The Mechanism of Insulin Release by Pancreatic β-cells

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  • Опубликовано: 18 апр 2019
  • ⚡ Welcome to Catalyst University! I am Kevin Tokoph, PT, DPT.
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Комментарии • 77

  • @normallochie7390
    @normallochie7390 Год назад +19

    This has the hardest intro I have ever seen

  • @xaviermagnate
    @xaviermagnate 2 года назад +16

    EXTRAORDINARY on every level! Thank you for the incredible and erudite tutorial. Simply PERFECTION!

  • @olgakaldou1606
    @olgakaldou1606 5 лет назад +8

    Great video! Thank you for your efforts! I study for my physiology exams and that helped me understand and visualize the whole process! Looking forward to other videos!

  • @domenicafigueroa9230
    @domenicafigueroa9230 3 года назад +3

    Just what I was looking for, thank you!!

  • @noname-mm9of
    @noname-mm9of 2 года назад

    This video is pure quality

  • @williewonka6694
    @williewonka6694 Год назад

    Excellent explanations of these mechanisms. Reviewed a couple of times to understand the K+ and Ca+2 gate operations on insulation release.

  • @imtinan7136
    @imtinan7136 2 года назад

    Couldn’t be easier! Thank you so much

  • @agnieszkapodraza3083
    @agnieszkapodraza3083 Год назад

    Thank you so much ! Amazing work

  • @weezy224
    @weezy224 Месяц назад

    very nice and well explained, thank you

  • @hafsa4901
    @hafsa4901 Год назад +1

    Thanks it helped me for my cell signaling exam .

  • @mahmuterzengin614
    @mahmuterzengin614 3 года назад

    Thanks a lot. Great video. Very nice explanation. I admire your job.

  • @mutuwamercyvivian5748
    @mutuwamercyvivian5748 2 года назад

    All I needed to understand... thanks

  • @erikfermin1787
    @erikfermin1787 Год назад

    very clear explanation thank you so much

  • @Zireael1410
    @Zireael1410 Год назад

    Excellent explanation!

  • @katefreedom9708
    @katefreedom9708 Год назад

    Learned a lot beautiful explanation

  • @ShemMwangi-no8nz
    @ShemMwangi-no8nz 13 дней назад

    easily well understood

  • @mahuubao
    @mahuubao 9 месяцев назад

    Excellent ... well done ...

  • @inglescomcremildo6803
    @inglescomcremildo6803 Год назад

    That's cool man. Thank you a bunch.

  • @malikoussama6378
    @malikoussama6378 Год назад

    Well explained 👏 👏 👏

  • @angellahnkhoma2762
    @angellahnkhoma2762 Год назад

    Best explanation 🤗

  • @AmirTalipov
    @AmirTalipov 2 месяца назад

    great, thank you!

  • @nynmlg2299
    @nynmlg2299 3 года назад

    Thank you!!

  • @gordisspegel4159
    @gordisspegel4159 3 года назад

    Thank you!

  • @itsiremm
    @itsiremm 4 месяца назад

    THANK U SO MUCH😭💙

  • @catherinesalim3173
    @catherinesalim3173 2 года назад

    Thank you so much,

  • @obscuredoblivion444
    @obscuredoblivion444 Год назад +1

    Im always so amazed how our body works.

  • @leonidalekseyev3809
    @leonidalekseyev3809 2 года назад

    Very helpful, thanks a lot! Could you resommend a good textbook or two on Biology?

  • @adelenemorrow8852
    @adelenemorrow8852 3 года назад

    Really appreciate your work! Thank you!

  • @moiez0192
    @moiez0192 2 года назад +1

    the intro killed me

  • @pranjalipranjali2751
    @pranjalipranjali2751 6 месяцев назад

    extraordinarily well

  • @medicalscience1528
    @medicalscience1528 Год назад

    Liked and subscribed 👍🏻 :)

  • @islamshihata4380
    @islamshihata4380 5 месяцев назад

    Great

  • @stevenwoldesellasie4520
    @stevenwoldesellasie4520 3 года назад

    And how is the release of calcium from the smooth ER regulated?

  • @odarissantos6538
    @odarissantos6538 2 года назад

    Around 5:36 you had mentioned that there is an increase in Potassium efflux. Did you mean Calcium Influx? I got a bit confused there.

  • @crimpers5543
    @crimpers5543 10 месяцев назад

    wow that intro

  • @matthayden1979
    @matthayden1979 Год назад

    Will calcium rich food or calcium supplement help in regenerating beta cells?

  • @tasneemaburaiya6944
    @tasneemaburaiya6944 4 года назад +6

    This really helps to make the process very clear! I have master degree presentation and this really helped me. Can you please send me references for the figures you are explaining??
    I will really appreciated
    Thank you :)

    • @CatalystUniversity
      @CatalystUniversity  4 года назад +1

      Thank you, and I'm glad it was helpful. I can't post files here, but if you type "lehninger insulin synthesis" into Google image search, you should find these images within the first 20 images in the results.

    • @tasneemaburaiya6944
      @tasneemaburaiya6944 4 года назад

      @@CatalystUniversity can I have your email if I ever have a question about anything thats rlevant to this , . I will appreciate it . Thank you and Good night

    • @saitdemir6677
      @saitdemir6677 4 года назад +1

      @@tasneemaburaiya6944 @Catalyst University she wants your email address give it to her :)

  • @zakirzak1494
    @zakirzak1494 10 месяцев назад

    ❤❤❤

  • @bio366geethasankar7
    @bio366geethasankar7 6 месяцев назад +1

    🙏

  • @medicalscience1528
    @medicalscience1528 Год назад +1

    What I really wanna know how beta cells detect or sense that there is glucose in blood ? Or glucose simply travel to beta cells by their own ? Please clear it.
    Thank you for video.

