Great video! Thank you for your efforts! I study for my physiology exams and that helped me understand and visualize the whole process! Looking forward to other videos!
This really helps to make the process very clear! I have master degree presentation and this really helped me. Can you please send me references for the figures you are explaining?? I will really appreciated Thank you :)
Thank you, and I'm glad it was helpful. I can't post files here, but if you type "lehninger insulin synthesis" into Google image search, you should find these images within the first 20 images in the results.
@@CatalystUniversity can I have your email if I ever have a question about anything thats rlevant to this , . I will appreciate it . Thank you and Good night
What I really wanna know how beta cells detect or sense that there is glucose in blood ? Or glucose simply travel to beta cells by their own ? Please clear it. Thank you for video.
@@liutasx hey idk if still relevant but, ...try to think this way , beta oxidation is not favoured in this kind of situation when u have a lot of glucose(a lot of potential energy) ..no need for further beta oxidation..i guess its a lot more complex than this but it makes sense :D
Even if you have moderate inhibition of potassium channels, there must be a certain minimum amount of ATP concentration needed since depolarisation is a all or nothing mechanism.
hey man, idk if still relevant but... beta blockers have nothing to do with beta pancreatic cells (i understood that u linked these two)...beta blockers are antagonists of beta adrenergic receptors (beta1,2,3). Beta 2 receptor activation normally leads to glycogen breakdown in liver and glucagon release from alpha cell of pancreas (glucagon stimulates glucose synthesis) so therefore beta blockers can actually lower ur plasma glucose ...cheers
@@iamliam6929 it is said that first gen beta blockers affects all types of beta cells in all types of tissue. So by taking beta blockers you might inhibit insulin also and will lead to high glucose in blood.
Can anyone tell me if the pancreas can suddenly stop producing insulin? I’m talking like over night or working hours? Or is it typically progressive? I’m sure many factors involved but just in general. Thank you.
Maybe the Insulin secretion is good enough 🤔, and the 3:44 body has all it needs , so it resists and glucose goes up , and the cell just produces more and more Insulin till it maximum out 😊
Thanks you Dr Igudia on RUclips for all you do in my life and my family. I went for a test today after taking the medication i ordered from Dr Igudia and I tested diabetes’s negative. Thanks doctor I will keep letting the world know about your good work sir.
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This has the hardest intro I have ever seen
EXTRAORDINARY on every level! Thank you for the incredible and erudite tutorial. Simply PERFECTION!
Thanks it helped me for my cell signaling exam .
your video has made the mechanism so simple! Compared to book reading , I would rather watch your video!
Very good explanation . It is clear to me now.
Im always so amazed how our body works.
Great video! Thank you for your efforts! I study for my physiology exams and that helped me understand and visualize the whole process! Looking forward to other videos!
Just what I was looking for, thank you!!
This video is pure quality
Learned a lot beautiful explanation
Excellent explanations of these mechanisms. Reviewed a couple of times to understand the K+ and Ca+2 gate operations on insulation release.
very clear explanation thank you so much
Excellent explanation!
very nice and well explained, thank you
Best explanation 🤗
Couldn’t be easier! Thank you so much
All I needed to understand... thanks
Thank you so much ! Amazing work
Excellent ... well done ...
easily well understood
Well explained 👏 👏 👏
That's cool man. Thank you a bunch.
Thanks a lot. Great video. Very nice explanation. I admire your job.
This really helps to make the process very clear! I have master degree presentation and this really helped me. Can you please send me references for the figures you are explaining??
I will really appreciated
Thank you :)
Thank you, and I'm glad it was helpful. I can't post files here, but if you type "lehninger insulin synthesis" into Google image search, you should find these images within the first 20 images in the results.
@@CatalystUniversity can I have your email if I ever have a question about anything thats rlevant to this , . I will appreciate it . Thank you and Good night
@@tasneemaburaiya6944 @Catalyst University she wants your email address give it to her :)
the intro killed me
What I really wanna know how beta cells detect or sense that there is glucose in blood ? Or glucose simply travel to beta cells by their own ? Please clear it.
