just self research/study topics such as these in my own time and really am enjoying your channel, keep uploading!
Thank you, and I'm glad you are able to do that with my channel. Best!
Awesome video- really clear and concise articulation of the process, just self-studying and found this was incredibly helpful! Thanks! do you happen to have a transcript of what you say in the video? I'd like to be able to read your verbal descriptions of the pathway :)
if you click on the three dots next to the share button next to the like buttom it will give you an option to view the transcript
The best explanation gotten on steroidogenesis so far, thank you.
Human CYPs are primarily membrane-associated proteins[20] located either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells. CYPs metabolize thousands of endogenous and exogenous chemicals. Some CYPs metabolize only one (or a very few) substrates, such as CYP19 (aromatase), while others may metabolize multiple substrates. Both of these characteristics account for their central importance in medicine. Cytochrome P450 enzymes are present in most tissues of the body, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. Cytochrome P450 enzymes also function to metabolize potentially toxic compounds, including drugs and products of endogenous metabolism such as bilirubin, principally in the liver.
The Human Genome Project has identified 57 human genes coding for the various cytochrome P450 enzymes.[21]
Nice explanation, are you an endocrinologist?
Love the energy and speed. First time i kinda understood this. As a med student i'd maybe like more clinical relevance, like deficiency in 5alfareductas, anti bodies against 21-hydroxylas (addison) and their consequense. This is what makes me remember the steps (like when u involved mice with corticoids, loved that). Just ideas mb for a follow up vid.
Very clear, very concisely explained!
Really concise and elucidating video! I especially like the use of this diagram.
Juat one note. I believe aldosterone was later discovered to lack an aldehyde group, so its etymological "aldo" naming is incorrect. The name wasn't changed since then, but even in your diagram, it can be seen that carbon 18, double-bonded to an oxygen, is bound to another carbon - not a hydrogen.
Love your videos. Thanks for all your good work!
Thanks man! Helping me understand my results a lot, and giving me insight in how to steer my doctor into measuring the right steroids upstream
That was AMAZIIIINGGGGGGGG🤩🤩🤩
Thank you 😊 this video really helped me 🤗
Excellent ❤
wow best explanation ever. ty!!!!
Awesome video, thank you!
Thanks a lot, this helped me😇
This guys name is toke-off like a smoking contest🤣😭😆😂
very sharp
A great video and very clear explanations.
Why are the pathways called delta-4 and delta-5?
Thanks
It is because of where the double bond it. Delta signifies a double bond and the pathways with delta in the name "move" the double bond
Awesome video. Curious to get your thoughts. What would make someone not be able to convert cholesterol into these hormones? I have lots of cholesterol but can't convert it.
Did you ever get an answer to your question? I seemed to be having the same issue
very nice sir
Can you please send first slide it's not so clear
i love this video thank you very much TT
Excellent
Woooooooooow!
شرح سيء
😊0
Can you speak in English please ?