  • @akashmajeed283
    @akashmajeed283 15 дней назад

  • @AdegbiteStephen-zz8bl
    @AdegbiteStephen-zz8bl Год назад +1

    Thanks you Dr Igudia on RUclips for all you do in my life and my family. I went for a test today after taking the medication i ordered from Dr Igudia and I tested diabetes’s negative. Thanks doctor I will keep letting the world know about your good work sir.

  • @adammichaelmueller115
    @adammichaelmueller115 Год назад

    You're the fuckin man!

  • @liutasx
    @liutasx 4 года назад +2

    So not glucose, but ATP/energy status of beta cell causes to release insulin?

    • @wakylaugh
      @wakylaugh 4 года назад +1

      You need glucose to produce the ATP

    • @liutasx
      @liutasx 4 года назад

      @@wakylaugh Beta cells can use fatty and amino acids to produce ATP, not only glucose.

    • @wakylaugh
      @wakylaugh 4 года назад

      liutasx but he’s specifically talking about GLYCOLYSIS and GLUCOSE

    • @iamliam6929
      @iamliam6929 3 года назад

      @@liutasx hey idk if still relevant but, ...try to think this way , beta oxidation is not favoured in this kind of situation when u have a lot of glucose(a lot of potential energy) ..no need for further beta oxidation..i guess its a lot more complex than this but it makes sense :D

  • @mo_nicole
    @mo_nicole 4 месяца назад

    Can anyone tell me if the pancreas can suddenly stop producing insulin? I’m talking like over night or working hours? Or is it typically progressive? I’m sure many factors involved but just in general. Thank you.

  • @pedrorodrigueztube
    @pedrorodrigueztube 3 года назад +2

    So beta blockers block insulin and elevate blood glucose levels ?

    • @iamliam6929
      @iamliam6929 3 года назад +1

      hey man, idk if still relevant but... beta blockers have nothing to do with beta pancreatic cells (i understood that u linked these two)...beta blockers are antagonists of beta adrenergic receptors (beta1,2,3). Beta 2 receptor activation normally leads to glycogen breakdown in liver and glucagon release from alpha cell of pancreas (glucagon stimulates glucose synthesis) so therefore beta blockers can actually lower ur plasma glucose ...cheers

    • @pedrorodrigueztube
      @pedrorodrigueztube 3 года назад +1

      @@iamliam6929 it is said that first gen beta blockers affects all types of beta cells in all types of tissue. So by taking beta blockers you might inhibit insulin also and will lead to high glucose in blood.

    • @iamliam6929
      @iamliam6929 3 года назад

      @@pedrorodrigueztube oh okay didnt know that :) i guess i need to dig deeper :) cheers !

    • @pedrorodrigueztube
      @pedrorodrigueztube 3 года назад +1

      @@iamliam6929 Iam no expert either

  • @stevenwoldesellasie4520
    @stevenwoldesellasie4520 3 года назад +1

    Even if you have moderate inhibition of potassium channels, there must be a certain minimum amount of ATP concentration needed since depolarisation is a all or nothing mechanism.

  • @granderondeproductions3286
    @granderondeproductions3286 3 года назад

    So, what part of this process gets broken if a person has type 1 diabetes?

    • @granderondeproductions3286
      @granderondeproductions3286 3 года назад

      @Hemlock Cocktail I see. thank you for explaining that to me.

    • @josephboronka1734
      @josephboronka1734 Год назад +1

      Maybe the Insulin secretion is good enough 🤔, and the 3:44 body has all it needs , so it resists and glucose goes up , and the cell just produces more and more Insulin till it maximum out 😊

    • @brabbit1692
      @brabbit1692 11 месяцев назад

      These cells are destroyed in T1D. None of this happens because there are no cells that contain insulin since the body destroyed them.

  • @ghaziturki9756
    @ghaziturki9756 2 года назад

    🙏🙏🙏🙏🙏💜🧡💙💚❤️

  • @dimphosarah2191
    @dimphosarah2191 2 года назад

    😁

  • @ohShittttYar
    @ohShittttYar Год назад +1

    Good but I'd really like to suggest to treat ur flu, its very disturbing
    Pardon

  • @jamesscott5509
    @jamesscott5509 2 года назад +1

    J

  • @JubayerAlMahmud-IUB
    @JubayerAlMahmud-IUB 3 года назад +1

    *in **5:35** you have made a mistake. ***

  • @loritaismaili2845
    @loritaismaili2845 2 года назад +1

    It’s the GLUT1 and GLUT3 for pancreatic ß-cells, NOT GLUT2 :)

    • @Chowanana
      @Chowanana 2 года назад +6

      Not true, GLUT1 is mainly expressed in RBC and GLUT3 in neurons and sperm. GLUT2 allows glucose intake into pancreatic beta cells and hepatocytes.

  • @michellemaat2198
    @michellemaat2198 Месяц назад

    I could not listen through your sniffing

    • @dd10fc18
      @dd10fc18 Месяц назад

      learn to be grateful, these videos are free