Thank you for video.
✔👍 perhaps through the GLUT2 transporter?
great, thank you!
so low insulin could be due to lack of calcium influx into the cells?
Thank you so much,
THANK U SO MUCH😭💙
Around 5:36 you had mentioned that there is an increase in Potassium efflux. Did you mean Calcium Influx? I got a bit confused there.
I think that's what he'd meant
Thank you!!
Will calcium rich food or calcium supplement help in regenerating beta cells?
extraordinarily well
Thank you!
Very helpful, thanks a lot! Could you resommend a good textbook or two on Biology?
Really appreciate your work! Thank you!
And how is the release of calcium from the smooth ER regulated?
So not glucose, but ATP/energy status of beta cell causes to release insulin?
You need glucose to produce the ATP
@@wakylaugh Beta cells can use fatty and amino acids to produce ATP, not only glucose.
liutasx but he’s specifically talking about GLYCOLYSIS and GLUCOSE
@@liutasx hey idk if still relevant but, ...try to think this way , beta oxidation is not favoured in this kind of situation when u have a lot of glucose(a lot of potential energy) ..no need for further beta oxidation..i guess its a lot more complex than this but it makes sense :D
Even if you have moderate inhibition of potassium channels, there must be a certain minimum amount of ATP concentration needed since depolarisation is a all or nothing mechanism.
So beta blockers block insulin and elevate blood glucose levels ?
hey man, idk if still relevant but... beta blockers have nothing to do with beta pancreatic cells (i understood that u linked these two)...beta blockers are antagonists of beta adrenergic receptors (beta1,2,3). Beta 2 receptor activation normally leads to glycogen breakdown in liver and glucagon release from alpha cell of pancreas (glucagon stimulates glucose synthesis) so therefore beta blockers can actually lower ur plasma glucose ...cheers
@@iamliam6929 it is said that first gen beta blockers affects all types of beta cells in all types of tissue. So by taking beta blockers you might inhibit insulin also and will lead to high glucose in blood.
@@PRTube01 oh okay didnt know that :) i guess i need to dig deeper :) cheers !
@@iamliam6929 Iam no expert either
Liked and subscribed 👍🏻 :)
wow that intro
Can anyone tell me if the pancreas can suddenly stop producing insulin? I’m talking like over night or working hours? Or is it typically progressive? I’m sure many factors involved but just in general. Thank you.
It's typically progressive
Great
So, what part of this process gets broken if a person has type 1 diabetes?
@Hemlock Cocktail I see. thank you for explaining that to me.
Maybe the Insulin secretion is good enough 🤔, and the 3:44 body has all it needs , so it resists and glucose goes up , and the cell just produces more and more Insulin till it maximum out 😊
These cells are destroyed in T1D. None of this happens because there are no cells that contain insulin since the body destroyed them.
🙏
Thanks you Dr Igudia on RUclips for all you do in my life and my family. I went for a test today after taking the medication i ordered from Dr Igudia and I tested diabetes’s negative. Thanks doctor I will keep letting the world know about your good work sir.
You're the fuckin man!
❤❤❤
its GLUT1
❤
Good but I'd really like to suggest to treat ur flu, its very disturbing
Pardon
🙏🙏🙏🙏🙏💜🧡💙💚❤️
*in **5:35** you have made a mistake. ***
😁
J
It’s the GLUT1 and GLUT3 for pancreatic ß-cells, NOT GLUT2 :)
Not true, GLUT1 is mainly expressed in RBC and GLUT3 in neurons and sperm. GLUT2 allows glucose intake into pancreatic beta cells and hepatocytes.
Super nice intro. However, the slurping forced me to stop watching.
Nevertheless, I got the take home message
I could not listen through your sniffing
learn to be grateful, these videos are free